The spatiotemporal regulation of the Keap1-Nrf2 pathway and its importance in cellular bioenergetics (Q26778368)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26551700%20AND%20SRC:MED&resulttype=core&format=json

29 February 2020

title

The spatiotemporal regulation of the Keap1-Nrf2 pathway and its importance in cellular bioenergetics (English)

1 reference

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29 February 2020

author

Albena Dinkova-Kostova

1

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29 February 2020

Kira Holmström

3

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29 February 2020

Andrey Y. Abramov

5

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29 February 2020

author name string

Liam Baird

2

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29 February 2020

Colin J Meyer

4

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29 February 2020

language of work or name

English

0 references

publication date

3 August 2015

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Biochemical Society Transactions

29 February 2020

published in

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29 February 2020

volume

43

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29 February 2020

issue

4

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29 February 2020

page(s)

602-610

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A diet rich in high-glucoraphanin broccoli interacts with genotype to reduce discordance in plasma metabolite profiles by modulating mitochondrial function

29 February 2020

cites work

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Glutathione peroxidase 2, the major cigarette smoke-inducible isoform of GPX in lungs, is regulated by Nrf2

7 April 2017

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7 April 2017

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Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2

7 April 2017

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Hereditary early-onset Parkinson's disease caused by mutations in PINK1

7 April 2017

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Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain

7 April 2017

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7 April 2017

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7 April 2017

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Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants

7 April 2017

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Topical application of the synthetic triterpenoid RTA 408 activates Nrf2 and induces cytoprotective genes in rat skin

7 April 2017

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Mechanism of chemical activation of Nrf2

7 April 2017

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Bioenergetic consequences of PINK1 mutations in Parkinson disease

7 April 2017

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PGAM5 tethers a ternary complex containing Keap1 and Nrf2 to mitochondria

7 April 2017

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An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements

7 April 2017

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The Keap1-BTB protein is an adaptor that bridges Nrf2 to a Cul3-based E3 ligase: oxidative stress sensing by a Cul3-Keap1 ligase

7 April 2017

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Protection against electrophile and oxidant stress by induction of the phase 2 response: fate of cysteines of the Keap1 sensor modified by inducers

7 April 2017

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Keap1-null mutation leads to postnatal lethality due to constitutive Nrf2 activation

7 April 2017

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Sulforaphane treatment of autism spectrum disorder (ASD).

7 April 2017

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Deficits in bioenergetics and impaired immune response in granulocytes from children with autism

28 September 2017

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Monitoring Keap1-Nrf2 interactions in single live cells

28 September 2017

1 reference

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The Nrf2 regulatory network provides an interface between redox and intermediary metabolism

28 September 2017

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Nrf2 affects the efficiency of mitochondrial fatty acid oxidation.

28 September 2017

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Regulation of the human thioredoxin gene promoter and its key substrates: a study of functional and putative regulatory elements.

28 September 2017

1 reference

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Regulatory flexibility in the Nrf2-mediated stress response is conferred by conformational cycling of the Keap1-Nrf2 protein complex

28 September 2017

1 reference

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Nrf2 impacts cellular bioenergetics by controlling substrate availability for mitochondrial respiration.

28 September 2017

1 reference

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KEAP1 is a redox sensitive target that arbitrates the opposing radiosensitive effects of parthenolide in normal and cancer cells

28 September 2017

1 reference

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Toward clinical application of the Keap1-Nrf2 pathway

28 September 2017

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The indirect antioxidant sulforaphane protects against thiopurine-mediated photooxidative stress

28 September 2017

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Dopamine induced neurodegeneration in a PINK1 model of Parkinson's disease

28 September 2017

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Activation of mitochondrial biogenesis by heme oxygenase-1-mediated NF-E2-related factor-2 induction rescues mice from lethal Staphylococcus aureus sepsis

28 September 2017

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Beneficial role of Nrf2 in regulating NADPH generation and consumption

28 September 2017

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Keap1 perceives stress via three sensors for the endogenous signaling molecules nitric oxide, zinc, and alkenals

28 September 2017

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Different susceptibility to the Parkinson's toxin MPTP in mice lacking the redox master regulator Nrf2 or its target gene heme oxygenase-1

28 September 2017

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Electrophilic tuning of the chemoprotective natural product sulforaphane.

