The Sound of Silence: Activating Silent Biosynthetic Gene Clusters in Marine Microorganisms (Q26799211)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26264003%20AND%20SRC:MED&resulttype=core&format=json

22 February 2020

review article

3 references

24 November 2020

18 January 2021

The Sound of Silence: Activating Silent Biosynthetic Gene Clusters in Marine Microorganisms (English)

1 reference

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22 February 2020

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16 September 2019

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24 November 2020

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18 January 2021

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22 February 2020

Stefano Romano

2

1 reference

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22 February 2020

Alan Dobson

3

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22 February 2020

Fergal O'Gara

4

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22 February 2020

author name string

F Jerry Reen

1

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Stefano Romano

2

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Alan D W Dobson

3

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Fergal O'Gara

4

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language of work or name

English

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publication date

31 July 2015

6 references

20 June 2019

16 September 2019

4 November 2019

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22 February 2020

24 November 2020

18 January 2021

6 references

20 June 2019

16 September 2019

4 November 2019

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issue

8

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22 February 2020

page(s)

4754-4783

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Creative Commons Attribution

22 February 2020

copyright license

5 references

20 June 2019

16 September 2019

4 November 2019

24 November 2020

18 January 2021

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28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4557003

Libertellenones A-D: induction of cytotoxic diterpenoid biosynthesis by marine microbial competition

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4557003

Phosphate control of the biosynthesis of antibiotics and other secondary metabolites is mediated by the PhoR-PhoP system: an unfinished story

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4557003

Natural products and combinatorial chemistry: back to the future

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4557003

Polyketide and nonribosomal peptide antibiotics: modularity and versatility

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4557003

Mining the microbial metabolome: a new frontier for natural product lead discovery

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4557003

Big effects from small changes: possible ways to explore nature's chemical diversity.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4557003

Pestalone, a new antibiotic produced by a marine fungus in response to bacterial challenge

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4557003

Rare genera of actinomycetes as potential producers of new antibiotics

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4557003

Characterization of the pathway-specific positive transcriptional regulator for actinorhodin biosynthesis in Streptomyces coelicolor A3(2) as a DNA-binding protein

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4557003

Induction of actinorhodin production by rpsL (encoding ribosomal protein S12) mutations that confer streptomycin resistance in Streptomyces lividans and Streptomyces coelicolor A3(2).

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4557003

The sequence of a 1.8-mb bacterial linear plasmid reveals a rich evolutionary reservoir of secondary metabolic pathways

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4557003

Biosynthesis of halogenated metabolites by bacteria

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4557003

Silent clusters - speak up!

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4557003

Perspective: Synthetic biology revives antibiotics

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4557003

Imaging mass spectrometry of a coral microbe interaction with fungi

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4557003

BAGEL3: Automated identification of genes encoding bacteriocins and (non-)bactericidal posttranslationally modified peptides.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4557003

Acyldepsipeptide HDAC inhibitor production induced in Burkholderia thailandensis

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4557003

Characterization and manipulation of the pathway-specific late regulator AlpW reveals Streptomyces ambofaciens as a new producer of Kinamycins

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4557003

Regulation of a novel gene cluster involved in secondary metabolite production in Streptomyces coelicolor.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4557003

SMURF: Genomic mapping of fungal secondary metabolite clusters

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4557003

Quorum sensing-controlled Evr regulates a conserved cryptic pigment biosynthetic cluster and a novel phenomycin-like locus in the plant pathogen, Pectobacterium carotovorum

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4557003

Chromatin-level regulation of biosynthetic gene clusters

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4557003

Histone deacetylase activity regulates chemical diversity in Aspergillus

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4557003

Genomics-driven discovery of PKS-NRPS hybrid metabolites from Aspergillus nidulans

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4557003

Quorum-sensing signaling is required for production of the antibiotic pyrrolnitrin in a rhizospheric biocontrol strain of Serratia plymuthica.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4557003

Partial activation of a silent angucycline-type gene cluster from a rubromycin beta producing Streptomyces sp. PGA64.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4557003

A polyketide biosynthetic gene cluster from Streptomyces antibioticus includes a LysR-type transcriptional regulator

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4557003

Cloning and analysis of the spinosad biosynthetic gene cluster of Saccharopolyspora spinosa

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4557003

Dereplication of microbial natural products by LC-DAD-TOFMS.

31 May 2018

1 reference

https://api.crossref.org/works/10.3390%2FMD13084754

An analysis of FDA-approved drugs: natural products and their derivatives.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMD13084754

Arugosins G and H: prenylated polyketides from the marine-derived fungus Emericellanidulans var. acristata

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMD13084754

Aspergillus fumigatus Fresenius, an endophytic fungus from Juniperus communis L. Horstmann as a novel source of the anticancer pro-drug deoxypodophyllotoxin.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMD13084754

Uncovering biosynthetic potential of plant-associated fungi: effect of culture conditions on metabolite production by Paraphaeosphaeria quadriseptata and Chaetomium chiversii

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMD13084754

Deletion of a regulatory gene within the cpk gene cluster reveals novel antibacterial activity in Streptomyces coelicolor A3(2).

