Cyclo-oxygenase-2: pharmacology, physiology, biochemistry and relevance to NSAID therapy (Q24675327)

British Journal of Pharmacology

Europe PubMed Central

title

Cyclo-oxygenase-2: pharmacology, physiology, biochemistry and relevance to NSAID therapy (English)

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1 reference

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J A Mitchell

1

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T D Warner

series ordinal

2

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language of work or name

English

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publication date

November 1999

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published in

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volume

128

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issue

6

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page(s)

1121-32

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cites work

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30 May 2018

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30 May 2018

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30 May 2018

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30 May 2018

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30 May 2018

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30 May 2018

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Selective cyclooxygenase-2 inhibitors as potential therapeutic agents for inflammatory diseases.

30 May 2018

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Induction of cyclooxygenase 2 in gastric mucosal lesions and its inhibition by the specific antagonist delays healing in mice

30 May 2018

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Analysis of the effects of cyclooxygenase (COX)-1 and COX-2 in spinal nociceptive transmission using indomethacin, a non-selective COX inhibitor, and NS-398, a COX-2 selective inhibitor.

30 May 2018

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Expression of inducible cyclooxygenase mRNA in the mouse brain after systemic administration of bacterial lipopolysaccharide.

30 May 2018

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Differential inhibition of prostaglandin endoperoxide synthase (cyclooxygenase) isozymes by aspirin and other non-steroidal anti-inflammatory drugs.

30 May 2018

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Comparative pharmacology of endothelium-derived relaxing factor, nitric oxide and prostacyclin in platelets

30 May 2018

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PGI3 production from eicosapentaenoic acid in 3T3 fibroblast cells and cultured bovine pulmonary artery endothelial cells

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571744

The induction and suppression of prostaglandin H2 synthase (cyclooxygenase) in human monocytes

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571744

Purification of the cyclooxygenase that forms prostaglandins. Demonstration of two forms of iron in the holoenzyme

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571744

Increased expression of cyclooxygenases and peroxisome proliferator-activated receptor-gamma in Alzheimer's disease brains.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571744

Constitutive expression of cyclooxygenase-2 in rat vas deferens

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571744

The role of IP prostanoid receptors in inflammatory pain.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571744

Too many COX (cyclo-oxygenase) spoil the broth: aspirin-sensitive asthma and 5-lypoxygenase

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571744

Maturational regulation and regional induction of cyclooxygenase-2 in rat brain: implications for Alzheimer's disease.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571744

Developmental expression of the cyclo-oxygenase-1 and cyclo-oxygenase-2 genes in the peri-implantation mouse uterus and their differential regulation by the blastocyst and ovarian steroids.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571744

Aspirin and the Risk of Colorectal Cancer in Women

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571744

Regulation of cyclooxygenase-2 expression in normal human articular chondrocytes.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1571744

Cyclooxygenase-2 overexpression enhances lymphatic invasion and metastasis in human gastric carcinoma

28 November 2018

1 reference

12 December 2020

Cyclooxygenase-2 expression is up-regulated in human pancreatic cancer

1 reference

12 December 2020

Effects of specific inhibition of cyclooxygenase-2 on sodium balance, hemodynamics, and vasoactive eicosanoids

1 reference

12 December 2020

Isoprostanes and PGE2 production in human isolated pulmonary artery smooth muscle cells: concomitant and differential release

1 reference

12 December 2020

Specific inhibition of cyclooxygenase-2 with MK-0966 is associated with less gastroduodenal damage than either aspirin or ibuprofen

1 reference

12 December 2020

Update on clinical developments with celecoxib, a new specific COX-2 inhibitor: what can we expect?

