Knockout and transgenic mice of Trp53: what have we learned about p53 in breast cancer? (Q24802378)

6 July 2017

4 references

3 December 2020

3 July 2022

17 February 2023

27 January 2024

Knockout and transgenic mice of Trp53: what have we learned about p53 in breast cancer? (English)

1 reference

6 July 2017

4 references

3 December 2020

3 July 2022

17 February 2023

27 January 2024

1 reference

19 September 2019

1 reference

22 October 2019

1 reference

3 December 2020

1 reference

Anneke C Blackburn

1

1 reference

6 July 2017

D Joseph Jerry

series ordinal

2

1 reference

6 July 2017

language of work or name

English

0 references

publication date

18 April 2002

11 references

6 July 2017

13 March 2019

3 April 2019

20 June 2019

17 June 2019

19 September 2019

22 October 2019

3 December 2020

3 July 2022

17 February 2023

27 January 2024

Breast Cancer Research

11 references

6 July 2017

13 March 2019

3 April 2019

20 June 2019

17 June 2019

19 September 2019

22 October 2019

3 December 2020

3 July 2022

17 February 2023

27 January 2024

4

1 reference

6 July 2017

3

1 reference

6 July 2017

101-111

1 reference

P53, apoptosis, and breast cancer

6 July 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=138724

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=138724

Tumor spectrum analysis in p53-mutant mice

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=138724

Is p53 haploinsufficient for tumor suppression? Implications for the p53+/- mouse model in carcinogenicity testing

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=138724

BRCA1-associated tumorigenesis: what have we learned from knockout mice?

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=138724

p53 induction and apoptosis in response to radio- and chemotherapy in vivo is tumor-type-dependent

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=138724

Development of spontaneous mammary tumors in BALB/c p53 heterozygous mice. A model for Li-Fraumeni syndrome

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=138724

Progesterone facilitates chromosome instability (aneuploidy) in p53 null normal mammary epithelial cells

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=138724

Conditional control of gene expression in the mammary gland

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=138724

Mutant p53 and genomic instability in a transgenic mouse model of breast cancer

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=138724

The C3(1)/SV40 T-antigen transgenic mouse model of mammary cancer: ductal epithelial cell targeting with multistage progression to carcinoma

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=138724

WAP-TAg transgenic mice and the study of dysregulated cell survival, proliferation, and mutation during breast carcinogenesis

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=138724

Regulation of p53 in response to DNA damage

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=138724

The cellular response to p53: the decision between life and death

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=138724

Conditional mutation of Brca1 in mammary epithelial cells results in blunted ductal morphogenesis and tumour formation.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=138724

Apoptosis, p53, and tumor cell sensitivity to anticancer agents

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=138724

Regulation of p53 downstream genes.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=138724

The dual role model for p53 in maintaining genomic integrity

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=138724

Retention of wild-type p53 in tumors from p53 heterozygous mice: reduction of p53 dosage can promote cancer formation

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=138724

Li-Fraumeni syndrome and the role of the p53 tumor suppressor gene in cancer susceptibility

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=138724

A farnesyltransferase inhibitor induces tumor regression in transgenic mice harboring multiple oncogenic mutations by mediating alterations in both cell cycle control and apoptosis

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=138724

Cre-mediated gene deletion in the mammary gland

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=138724

Li-Fraumeni syndrome--a molecular and clinical review

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=138724

neu/ERBB2 cooperates with p53-172H during mammary tumorigenesis in transgenic mice

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=138724

Transgenic mouse model for studying the transcriptional activity of the p53 protein: age- and tissue-dependent changes in radiation-induced activation during embryogenesis

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=138724

Increased tumor proliferation and genomic instability without decreased apoptosis in MMTV-ras mice deficient in p53

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=138724

Infrequent p53 mutations in 7,12-dimethylbenz[a]anthracene-induced mammary tumors in BALB/c and p53 hemizygous mice.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=138724

A transgenic mouse model for mammary carcinogenesis.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=138724

Reduced p53 dosage associated with mammary tumor metastases in C3(1)/TAG transgenic mice

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=138724

The MMTV/c-myc transgene and p53 null alleles collaborate to induce T-cell lymphomas, but not mammary carcinomas in transgenic mice.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=138724

Delay of dimethylbenz[a]anthracene-induced mammary tumorigenesis in transgenic mice by apoptosis induced by an unusual mutant p53 protein

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=138724

p53 mutations in breast cancer

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=138724

Synergistic tumor suppressor activity of BRCA2 and p53 in a conditional mouse model for breast cancer.

