Phosphodiesterase-5 Inhibitors: Action on the Signaling Pathways of Neuroinflammation, Neurodegeneration, and Cognition (Q26771954)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26770022%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

author name string

Christina Alves Peixoto

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26770022%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

Ana Karolina Santana Nunes

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26770022%20AND%20SRC:MED&resulttype=core&format=json

Mediators of Inflammation

10 June 2020

language of work or name

English

0 references

publication date

2015

0 references

3 December 2015

5 references

20 August 2019

27 September 2019

2 October 2019

25 January 2021

25 October 2022

6 references

20 August 2019

27 September 2019

2 October 2019

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26770022%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

25 January 2021

25 October 2022

2015

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26770022%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

page(s)

940207

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26770022%20AND%20SRC:MED&resulttype=core&format=json

Creative Commons Attribution 4.0 International

10 June 2020

copyright license

5 references

20 August 2019

27 September 2019

2 October 2019

25 January 2021

Synthesis of quinoline derivatives: discovery of a potent and selective phosphodiesterase 5 inhibitor for the treatment of Alzheimer's disease

25 October 2022

0 references

1 reference

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7 April 2017

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1 reference

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1 reference

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1 reference

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7 April 2017

1 reference

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7 April 2017

1 reference

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7 April 2017

1 reference

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1 reference

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1 reference

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7 April 2017

1 reference

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7 April 2017

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7 April 2017

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7 April 2017

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7 April 2017

1 reference

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Inhibitor of nuclear factor-kappaB induction by cAMP antagonizes interleukin-1-induced human macrophage-colony-stimulating-factor expression

7 April 2017

1 reference

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Postsynaptic cAMP pathway gates early LTP in hippocampal CA1 region

7 April 2017

1 reference

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7 April 2017

1 reference

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7 April 2017

1 reference

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7 April 2017

1 reference

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S100B in brain damage and neurodegeneration

7 April 2017

1 reference

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7 April 2017

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1 reference

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The molecular biology of memory storage: a dialogue between genes and synapses

7 April 2017

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Synaptic pruning by microglia is necessary for normal brain development

7 April 2017

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Neuroinflammation in Parkinson's disease: a target for neuroprotection?

7 April 2017

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The blood-brain barrier in health and chronic neurodegenerative disorders

7 April 2017

1 reference

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7 April 2017

1 reference

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7 April 2017

1 reference

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Oligodendrocytes: biology and pathology

25 May 2017

1 reference

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25 May 2017

1 reference

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28 September 2017

1 reference

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28 September 2017

1 reference

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Demyelination as a rational therapeutic target for ischemic or traumatic brain injury

28 September 2017

1 reference

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28 September 2017

1 reference

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28 September 2017

1 reference

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28 September 2017

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28 September 2017

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28 September 2017

1 reference

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28 September 2017

1 reference

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28 September 2017

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28 September 2017

1 reference

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28 September 2017

1 reference

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Phosphodiesterases as therapeutic targets for Huntington's disease

28 September 2017

1 reference

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28 September 2017

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28 September 2017

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28 September 2017

1 reference

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28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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Decreased oligodendrocyte nuclear diameter in Alzheimer's disease and Lewy body dementia

28 September 2017

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28 September 2017

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Oxidative stress and β-amyloid protein in Alzheimer's disease

28 September 2017

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Cyclic AMP: a selective modulator of NF-κB action.

28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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HMGB1 acts on microglia Mac1 to mediate chronic neuroinflammation that drives progressive neurodegeneration.

28 September 2017

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Sildenafil attenuates LPS-induced pro-inflammatory responses through down-regulation of intracellular ROS-related MAPK/NF-κB signaling pathways in N9 microglia

28 September 2017

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Antigen presentation in EAE: role of microglia, macrophages and dendritic cells

28 September 2017

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White matter damage and cognitive impairment after traumatic brain injury.

28 September 2017

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Regulation of tau pathology by the microglial fractalkine receptor

28 September 2017

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Early oligodendrocyte/myelin pathology in Alzheimer's disease mice constitutes a novel therapeutic target

28 September 2017

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28 September 2017

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Preclinical Alzheimer disease: brain oxidative stress, Abeta peptide and proteomics

28 September 2017

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Cyclooxygenase-2 expression in oligodendrocytes increases sensitivity to excitotoxic death

28 September 2017

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28 September 2017

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Cyclic GMP and nitric oxide synthase in aging and Alzheimer's disease.

