Navigating the Chemical Space of Multitarget-Directed Ligands: From Hybrids to Fragments in Alzheimer's Disease (Q26748936)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6273289&resulttype=core&format=json

13 May 2020

1 reference

cholinesterase inhibitors

1 reference

30 January 2021

Maria Laura Bolognesi

series ordinal

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27070562%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

Federica Prati

series ordinal

1

1 reference

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3 June 2020

author name string

Andrea Cavalli

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27070562%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

language of work or name

English

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publication date

2016

0 references

8 April 2016

1 reference

30 January 2021

2 references

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3 June 2020

30 January 2021

21

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3 June 2020

issue

4

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3 June 2020

page(s)

466

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Creative Commons Attribution

3 June 2020

copyright license

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30 January 2021

0 references

The efficiency of multi-target drugs: the network approach might help drug design

1 reference

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Network pharmacology: the next paradigm in drug discovery

21 January 2018

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Network medicine: a network-based approach to human disease

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New approaches to treating Alzheimer's disease

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1 reference

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Multi-target-directed ligands to combat neurodegenerative diseases

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A small molecule targeting the multifactorial nature of Alzheimer's disease.

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Polypharmacology in a single drug: multitarget drugs

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Can we rationally design promiscuous drugs?

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Designing multiple ligands - medicinal chemistry strategies and challenges

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From magic bullets to designed multiple ligands

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Molecular complexity and its impact on the probability of finding leads for drug discovery

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The role of fragment-based and computational methods in polypharmacology.

21 January 2018

1 reference

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Fragments, network biology and designing multiple ligands

21 January 2018

1 reference

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Recent advances in the development of hybrid molecules/designed multiple compounds with antiamnesic properties

21 January 2018

1 reference

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Dual inhibitors of β-amyloid aggregation and acetylcholinesterase as multi-target anti-Alzheimer drug candidates

21 January 2018

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Designing drugs with multi-target activity: the next step in the treatment of neurodegenerative disorders

21 January 2018

1 reference

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Recent advances in the multitarget-directed ligands approach for the treatment of Alzheimer's disease.

21 January 2018

1 reference

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Multi-Target-Directed Ligands and other Therapeutic Strategies in the Search of a Real Solution for Alzheimer's Disease

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Recent development of multifunctional agents as potential drug candidates for the treatment of Alzheimer's disease.

21 January 2018

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From Bitopic Inhibitors to Multitarget Drugs for the Future Treatment of Alzheimer's Disease.

21 January 2018

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Combining galantamine and memantine in multitargeted, new chemical entities potentially useful in Alzheimer's disease

21 January 2018

1 reference

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Combination therapy for Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21040466

Memantine and cholinesterase inhibitors: complementary mechanisms in the treatment of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21040466

Inhibition of acetylcholinesterase, beta-amyloid aggregation, and NMDA receptors in Alzheimer's disease: a promising direction for the multi-target-directed ligands gold rush

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21040466

Bivalent beta-carbolines as potential multitarget anti-Alzheimer agents

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21040466

NR2B-containing NMDA receptors expression and their relationship to apoptosis in hippocampus of Alzheimer's disease-like rats

21 January 2018

1 reference

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Allosteric modulators of NR2B-containing NMDA receptors: molecular mechanisms and therapeutic potential

21 January 2018

1 reference

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The NMDA receptor NR2B subunit: a valid therapeutic target for multiple CNS pathologies

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21040466

Multi-target design strategies in the context of Alzheimer's disease: acetylcholinesterase inhibition and NMDA receptor antagonism as the driving forces

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21040466

Galantamine potentiates the neuroprotective effect of memantine against NMDA-induced excitotoxicity.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMOLECULES21040466

Acetylcholinesterase inhibitors used in treatment of Alzheimer's disease prevent glutamate neurotoxicity via nicotinic acetylcholine receptors and phosphatidylinositol 3-kinase cascade

21 January 2018

1 reference

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Novel 8-Hydroxyquinoline Derivatives as Multitarget Compounds for the Treatment of Alzheimer's Disease

21 January 2018

1 reference

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Copper, iron and zinc in Alzheimer's disease senile plaques

21 January 2018

1 reference

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Histochemically-reactive zinc in amyloid plaques, angiopathy, and degenerating neurons of Alzheimer's diseased brains

21 January 2018

1 reference

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Alzheimer's disease amyloid-beta binds copper and zinc to generate an allosterically ordered membrane-penetrating structure containing superoxide dismutase-like subunits

21 January 2018

1 reference

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The redox chemistry of the Alzheimer's disease amyloid beta peptide.

21 January 2018

1 reference

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Evidence that the beta-amyloid plaques of Alzheimer's disease represent the redox-silencing and entombment of abeta by zinc

21 January 2018

1 reference

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Rapid restoration of cognition in Alzheimer's transgenic mice with 8-hydroxy quinoline analogs is associated with decreased interstitial Abeta

21 January 2018

1 reference

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Treatment with a copper-zinc chelator markedly and rapidly inhibits beta-amyloid accumulation in Alzheimer's disease transgenic mice.

21 January 2018

1 reference

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Genetic or pharmacological iron chelation prevents MPTP-induced neurotoxicity in vivo: a novel therapy for Parkinson's disease

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Clioquinol down-regulates mutant huntingtin expression in vitro and mitigates pathology in a Huntington's disease mouse model

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8-Hydroxyquinolines: a review of their metal chelating properties and medicinal applications

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Novel tacrine-8-hydroxyquinoline hybrids as multifunctional agents for the treatment of Alzheimer's disease, with neuroprotective, cholinergic, antioxidant, and copper-complexing properties

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21 January 2018

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Investigations of the molecular mechanism of metal-induced Abeta (1-40) amyloidogenesis

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1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27070562

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

The physicochemical challenges of designing multiple ligands

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27070562

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.3390/MOLECULES21040466

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27070562%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27070562%20AND%20SRC:MED&resulttype=core&format=json

3 June 2020

PubMed publication ID

27070562

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27070562%20AND%20SRC:MED&resulttype=core&format=json