Molecular mechanisms of inflammation and tissue injury after major trauma--is complement the "bad guy"? (Q26825724)

Sebastian Weckbach

series ordinal

2

1 reference

Michael A Flierl

series ordinal

3

1 reference

Philip F Stahel

series ordinal

5

1 reference

Journal of Biomedical Science

language of work or name

1 reference

30 November 2011

4 references

27 November 2019

14 October 2020

20 April 2021

4 references

27 November 2019

14 October 2020

20 April 2021

18

1 reference

page(s)

90

1 reference

Creative Commons Attribution 2.0 Generic

copyright license

1 reference

Europe PubMed Central

Creative Commons Attribution

27 November 2019

2 references

14 October 2020

20 April 2021

0 references

https://scigraph.springernature.com/pub.10.1186/1423-0127-18-90

0 references

cites work

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A putative chemoattractant receptor, C5L2, is expressed in granulocyte and immature dendritic cells, but not in mature dendritic cells

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The dark side of C5a in sepsis

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The complement anaphylatoxin C5a induces apoptosis in adrenomedullary cells during experimental sepsis

7 April 2017

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Complement inhibitors selectively attenuate injury following administration of cobra venom factor to rats

7 April 2017

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Expression and function of the C5a receptor in rat alveolar epithelial cells

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Requirement and role of C5a in acute lung inflammatory injury in rats

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Complement: a key system for immune surveillance and homeostasis

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Alveolar macrophage phagocytosis is enhanced after blunt chest trauma and alters the posttraumatic mediator release

7 April 2017

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An essential role for Stat3 in regulating IgG immune complex-induced pulmonary inflammation

28 September 2017

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Isolated blunt chest injury leads to transient activation of circulating neutrophils

28 September 2017

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Interactions between coagulation and complement--their role in inflammation

28 September 2017

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The role of toll-like receptor-4 in the development of multi-organ failure following traumatic haemorrhagic shock and resuscitation

28 September 2017

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Inhibiting the C5-C5a receptor axis

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28 September 2017

Complement in the brain.

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The effect of ischemia reperfusion injury on skeletal muscle

28 September 2017

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The anaphylatoxin receptor C5aR is present during fracture healing in rats and mediates osteoblast migration in vitro

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3247859

Nitric oxide and redox mechanisms in the immune response

28 September 2017

1 reference

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The regulation of the CNS innate immune response is vital for the restoration of tissue homeostasis (repair) after acute brain injury: a brief review

28 September 2017

1 reference

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New insights of an old defense system: structure, function, and clinical relevance of the complement system

28 September 2017

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Molecular intercommunication between the complement and coagulation systems

28 September 2017

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Management of traumatic brain injury

28 September 2017

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Secondary insults following traumatic brain injury enhance complement activation in the human brain and release of the tissue damage marker S100B

28 September 2017

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The role of the complement system in CNS inflammatory diseases

28 September 2017

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Current trends in resuscitation strategy for the multiply injured patient

28 September 2017

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Recent developments in low molecular weight complement inhibitors

28 September 2017

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Current theories on the pathophysiology of multiple organ failure after trauma

28 September 2017

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Sepsis, complement and the dysregulated inflammatory response

28 September 2017

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Complement and immune defense: from innate immunity to human diseases

28 September 2017

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DAMPs and inflammatory processes: the role of redox in the different outcomes

28 September 2017

1 reference

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Postinjury multiple organ failure

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3247859

The role of the anaphylatoxins in health and disease

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3247859

Complement-mediated ischemia-reperfusion injury: lessons learned from animal and clinical studies

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3247859

Heat shock protein 60 (HSP60) stimulates neutrophil effector functions.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3247859

C3a and C5a are chemotactic factors for human mesenchymal stem cells, which cause prolonged ERK1/2 phosphorylation

28 September 2017

1 reference

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The multiple roles of the innate immune system in the regulation of apoptosis and inflammation in the brain

28 September 2017

1 reference

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C1, MBL-MASPs and C1-inhibitor: novel approaches for targeting complement-mediated inflammation

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3247859

Sepsis, apoptosis and complement

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3247859

The complement cascade: Yin-Yang in neuroinflammation--neuro-protection and -degeneration

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3247859

Pharmacology of traumatic brain injury: where is the "golden bullet"?

