Oxidative stress causes ERK phosphorylation and cell death in cultured retinal pigment epithelium: prevention of cell death by AG126 and 15-deoxy-delta 12, 14-PGJ2 (Q24792721)

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English	Oxidative stress causes ERK phosphorylation and cell death in cultured retinal pigment epithelium: prevention of cell death by AG126 and 15-deoxy-delta 12, 14-PGJ2	scientific article

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Oxidative stress causes ERK phosphorylation and cell death in cultured retinal pigment epithelium: prevention of cell death by AG126 and 15-deoxy-delta 12, 14-PGJ2 (English)

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phosphorylation

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based on heuristic

inferred from title

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based on heuristic

inferred from title

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based on heuristic

inferred from title

author name string

Tarun K Garg

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Jason Y Chang

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language of work or name

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publication date

21 March 2003

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BMC Ophthalmology

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3

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1

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5

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https://scigraph.springernature.com/pub.10.1186/1471-2415-3-5

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Peroxisome proliferator-activated receptor agonists prevent 25-OH-cholesterol induced c-jun activation and cell death

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SAPK2/p38-dependent F-actin reorganization regulates early membrane blebbing during stress-induced apoptosis

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ARPE-19, a human retinal pigment epithelial cell line with differentiated properties

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Differential expression and activation of a family of murine peroxisome proliferator-activated receptors

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Photoreceptor phagocytosis selectively activates PPARgamma expression in retinal pigment epithelial cells

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7 April 2017

Cyclopentenone prostaglandins suppress activation of microglia: down-regulation of inducible nitric-oxide synthase by 15-deoxy-Delta12,14-prostaglandin J2

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Formation of stable microspikes containing actin and the 55 kDa actin bundling protein, fascin, is a consequence of cell adhesion to thrombospondin-1: implications for the anti-adhesive activities of thrombospondin-1

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Tyrphostins protect neuronal cells from oxidative stress

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Density-dependent expression of FGF-2 in response to oxidative stress in RPE cells in vitro

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The actin cytoskeleton response to oxidants: from small heat shock protein phosphorylation to changes in the redox state of actin itself

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Prostaglandin-J2 induces synthesis of interleukin-8 by endothelial cells in a PPAR-gamma-independent manner

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Oxidized alkyl phospholipids are specific, high affinity peroxisome proliferator-activated receptor gamma ligands and agonists

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Chloride channel expression in cultured human fetal RPE cells: response to oxidative stress.

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Peroxisome proliferator-activated receptor-gamma ligands inhibit choroidal neovascularization

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Roles of PPARs in health and disease.

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Central role of peroxisome proliferator-activated receptors in the actions of peroxisome proliferators

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Src and Cas mediate JNK activation but not ERK1/2 and p38 kinases by reactive oxygen species

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Oxidative damage and protection of the RPE.

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Hydrogen peroxide activation of multiple mitogen-activated protein kinases in an oligodendrocyte cell line: role of extracellular signal-regulated kinase in hydrogen peroxide-induced cell death

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Use of the ARPE-19 cell line as a model of RPE polarity: basolateral secretion of FGF5.

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28 September 2017

4-Hydroxynonenal interaction with rhodopsin

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Role of lipid aldehydes in cataractogenesis: 4-hydroxynonenal-induced cataract

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Attenuation of 4-hydroxynonenal-induced cataractogenesis in rat lens by butylated hydroxytoluene

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Immunohistochemical detection of 4-hydroxynonenal protein adducts in Parkinson disease

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Immunochemical detection of 4-hydroxynonenal protein adducts in oxidized hepatocytes

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The structure-activity relationship between peroxisome proliferator-activated receptor gamma agonism and the antihyperglycemic activity of thiazolidinediones

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Evaluation of oxidative processes in human pigment epithelial cells associated with retinal outer segment phagocytosis

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The cyclopentone prostaglandin 15-deoxy-Delta(12,14) prostaglandin J2 represses nitric oxide, TNF-alpha, and IL-12 production by microglial cells

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30 May 2018

The cellular response to oxidative stress: influences of mitogen-activated protein kinase signalling pathways on cell survival

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30 May 2018

Postischemic accumulation of lipid peroxidation products in the rat brain: immunohistochemical detection of 4-hydroxy-2-nonenal modified proteins.

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30 May 2018

Novel human ocular glutathione S-transferases with high activity toward 4-hydroxynonenal.

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30 May 2018

Blue light-induced reactivity of retinal age pigment. In vitro generation of oxygen-reactive species.

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21 January 2018

UVA-induced oxidative damage in retinal pigment epithelial cells after H2O2 or sparfloxacin exposure

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21 January 2018

Hydrogen peroxide stimulates apoptosis in cultured human retinal pigment epithelial cells

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21 January 2018

Nitric oxide and cGMP regulate endothelial permeability and F-actin distribution in hydrogen peroxide-treated endothelial cells.