28 September 2017

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28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4681825

Experimental models for analysis of oligodendrocyte pathophysiology in stroke

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4681825

Reduced NO-cGMP signaling contributes to vascular inflammation and insulin resistance induced by high-fat feeding.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4681825

Inflammation in neurodegenerative disorders: friend or foe?

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4681825

Structural and ultrastructural analysis of cerebral cortex, cerebellum, and hypothalamus from diabetic rats

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4681825

Regulate axon branching by the cyclic GMP pathway via inhibition of glycogen synthase kinase 3 in dorsal root ganglion sensory neurons.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4681825

Astrocytes and the regulation of cerebral blood flow

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4681825

Evidence for a cytokine model of cognitive function

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4681825

Macroscopic brain architecture changes and white matter pathology in acromegaly: a clinicoradiological study

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4681825

The NO-cGMP-PKG signaling pathway regulates synaptic plasticity and fear memory consolidation in the lateral amygdala via activation of ERK/MAP kinase

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4681825

Role of phosphodiesterase 5 in synaptic plasticity and memory

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4681825

Selective phosphodiesterase inhibitors: a promising target for cognition enhancement.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4681825

New therapeutic targets in the neurovascular pathway in Alzheimer's disease

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4681825

A vicious cycle involving release of heat shock protein 60 from injured cells and activation of toll-like receptor 4 mediates neurodegeneration in the CNS.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4681825

Differential regulation of central nervous system autoimmunity by T(H)1 and T(H)17 cells.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4681825

New concepts in the mechanism of ammonia-induced astrocyte swelling

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4681825

Two-photon imaging of astrocytic Ca2+ signaling and the microvasculature in experimental mice models of Alzheimer's disease

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4681825

Microtubule-associated protein tau as a therapeutic target in neurodegenerative disease

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4681825

Microglial control of neuronal death and synaptic properties

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4681825

cAMP-responsive element binding protein mediates a cGMP/protein kinase G-dependent anti-apoptotic signal induced by nitric oxide in retinal neuro-glial progenitor cells

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4681825

Oligodendrocyte cell death in pathogenesis of multiple sclerosis: Protection of oligodendrocytes from apoptosis by complement

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4681825

Molecular mechanisms involved in T cell migration across the blood-brain barrier.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4681825

Diabetes and mitochondrial function: role of hyperglycemia and oxidative stress.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4681825

Protein tyrosine nitration in hyperammonemia and hepatic encephalopathy

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4681825

Study of the localization of iron, ferritin, and hemosiderin in Alzheimer's disease hippocampus by analytical microscopy at the subcellular level.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4681825

Involvement of glutaredoxin-1 and thioredoxin-1 in beta-amyloid toxicity and Alzheimer's disease.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4681825

A negative feedback mechanism involving nitric oxide and nuclear factor kappa-B modulates endothelial nitric oxide synthase transcription

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4681825

Cyclic GMP metabolism and its role in brain physiology.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4681825

Reactive oxygen and nitrogen species: weapons of neuronal destruction in models of Parkinson's disease

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4681825

Involvement of cAMP in neuronal survival and axonal regeneration

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4681825

Regulating filopodial dynamics through actin-depolymerizing factor/cofilin

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4681825

Adenosine and cAMP are potent inhibitors of the NF-kappa B pathway downstream of immunoreceptors

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4681825

Persistent improvement in synaptic and cognitive functions in an Alzheimer mouse model after rolipram treatment

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4681825

Serotonin and neurogenesis in the hippocampal dentate gyrus of adult mammals.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4681825

Phosphodiesterase type 5 inhibition improves early memory consolidation of object information

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4681825

Antiinflammatory activity of soluble guanylate cyclase: cGMP-dependent down-regulation of P-selectin expression and leukocyte recruitment.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4681825

Requirements for passage of T lymphocytes across non-inflamed retinal microvessels

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4681825

Astrocyte-mediated control of cerebral microcirculation

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4681825

Proteomic identification of nitrated proteins in Alzheimer's disease brain

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4681825

Sildenafil (Viagra) induces neurogenesis and promotes functional recovery after stroke in rats

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4681825

Involvement of cyclic GMP and protein kinase G in the regulation of apoptosis and survival in neural cells