30 May 2018

1 reference

A detailed study of loss of heterozygosity on chromosome 17 in tumours from Li – Fraumeni patients carrying a mutation to the TP53 gene

21 January 2018

1 reference

The SV40 small t-antigen prevents mammary gland differentiation and induces breast cancer formation in transgenic mice; truncated large T-antigen molecules harboring the intact p53 and pRb binding region do not have this effect.

21 January 2018

1 reference

Combination therapy with interleukin-2 and wild-type p53 expressed by adenoviral vectors potentiates tumor regression in a murine model of breast cancer

21 January 2018

1 reference

Impact of ionizing radiation and genetic background on mammary tumorigenesis in p53-deficient mice.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=138724

TP53 mutations in breast cancer associated with BRCA1 or BRCA2 germ-line mutations: distinctive spectrum and structural distribution.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=138724

Germ-line mutations of TP53 in Li-Fraumeni families: an extended study of 39 families

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=138724

Tumour incidence, spectrum and ploidy in mice with a large deletion in the p53 gene

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=138724

Myc/p53 interactions in transgenic mouse mammary development, tumorigenesis and chromosomal instability

28 November 2018

1 reference

12 December 2020

p53 mutation with frequent novel condons but not a mutator phenotype in BRCA1- and BRCA2-associated breast tumours

1 reference

12 December 2020

Studies of mouse mammary glands. II. Cytomorphology of mammary transplants in inguinal fat pads, nipple-excised host glands, and whole mammary-gland transplants

1 reference

12 December 2020

Mammary tumor formation in p53- and BRCA1-deficient mice

1 reference

12 December 2020

Heterozygosity of p21WAF1/CIP1 enhances tumor cell proliferation and cyclin D1-associated kinase activity in a murine mammary cancer model

1 reference

12 December 2020

Delayed involution of the mammary epithelium in BALB/c-p53null mice

1 reference

12 December 2020

Cooperative interaction between mutant p53 and des(1-3)IGF-I accelerates mammary tumorigenesis

1 reference

12 December 2020

A transgenic mouse model for the ductal carcinoma in situ (DCIS) of the mammary gland

1 reference

12 December 2020

A mammary-specific model demonstrates the role of the p53 tumor suppressor gene in tumor development

1 reference

12 December 2020

Genetic determinants of response to chemotherapy in transgenic mouse mammary and salivary tumors

1 reference

12 December 2020

Cytoplasmic sequestration and functional repression of p53 in the mammary epithelium is reversed by hormonal treatment

1 reference

12 December 2020

Differential gene expression in mouse mammary adenocarcinomas in the presence and absence of wild type p53

1 reference

12 December 2020

Apoptosis or retinoblastoma: alternative fates of photoreceptors expressing the HPV-16 E7 gene in the presence or absence of p53

1 reference

12 December 2020

Preferential overexpression of a 172Arg-->Leu mutant p53 in the mammary gland of transgenic mice results in altered lobuloalveolar development

1 reference

12 December 2020

Deficiency of p53 accelerates mammary tumorigenesis in Wnt-1 transgenic mice and promotes chromosomal instability

1 reference

12 December 2020

Androgen suppressed apoptosis is modified in p53 deficient mice

1 reference

12 December 2020

A mutant p53 transgene accelerates tumour development in heterozygous but not nullizygous p53-deficient mice

1 reference

12 December 2020

Effects of genetic background on tumorigenesis in p53-deficient mice

1 reference

12 December 2020

SV40 T-antigen induces breast cancer formation with a high efficiency in lactating and virgin WAP-SV-T transgenic animals but with a low efficiency in ovariectomized animals

1 reference

12 December 2020

Apoptosis and remodeling of mammary gland tissue during involution proceeds through p53-independent pathways

1 reference

12 December 2020

Absence of p53 in a mouse mammary tumor model promotes tumor cell proliferation without affecting apoptosis

1 reference

12 December 2020

Breast cancer formation in transgenic animals induced by the whey acidic protein SV40 T antigen (WAP-SV-T) hybrid gene

1 reference

12 December 2020

p53-dependent apoptosis suppresses tumor growth and progression in vivo

1 reference

12 December 2020

Identifiers

DOI

10.1186/BCR427

1 reference

Dimensions Publication ID

6 July 2017

0 references

1 reference

6 July 2017

1 reference