Genistein and cancer: current status, challenges, and future directions (Q26801271)

Europe PubMed Central

title

Genistein and cancer: current status, challenges, and future directions (English)

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4

Solomon Habtemariam

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Maria Daglia

5

object named as

Maria Daglia

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Antoni Sureda Gomila

6

object named as

Antoni Sureda

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author name string

Carmela Spagnuolo

1

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Gian Luigi Russo

2

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Ilkay Erdogan Orhan

3

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Seyed Fazel Nabavi

7

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Kasi Pandima Devi

8

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Monica Rosa Loizzo

9

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Rosa Tundis

10

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Seyed Mohammad Nabavi

11

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language of work or name

English

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publication date

July 2015

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published in

Advances in Nutrition

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4496735

volume

6

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issue

4

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page(s)

408-19

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cites work

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Genistein inhibits tumor invasion by suppressing multiple signal transduction pathways in human hepatocellular carcinoma cells

28 September 2017

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Genistein attenuates cancer stem cell characteristics in gastric cancer through the downregulation of Gli1.

28 September 2017

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Genistein inhibits hepatocellular carcinoma cell migration by reversing the epithelial-mesenchymal transition: partial mediation by the transcription factor NFAT1.

28 September 2017

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Transport mechanisms for soy isoflavones and microbial metabolites dihydrogenistein and dihydrodaidzein across monolayers and membranes.

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Genistein induces G2/M arrest in gastric cancer cells by increasing the tumor suppressor PTEN expression

28 September 2017

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Inhibition of proliferation and induction of G1-phase cell-cycle arrest by dFMGEN, a novel genistein derivative, in lung carcinoma A549 cells

28 September 2017

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Genistein-induced mitotic arrest of gastric cancer cells by downregulating KIF20A, a proteomics study.

28 September 2017

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Genistein affects histone modifications on Dickkopf-related protein 1 (DKK1) gene in SW480 human colon cancer cell line.

28 September 2017

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Genistein enhances the effect of trichostatin A on inhibition of A549 cell growth by increasing expression of TNF receptor-1.

28 September 2017

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Involvement of nuclear factor κB (NF-κB) in the downregulation of cyclooxygenase-2 (COX-2) by genistein in gastric cancer cells

28 September 2017

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28 September 2017

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Genistein inhibits proliferation of colon cancer cells by attenuating a negative effect of epidermal growth factor on tumor suppressor FOXO3 activity

28 September 2017

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Genistein attenuates WNT signaling by up-regulating sFRP2 in a human colon cancer cell line

28 September 2017

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28 September 2017

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Circulating levels of genistein in the neonate, apart from dose and route, predict future adverse female reproductive outcomes

28 September 2017

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2'-hydroxylation of genistein enhanced antioxidant and antiproliferative activities in mcf-7 human breast cancer cells.

28 September 2017

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28 September 2017

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Genistein and beta-carotene enhance the growth-inhibitory effect of trichostatin A in A549 cells

28 September 2017

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Genistein sensitizes human hepatocellular carcinoma cells to TRAIL-mediated apoptosis by enhancing Bid cleavage

28 September 2017

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Genistein enhances TRAIL-induced apoptosis through inhibition of p38 MAPK signaling in human hepatocellular carcinoma Hep3B cells

28 September 2017

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Genistein enhances the effect of epidermal growth factor receptor tyrosine kinase inhibitors and inhibits nuclear factor kappa B in nonsmall cell lung cancer cell lines

28 September 2017

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Genistein sensitizes inhibitory effect of tamoxifen on the growth of estrogen receptor-positive and HER2-overexpressing human breast cancer cells

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Genistein induces apoptosis in human hepatocellular carcinomas via interaction of endoplasmic reticulum stress and mitochondrial insult.

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The intracellular genistein metabolite 5,7,3',4'-tetrahydroxyisoflavone mediates G2-M cell cycle arrest in cancer cells via modulation of the p38 signaling pathway.

28 September 2017

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28 September 2017

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Stimulatory effect of genistein and apigenin on the growth of breast cancer cells correlates with their ability to activate ER alpha

28 September 2017

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Soya phytonutrients act on a panel of genes implicated with BRCA1 and BRCA2 oncosuppressors in human breast cell lines

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Genistein inhibits invasive potential of human hepatocellular carcinoma by altering cell cycle, apoptosis, and angiogenesis

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28 September 2017

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Inactivation of nuclear factor kappaB by soy isoflavone genistein contributes to increased apoptosis induced by chemotherapeutic agents in human cancer cells

28 September 2017

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28 September 2017

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Genistein, a soy isoflavone, enhances necrotic-like cell death in a breast cancer cell treated with a chemotherapeutic agent.