28 September 2017

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Genetic analysis of cytoprotective functions supported by graded expression of Keap1

28 September 2017

1 reference

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Nrf2: friend or foe for chemoprevention?

28 September 2017

1 reference

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PINK1-associated Parkinson's disease is caused by neuronal vulnerability to calcium-induced cell death

28 September 2017

1 reference

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Nrf2-mediated neuroprotection in the MPTP mouse model of Parkinson's disease: Critical role for the astrocyte

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4613514

Heme oxygenase-1 regulates cardiac mitochondrial biogenesis via Nrf2-mediated transcriptional control of nuclear respiratory factor-1

28 September 2017

1 reference

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Two-site substrate recognition model for the Keap1-Nrf2 system: a hinge and latch mechanism

28 September 2017

1 reference

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PGAM5, a Bcl-XL-interacting protein, is a novel substrate for the redox-regulated Keap1-dependent ubiquitin ligase complex

28 September 2017

1 reference

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Modifying specific cysteines of the electrophile-sensing human Keap1 protein is insufficient to disrupt binding to the Nrf2 domain Neh2

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4613514

Transcriptional regulation of thioredoxin reductase 1 expression by cadmium in vascular endothelial cells: role of NF-E2-related factor-2.

28 September 2017

1 reference

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Identification of the NF-E2-related factor-2-dependent genes conferring protection against oxidative stress in primary cortical astrocytes using oligonucleotide microarray analysis

28 September 2017

1 reference

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Electrophile response element-mediated induction of the cystine/glutamate exchange transporter gene expression

28 September 2017

1 reference

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Powerful and prolonged protection of human retinal pigment epithelial cells, keratinocytes, and mouse leukemia cells against oxidative damage: the indirect antioxidant effects of sulforaphane

28 September 2017

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Regulation of gamma-glutamylcysteine synthetase subunit gene expression by the transcription factor Nrf2.

28 September 2017

1 reference

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Nrf2 regulates ROS production by mitochondria and NADPH oxidase

28 September 2017

1 reference

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SKN-1 and Nrf2 couples proline catabolism with lipid metabolism during nutrient deprivation

31 May 2018

1 reference

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Targeting Nrf2-mediated gene transcription by extremely potent synthetic triterpenoids attenuate dopaminergic neurotoxicity in the MPTP mouse model of Parkinson's disease

31 May 2018

1 reference

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Nrf2 redirects glucose and glutamine into anabolic pathways in metabolic reprogramming.

31 May 2018

1 reference

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Highly potent activation of Nrf2 by topical tricyclic bis(cyano enone): implications for protection against UV radiation during thiopurine therapy.

28 November 2018

1 reference

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NRF2 blockade suppresses colon tumor angiogenesis by inhibiting hypoxia-induced activation of HIF-1α.

28 November 2018

1 reference

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The cap'n'collar transcription factor Nrf2 mediates both intrinsic resistance to environmental stressors and an adaptive response elicited by chemopreventive agents that determines susceptibility to electrophilic xenobiotics

28 November 2018

1 reference

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In vivo modulation of the Parkinsonian phenotype by Nrf2.

28 November 2018

1 reference

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Dimerization of substrate adaptors can facilitate cullin-mediated ubiquitylation of proteins by a "tethering" mechanism: a two-site interaction model for the Nrf2-Keap1 complex.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4613514

Keap1, the sensor for electrophiles and oxidants that regulates the phase 2 response, is a zinc metalloprotein.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4613514

Nitric oxide activates an Nrf2/sulfiredoxin antioxidant pathway in macrophages

28 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26551700

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Susceptibility of Nrf2-null mice to steatohepatitis and cirrhosis upon consumption of a high-fat diet is associated with oxidative stress, perturbation of the unfolded protein response, and disturbance in the expression of metabolic enzymes but not w

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26551700

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1042/BST20150003

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26551700%20AND%20SRC:MED&resulttype=core&format=json

29 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26551700%20AND%20SRC:MED&resulttype=core&format=json

29 February 2020

PubMed publication ID

26551700

1 reference