Properties of Resveratrol: In Vitro and In Vivo Studies about Metabolism, Bioavailability, and Biological Effects in Animal Models and Humans (Q26801926)

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scientific article (publication date: 2015)

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English	Properties of Resveratrol: In Vitro and In Vivo Studies about Metabolism, Bioavailability, and Biological Effects in Animal Models and Humans	scientific article (publication date: 2015)

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scholarly article

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7 November 2019

8 April 2021

Properties of Resveratrol: In Vitro and In Vivo Studies about Metabolism, Bioavailability, and Biological Effects in Animal Models and Humans (English)

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7 November 2019

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8 April 2021

bioavailability

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based on heuristic

inferred from title

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15 June 2020

Raul Lopez-Grueso

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Lucía Gimeno-Mallench

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Cristina Mas-Bargues

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Mari-Carmen Gómez-Cabrera

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Consuelo Borras

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J Gambini

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G Olaso

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V Bonet-Costa

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K M Abdelaziz

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J Vina

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2015

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28 June 2015

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7 November 2019

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Oxidative medicine and cellular longevity

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8 April 2021

2015

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15 June 2020

837042

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15 June 2020

copyright license

Creative Commons Attribution 3.0 Unported

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7 November 2019

Europe PubMed Central

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copyright status

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SRT1720, SRT2183, SRT1460, and resveratrol are not direct activators of SIRT1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4499410

7 April 2017

Simple spectrophotometric assessment of the trans-/cis-resveratrol ratio in aqueous solutions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4499410

7 April 2017

Resveratrol, a polyphenolic compound found in grapes and wine, is an agonist for the estrogen receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4499410

7 April 2017

Effects of chronic calorie restriction or dietary resveratrol supplementation on insulin sensitivity markers in a primate, Microcebus murinus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4499410

7 April 2017

Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4499410

7 April 2017

Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4499410

7 April 2017

Mediation of endogenous antioxidant enzymes and apoptotic signaling by resveratrol following muscle disuse in the gastrocnemius muscles of young and old rats

1 reference

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7 April 2017

Mechanism of human SIRT1 activation by resveratrol

1 reference

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7 April 2017

Substrate-specific activation of sirtuins by resveratrol

1 reference

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7 April 2017

Resveratrol has antagonist activity on the aryl hydrocarbon receptor: implications for prevention of dioxin toxicity

1 reference

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7 April 2017

Cancer chemopreventive activity of resveratrol, a natural product derived from grapes

1 reference

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7 April 2017

A new class of phytoalexins from grapevines

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7 April 2017

Therapeutic potential of resveratrol: the in vivo evidence

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7 April 2017

Sirtuin activators mimic caloric restriction and delay ageing in metazoans

1 reference

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7 April 2017

Oxidative stress, inflammation, and cancer: how are they linked?

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7 April 2017

PTEN mediates the antioxidant effect of resveratrol at nutritionally relevant concentrations

1 reference

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28 September 2017

The lifespan extension effects of resveratrol are conserved in the honey bee and may be driven by a mechanism related to caloric restriction

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28 September 2017

Pilot study of resveratrol in older adults with impaired glucose tolerance.

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28 September 2017

Calorie Restriction-like Effects of 30 Days of Resveratrol Supplementation on Energy Metabolism and Metabolic Profile in Obese Humans

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28 September 2017

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4499410

28 November 2018

Role of resveratrol and its analogues in the treatment of neurodegenerative diseases: focus on recent discoveries

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28 September 2017

Absence of effects of Sir2 overexpression on lifespan in C. elegans and Drosophila

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28 September 2017

Resveratrol promotes osteogenesis of human mesenchymal stem cells by upregulating RUNX2 gene expression via the SIRT1/FOXO3A axis

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28 September 2017

The controversial links among calorie restriction, SIRT1, and resveratrol

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28 September 2017

Resveratrol regulates lipolysis via adipose triglyceride lipase.

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28 September 2017

Transport, stability, and biological activity of resveratrol

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28 September 2017

Cyclodextrins for drug delivery

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1,4-Naphthoquinones as inducers of oxidative damage and stress signaling in HaCaT human keratinocytes.