28 September 2017

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Potential synergy of phytochemicals in cancer prevention: mechanism of action

28 September 2017

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Apoptosis of human primary gastric carcinoma cells induced by genistein

28 September 2017

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Soy consumption and colorectal cancer

28 September 2017

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Tea polyphenol (-)-epigallocatechin-3-gallate inhibits DNA methyltransferase and reactivates methylation-silenced genes in cancer cell lines.

28 September 2017

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Soy, isoflavones, and breast cancer risk in Japan

28 September 2017

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Bioactive compounds in foods: their role in the prevention of cardiovascular disease and cancer

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Hormonal effects of soy in premenopausal women and men.

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28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4496735

Polyphenols as cancer chemopreventive agents.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4496735

Enzymic synthesis of isoflavones

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4496735

Cancers of the prostate and breast among Japanese and white immigrants in Los Angeles County

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4496735

Plasma isoflavones and risk of primary liver cancer in Japanese women and men with hepatitis virus infection: a nested case-control study

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4496735

Estrogen receptor-β mediates the inhibition of DLD-1 human colon adenocarcinoma cells by soy isoflavones

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4496735

Genistein potentiates the effect of arsenic trioxide against human hepatocellular carcinoma: role of Akt and nuclear factor-κB.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4496735

Primary and secondary metabolite profiling of doenjang, a fermented soybean paste during industrial processing.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4496735

Design, synthesis and evaluation of genistein-O-alkylbenzylamines as potential multifunctional agents for the treatment of Alzheimer's disease.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4496735

Plasma isoflavone concentrations are not associated with gastric cancer risk among Japanese men and women

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4496735

Plasma isoflavones and the risk of lung cancer in women: a nested case-control study in Japan

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4496735

Isoflavones from phytoestrogens and gastric cancer risk: a nested case-control study within the Korean Multicenter Cancer Cohort

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4496735

Identification and quantification of daidzein-7-glucuronide-4'-sulfate, genistein-7-glucuronide-4'-sulfate and genistein-4',7-diglucuronide as major metabolites in human plasma after administration of kinako

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4496735

Comprehensive profiling of isoflavones, phytosterols, tocopherols, minerals, crude protein, lipid, and sugar during soybean (Glycine max) germination

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4496735

Isoflavone intake and risk of lung cancer: a prospective cohort study in Japan.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4496735

Changes of isoflavone profile in the hypocotyls and cotyledons of soybeans during dry heating and germination

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4496735

Interaction of genistein benzyl derivatives with lipid bilayers--fluorescence spectroscopic and calorimetric study.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4496735

Breast safety and efficacy of genistein aglycone for postmenopausal bone loss: a follow-up study.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4496735

Genistein- and daidzein 7-O-beta-D-glucuronic acid retain the ability to inhibit copper-mediated lipid oxidation of low density lipoprotein

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4496735

Effects of phytoestrogen genistein on cytogenetic biomarkers in postmenopausal women: 1 year randomized, placebo-controlled study.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4496735

One-pot synthesis of genistein from tyrosine by coincubation of genetically engineered Escherichia coli and Saccharomyces cerevisiae cells.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4496735

Identification of both Myt-1 and Wee-1 as necessary mediators of the p21-independent inactivation of the cdc-2/cyclin B1 complex and growth inhibition of TRAMP cancer cells by genistein.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4496735

Flavonoids and colorectal cancer in Italy

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4496735

Genistein inhibits insulin-like growth factor-I receptor signaling in HT-29 human colon cancer cells: a possible mechanism of the growth inhibitory effect of Genistein

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4496735

Dietary phytoestrogens and lung cancer risk

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4496735

Novel tempeh (fermented soyabean) isoflavones inhibit in vivo angiogenesis in the chicken chorioallantoic membrane assay.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4496735

Effects of dual-action genistein derivatives on relaxation in rat aorta

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4496735

Cytostatic and cytotoxic activity of synthetic genistein glycosides against human cancer cell lines

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4496735

Plasma isoflavone levels versus self-reported soy isoflavone levels in Asian-American women in Los Angeles County

