Metabolomics methods for the synthetic biology of secondary metabolism (Q26822396)

Marnix H. Medema

3

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Eriko Takano

Eriko Takano

6

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Rainer Breitling

Rainer Breitling

5

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Andris Jankevics

Andris Jankevics

4

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author name string

Maria E. Merlo

2

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language of work or name

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16 July 2012

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586

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PubMed

issue

15

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PubMed

page(s)

2177-83

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The future of industrial antibiotic production: from random mutagenesis to synthetic biology

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Exploiting plug-and-play synthetic biology for drug discovery and production in microorganisms

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The next wave in metabolome analysis

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Secondary metabolomics: natural products mass spectrometry goes global

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antiSMASH: rapid identification, annotation and analysis of secondary metabolite biosynthesis gene clusters in bacterial and fungal genome sequences

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Identification of a bioactive 51-membered macrolide complex by activation of a silent polyketide synthase in Streptomyces ambofaciens

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Type III polyketide synthase beta-ketoacyl-ACP starter unit and ethylmalonyl-CoA extender unit selectivity discovered by Streptomyces coelicolor genome mining

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A Type II Polyketide Synthase from the Gram-Negative BacteriumStigmatella aurantiaca Is Involved in Aurachin Alkaloid Biosynthesis

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Discovering the hidden secondary metabolome of Myxococcus xanthus: a study of intraspecific diversity

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Characterization and manipulation of the pathway-specific late regulator AlpW reveals Streptomyces ambofaciens as a new producer of Kinamycins

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Elansolid A3, a unique p-quinone methide antibiotic from Chitinophaga sancti.

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A mass spectrometry-guided genome mining approach for natural product peptidogenomics

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The biosynthetic genes for disorazoles, potent cytotoxic compounds that disrupt microtubule formation.

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The plant pathogen Streptomyces scabies 87-22 has a functional pyochelin biosynthetic pathway that is regulated by TetR- and AfsR-family proteins

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Completing the puzzle of aurachin biosynthesis in Stigmatella aurantiaca Sg a15.

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Metabolic modeling and analysis of the metabolic switch in Streptomyces coelicolor

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Genome-wide gene expression changes in an industrial clavulanic acid overproduction strain of Streptomyces clavuligerus

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The ethylmalonyl-CoA pathway is used in place of the glyoxylate cycle by Methylobacterium extorquens AM1 during growth on acetate.

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Demonstration of the ethylmalonyl-CoA pathway by using 13C metabolomics.

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What are the obstacles for an integrated system for comprehensive interpretation of cross-platform metabolic profile data?

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Enacyloxins Are Products of an Unusual Hybrid Modular Polyketide Synthase Encoded by a Cryptic Burkholderia ambifaria Genomic Island

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Identification and Characterization of the Althiomycin Biosynthetic Gene Cluster in Myxococcus xanthus DK897

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Myxoprincomide: A Natural Product from Myxococcus xanthus Discovered by Comprehensive Analysis of the Secondary Metabolome

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Roimatacene: An Antibiotic against Gram-Negative Bacteria Isolated from Cystobacter ferrugineus Cb G35 (Myxobacteria)

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Synthetic Biology in Streptomyces Bacteria

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TARDIS-based microbial metabolomics: time and relative differences in systems

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Identification of bottlenecks in Escherichia coli engineered for the production of CoQ(10)

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Unprecedented Anthranilate Priming Involving Two Enzymes of the Acyl Adenylating Superfamily in Aurachin Biosynthesis

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p-Hydroxyacetophenone Amides fromCystobacter ferrugineus, strain Cb G35

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Bioactive microbial metabolites

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Synergies between synthetic biology and metabolic engineering

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Triggering cryptic natural product biosynthesis in microorganisms

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Mining microbial genomes for new natural products and biosynthetic pathways

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