To edit or not to edit: regulation of ADAR editing specificity and efficiency (Q26776422)

Wiley interdisciplinary reviews. RNA

PubMed

published in

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Transfer RNA modifications: nature's combinatorial chemistry playground.

PubMed

volume

7

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issue

1

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page(s)

113-27

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cites work

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Site-selective versus promiscuous A-to-I editing

21 January 2018

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Adenosine-to-inosine RNA editing

21 January 2018

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Functions and mechanisms of RNA editing

21 January 2018

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A-to-I RNA editing occurs at over a hundred million genomic sites, located in a majority of human genes

21 January 2018

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Stress-induced Apoptosis Associated with Null Mutation of ADAR1 RNA Editing Deaminase Gene

21 January 2018

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Point mutation in an AMPA receptor gene rescues lethality in mice deficient in the RNA-editing enzyme ADAR2

21 January 2018

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A-to-I pre-mRNA editing in Drosophila is primarily involved in adult nervous system function and integrity

21 January 2018

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RNA editing by ADARs is important for normal behavior in Caenorhabditis elegans

21 January 2018

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The snoRNA HBII-52 regulates alternative splicing of the serotonin receptor 2C

21 January 2018

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Hippocampus-specific deficiency in RNA editing of GluA2 in Alzheimer's disease.

21 January 2018

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Deficient RNA editing of GluR2 and neuronal death in amyotropic lateral sclerosis

21 January 2018

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Underediting of glutamate receptor GluR-B mRNA in malignant gliomas

21 January 2018

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RNA editing in RHOQ promotes invasion potential in colorectal cancer

21 January 2018

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Adenosine-to-inosine RNA editing mediated by ADARs in esophageal squamous cell carcinoma

21 January 2018

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Functions and regulation of RNA editing by ADAR deaminases

21 January 2018

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ADAR editing in double-stranded UTRs and other noncoding RNA sequences

21 January 2018

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ADAR enzyme and miRNA story: a nucleotide that can make the difference.

21 January 2018

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Adenosine deaminases acting on RNA (ADARs) are both antiviral and proviral

21 January 2018

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A-to-I RNA editing: effects on proteins key to neural excitability

21 January 2018

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Down-regulation of RNA editing in pediatric astrocytomas: ADAR2 editing activity inhibits cell migration and proliferation

21 January 2018

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Blockage of Ca(2+)-permeable AMPA receptors suppresses migration and induces apoptosis in human glioblastoma cells

21 January 2018

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RNA editing of the GLI1 transcription factor modulates the output of Hedgehog signaling

21 January 2018

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Recoding RNA editing of AZIN1 predisposes to hepatocellular carcinoma

21 January 2018

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Human coding RNA editing is generally nonadaptive

21 January 2018

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Analysis of intron sequences reveals hallmarks of circular RNA biogenesis in animals

21 January 2018

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Circular RNAs in the Mammalian Brain Are Highly Abundant, Conserved, and Dynamically Expressed.

21 January 2018

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Inosine exists in mRNA at tissue-specific levels and is most abundant in brain mRNA

21 January 2018

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Deciphering the functions and regulation of brain-enriched A-to-I RNA editing

21 January 2018

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ADAR1 regulates ARHGAP26 gene expression through RNA editing by disrupting miR-30b-3p and miR-573 binding

21 January 2018

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Redirection of silencing targets by adenosine-to-inosine editing of miRNAs

21 January 2018

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Noise in gene expression: origins, consequences, and control

21 January 2018

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One hundred million adenosine-to-inosine RNA editing sites: hearing through the noise

21 January 2018

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Mammalian conserved ADAR targets comprise only a small fragment of the human editosome

21 January 2018

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RNA-interacting proteins act as site-specific repressors of ADAR2-mediated RNA editing and fluctuate upon neuronal stimulation

21 January 2018

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The dsRBP and inactive editor ADR-1 utilizes dsRNA binding to regulate A-to-I RNA editing across the C. elegans transcriptome

21 January 2018

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Altered adenosine-to-inosine RNA editing in human cancer

21 January 2018

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A-to-G hypermutation in the genome of lymphocytic choriomeningitis virus

21 January 2018

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Editing of HIV-1 RNA by the double-stranded RNA deaminase ADAR1 stimulates viral infection

21 January 2018

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ADAR1 is essential for the maintenance of hematopoiesis and suppression of interferon signaling

21 January 2018

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RNA editing by ADAR1 prevents MDA5 sensing of endogenous dsRNA as nonself

21 January 2018

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The RNA-editing enzyme ADAR1 controls innate immune responses to RNA.