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28 September 2017

Resveratrol mobilizes endogenous copper in human peripheral lymphocytes leading to oxidative DNA breakage: a putative mechanism for chemoprevention of cancer

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Resveratrol bioavailability and toxicity in humans

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Dietary phenolics: chemistry, bioavailability and effects on health

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Positive and negative regulation of insulin signaling by reactive oxygen and nitrogen species

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28 September 2017

Inhibitory effects of trans-resveratrol analogs molecules on the proliferation and the cell cycle progression of human colon tumoral cells

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28 September 2017

Comparative studies of the antioxidant effects of a naturally occurring resveratrol analogue -- trans-3,3',5,5'-tetrahydroxy-4'-methoxystilbene and resveratrol -- against oxidation and nitration of biomolecules in blood platelets.

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28 September 2017

Effects of resveratrol on lifespan in Drosophila melanogaster and Caenorhabditis elegans

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28 September 2017

Effects of trans- and cis-resveratrol on Ca2+ handling in A7r5 vascular myocytes

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Autoxidative quinone formation in vitro and metabolite formation in vivo from tea polyphenol (-)-epigallocatechin-3-gallate: studied by real-time mass spectrometry combined with tandem mass ion mapping

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28 September 2017

Stereospecific determination of cis- and trans-resveratrol in rat plasma by HPLC: application to pharmacokinetic studies

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28 September 2017

HPLC-tandem mass spectrometric method to characterize resveratrol metabolism in humans.

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28 September 2017

Quantitation of trans-resveratrol and detection of its metabolites in human plasma and urine by high performance liquid chromatography

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28 September 2017

Genistein, a soy isoflavone, up-regulates expression of antioxidant genes: involvement of estrogen receptors, ERK1/2, and NFkappaB.

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28 September 2017

Integrin alphaVbeta3 contains a receptor site for resveratrol

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28 September 2017

Comparative studies of the antioxidant effects of cis- and trans-resveratrol

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28 September 2017

17beta-oestradiol up-regulates longevity-related, antioxidant enzyme expression via the ERK1 and ERK2[MAPK]/NFkappaB cascade

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28 September 2017

Bioavailability of trans-resveratrol from red wine in humans.

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28 September 2017

Metabolism and bioavailability of trans-resveratrol.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4499410

28 September 2017

Resveratrol-induced apoptosis in MCF-7 human breast cancer cells involves a caspase-independent mechanism with downregulation of Bcl-2 and NF-kappaB.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4499410

28 September 2017

Oxidative stress and vascular disease

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28 September 2017

From chemoprevention to chemotherapy: common targets and common goals

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28 September 2017

Resveratrol glucuronides as the metabolites of resveratrol in humans: characterization, synthesis, and anti-HIV activity

1 reference

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28 September 2017

High absorption but very low bioavailability of oral resveratrol in humans

1 reference

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28 September 2017

An accelerated assay for the identification of lifespan-extending interventions in Drosophila melanogaster

1 reference

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28 September 2017

Transport of resveratrol, a cancer chemopreventive agent, to cellular targets: plasmatic protein binding and cell uptake

1 reference

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28 September 2017

Human hepatic cell uptake of resveratrol: involvement of both passive diffusion and carrier-mediated process

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4499410

28 September 2017

Role of aryl hydrocarbon receptor-mediated induction of the CYP1 enzymes in environmental toxicity and cancer

1 reference

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28 September 2017

Relationship between mechanisms, bioavailibility, and preclinical chemopreventive efficacy of resveratrol: a conundrum

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28 September 2017

Effects of resveratrol on secondary damages after acute spinal cord injury in rats.

1 reference

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28 September 2017

Absorption of three wine-related polyphenols in three different matrices by healthy subjects

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28 September 2017

Suppression of N-nitrosomethylbenzylamine (NMBA)-induced esophageal tumorigenesis in F344 rats by resveratrol

1 reference

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28 September 2017

Metabolism and disposition of resveratrol in rats: extent of absorption, glucuronidation, and enterohepatic recirculation evidenced by a linked-rat model

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28 September 2017

Phytoalexins from the Vitaceae: biosynthesis, phytoalexin gene expression in transgenic plants, antifungal activity, and metabolism

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28 September 2017

Effect of resveratrol on platelet aggregation in vivo and in vitro.

