Small-Molecule Inhibitors of GSK-3: Structural Insights and Their Application to Alzheimer's Disease Models (Q36128825)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22888461%20AND%20SRC:MED&resulttype=core&format=json

11 February 2020

title

Small-Molecule Inhibitors of GSK-3: Structural Insights and Their Application to Alzheimer's Disease Models (English)

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11 February 2020

0 references

2

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11 February 2020

author name string

Thomas Kramer

series ordinal

1

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11 February 2020

Fabio Lo Monte

series ordinal

3

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publication date

22 July 2012

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International journal of Alzheimer's disease

11 February 2020

published in

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11 February 2020

volume

2012

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11 February 2020

page(s)

381029

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Creative Commons Attribution 3.0 Unported

11 February 2020

copyright license

start time

1 January 2012

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April 2022 Public Data File from Crossref

copyright status

copyrighted

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April 2022 Public Data File from Crossref

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2 July 2018

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First non-ATP competitive glycogen synthase kinase 3 beta (GSK-3beta) inhibitors: thiadiazolidinones (TDZD) as potential drugs for the treatment of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F381029

Lithium inhibits caspase 3 activation and dephosphorylation of PKB and GSK3 induced by K+ deprivation in cerebellar granule cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F381029

3-Anilino-4-arylmaleimides: potent and selective inhibitors of glycogen synthase kinase-3 (GSK-3).

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F381029

Substituted 3-imidazo[1,2-a]pyridin-3-yl- 4-(1,2,3,4-tetrahydro-[1,4]diazepino-[6,7,1-hi]indol-7-yl)pyrrole-2,5-diones as highly selective and potent inhibitors of glycogen synthase kinase-3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F381029

Synthesis and discovery of macrocyclic polyoxygenated bis-7-azaindolylmaleimides as a novel series of potent and highly selective glycogen synthase kinase-3beta inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F381029

Macrocyclic bisindolylmaleimides as inhibitors of protein kinase C and glycogen synthase kinase-3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F381029

Structure-based design leads to the identification of lithium mimetics that block mania-like effects in rodents. possible new GSK-3beta therapies for bipolar disorders.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F381029

Absolute Configuration of Staurosporine By X-Ray Analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F381029

Indirubins inhibit glycogen synthase kinase-3 beta and CDK5/p25, two protein kinases involved in abnormal tau phosphorylation in Alzheimer's disease. A property common to most cyclin-dependent kinase inhibitors?

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F381029

Structural basis for the synthesis of indirubins as potent and selective inhibitors of glycogen synthase kinase-3 and cyclin-dependent kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F381029

Synthesis and kinase inhibitory activity of novel substituted indigoids.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F381029

Intracellular Targets of Paullones. Identification following affinity purification on immobilized inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F381029

1-Azakenpaullone is a selective inhibitor of glycogen synthase kinase-3 beta

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F381029

5-aryl-pyrazolo[3,4-b]pyridazines: potent inhibitors of glycogen synthase kinase-3 (GSK-3).

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F381029

6-aryl-pyrazolo[3,4-b]pyridines: potent inhibitors of glycogen synthase kinase-3 (GSK-3).

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F381029

6-heteroaryl-pyrazolo[3,4-b]pyridines: potent and selective inhibitors of glycogen synthase kinase-3 (GSK-3).

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F381029

Efficacy of a novel, orally active GSK-3 inhibitor 6-Methyl-N-[3-[[3-(1-methylethoxy)propyl]carbamoyl]-1H-pyrazol-4-yl]pyridine-3-carboxamide in tau transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F381029

4-Acylamino-6-arylfuro[2,3-d]pyrimidines: potent and selective glycogen synthase kinase-3 inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F381029

Rational design of 4-amino-5,6-diaryl-furo[2,3-d]pyrimidines as potent glycogen synthase kinase-3 inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F381029

Synthesis and in vitro characterization of 1-(4-aminofurazan-3-yl)-5-dialkylaminomethyl-1H-[1,2,3]triazole-4-carboxylic acid derivatives. A new class of selective GSK-3 inhibitors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F381029

4-(Benzimidazol-2-yl)-1,2,5-oxadiazol-3-ylamine derivatives: potent and selective p70S6 kinase inhibitors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F381029

A novel glycogen synthase kinase-3 inhibitor 2-methyl-5-(3-{4-[(S )-methylsulfinyl]phenyl}-1-benzofuran-5-yl)-1,3,4-oxadiazole decreases tau phosphorylation and ameliorates cognitive deficits in a transgenic model of Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F381029

Novel 9-oxo-thiazolo[5,4-f]quinazoline-2-carbonitrile derivatives as dual cyclin-dependent kinase 1 (CDK1)/glycogen synthase kinase-3 (GSK-3) inhibitors: synthesis, biological evaluation and molecular modeling studies.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F381029

Propentofylline attenuates tau hyperphosphorylation in Alzheimer's Swedish mutant model Tg2576.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F381029

Structural features underlying selective inhibition of GSK3β by dibromocantharelline: implications for rational drug design

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F381029

Structural basis for the GSK-3beta binding affinity and selectivity against CDK-2 of 1-(4-aminofurazan-3yl)-5-dialkylaminomethyl-1H-[1,2,3] triazole-4-carboxylic acid derivatives

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F381029

Characterization of a double (amyloid precursor protein-tau) transgenic: tau phosphorylation and aggregation

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F381029

Accelerated amyloid deposition, neurofibrillary degeneration and neuronal loss in double mutant APP/tau transgenic mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F381029

Stress-induced hyperphosphorylation of tau in the mouse brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F381029

Lithium inhibits stress-induced changes in tau phosphorylation in the mouse hippocampus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F381029

Developmental expression and localization of glycogen synthase kinase-3beta in rat brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F381029

Distribution of tau protein kinase I/glycogen synthase kinase-3beta, phosphatases 2A and 2B, and phosphorylated tau in the developing rat brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F381029

Tau and GSK3beta dephosphorylations are required for regulating Pin1 phosphorylation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F381029

Effects of a glycogen synthase kinase-3 inhibitor, lithium, in adenomatous polyposis coli mutant mice.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3408674

Selective loss of glycogen synthase kinase-3α in birds reveals distinct roles for GSK-3 isozymes in tau phosphorylation

23 September 2018

1 reference

https://api.crossref.org/works/10.1155%2F2012%2F381029

5-aryl-pyrazolo[3,4-b]pyridines: potent inhibitors of glycogen synthase kinase-3 (GSK-3)

21 January 2018

1 reference

12 December 2020

An organometallic inhibitor for glycogen synthase kinase 3

1 reference

12 December 2020

Discovery of novel, potent, selective, and orally active human glucagon receptor antagonists containing a pyrazole core

1 reference

12 December 2020

Transgenic zebrafish as a novel animal model to study tauopathies and other neurodegenerative disorders in vivo

1 reference

12 December 2020

New potent antihyperglycemic agents in db/db mice: synthesis and structure-activity relationship studies of (4-substituted benzyl) (trifluoromethyl)pyrazoles and -pyrazolones

1 reference

12 December 2020

The protein kinase C inhibitors bisindolylmaleimide I (GF 109203x) and IX (Ro 31-8220) are potent inhibitors of glycogen synthase kinase-3 activity

1 reference

12 December 2020

Identifiers

DOI

10.1155/2012/381029

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22888461%20AND%20SRC:MED&resulttype=core&format=json

11 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22888461%20AND%20SRC:MED&resulttype=core&format=json

11 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22888461%20AND%20SRC:MED&resulttype=core&format=json