The docking protein Gab1 is the primary mediator of EGF-stimulated activation of the PI-3K/Akt cell survival pathway (Q24799816)

4

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author name string

Dawn R Mattoon

1

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Betty Lamothe

2

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Irit Lax

https://scigraph.springernature.com/pub.10.1186/1741-7007-2-24

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language of work or name

English

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publication date

2004

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published in

BMC Biology

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volume

2

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issue

1

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page(s)

24

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exact match

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cites work

Stimulation of phosphatidylinositol 3-kinase by fibroblast growth factor receptors is mediated by coordinated recruitment of multiple docking proteins

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Phosphotyrosines 627 and 659 of Gab1 constitute a bisphosphoryl tyrosine-based activation motif (BTAM) conferring binding and activation of SHP2

7 April 2017

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Essential role of Gab1 for signaling by the c-Met receptor in vivo

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The Gab1 PH domain is required for localization of Gab1 at sites of cell-cell contact and epithelial morphogenesis downstream from the met receptor tyrosine kinase

7 April 2017

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Grb2-associated binder-1 mediates phosphatidylinositol 3-kinase activation and the promotion of cell survival by nerve growth factor

7 April 2017

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A Grb2-associated docking protein in EGF- and insulin-receptor signalling

7 April 2017

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Identification of c-erbB-3 binding sites for phosphatidylinositol 3'-kinase and SHC using an EGF receptor/c-erbB-3 chimera

7 April 2017

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Hierarchy of binding sites for Grb2 and Shc on the epidermal growth factor receptor

7 April 2017

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Association of phosphatidylinositol kinase activity with polyoma middle-T competent for transformation

7 April 2017

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Ligand-induced, receptor-mediated dimerization and activation of EGF receptor

7 April 2017

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Gene dosage-dependent functions for phosphotyrosine-Grb2 signaling during mammalian tissue morphogenesis

7 April 2017

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A novel positive feedback loop mediated by the docking protein Gab1 and phosphatidylinositol 3-kinase in epidermal growth factor receptor signaling

7 April 2017

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Epidermal growth factor receptor: mechanisms of activation and signalling.

7 April 2017

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Receptor-specific regulation of phosphatidylinositol 3'-kinase activation by the protein tyrosine phosphatase Shp2.

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ERK negatively regulates the epidermal growth factor-mediated interaction of Gab1 and the phosphatidylinositol 3-kinase

28 September 2017

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A critical role for phosphoinositide 3-kinase upstream of Gab1 and SHP2 in the activation of ras and mitogen-activated protein kinases by epidermal growth factor.

28 September 2017

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Identification of an atypical Grb2 carboxyl-terminal SH3 domain binding site in Gab docking proteins reveals Grb2-dependent and -independent recruitment of Gab1 to receptor tyrosine kinases

28 September 2017

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Molecular mechanism for the Shp-2 tyrosine phosphatase function in promoting growth factor stimulation of Erk activity

28 September 2017

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Cloning of the rat ErbB3 cDNA and characterization of the recombinant protein

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ErbB3 is involved in activation of phosphatidylinositol 3-kinase by epidermal growth factor

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Activated type I phosphatidylinositol kinase is associated with the epidermal growth factor (EGF) receptor following EGF stimulation

28 September 2017

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The docking protein Gab1 is an essential component of an indirect mechanism for fibroblast growth factor stimulation of the phosphatidylinositol 3-kinase/Akt antiapoptotic pathway

28 September 2017

1 reference

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Gab1 is required for EGF receptor signaling and the transformation by activated ErbB2

28 September 2017

1 reference

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28 November 2018

Identifiers

DOI

10.1186/1741-7007-2-24

1 reference

Dimensions Publication ID

4723483

1002798950

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4723483

1 reference

1 reference

1 reference