21 January 2018

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A third member of the RNA-specific adenosine deaminase gene family, ADAR3, contains both single- and double-stranded RNA binding domains

21 January 2018

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Expression and regulation by interferon of a double-stranded-RNA-specific adenosine deaminase from human cells: evidence for two forms of the deaminase

21 January 2018

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RNA-regulated interaction of transportin-1 and exportin-5 with the double-stranded RNA-binding domain regulates nucleocytoplasmic shuttling of ADAR1

21 January 2018

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Nucleocytoplasmic distribution of human RNA-editing enzyme ADAR1 is modulated by double-stranded RNA-binding domains, a leucine-rich export signal, and a putative dimerization domain.

21 January 2018

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Coordination of editing and splicing of glutamate receptor pre-mRNA

21 January 2018

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Characterization and comparison of human nuclear and cytosolic editomes

21 January 2018

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Modulation of RNA editing by functional nucleolar sequestration of ADAR2

21 January 2018

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Dynamic association of RNA-editing enzymes with the nucleolus

21 January 2018

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Pin1 and WWP2 regulate GluR2 Q/R site RNA editing by ADAR2 with opposing effects

21 January 2018

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Editing of glutamate receptor B subunit ion channel RNAs by four alternatively spliced DRADA2 double-stranded RNA adenosine deaminases

21 January 2018

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Regulation of alternative splicing by RNA editing

21 January 2018

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RNA editing by ADAR2 is metabolically regulated in pancreatic islets and beta-cells.

21 January 2018

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RED2, a brain-specific member of the RNA-specific adenosine deaminase family

21 January 2018

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Biochemical analysis and scanning force microscopy reveal productive and nonproductive ADAR2 binding to RNA substrates

21 January 2018

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ADAR2 A-->I editing: site selectivity and editing efficiency are separate events

21 January 2018

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Editing independent effects of ADARs on the miRNA/siRNA pathways

21 January 2018

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ADAR1 forms a complex with Dicer to promote microRNA processing and RNA-induced gene silencing

21 January 2018

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Effects of ADARs on small RNA processing pathways in C. elegans

21 January 2018

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Chimeric double-stranded RNA-specific adenosine deaminase ADAR1 proteins reveal functional selectivity of double-stranded RNA-binding domains from ADAR1 and protein kinase PKR.

21 January 2018

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Substrate-dependent contribution of double-stranded RNA-binding motifs to ADAR2 function

21 January 2018

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In vitro analysis of the binding of ADAR2 to the pre-mRNA encoding the GluR-B R/G site

21 January 2018

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The Solution Structure of the ADAR2 dsRBM-RNA Complex Reveals a Sequence-Specific Readout of the Minor Groove

21 January 2018

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Structure and specific RNA binding of ADAR2 double-stranded RNA binding motifs

21 January 2018

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The binding selectivity of ADAR2's dsRBMs contributes to RNA-editing selectivity

21 January 2018

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Alu elements shape the primate transcriptome by cis-regulation of RNA editing

21 January 2018

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A distant cis acting intronic element induces site-selective RNA editing.

21 January 2018

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Suppression of APOBEC3-mediated restriction of HIV-1 by Vif

21 January 2018

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Dynamic profiling of double-stranded RNA binding proteins

21 January 2018

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ATP-independent diffusion of double-stranded RNA binding proteins

21 January 2018

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Genome-wide analysis of A-to-I RNA editing by single-molecule sequencing in Drosophila.

21 January 2018

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Noncoding regions of C. elegans mRNA undergo selective adenosine to inosine deamination and contain a small number of editing sites per transcript

21 January 2018

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Specificity of ADAR-mediated RNA editing in newly identified targets

21 January 2018

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Substrate recognition by ADAR1 and ADAR2

21 January 2018

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Mechanistic insights into editing-site specificity of ADARs

21 January 2018

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RNA-Seq analysis identifies a novel set of editing substrates for human ADAR2 present in Saccharomyces cerevisiae

21 January 2018

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Recognition of duplex RNA by the deaminase domain of the RNA editing enzyme ADAR2

21 January 2018

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Predicting sites of ADAR editing in double-stranded RNA.

