The therapeutic potential of modulators of the Hedgehog-Gli signaling pathway (Q24794932)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12437768%20AND%20SRC:MED&resulttype=core&format=json

15 December 2019

6 references

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18 July 2021

The therapeutic potential of modulators of the Hedgehog-Gli signaling pathway (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12437768%20AND%20SRC:MED&resulttype=core&format=json

15 December 2019

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11 December 2019

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18 December 2019

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22 December 2019

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23 December 2019

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26 August 2020

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17 July 2021

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18 July 2021

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12437768%20AND%20SRC:MED&resulttype=core&format=json

15 December 2019

author name string

Ariel Ruiz i Altaba

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12437768%20AND%20SRC:MED&resulttype=core&format=json

15 December 2019

language of work or name

English

0 references

publication date

6 November 2002

8 references

11 December 2019

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12437768%20AND%20SRC:MED&resulttype=core&format=json

15 December 2019

18 December 2019

22 December 2019

23 December 2019

26 August 2020

17 July 2021

18 July 2021

9 references

11 December 2019

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12437768%20AND%20SRC:MED&resulttype=core&format=json

15 December 2019

18 December 2019

22 December 2019

23 December 2019

26 August 2020

17 July 2021

18 July 2021

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12437768%20AND%20SRC:MED&resulttype=core&format=json

15 December 2019

issue

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12437768%20AND%20SRC:MED&resulttype=core&format=json

15 December 2019

page(s)

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12437768%20AND%20SRC:MED&resulttype=core&format=json

Small-molecule modulators of Hedgehog signaling: identification and characterization of Smoothened agonists and antagonists

15 December 2019

cites work

1 reference

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Small molecule modulation of Smoothened activity

7 April 2017

1 reference

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Induction of basal cell carcinomas and trichoepitheliomas in mice overexpressing GLI-1

7 April 2017

1 reference

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GLI3 mutations in human disorders mimic Drosophila cubitus interruptus protein functions and localization

7 April 2017

1 reference

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Mutations in the human Sonic Hedgehog gene cause holoprosencephaly

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=137069

Mutations in PATCHED-1, the receptor for SONIC HEDGEHOG, are associated with holoprosencephaly

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=137069

Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine

7 April 2017

1 reference

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Regulation of Gli2 and Gli3 activities by an amino-terminal repression domain: implication of Gli2 and Gli3 as primary mediators of Shh signaling

7 April 2017

1 reference

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Gli proteins encode context-dependent positive and negative functions: implications for development and disease

7 April 2017

1 reference

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Activation of the transcription factor Gli1 and the Sonic hedgehog signalling pathway in skin tumours

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=137069

The Sonic Hedgehog-Gli pathway regulates dorsal brain growth and tumorigenesis

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=137069

Altered neural cell fates and medulloblastoma in mouse patched mutants

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=137069

Prediction of central nervous system embryonal tumour outcome based on gene expression

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=137069

Identification of a small molecule inhibitor of the hedgehog signaling pathway: effects on basal cell carcinoma-like lesions.

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=137069

Pathways and consequences: Hedgehog signaling in human disease.

28 September 2017

1 reference

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Hedgehog signal transduction: recent findings

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=137069

Mutations in SUFU predispose to medulloblastoma

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=137069

Gli and hedgehog in cancer: tumours, embryos and stem cells.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=137069

Sonic hedgehog in the nervous system: functions, modifications and mechanisms

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=137069

Long-acting forms of Sonic hedgehog with improved pharmacokinetic and pharmacodynamic properties are efficacious in a nerve injury model

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=137069

Hedgehog-Gli signalling and the growth of the brain.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=137069

Intrastriatal injection of sonic hedgehog reduces behavioral impairment in a rat model of Parkinson's disease

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=137069

The teratogenic Veratrum alkaloid cyclopamine inhibits sonic hedgehog signal transduction.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=137069

Two critical periods of Sonic Hedgehog signaling required for the specification of motor neuron identity

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=137069

Basal cell carcinomas in mice overexpressing Gli2 in skin

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=137069

Mutations in the human homologue of the Drosophila segment polarity gene patched (PTCH) in sporadic basal cell carcinomas of the skin and primitive neuroectodermal tumors of the central nervous system.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=137069

Basal cell carcinomas in mice overexpressing sonic hedgehog

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=137069

Sporadic medulloblastomas contain PTCH mutations.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=137069

Induction of dopaminergic neuron phenotype in the midbrain by Sonic hedgehog protein

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=137069

Medulloblastoma growth inhibition by hedgehog pathway blockade

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=137069

Trojan peptides: the penetratin system for intracellular delivery

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=137069

Teratogen-mediated inhibition of target tissue response to Shh signaling.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=137069

Long-range sclerotome induction by sonic hedgehog: direct role of the amino-terminal cleavage product and modulation by the cyclic AMP signaling pathway

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=137069

Induction of midbrain dopaminergic neurons by Sonic hedgehog

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=137069

Sonic hedgehog promotes the survival of specific CNS neuron populations and protects these cells from toxic insult In vitro

28 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/12437768

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1186/1475-4924-1-9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12437768%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

15 December 2019

1 reference

9 September 2019

https://scigraph.springernature.com/pub.10.1186/1475-4924-1-9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12437768%20AND%20SRC:MED&resulttype=core&format=json

15 December 2019

1 reference