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28 September 2017

Resveratrol acts as a mixed agonist/antagonist for estrogen receptors alpha and beta

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28 September 2017

Resveratrol modulates arachidonic acid release, prostaglandin synthesis, and 3T6 fibroblast growth

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28 September 2017

trans-Resveratrol inhibits calcium influx in thrombin-stimulated human platelets

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28 September 2017

Resveratrol suppresses cell transformation and induces apoptosis through a p53-dependent pathway

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28 September 2017

Partial and weak oestrogenicity of the red wine constituent resveratrol: consideration of its superagonist activity in MCF-7 cells and its suggested cardiovascular protective effects

1 reference

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28 September 2017

Phytoalexin resveratrol (3-4'-5-trihydroxystilbene) modulates granulocyte and monocyte endothelial adhesion

1 reference

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28 September 2017

Activity in vitro of resveratrol on granulocyte and monocyte adhesion to endothelium

1 reference

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28 September 2017

Resveratrol, a phytoestrogen found in red wine. A possible explanation for the conundrum of the 'French paradox'?

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28 September 2017

The red wine phenolics trans-resveratrol and quercetin block human platelet aggregation and eicosanoid synthesis: implications for protection against coronary heart disease.

1 reference

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28 September 2017

Protein, lipid and DNA repair systems in oxidative stress: the free-radical theory of aging revisited

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28 September 2017

Wine, alcohol, platelets, and the French paradox for coronary heart disease

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28 September 2017

Resveratrol prevents the wasting disorders of mechanical unloading by acting as a physical exercise mimetic in the rat.

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31 May 2018

Free [NADH]/[NAD(+)] regulates sirtuin expression.

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31 May 2018

Hydroxystilbenes of Eucalyptus wandoo

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31 May 2018

Resveratrol depresses the growth of colorectal aberrant crypt foci by affecting bax and p21(CIP) expression.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4499410

31 May 2018

Wine as a biological fluid: history, production, and role in disease prevention

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4499410

31 May 2018

Resveratrol: a molecule whose time has come? And gone?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4499410

31 May 2018

Resveratrol attenuates oxidative damage and ameliorates cognitive impairment in the brain of senescence-accelerated mice.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4499410

28 November 2018

Neurons from senescence-accelerated SAMP8 mice are protected against frailty by the sirtuin 1 promoting agents melatonin and resveratrol.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4499410

28 November 2018

Steady-State pharmacokinetics and tolerability of trans-resveratrol 2000 mg twice daily with food, quercetin and alcohol (ethanol) in healthy human subjects.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4499410

28 November 2018

Neuroprotective role of intermittent fasting in senescence-accelerated mice P8 (SAMP8).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4499410

28 November 2018

Effects of resveratrol analogs on cell cycle progression, cell cycle associated proteins and 5fluoro-uracil sensitivity in human derived colon cancer cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4499410

28 November 2018

Pharmacokinetic and safety profile of trans-resveratrol in a rising multiple-dose study in healthy volunteers

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4499410

28 November 2018

Resveratrol protects primary rat hepatocytes against oxidative stress damage: activation of the Nrf2 transcription factor and augmented activities of antioxidant enzymes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4499410

28 November 2018

Diagnostic performance of urinary resveratrol metabolites as a biomarker of moderate wine consumption.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4499410

28 November 2018

Inhibitory effects of cis- and trans-resveratrol on noradrenaline and 5-hydroxytryptamine uptake and on monoamine oxidase activity.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4499410

28 November 2018

A role for SIR-2.1 regulation of ER stress response genes in determining C. elegans life span

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4499410

28 November 2018

Uptake of diet resveratrol into the human low-density lipoprotein. Identification and quantification of resveratrol metabolites by liquid chromatography coupled with tandem mass spectrometry.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4499410

28 November 2018

Resveratrol, a red wine polyphenol, protects spinal cord from ischemia-reperfusion injury

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4499410

28 November 2018

Differential recognition of resveratrol isomers by the human estrogen receptor-alpha: molecular dynamics evidence for stereoselective ligand binding

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4499410

28 November 2018

Isorhapontigenin and resveratrol suppress oxLDL-induced proliferation and activation of ERK1/2 mitogen-activated protein kinases of bovine aortic smooth muscle cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4499410

28 November 2018

Resveratrol modulates apoptosis and oxidation in human blood mononuclear cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4499410