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4681825

Alpha4-integrin-VCAM-1 binding mediates G protein-independent capture of encephalitogenic T cell blasts to CNS white matter microvessels

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4681825

Transcription-dependent and -independent control of neuronal survival by the PI3K-Akt signaling pathway

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4681825

Molecular mechanisms and Th1/Th2 pathways in corticosteroid regulation of cytokine production

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4681825

Mini-review: in vivo neurogenesis in the adult brain: regulation and functional implications

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4681825

Microglial response to brain injury: a brief synopsis

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4681825

Nitric oxide signaling contributes to late-phase LTP and CREB phosphorylation in the hippocampus.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4681825

Different training procedures recruit either one or two critical periods for contextual memory consolidation, each of which requires protein synthesis and PKA.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4681825

Cyclic GMP phosphodiesterase-5: target of sildenafil

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4681825

Cross talk between ERK and PKA is required for Ca2+ stimulation of CREB-dependent transcription and ERK nuclear translocation.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4681825

Regulation of gene expression by cyclic GMP-dependent protein kinase requires nuclear translocation of the kinase: identification of a nuclear localization signal

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4681825

NO honey, I don't remember

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4681825

Inhibition of NF-kappaB DNA binding by nitric oxide

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4681825

Injection of the cAMP-responsive element into the nucleus of Aplysia sensory neurons blocks long-term facilitation

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4681825

Neurotrophic protein S100 beta stimulates glial cell proliferation

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4681825

Effects of aldose reductase inhibitors on the progression of nerve fiber damage in diabetic neuropathy

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4681825

Glutamine Synthetase: Glial Localization in Brain

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4681825

Regulation of gene expression by cGMP-dependent protein kinase. Transactivation of the c-fos promoter

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4681825

A novel phosphodiesterase-5 Inhibitor: Yonkenafil modulates neurogenesis, gliosis to improve cognitive function and ameliorates amyloid burden in an APP/PS1 transgenic mice model.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4681825

Sildenafil (Viagra) protective effects on neuroinflammation: the role of iNOS/NO system in an inflammatory demyelination model

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4681825

Cyclic AMP response element-binding protein (CREB) phosphorylation: a mechanistic marker in the development of memory enhancing Alzheimer's disease therapeutics

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4681825

Phosphodiesterase-5 is a therapeutic target for peripheral neuropathy in diabetic mice

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4681825

Cilostazol prevents amyloid β peptide(25-35)-induced memory impairment and oxidative stress in mice

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4681825

Defective insulin signaling pathway and increased glycogen synthase kinase-3 activity in the brain of diabetic mice: parallels with Alzheimer's disease and correction by insulin

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4681825

Brain CD8+ and cytotoxic T lymphocytes are associated with, and may be specific for, human immunodeficiency virus type 1 encephalitis in patients with acquired immunodeficiency syndrome

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4681825

Critical role of nitric oxide-cGMP cascade in the formation of cAMP-dependent long-term memory

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4681825

NMDA receptors are expressed in oligodendrocytes and activated in ischaemia.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4681825

The role of astrocytes in the development of hepatic encephalopathy

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4681825

Inhibition of endothelial vascular cell adhesion molecule-1 expression by nitric oxide involves the induction and nuclear translocation of IkappaBalpha.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4681825

Effects of cAMP simulate a late stage of LTP in hippocampal CA1 neurons.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4681825

Role of guanylyl cyclase and cGMP-dependent protein kinase in long-term potentiation.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4681825

Spatially resolved dynamics of cAMP and protein kinase A subunits in Aplysia sensory neurons.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4681825

Reduced nitric oxide responsive soluble guanylyl cyclase activity in the superior temporal cortex of patients with Alzheimer's disease.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4681825

Blockade of long-term potentiation in rat hippocampal CA1 region by inhibitors of protein synthesis.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4681825

Memory impairment during prolonged training in mice given inhibitors of cerebral protein synthesis

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4681825

mRNA expression patterns of the cGMP‐hydrolyzing phosphodiesterases types 2, 5, and 9 during development of the rat brain

31 May 2018

1 reference

https://api.crossref.org/works/10.1155%2F2015%2F940207

Role of iNOS-NO-cGMP signaling in modulation of inflammatory and myelination processes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2015%2F940207

