The role of complement in danger sensing and transmission (Q36499763)

14 August 2017

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title

The role of complement in danger sensing and transmission (English)

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14 August 2017

Jörg Köhl

1

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14 August 2017

1 January 2006

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14 August 2017

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14 August 2017

34

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14 August 2017

2

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14 August 2017

157-176

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https://scigraph.springernature.com/pub.10.1385/ir:34:2:157

14 August 2017

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cites work

Mice Deficient in Complement Receptors 1 and 2 Lack a Tissue Injury-Inducing Subset of the Natural Antibody Repertoire

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12 December 2020

Detection of anaphylatoxin receptors on CD83+ dendritic cells derived from human skin

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12 December 2020

Actively acquired tolerance of foreign cells

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12 December 2020

C5L2, a nonsignaling C5A binding protein

1 reference

12 December 2020

Antibody-independent activation of the complement system by mitochondria is mediated by cardiolipin

1 reference

12 December 2020

Hydrophobicity: an ancient damage-associated molecular pattern that initiates innate immune responses.

1 reference

12 December 2020

Structures of complement component C3 provide insights into the function and evolution of immunity

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12 December 2020

Complement C3a receptors in the pituitary gland: a novel pathway by which an innate immune molecule releases hormones involved in the control of inflammation.

1 reference

12 December 2020

Disruption of the Cr2 locus results in a reduction in B-1a cells and in an impaired B cell response to T-dependent antigen.

1 reference

12 December 2020

C1q and mannose binding lectin engagement of cell surface calreticulin and CD91 initiates macropinocytosis and uptake of apoptotic cells

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12 December 2020

Role of C5a in inflammatory responses

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12 December 2020

Innate immune recognition

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12 December 2020

Complement factor 5 is a quantitative trait gene that modifies liver fibrogenesis in mice and humans

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12 December 2020

Coupling of the C5a receptor to Gi in U-937 cells and in cells transfected with C5a receptor cDNA.

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12 December 2020

Anti-phospholipid antibodies restore mesenteric ischemia/reperfusion-induced injury in complement receptor 2/complement receptor 1-deficient mice.

1 reference

12 December 2020

Liver inflammation and regeneration: two distinct biological phenomena or parallel pathophysiologic processes?

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12 December 2020

A putative chemoattractant receptor, C5L2, is expressed in granulocyte and immature dendritic cells, but not in mature dendritic cells

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12 December 2020

Expression and function of C5a receptor in mouse microvascular endothelial cells

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12 December 2020

Signaling properties of CR3 (CD11b/CD18) and CR1 (CD35) in relation to phagocytosis of complement-opsonized particles

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12 December 2020

Complement and Toll-like receptors: key regulators of adaptive immune responses

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12 December 2020

The C5-sufficient A/J congenic mouse strain. Inflammatory response and resistance to Listeria monocytogenes.

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12 December 2020

T lymphocyte expression of complement receptor 2 (CR2/CD21): a role in adhesive cell-cell interactions and dysregulation in a patient with systemic lupus erythematosus (SLE)

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12 December 2020

The complement system in B cell regulation

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12 December 2020

The role of complement in the development of systemic lupus erythematosus

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12 December 2020

Expression cloning of the human C3a anaphylatoxin receptor (C3aR) from differentiated U-937 cells

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12 December 2020

The C5a receptor is expressed by human renal proximal tubular epithelial cells

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12 December 2020

Expression of C5a receptor in mouse brain: role in signal transduction and neurodegeneration.

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12 December 2020

Both C3a and C3a(desArg) regulate interleukin-6 synthesis in human peripheral blood mononuclear cells.

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12 December 2020

C5a anaphylatoxin is a major regulator of activating versus inhibitory FcgammaRs in immune complex-induced lung disease

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12 December 2020

Regulation by complement C3a and C5a anaphylatoxins of cytokine production in human umbilical vein endothelial cells

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12 December 2020

The proinflammatory mediators C3a and C5a are essential for liver regeneration

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12 December 2020

Blood- and skin-derived monocytes/macrophages respond to C3a but not to C3a(desArg) with a transient release of calcium via a pertussis toxin-sensitive signal transduction pathway

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12 December 2020

The lectin-complement pathway--its role in innate immunity and evolution

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12 December 2020

Neuronal expression of a functional receptor for the C5a complement activation fragment

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12 December 2020

Anti-C5 monoclonal antibody therapy prevents collagen-induced arthritis and ameliorates established disease

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12 December 2020

Homozygous C1q deficiency causes glomerulonephritis associated with multiple apoptotic bodies

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12 December 2020

Amelioration of lupus-like autoimmune disease in NZB/WF1 mice after treatment with a blocking monoclonal antibody specific for complement component C5.

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12 December 2020

Opposing regulatory roles of complement factor 5 in the development of bleomycin-induced pulmonary fibrosis

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12 December 2020

CD46 plays a key role in tailoring innate immune recognition of apoptotic and necrotic cells

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12 December 2020

The danger model: a renewed sense of self

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12 December 2020

Complement factors C3a and C5a are increased in bronchoalveolar lavage fluid after segmental allergen provocation in subjects with asthma

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12 December 2020

Multiple roles of antimicrobial defensins, cathelicidins, and eosinophil-derived neurotoxin in host defense.

