p21-Activated kinase 5 (Pak5) localizes to mitochondria and inhibits apoptosis by phosphorylating BAD (Q24679330)

Molecular and Cellular Biology

GOA release 2020-03-11

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Jonathan Chernoff

4

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author name string

Sophie Cotteret

series ordinal

1

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Zahara M Jaffer

series ordinal

2

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Alexander Beeser

series ordinal

3

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language of work or name

English

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publication date

August 2003

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published in

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volume

23

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issue

16

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page(s)

5526-39

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cites work

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A novel p21-activated kinase binds the actin and microtubule networks and induces microtubule stabilization

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Activation of LIM-kinase by Pak1 couples Rac/Cdc42 GTPase signalling to actin cytoskeletal dynamics

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PAK4, a novel effector for Cdc42Hs, is implicated in the reorganization of the actin cytoskeleton and in the formation of filopodia

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Expression of constitutively active alpha-PAK reveals effects of the kinase on actin and focal complexes

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Human Ste20 homologue hPAK1 links GTPases to the JNK MAP kinase pathway

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Structure of PAK1 in an autoinhibited conformation reveals a multistage activation switch

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Structure of Cdc42 bound to the GTPase binding domain of PAK

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Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery

7 April 2017

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The mechanism of PAK activation. Autophosphorylation events in both regulatory and kinase domains control activity

7 April 2017

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AR and ER interaction with a p21-activated kinase (PAK6)

7 April 2017

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Cytoskeletal changes regulated by the PAK4 serine/threonine kinase are mediated by LIM kinase 1 and cofilin

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The serine/threonine kinase PAK4 prevents caspase activation and protects cells from apoptosis

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Androgen receptor specifically interacts with a novel p21-activated kinase, PAK6

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p21-activated kinase 1 phosphorylates the death agonist bad and protects cells from apoptosis

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Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt

7 April 2017

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Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-X(L)

7 April 2017

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Characterization of the signal that directs Bcl-x(L), but not Bcl-2, to the mitochondrial outer membrane

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Temporal and spatial distribution of activated Pak1 in fibroblasts

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Bid induces the oligomerization and insertion of Bax into the outer mitochondrial membrane

7 April 2017

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p21-activated protein kinase: a crucial component of morphological signaling?

7 April 2017

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Mitochondria and apoptosis

7 April 2017

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The Ste20 group kinases as regulators of MAP kinase cascades

7 April 2017

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Emerging from the Pak: the p21-activated protein kinase family.

7 April 2017

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p21-activated kinases: three more join the Pak.

28 September 2017

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The Akt proto-oncogene links Ras to Pak and cell survival signals

28 September 2017

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A role for p21-activated kinase in endothelial cell migration.

28 September 2017

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p21-activated kinase 1 (Pak1) regulates cell motility in mammalian fibroblasts

28 September 2017

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Genetic evidence for Pak1 autoinhibition and its release by Cdc42.

28 September 2017

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Cleavage and activation of p21-activated protein kinase gamma-PAK by CPP32 (caspase 3). Effects of autophosphorylation on activity

28 September 2017

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Differential effects of PAK1-activating mutations reveal activity-dependent and -independent effects on cytoskeletal regulation

28 September 2017

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Activation of hPAK65 by caspase cleavage induces some of the morphological and biochemical changes of apoptosis

28 September 2017

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p21-activated protein kinase gamma-PAK suppresses programmed cell death of BALB3T3 fibroblasts

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=166342

Characterization of Pak2p, a pleckstrin homology domain-containing, p21-activated protein kinase from fission yeast.

30 May 2018

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Membrane and morphological changes in apoptotic cells regulated by caspase-mediated activation of PAK2

30 May 2018

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12 December 2020

Controlling cell death

1 reference

12 December 2020

Phosphorylation and inactivation of BAD by mitochondria-anchored protein kinase A

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12 December 2020

Apoptosis meets signal transduction: elimination of a BAD influence

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12 December 2020