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4496735

Reduction of genistein clastogenicity in Chinese hamster V79 cells by daidzein and other flavonoids

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4496735

Inactivation of NF-kappaB by genistein is mediated via Akt signaling pathway in breast cancer cells

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4496735

Effects of soy isoflavones on apoptosis induction and G2-M arrest in human hepatoma cells involvement of caspase-3 activation, Bcl-2 and Bcl-XL downregulation, and Cdc2 kinase activity

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4496735

Isoflavone intake in four different European countries: the VENUS approach.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4496735

6-Carboxymethyl genistein: a novel selective oestrogen receptor modulator (SERM) with unique, differential effects on the vasculature, bone and uterus

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4496735

Anaerobic C-ring cleavage of genistein and daidzein by Eubacterium ramulus.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4496735

Antitumoral activity of a sulphur-containing platinum complex with an acidic pH optimum

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4496735

Attenuation by genistein of sodium-chloride-enhanced gastric carcinogenesis induced by N-methyl-N'-nitro-N-nitrosoguanidine in Wistar rats.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4496735

Genistein studies in rats: potential for breast cancer prevention and reproductive and developmental toxicity.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4496735

Safety and pharmacokinetics of purified soy isoflavones: single-dose administration to postmenopausal women

28 November 2018

1 reference

12 December 2020

Two-week dietary soy supplementation has an estrogenic effect on normal premenopausal breast

1 reference

12 December 2020

Comparison of oral bioavailability of genistein and genistin in rats

1 reference

12 December 2020

Inhibition of cell proliferation and induction of apoptosis by genistein in experimental hepatocellular carcinoma

1 reference

12 December 2020

Bioavailability of genistein and its glycoside genistin as measured in the portal vein of freely moving unanesthetized rats

1 reference

12 December 2020

Estrogenic effects of genistein on the growth of estrogen receptor-positive human breast cancer (MCF-7) cells in vitro and in vivo

1 reference

12 December 2020

Low-dose dietary phytoestrogen abrogates tamoxifen-associated mammary tumor prevention

1 reference

12 December 2020

Pharmacokinetics of the glucuronide and sulfate conjugates of genistein and daidzein in men and women after consumption of a soy beverage

1 reference

12 December 2020

Meta-analysis of soy food and risk of prostate cancer in men

1 reference

12 December 2020

Animal fat consumption and prostate cancer: a prospective study in Hawaii

1 reference

12 December 2020

Genistein, a soya isoflavone, prevents azoxymethane-induced up-regulation of WNT/β-catenin signalling and reduces colon pre-neoplasia in rats

1 reference

12 December 2020

Daidzein and genistein content of fruits and nuts

1 reference

12 December 2020

HPLC analysis of isoflavonoids and other phenolic agents from foods and from human fluids

1 reference

12 December 2020

Prevention of precancerous colonic lesions in rats by soy flakes, soy flour, genistein, and calcium

1 reference

12 December 2020

Antiproliferative efficacy of lipophilic soy isoflavone phytoestrogens delivered by low density lipoprotein particles into cultured U937 cells

1 reference

12 December 2020

Daidzein and genistein contents of vegetables

1 reference

12 December 2020

Intestinal uptake and biliary excretion of the isoflavone genistein in rats

1 reference

12 December 2020

Novel phenoxyalkylcarboxylic acid derivatives as hypolipidaemic agents

1 reference

12 December 2020

Profile of the contents of different forms of soybean isoflavones and the effect of germination time on these compounds and the physical parameters in soybean sprouts

1 reference

12 December 2020

Phyto-oestrogens and breast cancer

1 reference

12 December 2020

[Soy food intake and breast cancer risk: a meta-analysis]

1 reference

12 December 2020

Production of the isoflavones genistein and daidzein in non-legume dicot and monocot tissues

1 reference

12 December 2020

Effects of soy-protein supplementation on epithelial proliferation in the histologically normal human breast

1 reference

12 December 2020

Genistein exhibits anti-cancer effects via down-regulating FoxM1 in H446 small-cell lung cancer cells

1 reference

Crossref

https://api.crossref.org/works/10.3945%2FAN.114.008052

7 January 2021

inferred from DOI database lookup

Identifiers

DOI

10.3945/AN.114.008052

1 reference

3657240

3657240

1 reference

1 reference

1 reference