Transcriptional mutagenesis by 8-oxodG in α-synuclein aggregation and the pathogenesis of Parkinson's disease (Q26796502)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26315598%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

Goun Je

2

Goun

Je

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26315598%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

Yoon-Seong Kim

series ordinal

3

author given names

Yoon-Seong

author last names

Kim

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26315598%20AND%20SRC:MED&resulttype=core&format=json

Experimental and Molecular Medicine

1 June 2020

language of work or name

English

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publication date

28 August 2015

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20 August 2019

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17 September 2019

19 December 2019

20 December 2019

8 October 2022

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25 April 2019

20 August 2019

12 September 2019

17 September 2019

19 December 2019

20 December 2019

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26315598%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

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8 October 2022

47

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issue

8

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page(s)

e179

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Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International

1 June 2020

copyright license

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25 April 2019

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on focus list of Wikimedia project

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cites work

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The neurodegenerative disease protein aprataxin resolves abortive DNA ligation intermediates

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Molecular Basis of Transcriptional Mutagenesis at 8-Oxoguanine

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alpha-Synuclein locus triplication causes Parkinson's disease

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Mutation in the alpha-synuclein gene identified in families with Parkinson's disease

7 April 2017

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7 April 2017

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Transcriptional mutagenesis induced by 8-oxoguanine in mammalian cells

7 April 2017

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Prediction of sequence-dependent and mutational effects on the aggregation of peptides and proteins

7 April 2017

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Oxidative stress in neurodegeneration: cause or consequence?

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Epidemiology of mutations in superoxide dismutase in amyotrophic lateral sclerosis

7 April 2017

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Hydroxylation of deoxyguanosine at the C-8 position by ascorbic acid and other reducing agents

7 April 2017

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The new mutation, E46K, of alpha-synuclein causes Parkinson and Lewy body dementia

7 April 2017

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Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease

7 April 2017

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Pathological α-synuclein transmission initiates Parkinson-like neurodegeneration in nontransgenic mice

7 April 2017

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Single-strand break repair and genetic disease

7 April 2017

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Alpha-synuclein locus duplication as a cause of familial Parkinson's disease

7 April 2017

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Chronic systemic pesticide exposure reproduces features of Parkinson's disease

7 April 2017

1 reference

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Insertion of specific bases during DNA synthesis past the oxidation-damaged base 8-oxodG

7 April 2017

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Structural and functional characterization of two alpha-synuclein strains

7 April 2017

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G51D α-synuclein mutation causes a novel parkinsonian-pyramidal syndrome

28 September 2017

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Alpha-synuclein p.H50Q, a novel pathogenic mutation for Parkinson's disease.

28 September 2017

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The many faces of α-synuclein: from structure and toxicity to therapeutic target

28 September 2017

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NADPH oxidase 1 mediates α-synucleinopathy in Parkinson's disease

28 September 2017

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Ogg1 null mice exhibit age-associated loss of the nigrostriatal pathway and increased sensitivity to MPTP.

28 September 2017

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Transcriptional mutagenesis: causes and involvement in tumour development

28 September 2017

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Seeded aggregation and toxicity of {alpha}-synuclein and tau: cellular models of neurodegenerative diseases

28 September 2017

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Exogenous alpha-synuclein fibrils seed the formation of Lewy body-like intracellular inclusions in cultured cells

28 September 2017

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28 September 2017

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Chronic, low-dose rotenone reproduces Lewy neurites found in early stages of Parkinson's disease, reduces mitochondrial movement and slowly kills differentiated SH-SY5Y neural cells

28 September 2017

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8-Oxoguanine-mediated transcriptional mutagenesis causes Ras activation in mammalian cells

28 September 2017

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28 September 2017

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DNA repair in neurons: so if they don't divide what's to repair?

28 September 2017

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DNA repair in terminally differentiated cells

28 September 2017

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Pathogenesis of Parkinson's disease: dopamine, vesicles and alpha-synuclein

28 September 2017

1 reference

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Cell-selfish modes of evolution and mutations directed after transcriptional bypass

28 September 2017

1 reference

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Evidence that amyloid beta-peptide-induced lipid peroxidation and its sequelae in Alzheimer's disease brain contribute to neuronal death

28 September 2017

1 reference

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Choreography of oxidative damage repair in mammalian genomes

28 September 2017

1 reference

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Parkinson's disease: one biochemical pathway to fit all genes?

28 September 2017

1 reference

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alpha-Synuclein is phosphorylated in synucleinopathy lesions

28 September 2017

1 reference

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Induction of alpha-synuclein aggregation by intracellular nitrative insult.

28 September 2017

1 reference

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Acceleration of oligomerization, not fibrillization, is a shared property of both alpha-synuclein mutations linked to early-onset Parkinson's disease: implications for pathogenesis and therapy

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4558488

Parkinson's disease is associated with oxidative damage to cytoplasmic DNA and RNA in substantia nigra neurons

28 September 2017

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A generalised increase in protein carbonyls in the brain in Parkinson's but not incidental Lewy body disease.