28 September 2017

1 reference

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Functional roles for C5a receptors in sepsis

28 September 2017

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Polytrauma--pathophysiology and management principles

28 September 2017

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C5a, a therapeutic target in sepsis

28 September 2017

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Role of biological modifiers regulating the immune response after trauma

28 September 2017

1 reference

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Regulation of lung inflammation in the model of IgG immune-complex injury

28 September 2017

1 reference

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Anaphylatoxins: their role in bacterial infection and inflammation

28 September 2017

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Innate immunity and protective neuroinflammation: new emphasis on the role of neuroimmune regulatory proteins

28 September 2017

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Macrophage complement receptors and pathogen clearance

28 September 2017

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Inhibition of the alternative complement activation pathway in traumatic brain injury by a monoclonal anti-factor B antibody: a randomized placebo-controlled study in mice

28 September 2017

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Impact of the complement cascade on posttraumatic cartilage inflammation and degradation

28 September 2017

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The impact of endogenous triggers on trauma-associated inflammation

28 September 2017

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Apoptosis and caspases regulate death and inflammation in sepsis

28 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3247859

S100 proteins expressed in phagocytes: a novel group of damage-associated molecular pattern molecules

28 September 2017

1 reference

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Complement receptor 2, natural antibodies and innate immunity: Inter-relationships in B cell selection and activation

28 September 2017

1 reference

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Complement mediators in ischemia-reperfusion injury

28 September 2017

1 reference

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Reduced neuronal cell death after experimental brain injury in mice lacking a functional alternative pathway of complement activation

28 September 2017

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The role of complement, C5a and its receptors in sepsis and multiorgan dysfunction syndrome

28 September 2017

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The role of complement in danger sensing and transmission

28 September 2017

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Trauma: the role of the innate immune system

28 September 2017

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An essential role for complement C5a in the pathogenesis of septic cardiac dysfunction

28 September 2017

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The two-event construct of postinjury multiple organ failure

28 September 2017

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Pathophysiology of polytrauma

28 September 2017

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Role of C5a in inflammatory responses

28 September 2017

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Complement: a unique innate immune sensor for danger signals

28 September 2017

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Complement C3 and C5 play critical roles in traumatic brain cryoinjury: blocking effects on neutrophil extravasation by C5a receptor antagonist.

28 September 2017

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Initiation of complement activation following oxidative stress. In vitro and in vivo observations

28 September 2017

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The alternative pathway of complement in disease: opportunities for therapeutic targeting

28 September 2017

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Complement activation: beneficial and detrimental effects in the CNS.

28 September 2017

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Central nervous system-targeted complement inhibition mediates neuroprotection after closed head injury in transgenic mice

28 September 2017

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Complement therapeutics; history and current progress.

28 September 2017

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"Eat me" and "don't eat me" signals govern the innate immune response and tissue repair in the CNS: emphasis on the critical role of the complement system

28 September 2017

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Complement: structure, functions, evolution, and viral molecular mimicry

28 September 2017

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Activation of complement in the central nervous system: roles in neurodegeneration and neuroprotection

28 September 2017

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C5a anaphylatoxin is a major regulator of activating versus inhibitory FcgammaRs in immune complex-induced lung disease

28 September 2017

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Tailoring anti-complement therapeutics

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3247859

Complement in central nervous system inflammation

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3247859

Inflammatory response in acute traumatic brain injury: a double-edged sword

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3247859

Activator protein-1 activation in acute lung injury

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3247859

Increased C5a receptor expression in sepsis

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3247859

Anti-c5a ameliorates coagulation/fibrinolytic protein changes in a rat model of sepsis

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3247859

Identification of a subpopulation of rapidly self-renewing and multipotential adult stem cells in colonies of human marrow stromal cells

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3247859

Complement anaphylatoxin C3a is selectively protective against NMDA-induced neuronal cell death

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3247859

Protective effects of anti-C5a in sepsis-induced thymocyte apoptosis

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3247859

Complement components of the innate immune system in health and disease in the CNS.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3247859

Complement activation following oxidative stress

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3247859

Inhibition of complement as a therapeutic approach in inflammatory central nervous system (CNS) disease

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3247859

Complement anaphylatoxin receptors on neurons: new tricks for old receptors?