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21 January 2018

Prostaglandin D2 and its metabolites induce caspase-dependent granulocyte apoptosis that is mediated via inhibition of I kappa B alpha degradation using a peroxisome proliferator-activated receptor-gamma-independent mechanism

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In Alzheimer's disease, heme oxygenase is coincident with Alz50, an epitope of tau induced by 4-hydroxy-2-nonenal modification.

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4-Hydroxynonenal, an aldehydic product of membrane lipid peroxidation, impairs glutamate transport and mitochondrial function in synaptosomes.

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21 January 2018

Oxidative stress and reactive nitrogen species generation during renal ischemia

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21 January 2018

Inhibition of MAP Kinase Kinase Blocks the Differentiation of PC-12 Cells Induced by Nerve Growth Factor

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21 January 2018

Ceramide: a potential mediator of apoptosis in human retinal pigment epithelial cells

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28 November 2018

Oxidant stress in rat liver after lipopolysaccharide administration: effect of inducible nitric-oxide synthase inhibition.

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28 November 2018

The lipid peroxidation product, 4-hydroxy-2-trans-nonenal, alters the conformation of cortical synaptosomal membrane proteins.

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28 November 2018

Evidence that 4-hydroxynonenal mediates oxidative stress-induced neuronal apoptosis.

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28 November 2018

Roles of lipid peroxidation in modulation of cellular signaling pathways, cell dysfunction, and death in the nervous system

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12 December 2020

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15-Deoxy-Delta12,1412,14-prostaglandin J2 inhibits the beta2 integrin-dependent oxidative burst: involvement of a mechanism distinct from peroxisome proliferator-activated receptor gamma ligation

1 reference

https://pubmed.ncbi.nlm.nih.gov/12659653

12 December 2020

based on heuristic

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4-hydroxynonenal increases neuronal susceptibility to oxidative stress

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https://pubmed.ncbi.nlm.nih.gov/12659653

12 December 2020

based on heuristic

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Accumulation of 4-hydroxynonenal-modified proteins in hippocampal CA1 pyramidal neurons precedes delayed neuronal damage in the gerbil brain

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https://pubmed.ncbi.nlm.nih.gov/12659653

12 December 2020

based on heuristic

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4-hydroxynonenal, a lipid peroxidation product, rapidly accumulates following traumatic spinal cord injury and inhibits glutamate uptake

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Regulation of ubiquitin-conjugating enzymes by glutathione following oxidative stress

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https://pubmed.ncbi.nlm.nih.gov/12659653

12 December 2020

based on heuristic

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Cytoskeletal reorganization induced by retinoic acid treatment of human endometrial adenocarcinoma (RL95-2) cells is correlated with alterations in protein kinase C-alpha

1 reference

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12 December 2020

based on heuristic

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Formation of 4-hydroxy-2-nonenal-modified proteins in ischemic rat heart

1 reference

https://pubmed.ncbi.nlm.nih.gov/12659653

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Zinc protects against oxidative damage in cultured human retinal pigment epithelial cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/12659653

12 December 2020

based on heuristic

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Hydrogen peroxide causes significant mitochondrial DNA damage in human RPE cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/12659653

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lipid peroxidation in proliferative vitreoretinopathies

1 reference

https://pubmed.ncbi.nlm.nih.gov/12659653

12 December 2020

based on heuristic

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Induction of glutathione S-transferase hGST 5.8 is an early response to oxidative stress in RPE cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/12659653

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of the peroxisome proliferator-activated receptor-gamma (PPAR-gamma) and its natural ligand 15-deoxy-Delta12, 14-prostaglandin J2 in the regulation of microglial functions

1 reference

https://pubmed.ncbi.nlm.nih.gov/12659653

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Peroxisome proliferator-activated receptor-gamma agonist 15-deoxy-Delta(12,14)-prostaglandin J(2) ameliorates experimental autoimmune encephalomyelitis

1 reference

https://pubmed.ncbi.nlm.nih.gov/12659653

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antioxidant enzymes in the aging human retinal pigment epithelium

1 reference

https://pubmed.ncbi.nlm.nih.gov/12659653

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Metallothionein shows an age-related decrease in human macular retinal pigment epithelium

1 reference

https://pubmed.ncbi.nlm.nih.gov/12659653

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phagocytosis and H2O2 induce catalase and metallothionein gene expression in human retinal pigment epithelial cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/12659653

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of epitopes recognized by 4-hydroxy-2-nonenal specific antibodies

1 reference

https://pubmed.ncbi.nlm.nih.gov/12659653

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1186/1471-2415-3-5

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9 September 2019

https://scigraph.springernature.com/pub.10.1186/1471-2415-3-5

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