28 September 2017

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Oxidative DNA damage in the parkinsonian brain: an apparent selective increase in 8-hydroxyguanine levels in substantia nigra.

28 September 2017

1 reference

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Role of oxidative stress in development of complications in diabetes

28 September 2017

1 reference

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Immunohistochemical evidence of oxidative [corrected] stress in Alzheimer's disease

28 September 2017

1 reference

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Oxidative pathways for catecholamines in the genesis of neuromelanin and cytotoxic quinones

28 September 2017

1 reference

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Genome-wide profiling of 8-oxoguanine reveals its association with spatial positioning in nucleus

28 September 2017

1 reference

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Emerging links between premature ageing and defective DNA repair

31 May 2018

1 reference

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alpha-synuclein fibrillogenesis is nucleation-dependent. Implications for the pathogenesis of Parkinson's disease

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4558488

Parkinson's disease: a disorder due to nigral glutathione deficiency?

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4558488

Basal lipid peroxidation in substantia nigra is increased in Parkinson's disease

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4558488

Increased nigral iron content and alterations in other metal ions occurring in brain in Parkinson's disease

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4558488

Superoxide dismutase activity in Alzheimer's disease: possible mechanism for paired helical filament formation

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4558488

Iron-melanin interaction and lipid peroxidation: implications for Parkinson's disease.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4558488

Novel antibodies to synuclein show abundant striatal pathology in Lewy body diseases.

31 May 2018

1 reference

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Transcriptional mutagenesis induced by uracil and 8-oxoguanine in Escherichia coli.

21 January 2018

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Increased DNA oxidation and decreased levels of repair products in Alzheimer's disease ventricular CSF.

21 January 2018

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Protein nitration in Parkinson's disease.

21 January 2018

1 reference

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Increased oxidative damage in nuclear and mitochondrial DNA in Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMM.2015.54

The hOGG1 Ser326Cys polymorphism is not associated with sporadic Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMM.2015.54

The Arg194Trp polymorphism in DNA repair gene XRCC1 and the risk for sporadic late-onset Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMM.2015.54

Association of polymorphism of DNA repair gene XRCC1 with sporadic late-onset Alzheimer's disease and age of onset in elderly Han Chinese

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMM.2015.54

Mitochondrial and nuclear DNA-repair capacity of various brain regions in mouse is altered in an age-dependent manner.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMM.2015.54

Effects of endogenous DNA base lesions on transcription elongation by mammalian RNA polymerase II. Implications for transcription-coupled DNA repair and transcriptional mutagenesis.

21 January 2018

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alpha-Synuclein gene duplication is present in sporadic Parkinson disease.

21 January 2018

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https://api.crossref.org/works/10.1038%2FEMM.2015.54

The impact of the E46K mutation on the properties of alpha-synuclein in its monomeric and oligomeric states.

21 January 2018

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Accelerated in vitro fibril formation by a mutant alpha-synuclein linked to early-onset Parkinson disease.

21 January 2018

1 reference

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Release and aggregation of cytochrome c and alpha-synuclein are inhibited by the antiparkinsonian drugs, talipexole and pramipexole

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMM.2015.54

Enhanced substantia nigra mitochondrial pathology in human alpha-synuclein transgenic mice after treatment with MPTP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMM.2015.54

Subcutaneous rotenone exposure causes highly selective dopaminergic degeneration and alpha-synuclein aggregation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMM.2015.54

Pathological biochemistry of alpha-synucleinopathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMM.2015.54

Widespread peroxynitrite-mediated damage in Alzheimer's disease.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4558488

Protein modification by the lipid peroxidation product 4-hydroxynonenal in the spinal cords of amyotrophic lateral sclerosis patients

28 November 2018

1 reference

12 December 2020

The A53T alpha-synuclein mutation increases iron-dependent aggregation and toxicity

1 reference

12 December 2020

Causal relation between alpha-synuclein gene duplication and familial Parkinson's disease

1 reference

12 December 2020

Novel α-synuclein mutation A53E associated with atypical multiple system atrophy and Parkinson's disease-type pathology

1 reference

12 December 2020

Nitration of manganese superoxide dismutase in cerebrospinal fluids is a marker for peroxynitrite-mediated oxidative stress in neurodegenerative diseases

1 reference

12 December 2020

Transition Metals, Ferritin, Glutathione, and Ascorbic Acid in Parkinsonian Brains

1 reference

12 December 2020

Coupling of dopamine oxidation (monoamine oxidase activity) to glutathione oxidation via the generation of hydrogen peroxide in rat brain homogenates

1 reference

12 December 2020

Phenotypic change caused by transcriptional bypass of uracil in nondividing cells

1 reference

12 December 2020

1 reference

12 December 2020

Identifiers

DOI

10.1038/EMM.2015.54

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26315598%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

1 June 2020

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26315598%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26315598%20AND%20SRC:MED&resulttype=core&format=json