28 September 2017

1 reference

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Regulation of the complement membrane attack pathway

28 September 2017

1 reference

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Selection of a C5a receptor antagonist from phage libraries attenuating the inflammatory response in immune complex disease and ischemia/reperfusion injury.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3247859

Complement C1s activation in degenerating articular cartilage of rheumatoid arthritis patients: immunohistochemical studies with an active form specific antibody

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3247859

Synergistic enhancement of chemokine generation and lung injury by C5a or the membrane attack complex of complement

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3247859

Role of complement in in vitro and in vivo lung inflammatory reactions.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3247859

NF-kappaB activation during IgG immune complex-induced lung injury: requirements for TNF-alpha and IL-1beta but not complement

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3247859

Inflammatory signals induce neurotrophin expression in human microglial cells

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3247859

Activation of the clotting system and complement after trauma.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3247859

Reperfusion injury of ischemic skeletal muscle is mediated by natural antibody and complement

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3247859

Complement and the recruitment of mononuclear osteoclasts

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3247859

Evolving concepts in the pathogenesis of postinjury multiple organ failure

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3247859

The complement system in trauma-related and ischemic tissue damage: a brief review.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3247859

Complement biosynthesis in the central nervous system

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3247859

Effects of anti-C5a antibodies on the adult respiratory distress syndrome in septic primates

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3247859

Mechanism for the inflammatory response in primate lungs. Demonstration and partial characterization of an alveolar macrophage-derived chemotactic factor with preferential activity for polymorphonuclear leukocytes

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3247859

Absence of the complement regulatory molecule CD59a leads to exacerbated neuropathology after traumatic brain injury in mice.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3247859

Predictors of reoperation following operative management of fractures of the tibial shaft

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3247859

Circulating complement proteins in multiple trauma patients--correlation with injury severity, development of sepsis, and outcome

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3247859

Complement activation in the central nervous system following blood-brain barrier damage in man.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3247859

Rous-Whipple Award Lecture. Role of complement in lung inflammatory injury

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3247859

Posttraumatic complications and inflammatory mediators

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3247859

Estimation of serum complement and its role in management of trauma

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3247859

The specific production of the third component of complement by osteoblastic cells treated with 1 alpha,25-dihydroxyvitamin D3.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3247859

1 alpha,25-dihydroxyvitamin D3 regulates in vivo production of the third component of complement (C3) in bone

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3247859

Epidemiology, severity classification, and outcome of moderate and severe traumatic brain injury: a prospective multicenter study.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3247859

Injury mortality indicators: recommendations from the International Collaborative Effort on Injury Statistics

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3247859

Role of C5 activation products in sepsis.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3247859

Current trends in neurotrauma care

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3247859

Blunt chest trauma induces mediator-dependent monocyte migration to the lung.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3247859

Immunology. Dangers in and out.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3247859

C1-inhibitor attenuates neurobehavioral deficits and reduces contusion volume after controlled cortical impact brain injury in mice.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3247859

Mannose binding lectin gene deficiency increases susceptibility to traumatic brain injury in mice

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3247859

Properdin can initiate complement activation by binding specific target surfaces and providing a platform for de novo convertase assembly

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3247859

Role of the alternative pathway in the early complement activation following major trauma

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3247859

Vaccinia virus complement control protein significantly improves sensorimotor function recovery after severe head trauma

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3247859

Reduced tissue damage and improved recovery of motor function after traumatic brain injury in mice deficient in complement component C4.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3247859

[Method and conditions of isolation and proliferation of multipotent mesenchymal stem cells].