21 January 2018

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Extra double-stranded RNA binding domain (dsRBD) in a squid RNA editing enzyme confers resistance to high salt environment

21 January 2018

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Systematic identification of abundant A-to-I editing sites in the human transcriptome

21 January 2018

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Structural Requirements for RNA Editing in Glutamate Receptor Pre-mRNAs by Recombinant Double-stranded RNA Adenosine Deaminase

21 January 2018

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Tertiary structural elements determine the extent and specificity of messenger RNA editing

21 January 2018

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Consistent levels of A-to-I RNA editing across individuals in coding sequences and non-conserved Alu repeats

21 January 2018

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Identification of widespread ultra-edited human RNAs.

21 January 2018

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A genome-wide map of hyper-edited RNA reveals numerous new sites

21 January 2018

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The majority of transcripts in the squid nervous system are extensively recoded by A-to-I RNA editing

21 January 2018

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Regulation of serotonin-2C receptor G-protein coupling by RNA editing

21 January 2018

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The emerging role of RNA editing in plasticity

21 January 2018

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RNA editing underlies temperature adaptation in K+ channels from polar octopuses

21 January 2018

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Dynamic response of RNA editing to temperature in Drosophila.

21 January 2018

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A developmentally regulated activity that unwinds RNA duplexes

21 January 2018

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Large-scale mRNA sequencing determines global regulation of RNA editing during brain development.

21 January 2018

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Altered A-to-I RNA editing in human embryogenesis

21 January 2018

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Spatio-temporal regulation of ADAR editing during development in porcine neural tissues

21 January 2018

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RNA editome in rhesus macaque shaped by purifying selection

21 January 2018

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A novel tissue-specific alternatively spliced form of the A-to-I RNA editing enzyme ADAR2.

21 January 2018

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Adenosine to inosine editing by ADAR2 requires formation of a ternary complex on the GluR-B R/G site

21 January 2018

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RNA binding-independent dimerization of adenosine deaminases acting on RNA and dominant negative effects of nonfunctional subunits on dimer functions

21 January 2018

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Altered G protein-coupling functions of RNA editing isoform and splicing variant serotonin2C receptors

21 January 2018

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An adenosine deaminase that generates inosine at the wobble position of tRNAs

21 January 2018

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Ca2+-permeable AMPA receptors regulate growth of human glioblastoma via Akt activation

21 January 2018

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Spatio-temporal profiling of Filamin A RNA-editing reveals ADAR preferences and high editing levels outside neuronal tissues

21 January 2018

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Tat-dependent adenosine-to-inosine modification of wild-type transactivation response RNA.

21 January 2018

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Hepatitis delta virus RNA editing is highly specific for the amber/W site and is suppressed by hepatitis delta antigen

21 January 2018

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ADAR2-mediated editing of RNA substrates in the nucleolus is inhibited by C/D small nucleolar RNAs

21 January 2018

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Synthetic substrate analogs for the RNA-editing adenosine deaminase ADAR-2.

21 January 2018

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Mice with altered serotonin 2C receptor RNA editing display characteristics of Prader-Willi syndrome

21 January 2018

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Preferential selection of adenosines for modification by double-stranded RNA adenosine deaminase.

21 January 2018

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7 January 2021

Substitutional A‐to‐I RNA editing

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7 January 2021

The importance of internal loops within RNA substrates of ADAR1

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7 January 2021

An unwinding activity that covalently modifies its double-stranded RNA substrate

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7 January 2021

Double-stranded RNA adenosine deaminases ADAR1 and ADAR2 have overlapping specificities

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7 January 2021

RNA hyperediting and alternative splicing of hematopoietic cell phosphatase (PTPN6) gene in acute myeloid leukemia

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7 January 2021

Aberrant alternative splicing pattern of ADAR2 downregulates adenosine-to-inosine editing in glioma

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7 January 2021

Identifiers

DOI

10.1002/WRNA.1319

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Consolidated OpenCitations Corpus – April 2017

1 reference

Consolidated OpenCitations Corpus – April 2017

PubMed publication ID

26612708

1 reference

Consolidated OpenCitations Corpus – April 2017