PGAM5, a Bcl-XL-interacting protein, is a novel substrate for the redox-regulated Keap1-dependent ubiquitin ligase complex (Q40219081)

18 September 2017

PGAM5, a Bcl-XL-interacting protein, is a novel substrate for the redox-regulated Keap1-dependent ubiquitin ligase complex (English)

1 reference

18 September 2017

Shih-Ching Lo

1

1 reference

PubMed ID

17046835

18 September 2017

Mark Hannink

series ordinal

2

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PubMed ID

17046835

18 September 2017

language of work or name

English

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publication date

17 October 2006

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Journal of Biological Chemistry

18 September 2017

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18 September 2017

281

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18 September 2017

37893-37903

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18 September 2017

49

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Pathways of Oxidative Damage

18 September 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M606539200

Oxidative damage is the earliest event in Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M606539200

Coronary atherosclerosis and somatic mutations: an overview of the contributive factors for oxidative DNA damage.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M606539200

Points of control in inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M606539200

The contribution of endogenous sources of DNA damage to the multiple mutations in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M606539200

Dimethylarsinic acid effects on DNA damage and oxidative stress related biochemical parameters in B6C3F1 mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M606539200

The Keap1-BTB protein is an adaptor that bridges Nrf2 to a Cul3-based E3 ligase: oxidative stress sensing by a Cul3-Keap1 ligase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M606539200

Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M606539200

Keap1 is a redox-regulated substrate adaptor protein for a Cul3-dependent ubiquitin ligase complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M606539200

CAND1-mediated substrate adaptor recycling is required for efficient repression of Nrf2 by Keap1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M606539200

Identification of sensor cysteines in human Keap1 modified by the cancer chemopreventive agent sulforaphane

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M606539200

Specific patterns of electrophile adduction trigger Keap1 ubiquitination and Nrf2 activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M606539200

Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M606539200

Modifying specific cysteines of the electrophile-sensing human Keap1 protein is insufficient to disrupt binding to the Nrf2 domain Neh2

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M606539200

Protection against electrophile and oxidant stress by induction of the phase 2 response: fate of cysteines of the Keap1 sensor modified by inducers

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M606539200

Distinct Cysteine Residues in Keap1 Are Required for Keap1-Dependent Ubiquitination of Nrf2 and for Stabilization of Nrf2 by Chemopreventive Agents and Oxidative Stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M606539200

Comparison of (-)-epigallocatechin-3-gallate elicited liver and small intestine gene expression profiles between C57BL/6J mice and C57BL/6J/Nrf2 (-/-) mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M606539200

Identification of the NF-E2-related factor-2-dependent genes conferring protection against oxidative stress in primary cortical astrocytes using oligonucleotide microarray analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M606539200

Modulation of gene expression by cancer chemopreventive dithiolethiones through the Keap1-Nrf2 pathway. Identification of novel gene clusters for cell survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M606539200

Structure of the Keap1:Nrf2 interface provides mechanistic insight into Nrf2 signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M606539200

Identification of the interactive interface and phylogenic conservation of the Nrf2-Keap1 system.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M606539200

Structural basis for defects of Keap1 activity provoked by its point mutations in lung cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M606539200

Fetal Alz-50 clone 1 interacts with the human orthologue of the Kelch-like Ech-associated protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M606539200

Nuclear oncoprotein prothymosin alpha is a partner of Keap1: implications for expression of oxidative stress-protecting genes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M606539200

Nrf1 is targeted to the endoplasmic reticulum membrane by an N-terminal transmembrane domain. Inhibition of nuclear translocation and transacting function

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M606539200

Structural basis for phosphodependent substrate selection and orientation by the SCFCdc4 ubiquitin ligase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M606539200

Function and regulation of cullin-RING ubiquitin ligases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M606539200

Development of Protacs to Target Cancer-promoting Proteins for Ubiquitination and Degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M606539200

The SCFbeta-TRCP-ubiquitin ligase complex associates specifically with phosphorylated destruction motifs in IkappaBalpha and beta-catenin and stimulates IkappaBalpha ubiquitination in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M606539200

Structure of a beta-TrCP1-Skp1-beta-catenin complex: destruction motif binding and lysine specificity of the SCF(beta-TrCP1) ubiquitin ligase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M606539200

In vitro selection and characterization of Bcl-X(L)-binding proteins from a mix of tissue-specific mRNA display libraries

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M606539200

Rbx1, a component of the VHL tumor suppressor complex and SCF ubiquitin ligase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M606539200

Bcl-x(L) sequesters its C-terminal membrane anchor in soluble, cytosolic homodimers

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M606539200

Regulation of ZAP-70 activation and TCR signaling by two related proteins, Sts-1 and Sts-2

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M606539200

Suppressors of T-cell receptor signaling Sts-1 and Sts-2 bind to Cbl and inhibit endocytosis of receptor tyrosine kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M606539200

Structure, function, and evolution of phosphoglycerate mutases: comparison with fructose-2,6-bisphosphatase, acid phosphatase, and alkaline phosphatase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M606539200

Crystal structure of the Kelch domain of human Keap1

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M606539200

Oxidative and electrophilic stresses activate Nrf2 through inhibition of ubiquitination activity of Keap1

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M606539200

Expression of the fetal Alz-50 clone 1 protein induces apoptotic cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M606539200

The processivity of multiubiquitination by the APC determines the order of substrate degradation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M606539200

Evolution of the phosphoglycerate mutase processed gene in human and chimpanzee revealing the origin of a new primate gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M606539200

TIGAR, a p53-inducible regulator of glycolysis and apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M606539200

Identification, cDNA cloning, and targeted deletion of p70, a novel, ubiquitously expressed SH3 domain-containing protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M606539200

Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M606539200

21 January 2018

Identifiers

DOI

10.1074/JBC.M606539200

1 reference

18 September 2017

1 reference

PubMed ID

17046835