Regulation of p53 in response to DNA damage (Q33807801)

29 July 2017

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title

Regulation of p53 in response to DNA damage (English)

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29 July 2017

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N D Lakin

1

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29 July 2017

S P Jackson

series ordinal

2

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29 July 2017

language of work or name

English

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publication date

1 December 1999

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29 July 2017

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29 July 2017

18

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29 July 2017

53

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29 July 2017

7644-7655

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https://scigraph.springernature.com/pub.10.1038/sj.onc.1203015

29 July 2017

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cites work

Phosphorylation of p53 protein in response to ionizing radiation occurs at multiple sites in both normal and DNA-PK deficient cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203015

7 January 2021

DNA damage and the DNA-activated protein kinase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203015

7 January 2021

Regulation of p53 function and stability by phosphorylation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203015

7 January 2021

Recruitment of p300/CBP in p53-dependent signal pathways

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203015

7 January 2021

Enhanced phosphorylation of p53 by ATM in response to DNA damage

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203015

7 January 2021

mdm2 expression is induced by wild type p53 activity

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203015

7 January 2021

Characterization of the tumor suppressor protein p53 as a protein kinase C substrate and a S100b-binding protein

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203015

7 January 2021

The Schizosaccharomyces pombe rad3 checkpoint gene

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203015

7 January 2021

Human p53 is phosphorylated by p60-cdc2 and cyclin B-cdc2

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203015

7 January 2021

A human homologue of the checkpoint kinase Cds1 directly inhibits Cdc25 phosphatase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203015

7 January 2021

DNA damage induced p53 stabilization: no indication for an involvement of p53 phosphorylation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203015

7 January 2021

DNA damage triggers DRB-resistant phosphorylation of human p53 at the CK2 site

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203015

7 January 2021

p53 is required for both radiation-induced differentiation and rescue of V(D)J rearrangement in scid mouse thymocytes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203015

7 January 2021

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203015

7 January 2021

p53-dependent apoptosis and transcription of p21waf/cip1/sdi1 in SCID mice following gamma-irradiation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203015

7 January 2021

Activation of the ATM kinase by ionizing radiation and phosphorylation of p53

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203015

7 January 2021

The hMre11/hRad50 protein complex and Nijmegen breakage syndrome: linkage of double-strand break repair to the cellular DNA damage response

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203015

7 January 2021

Interactions between p53 and MDM2 in a mammalian cell cycle checkpoint pathway

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203015

7 January 2021

Chk1 complements the G2/M checkpoint defect and radiosensitivity of ataxia-telangiectasia cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203015

7 January 2021

cDNA cloning and gene mapping of a candidate human cell cycle checkpoint protein

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203015

7 January 2021

Overexpression of a kinase-inactive ATR protein causes sensitivity to DNA-damaging agents and defects in cell cycle checkpoints

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203015

7 January 2021

Transcriptional activation by p53 correlates with suppression of growth but not transformation.

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1203015

7 January 2021

DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203015

7 January 2021

Molecular cloning and functional analysis of the adenovirus E1A-associated 300-kD protein (p300) reveals a protein with properties of a transcriptional adaptor

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203015

7 January 2021

Association of p300 and CBP with simian virus 40 large T antigen

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203015

7 January 2021

DNA repair: The Nijmegen breakage syndrome protein

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203015

7 January 2021

Nuclear export is required for degradation of endogenous p53 by MDM2 and human papillomavirus E6

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203015

7 January 2021

The DNA damage response in DNA-dependent protein kinase-deficient SCID mouse cells: replication protein A hyperphosphorylation and p53 induction.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203015

7 January 2021

Participation of the human p53 3'UTR in translational repression and activation following gamma-irradiation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203015

7 January 2021

Mdm2 association with p53 targets its ubiquitination

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1203015

7 January 2021

Localization of an ataxia-telangiectasia gene to chromosome 11q22-23.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203015

7 January 2021

The complexity of p53 modulation: emerging patterns from divergent signals

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1203015

7 January 2021

The DNA-dependent protein kinase: requirement for DNA ends and association with Ku antigen