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMD13084754

Quorum sensing signals are produced by Aeromonas salmonicida and quorum sensing inhibitors can reduce production of a potential virulence factor

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMD13084754

Biosynthesis of carbapenem antibiotic and prodigiosin pigment in Serratia is under quorum sensing control.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMD13084754

Quorum sensing, communication and cross-kingdom signalling in the bacterial world.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMD13084754

Antibacterial discovery in actinomycetes strains with mutations in RNA polymerase or ribosomal protein S12.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMD13084754

RNA Polymerase Mutation Activates the Production of a Dormant Antibiotic 3,3′-Neotrehalosadiamine via an Autoinduction Mechanism in Bacillus subtilis

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMD13084754

Natural merodiploidy involving duplicated rpoB alleles affects secondary metabolism in a producer actinomycete.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMD13084754

Identification of transcriptional activators for thienamycin and cephamycin C biosynthetic genes within the thienamycin gene cluster from Streptomyces cattleya

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMD13084754

The role of two SARP family transcriptional regulators in regulation of the auricin gene cluster in Streptomyces aureofaciens CCM 3239.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMD13084754

Involvement of AlpV, a new member of the Streptomyces antibiotic regulatory protein family, in regulation of the duplicated type II polyketide synthase alp gene cluster in Streptomyces ambofaciens.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMD13084754

A gene determining a new member of the SARP family contributes to transcription of genes for the synthesis of the angucycline polyketide auricin in Streptomyces aureofaciens CCM 3239.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMD13084754

The role of the TetR-family transcriptional regulator Aur1R in negative regulation of the auricin gene cluster in Streptomyces aureofaciens CCM 3239.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMD13084754

Exploiting the mosaic structure of trans-acyltransferase polyketide synthases for natural product discovery and pathway dissection

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMD13084754

Overproduction of Ristomycin A by activation of a silent gene cluster in Amycolatopsis japonicum MG417-CF17.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMD13084754

A new high-performance heterologous fungal expression system based on regulatory elements from the Aspergillus terreus terrein gene cluster.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMD13084754

Natural Organohalogens: A New Frontier for Medicinal Agents?

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMD13084754

Exploiting plug-and-play synthetic biology for drug discovery and production in microorganisms

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMD13084754

Synthetic Biology in Streptomyces Bacteria

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMD13084754

A novel semi-biosynthetic route for artemisinin production using engineered substrate-promiscuous P450(BM3).

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMD13084754

High-level production of amorpha-4,11-diene in a two-phase partitioning bioreactor of metabolically engineered Escherichia coli

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMD13084754

Manipulation of regulatory genes reveals complexity and fidelity in hormaomycin biosynthesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMD13084754

Differential expression of silent polyketide biosynthesis gene clusters in chemostat cultures of Aspergillus nidulans

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMD13084754

Temperature shift-induced reactive oxygen species enhanced validamycin A production in fermentation of Streptomyces hygroscopicus 5008

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMD13084754

Enhancement of validamycin A production by addition of ethanol in fermentation of Streptomyces hygroscopicus 5008

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMD13084754

Enacyloxins Are Products of an Unusual Hybrid Modular Polyketide Synthase Encoded by a Cryptic Burkholderia ambifaria Genomic Island

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FMD13084754

Detection of quorum sensing signal molecules in the family Vibrionaceae

21 January 2018

1 reference

12 December 2020

One pathway, many products

1 reference

12 December 2020

Epigenetic remodeling of the fungal secondary metabolome

1 reference

12 December 2020

Conditions for the production of jadomycin B by Streptomyces venezuelae ISP5230: effects of heat shock, ethanol treatment and phage infection

1 reference

12 December 2020

Induced Biosynthesis of Cryptic Polyketide Metabolites in a Burkholderia thailandensis Quorum Sensing Mutant

1 reference

12 December 2020

Spicochalasin A and New Aspochalasins from the Marine-Derived FungusSpicaria elegans

1 reference

https://api.crossref.org/works/10.3390%2FMD13084754

7 January 2021

inferred from DOI database lookup

Secondary Metabolites by Chemical Screening, 34. – Aspinolides and Aspinonene/Aspyrone Co-Metabolites, New Pentaketides Produced byAspergillus ochraceus

1 reference

https://api.crossref.org/works/10.3390%2FMD13084754

7 January 2021

inferred from DOI database lookup

Identifiers

DOI

10.3390/MD13084754

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26264003%20AND%20SRC:MED&resulttype=core&format=json

22 February 2020

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26264003%20AND%20SRC:MED&resulttype=core&format=json

22 February 2020

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26264003%20AND%20SRC:MED&resulttype=core&format=json