1 reference

12 December 2020

Analgesic efficacy of the cyclooxygenase-2-specific inhibitor rofecoxib in post-dental surgery pain: a randomized, controlled trial

1 reference

12 December 2020

Selective COX-2 inhibitors and human inflammatory bowel disease

1 reference

12 December 2020

Identification of a pharmacologically distinct prostaglandin H synthase in cultured epithelial cells

1 reference

12 December 2020

Influence of dietary fish on eicosanoid metabolism in man

1 reference

12 December 2020

Vascular prostacyclin is increased in patients ingesting omega-3 polyunsaturated fatty acids before coronary artery bypass graft surgery

1 reference

12 December 2020

Identification of a cyclooxygenase-related gene and its potential role in prostaglandin formation

1 reference

12 December 2020

Arachidonic acid strongly stimulates prostaglandin I3 (PGI3) production from eicosapentaenoic acid in human endothelial cells

1 reference

12 December 2020

The anti-aggregating properties of vascular endothelium: interactions between prostacyclin and nitric oxide

1 reference

12 December 2020

Role of prostaglandin-mediated vasodilatation in inflammation

1 reference

12 December 2020

Cyclooxygenase-dependent formation of the isoprostane, 8-epi prostaglandin F2 alpha

1 reference

12 December 2020

Endothelin-1 induction of cyclooxygenase-2 expression in rat mesangial cells

1 reference

12 December 2020

In vivo glucocorticoids regulate cyclooxygenase-2 but not cyclooxygenase-1 in peritoneal macrophages

1 reference

12 December 2020

Purification and characterization of recombinant human cyclooxygenase-2

1 reference

12 December 2020

Regulation of cyclooxygenase-2 expression in aortic smooth muscle cells

1 reference

12 December 2020

Signal transduction pathways responsible for serotonin-mediated prostaglandin G/H synthase expression in rat mesangial cells

1 reference

12 December 2020

Purification of prostaglandin endoperoxide synthetase from bovine vesicular gland microsomes

1 reference

12 December 2020

Up-regulation of cyclooxygenase-2 mRNA in the rat spinal cord following peripheral inflammation

1 reference

12 December 2020

Expression of cyclooxygenase-2 in human and an animal model of rheumatoid arthritis

1 reference

12 December 2020

Up-regulation of cyclooxygenase-2 gene expression by chorionic gonadotropin in mucosal cells from human fallopian tubes

1 reference

12 December 2020

Induction of cyclooxygenase-2 mRNA and protein following transient focal ischemia in the rat brain

1 reference

12 December 2020

The potential role of spinal cord cyclooxygenase-2 in the development of Freund's complete adjuvant-induced changes in hyperalgesia and allodynia

1 reference

12 December 2020

Release of isoprostanes by human pulmonary artery in organ culture: a cyclo-oxygenase and nitric oxide dependent pathway

1 reference

12 December 2020

Pulsating fluid flow stimulates prostaglandin release and inducible prostaglandin G/H synthase mRNA expression in primary mouse bone cells

1 reference

12 December 2020

Renal identification of cyclooxygenase-2 in a subset of thick ascending limb cells

1 reference

12 December 2020

Induction of cyclooxygenase-2 in human saphenous vein and internal mammary artery

1 reference

12 December 2020

Risk of hospitalization for upper gastrointestinal tract bleeding associated with ketorolac, other nonsteroidal anti-inflammatory drugs, calcium antagonists, and other antihypertensive drugs

1 reference

12 December 2020

Distribution of COX-1 and COX-2 in normal and inflamed tissues

1 reference

12 December 2020

Prostanoid receptor heterogeneity through alternative mRNA splicing

1 reference

12 December 2020

Dominance of cyclooxygenase-2 in the regulation of pancreatic islet prostaglandin synthesis

1 reference

12 December 2020

Effects of cyclooxygenase-2 selective and nitric oxide-releasing nonsteroidal antiinflammatory drugs on mucosal ulcerogenic and healing responses of the stomach

1 reference

12 December 2020

Differential induction of cyclooxygenase-2 in human arterial and venous smooth muscle: role of endogenous prostanoids

1 reference

12 December 2020

Cyclooxygenase-2 as a therapeutic target

1 reference

12 December 2020

Selective inhibitors of cyclooxygenase-2: are they really effective, selective, and GI-safe?

1 reference

12 December 2020

Cyclooxygenase-2 expression in human esophageal carcinoma

1 reference

12 December 2020

Synergy between cyclo-oxygenase-2 induction and arachidonic acid supply in vivo: consequences for nonsteroidal antiinflammatory drug efficacy

1 reference

12 December 2020

Identifiers

DOI

10.1038/SJ.BJP.0702897

1 reference

1525477

1525477

1 reference

1 reference

1 reference