Phosphodiesterase type 5 (PDE5) inhibition improves object recognition memory: indications for central and peripheral mechanisms.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2015%2F940207

Phosphodiesterase 5 inhibition improves synaptic function, memory, and amyloid-beta load in an Alzheimer's disease mouse model.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2015%2F940207

Tadalafil crosses the blood-brain barrier and reverses cognitive dysfunction in a mouse model of AD.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2015%2F940207

The induction of ICAM-1 in human cerebromicrovascular endothelial cells (HCEC) by ischemia-like conditions promotes enhanced neutrophil/HCEC adhesion.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2015%2F940207

Evaluation of a novel kit for the rapid detection of extended-spectrum beta-lactamases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2015%2F940207

Astrocytic and microglial response in experimentally induced diabetic rat brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2015%2F940207

Hippocampal neuronal apoptosis in type 1 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2015%2F940207

The neurotoxic effect of astrocytes activated with toll-like receptor ligands.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2015%2F940207

Secretion of interleukin-1beta by astrocytes mediates endothelin-1 and tumour necrosis factor-alpha effects on human brain microvascular endothelial cell permeability.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2015%2F940207

What is the blood-brain barrier (not)?

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2015%2F940207

Circulating monocytic cells infiltrate layers of anterograde axonal degeneration where they transform into microglia

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2015%2F940207

CXCR4-activated astrocyte glutamate release via TNFalpha: amplification by microglia triggers neurotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2015%2F940207

Identification and quantification of oligodendrocyte precursor cells in multiple system atrophy, progressive supranuclear palsy and Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2015%2F940207

Intranasal insulin prevents cognitive decline, cerebral atrophy and white matter changes in murine type I diabetic encephalopathy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2015%2F940207

Cognitive dysfunction and hippocampal changes in experimental type 1 diabetes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2015%2F940207

Danshensu ameliorates the cognitive decline in streptozotocin-induced diabetic mice by attenuating advanced glycation end product-mediated neuroinflammation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2015%2F940207

Neurodegeneration in streptozotocin-induced diabetic rats is attenuated by treatment with resveratrol

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2015%2F940207

Dynamic changes in myelin aberrations and oligodendrocyte generation in chronic amyloidosis in mice and men.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2015%2F940207

Interleukin-1 regulates proliferation and differentiation of oligodendrocyte progenitor cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2015%2F940207

Role of phosphodiesterase 3 in NO/cGMP-mediated antiinflammatory effects in vascular smooth muscle cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2015%2F940207

ANP inhibits TNF-alpha-induced endothelial MCP-1 expression--involvement of p38 MAPK and MKP-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2015%2F940207

Adiponectin suppresses IkappaB kinase activation induced by tumor necrosis factor-alpha or high glucose in endothelial cells: role of cAMP and AMP kinase signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2015%2F940207

Functional recovery in aged and young rats after embolic stroke: treatment with a phosphodiesterase type 5 inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2015%2F940207

Tadalafil, a long-acting type 5 phosphodiesterase isoenzyme inhibitor, improves neurological functional recovery in a rat model of embolic stroke.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2015%2F940207

Tadalafil enhances the neuroprotective effects of ischemic postconditioning in mice, probably in a nitric oxide associated manner.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2015%2F940207

Effect of vardenafil on cerebral vasospasm following experimental subarachnoid hemorrhage in rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2015%2F940207

Chronic administration of Sildenafil improves markers of endothelial function in men with Type 2 diabetes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2015%2F940207

Endothelial dysfunction markers as a therapeutic target for Sildenafil treatment and effects on metabolic control in type 2 diabetes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2015%2F940207

Phosphodiesterase-5 inhibitor tadalafil attenuates oxidative stress and protects against myocardial ischemia/reperfusion injury in type 2 diabetic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2015%2F940207

PDE5 inhibitors in diabetic peripheral neuropathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2015%2F940207

Modulatory effect of the PDE-5 inhibitor sildenafil in diabetic neuropathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2015%2F940207

Oxidative stress in skeletal muscle stimulates early expression of Rad in a mouse model of amyotrophic lateral sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2015%2F940207

Increased oxidative stress is related to disease severity in the ALS motor cortex: A PET study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2015%2F940207

Phosphodiesterase inhibitors are neuroprotective to cultured spinal motor neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2015%2F940207