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3247859

In vivo regulation of neutrophil apoptosis by C5a during sepsis.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3247859

Pharmacological complement inhibition at the C3 convertase level promotes neuronal survival, neuroprotective intracerebral gene expression, and neurological outcome after traumatic brain injury.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3247859

[Emergency management of thoracic trauma].

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3247859

Stat3 activation in acute lung injury.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3247859

Protective effects of a potent C5a receptor antagonist on experimental acute limb ischemia-reperfusion in rats

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3247859

Lung injury severity scoring in the era of lung protective mechanical ventilation: the PaO2/FIO2 ratio.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3247859

Identification of genes regulated during osteoblastic differentiation by genome-wide expression analysis of mouse calvaria primary osteoblasts in vitro.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3247859

Intracerebroventricular injection of the terminal complement complex causes inflammatory reaction in the rat brain.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3247859

Formation of complement membrane attack complex in mammalian cerebral cortex evokes seizures and neurodegeneration.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3247859

Vaccinia virus complement control protein enhances functional recovery after traumatic brain injury

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3247859

Intrathecal levels of complement-derived soluble membrane attack complex (sC5b-9) correlate with blood-brain barrier dysfunction in patients with traumatic brain injury.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3247859

Moderation of skeletal muscle reperfusion injury by a sLe(x)-glycosylated complement inhibitory protein

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3247859

Role of C5a in multiorgan failure during sepsis

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3247859

Protective effects of C5a blockade in sepsis

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3247859

Elevated levels of the complement components C3 and factor B in ventricular cerebrospinal fluid of patients with traumatic brain injury.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3247859

Complement proteins are present in developing endochondral bone and may mediate cartilage cell death and vascularization

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3247859

Activation of the complement cascade and increase of clusterin in the brain following a cortical contusion in the adult rat.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3247859

Increased phospholipase C activity after experimental brain injury.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3247859

C5a modulation of interleukin-1 beta-induced interleukin-6 production by human osteoblast-like cells

28 November 2018

1 reference

12 December 2020

The effect of trauma on serum C3 activation and its correlation with injury severity score in man

1 reference

12 December 2020

Is the function of alveolar macrophages altered following blunt chest trauma?

1 reference

12 December 2020

The effect of recent trauma on serum complement activation and serum C3 levels correlated with the injury severity score

1 reference

12 December 2020

The differing roles of the classical and mannose-binding lectin complement pathways in the events following skeletal muscle ischemia-reperfusion

1 reference

12 December 2020

Postinjury neutrophil priming and activation: an early vulnerable window

1 reference

12 December 2020

Sepsis-induced apoptosis causes progressive profound depletion of B and CD4+ T lymphocytes in humans

1 reference

12 December 2020

Complement in inflammatory tissue damage and disease

1 reference

12 December 2020

Complement C5a in the sepsis syndrome--too much of a good thing?

1 reference

12 December 2020

Anaphylatoxin formation in sepsis

1 reference

12 December 2020

In vitro and in vivo dependency of chemokine generation on C5a and TNF-alpha

1 reference

12 December 2020

Roles for C-X-C chemokines and C5a in lung injury after hindlimb ischemia-reperfusion

1 reference

12 December 2020

Decay-accelerating factor attenuates remote ischemia-reperfusion-initiated organ damage

1 reference

12 December 2020

Multiple trauma induces serum production of host defence peptides

1 reference

12 December 2020

Complement activation in the human brain after traumatic head injury

1 reference

12 December 2020

Complement and the severity of pulmonary failure

1 reference

12 December 2020

Serum complement levels and severity of sepsis

1 reference

12 December 2020

Differential expression of individual complement regulators in the brain and choroid plexus

1 reference

12 December 2020

Neutrophil mediated remote organ injury after lower torso ischemia and reperfusion is selectin and complement dependent