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203015

7 January 2021

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203015

7 January 2021

Histone acetylation in chromatin structure and transcription

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203015

7 January 2021

Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1203015

7 January 2021

Synergistic activation of transcription by CBP and p53

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1203015

7 January 2021

Growth retardation and leaky SCID phenotype of Ku70-deficient mice.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203015

7 January 2021

V(D)J recombination activates a p53-dependent DNA damage checkpoint in scid lymphocyte precursors.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203015

7 January 2021

Phosphorylation of p53 at the casein kinase II site selectively regulates p53-dependent transcriptional repression but not transactivation

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1203015

7 January 2021

Wild-type p53 adopts a 'mutant'-like conformation when bound to DNA.

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1203015

7 January 2021

Mdm2 promotes the rapid degradation of p53

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1203015

7 January 2021

14-3-3sigma is a p53-regulated inhibitor of G2/M progression

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203015

7 January 2021

Responses to DNA damage and regulation of cell cycle checkpoints by the ATM protein kinase family

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203015

7 January 2021

Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203015

7 January 2021

Sensitivity and selectivity of the DNA damage sensor responsible for activating p53-dependent G1 arrest

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1203015

7 January 2021

Allosteric activation of latent p53 tetramers

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1203015

7 January 2021

Regulation of the specific DNA binding function of p53

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1203015

7 January 2021

Small peptides activate the latent sequence-specific DNA binding function of p53.

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1203015

7 January 2021

Activation of p53 sequence-specific DNA binding by short single strands of DNA requires the p53 C-terminus

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1203015

7 January 2021

Nijmegen breakage syndrome cells fail to induce the p53-mediated DNA damage response following exposure to ionizing radiation

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1203015

7 January 2021

Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203015

7 January 2021

Functional activation of p53 via phosphorylation following DNA damage by UV but not gamma radiation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203015

7 January 2021

A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203015

7 January 2021

The Atr and Atm protein kinases associate with different sites along meiotically pairing chromosomes.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203015

7 January 2021

ATM associates with and phosphorylates p53: mapping the region of interaction

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203015

7 January 2021

p53: puzzle and paradigm

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203015

7 January 2021

p53 is phosphorylated by CDK7-cyclin H in a p36MAT1-dependent manner

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203015

7 January 2021

Histone acetylases and deacetylases in cell proliferation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203015

7 January 2021

Regulation of p53 stability by Mdm2

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203015

7 January 2021

Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203015

7 January 2021

Phosphorylation of p53 serine 15 increases interaction with CBP

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1203015

7 January 2021

p53 and its 14 kDa C-terminal domain recognize primary DNA damage in the form of insertion/deletion mismatches

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203015

7 January 2021

Human cells contain a DNA-activated protein kinase that phosphorylates simian virus 40 T antigen, mouse p53, and the human Ku autoantigen

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203015

7 January 2021

Human DNA-activated protein kinase phosphorylates serines 15 and 37 in the amino-terminal transactivation domain of human p53.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203015

7 January 2021

p53, the cellular gatekeeper for growth and division

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203015

7 January 2021

Binding and modulation of p53 by p300/CBP coactivators

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203015

7 January 2021

Several hydrophobic amino acids in the p53 amino-terminal domain are required for transcriptional activation, binding to mdm-2 and the adenovirus 5 E1B 55-kD protein

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203015

7 January 2021

p53 sites acetylated in vitro by PCAF and p300 are acetylated in vivo in response to DNA damage

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203015

7 January 2021

Differential induction of transcriptionally active p53 following UV or ionizing radiation: defects in chromosome instability syndromes?