28 November 2018

Distribution of [14C]-trans-resveratrol, a cancer chemopreventive polyphenol, in mouse tissues after oral administration

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4499410

28 November 2018

Suppression of 7,12-dimethylbenz(a)anthracene-induced mammary carcinogenesis in rats by resveratrol: role of nuclear factor-kappaB, cyclooxygenase 2, and matrix metalloprotease 9.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4499410

28 November 2018

Plant foods and herbal sources of resveratrol

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4499410

28 November 2018

Occurrence of resveratrol and pterostilbene in age-old darakchasava, an ayurvedic medicine from India.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4499410

28 November 2018

Effects of resveratrol on the rat brain respiratory chain.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4499410

28 November 2018

Differential effects on growth, cell cycle arrest, and induction of apoptosis by resveratrol in human prostate cancer cell lines.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4499410

28 November 2018

Is resveratrol an estrogen agonist in growing rats?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4499410

28 November 2018

An antiplatelet principle of Veratrum formosanum

1 reference

https://pubmed.ncbi.nlm.nih.gov/26221416

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Gas chromatographic analysis of resveratrol in plasma, lipoproteins and cells after in vitro incubations

1 reference

https://pubmed.ncbi.nlm.nih.gov/26221416

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Resveratrol, a remarkable inhibitor of ribonucleotide reductase

1 reference

https://pubmed.ncbi.nlm.nih.gov/26221416

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hepatic Glucuronidation of Resveratrol: Interspecies Comparison of Enzyme Kinetic Profiles in Human, Mouse, Rat, and Dog

1 reference

https://pubmed.ncbi.nlm.nih.gov/26221416

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Resveratrol ameliorates metabolic disorders and muscle wasting in streptozotocin-induced diabetic rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/26221416

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Myocardial protection by protykin, a novel extract of trans-resveratrol and emodin

1 reference

https://pubmed.ncbi.nlm.nih.gov/26221416

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Estrogenic/antiestrogenic and scavenging properties of (E)- and (Z)-resveratrol

1 reference

https://pubmed.ncbi.nlm.nih.gov/26221416

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Study of polyphenols in grape berries by reversed-phase high-performance liquid chromatography

1 reference

https://pubmed.ncbi.nlm.nih.gov/26221416

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Anti-allergic action of resveratrol and related hydroxystilbenes

1 reference

https://pubmed.ncbi.nlm.nih.gov/26221416

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CHEMICAL CONSTITUENTS OF POLYGONACEOUS PLANTS. I. STUDIES ON THE COMPONENTS OF KO-J O-KON. (POLYGONUM CUSPIDATUM SIEB. ET ZUCC.)

1 reference

https://pubmed.ncbi.nlm.nih.gov/26221416

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Wine as a biological fluid: History, production, and role in disease prevention

1 reference

https://api.crossref.org/works/10.1155%2F2015%2F837042

7 January 2021

based on heuristic

inferred from DOI database lookup

Antifungal stress compounds from Veratrum grandiflorum leaves treated with cupric chloride

1 reference

https://api.crossref.org/works/10.1155%2F2015%2F837042

7 January 2021

based on heuristic

inferred from DOI database lookup

Polyphenols as dietary fiber associated compounds. Comparative study on in vivo and in vitro properties

1 reference

https://api.crossref.org/works/10.1155%2F2015%2F837042

7 January 2021

based on heuristic

inferred from DOI database lookup

Biological Activity of Resveratrol, a Stilbenic Compound from Grapevines, Against Botrytis cinerea, the Causal Agent for Gray Mold

1 reference

https://api.crossref.org/works/10.1155%2F2015%2F837042

7 January 2021

based on heuristic

inferred from DOI database lookup

Chemical Constituents of Polygonaceous Plants. I

1 reference

https://api.crossref.org/works/10.1155%2F2015%2F837042

7 January 2021

based on heuristic

inferred from DOI database lookup

Identifiers

10.1155/2015/837042

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26221416%20AND%20SRC:MED&resulttype=core&format=json

15 June 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26221416%20AND%20SRC:MED&resulttype=core&format=json

15 June 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26221416%20AND%20SRC:MED&resulttype=core&format=json

15 June 2020

ResearchGate publication ID

0 references

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