1 reference

12 December 2020

Transcriptional regulation of the production of the third component of complement (C3) by 1 alpha,25-dihydroxyvitamin D3 in mouse marrow-derived stromal cells (ST2) and primary osteoblastic cells

1 reference

12 December 2020

Trauma and long-term mortality

1 reference

12 December 2020

Terminal complement complexes and anaphylatoxins in septic and ischemic patients

1 reference

12 December 2020

Local neutrophil influx following lateral fluid-percussion brain injury in rats is associated with accumulation of complement activation fragments of the third component (C3) of the complement system

1 reference

12 December 2020

Neutrophil priming and activation in the pathogenesis of postinjury multiple organ failure

1 reference

12 December 2020

Association of complement activation and elevated plasma-C5a with adult respiratory distress syndrome. Pathophysiological relevance and possible prognostic value

1 reference

12 December 2020

The role of the complement system in traumatic brain injury

1 reference

12 December 2020

C5a receptor and thymocyte apoptosis in sepsis

1 reference

12 December 2020

Complement activation in injured patients occurs immediately and is dependent on the severity of the trauma

1 reference

12 December 2020

Effect of soluble complement receptor-1 on neutrophil accumulation after traumatic brain injury in rats

1 reference

12 December 2020

Generation of C5a in the absence of C3: a new complement activation pathway

1 reference

12 December 2020

Trauma-activated polymorphonucleated leukocytes damage endothelial progenitor cells: probable role of CD11b/CD18-CD54 interaction and release of reactive oxygen species

1 reference

12 December 2020

Pulmonary contusion induces alveolar type 2 epithelial cell apoptosis: role of alveolar macrophages and neutrophils

1 reference

12 December 2020

Intracerebral complement C5a receptor (CD88) expression is regulated by TNF and lymphotoxin-alpha following closed head injury in mice

1 reference

12 December 2020

Neurogenic amplification of immune complex inflammation

1 reference

12 December 2020

The role of the lung in postinjury multiple organ failure

1 reference

12 December 2020

IgM binding to injured tissue precedes complement activation during skeletal muscle ischemia-reperfusion

1 reference

12 December 2020

Murine hindlimb reperfusion injury can be initiated by a self-reactive monoclonal IgM

1 reference

12 December 2020

Early expression changes of complement regulatory proteins and C5A receptor (CD88) on leukocytes after multiple injury in humans

1 reference

12 December 2020

The role of C5a in the innate immune response after experimental blunt chest trauma

1 reference

12 December 2020

Protection of innate immunity by C5aR antagonist in septic mice

1 reference

12 December 2020

Protective effects of anti-C5a peptide antibodies in experimental sepsis

1 reference

12 December 2020

Effect of IL-1beta, TNF-alpha and IL-4 on complement regulatory protein mRNA expression in human articular chondrocytes

1 reference

12 December 2020

Hypoxia and hypotension, the "lethal duo" in traumatic brain injury: implications for prehospital care

1 reference

12 December 2020

The evolution, structure, biology and pathophysiology of complement

1 reference

12 December 2020

Chemotactic factor generation and cell accumulation in acute lung injury induced by endotracheal acid instillation

1 reference

12 December 2020

Inflammatory mediators in relation to the development of multiple organ failure in patients after severe blunt trauma

1 reference

12 December 2020

C1-esterase inhibitor and a novel peptide inhibitor improve contractile function in reperfused skeletal muscle

1 reference

12 December 2020

Immune deposits in articular cartilage of patients with rheumatoid arthritis have a granular pattern not seen in osteoarthritis

1 reference

12 December 2020

Complement Cls, a classical enzyme with novel functions at the endochondral ossification center: immunohistochemical staining of activated Cls with a neoantigen-specific antibody

1 reference

12 December 2020

Skeletal muscle reperfusion injury is mediated by neutrophils and the complement membrane attack complex

1 reference

12 December 2020

Identifiers

DOI

10.1186/1423-0127-18-90

1 reference

Dimensions Publication ID

1359855

1008819207

0 references

1359855

1 reference

1 reference

1 reference