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203015

7 January 2021

Ultraviolet radiation, but not gamma radiation or etoposide-induced DNA damage, results in the phosphorylation of the murine p53 protein at serine-389

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203015

7 January 2021

Ubiquitination of p53 and p21 is differentially affected by ionizing and UV radiation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203015

7 January 2021

UV Irradiation Stimulates Levels of p53 Cellular Tumor Antigen in Nontransformed Mouse Cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203015

7 January 2021

Linkage of ATM to cell cycle regulation by the Chk2 protein kinase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203015

7 January 2021

Positional cloning of the gene for Nijmegen breakage syndrome

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203015

7 January 2021

Radiation induction of p53 in cells from Nijmegen breakage syndrome is defective but not similar to ataxia-telangiectasia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203015

7 January 2021

The novel ATM-related protein TRRAP is an essential cofactor for the c-Myc and E2F oncoproteins

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203015

7 January 2021

p53 protein stability in tumour cells is not determined by mutation but is dependent on Mdm2 binding.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203015

7 January 2021

p53 is phosphorylated in vitro and in vivo by an ultraviolet radiation-induced protein kinase characteristic of the c-Jun kinase, JNK1.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203015

7 January 2021

The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203015

7 January 2021

Negative feedback regulation of wild-type p53 biosynthesis.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203015

7 January 2021

Identification of an additional negative regulatory region for p53 sequence-specific DNA binding

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203015

7 January 2021

Mutations in the p53 and SCID genes cooperate in tumorigenesis.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203015

7 January 2021

Requirement for Ku80 in growth and immunoglobulin V(D)J recombination

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203015

7 January 2021

Amplification of a gene encoding a p53-associated protein in human sarcomas

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203015

7 January 2021

Oncoprotein MDM2 conceals the activation domain of tumour suppressor p53

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203015

7 January 2021

The mdm-2 gene is induced in response to UV light in a p53-dependent manner

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203015

7 January 2021

Signaling to p53: breaking the MDM2-p53 circuit

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203015

7 January 2021

ATM: from gene to function

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203015

7 January 2021

DNA damage activates p53 through a phosphorylation-acetylation cascade

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203015

7 January 2021

Tra1p is a component of the yeast Ada.Spt transcriptional regulatory complexes.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203015

7 January 2021

A single ataxia telangiectasia gene with a product similar to PI-3 kinase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203015

7 January 2021

Restoration of the growth suppression function of mutant p53 by a synthetic peptide derived from the p53 C-terminal domain

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203015

7 January 2021

DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203015

7 January 2021

DNA damage-inducible phosphorylation of p53 at N-terminal sites including a novel site, Ser20, requires tetramerization

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203015

7 January 2021

DNA damage induces phosphorylation of the amino terminus of p53

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203015

7 January 2021

The transforming and suppressor functions of p53 alleles: effects of mutations that disrupt phosphorylation, oligomerization and nuclear translocation.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203015

7 January 2021

The DNA-dependent protein kinase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203015

7 January 2021

Adenovirus E1A proteins inhibit activation of transcription by p53.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203015

7 January 2021

Regulation of the sequence-specific DNA binding function of p53 by protein kinase C and protein phosphatases

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203015

7 January 2021

Nucleocytoplasmic shuttling of oncoprotein Hdm2 is required for Hdm2-mediated degradation of p53

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203015

7 January 2021

A role for ATR in the DNA damage-induced phosphorylation of p53

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203015

7 January 2021

Signalling through the lipid products of phosphoinositide-3-OH kinase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203015

7 January 2021

Critical role for Ser20 of human p53 in the negative regulation of p53 by Mdm2.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203015

7 January 2021

Nibrin, a novel DNA double-strand break repair protein, is mutated in Nijmegen breakage syndrome

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203015

7 January 2021

The 400 kDa subunit of the PCAF histone acetylase complex belongs to the ATM superfamily

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203015

7 January 2021

Phosphorylation sites in the amino-terminal region of mouse p53

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203015

7 January 2021

Increased and altered DNA binding of human p53 by S and G2/M but not G1 cyclin-dependent kinases

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203015

7 January 2021

ATM-dependent activation of p53 involves dephosphorylation and association with 14-3-3 proteins

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203015

7 January 2021

DNA-dependent protein kinase acts upstream of p53 in response to DNA damage

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203015

7 January 2021

Protein kinase mutants of human ATR increase sensitivity to UV and ionizing radiation and abrogate cell cycle checkpoint control

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203015

7 January 2021

The p53-mdm-2 autoregulatory feedback loop

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1203015

7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1203015

1 reference

Dimensions Publication ID

29 July 2017

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1 reference