Long-term memory deficits in Huntington's disease are associated with reduced CBP histone acetylase activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2015%2F940207

Beneficial effects of rolipram in the R6/2 mouse model of Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2015%2F940207

Sildenafil protects against 3-nitropropionic acid neurotoxicity through the modulation of calpain, CREB, and BDNF.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2015%2F940207

Sildenafil (Viagra®) down regulates cytokines and prevents demyelination in a cuprizone-induced MS mouse model.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2015%2F940207

Phosphodiesterase 5 inhibition at disease onset prevents experimental autoimmune encephalomyelitis progression through immunoregulatory and neuroprotective actions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2015%2F940207

Activity-dependent long-term enhancement of transmitter release by presynaptic 3',5'-cyclic GMP in cultured hippocampal neurons.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2015%2F940207

Time-dependent involvement of cAMP and cGMP in consolidation of object memory: studies using selective phosphodiesterase type 2, 4 and 5 inhibitors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2015%2F940207

Phosphodiesterase inhibitors enhance object memory independent of cerebral blood flow and glucose utilization in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2015%2F940207

Inhibition of phosphodiesterase-5 rescues age-related impairment of synaptic plasticity and memory

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2015%2F940207

Sildenafil ameliorates cognitive deficits and tau pathology in a senescence-accelerated mouse model.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2015%2F940207

Effects of daily low-dose treatment with phosphodiesterase type 5 inhibitor on cognition, depression, somatization and erectile function in patients with erectile dysfunction: a double-blind, placebo-controlled study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2015%2F940207

Effects of repeated dosing with Udenafil (Zydena) on cognition, somatization and erection in patients with erectile dysfunction: a pilot study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2015%2F940207

Icariin, a phosphodiesterase-5 inhibitor, improves learning and memory in APP/PS1 transgenic mice by stimulation of NO/cGMP signalling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2015%2F940207

Amyloid-beta peptide inhibits activation of the nitric oxide/cGMP/cAMP-responsive element-binding protein pathway during hippocampal synaptic plasticity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2015%2F940207

Beta-amyloid peptides decrease soluble guanylyl cyclase expression in astroglial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2015%2F940207

Decreased levels of guanosine 3', 5'-monophosphate (cGMP) in cerebrospinal fluid (CSF) are associated with cognitive decline and amyloid pathology in Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2015%2F940207

Sildenafil Decreases BACE1 and Cathepsin B Levels and Reduces APP Amyloidogenic Processing in the SAMP8 Mouse.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2015%2F940207

Icariin decreases both APP and Aβ levels and increases neurogenesis in the brain of Tg2576 mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2015%2F940207

Effect of phosphodiesterase-5 inhibition on apoptosis and beta amyloid load in aged mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2015%2F940207

The ANP-cGMP-protein kinase G pathway induces a phagocytic phenotype but decreases inflammatory gene expression in microglial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2015%2F940207

Sildenafil (Viagra) ameliorates clinical symptoms and neuropathology in a mouse model of multiple sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2015%2F940207

α4-integrin-VCAM-1 binding mediates G protein–independent capture of encephalitogenic T cell blasts to CNS white matter microvessels

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2015%2F940207

A mouse model for eukaryotic translation initiation factor 2B-leucodystrophy reveals abnormal development of brain white matter

21 January 2018

1 reference

https://api.crossref.org/works/10.1155%2F2015%2F940207

S100 protein family and its application in clinical practice

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4681825

Ryanodine receptors contribute to cGMP-induced late-phase LTP and CREB phosphorylation in the hippocampus

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4681825

Aging modulates nitric oxide synthesis and cGMP levels in hippocampus and cerebellum. Effects of amyloid beta peptide.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4681825

Immunohistochemical localization of cGMP-binding cGMP-specific phosphodiesterase (PDE5) in rat tissues

28 November 2018

1 reference

PubMed

12 December 2020

Leukocyte-endothelial cell interactions in nitric oxide synthase-deficient mice

1 reference

PubMed

12 December 2020

1 reference

12 December 2020

Effect of endotoxin on permeability of bovine cerebral endothelial cell layers in vitro

1 reference

PubMed

12 December 2020

Identifiers

DOI

10.1155/2015/940207

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26770022%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26770022%20AND%20SRC:MED&resulttype=core&format=json

10 June 2020

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26770022%20AND%20SRC:MED&resulttype=core&format=json