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12 December 2020

Mitogen-activated protein kinase activation requires two signal inputs from the human anaphylatoxin C5a receptor

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12 December 2020

Activation of the complement system generates antibacterial peptides

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12 December 2020

C1q and systemic lupus erythematosus

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12 December 2020

Assembly and activation of the plasma kallikrein/kinin system: a new interpretation

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12 December 2020

Discrimination of sepsis and systemic inflammatory response syndrome by determination of circulating plasma concentrations of procalcitonin, protein complement 3a, and interleukin-6

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12 December 2020

Arthritis critically dependent on innate immune system players

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12 December 2020

Functional expression and modulation of C5a receptor (CD88) on skin dendritic cells

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12 December 2020

Local synthesis of complement component C3 regulates acute renal transplant rejection

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12 December 2020

Mechanism of suppression of cell-mediated immunity by measles virus

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12 December 2020

The dark side of C5a in sepsis

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12 December 2020

Mechanisms of activation of the classical pathway of complement by Hageman factor fragment

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12 December 2020

C5a initiates the inflammatory cascade in immune complex peritonitis

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12 December 2020

Taking our breath away: dendritic cells in the pathogenesis of asthma

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12 December 2020

Complement. First of two parts

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12 December 2020

C5a negatively regulates toll-like receptor 4-induced immune responses

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12 December 2020

Expression of the complement anaphylatoxin C3a and C5a receptors on bronchial epithelial and smooth muscle cells in models of sepsis and asthma

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12 December 2020

Expression cloning of a receptor for C5a anaphylatoxin on differentiated HL-60 cells

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12 December 2020

Complement-regulatory proteins in severe malaria: too little or too much of a good thing?

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12 December 2020

Acylation stimulating protein and the adipocyte

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12 December 2020

The chemoattractant receptor-like protein C5L2 binds the C3a des-Arg77/acylation-stimulating protein

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12 December 2020

Anaphylatoxins and infectious and non-infectious inflammatory diseases

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12 December 2020

CR1 and CR1-like: the primate immune adherence receptors

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12 December 2020

Complement receptors and the shaping of the natural antibody repertoire

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12 December 2020

The orphan receptor C5L2 has high affinity binding sites for complement fragments C5a and C5a des-Arg(74)

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12 December 2020

The anaphylatoxins bridge innate and adaptive immune responses in allergic asthma.

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12 December 2020

Structure-function relationships of complement receptor type 1.

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12 December 2020

Oleic acid increases cell surface expression and activity of CD11b on human neutrophils

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12 December 2020

Differential regulation of responsiveness to fMLP and C5a upon dendritic cell maturation: correlation with receptor expression

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12 December 2020

Interaction between complement receptor gC1qR and hepatitis C virus core protein inhibits T-lymphocyte proliferation

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12 December 2020

Early IL-12 p70, but not p40, production by splenic macrophages correlates with host resistance to blood-stage Plasmodium chabaudi AS malaria.

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12 December 2020

Tolerance, danger, and the extended family

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12 December 2020

Primitive complement system of invertebrates

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12 December 2020

The human S100 protein MRP-14 is a novel activator of the beta 2 integrin Mac-1 on neutrophils

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12 December 2020

Molecular cloning and characterization of the human anaphylatoxin C3a receptor

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12 December 2020

Transfer of immune complexes from erythrocyte CR1 to mouse macrophages

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12 December 2020

Regulation of B cell functions by C3a and C3a(desArg): suppression of TNF-alpha, IL-6, and the polyclonal immune response

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12 December 2020

C5a suppresses the production of IL-12 by IFN-gamma-primed and lipopolysaccharide-challenged human monocytes

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12 December 2020

Constitutively active Galpha16 stimulates STAT3 via a c-Src/JAK- and ERK-dependent mechanism

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12 December 2020

Mechanisms of proliferation synergy by receptor tyrosine kinase and G protein-coupled receptor activation in human airway smooth muscle.

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12 December 2020

Expression of CR2 (the C3dg/EBV receptor, CD21) on normal human peripheral blood T lymphocytes

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12 December 2020

A role for the C3a anaphylatoxin receptor in the effector phase of asthma

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12 December 2020

The lineage decisions of helper T cells

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12 December 2020

Dendritic cells are recruited into the airway epithelium during the inflammatory response to a broad spectrum of stimuli

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12 December 2020

Early local generation of C5a initiates the elicitation of contact sensitivity by leading to early T cell recruitment

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12 December 2020

Specificity of the thioester-containing reactive site of human C3 and its significance to complement activation

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12 December 2020

C1q binding and C1 activation by various isolated cellular membranes.

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12 December 2020

Two signaling mechanisms for activation of alphaM beta2 avidity in polymorphonuclear neutrophils

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12 December 2020

Relationship of acute lung inflammatory injury to Fas/FasL system

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12 December 2020

The C5a chemoattractant receptor mediates mucosal defence to infection

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12 December 2020

The complement system in regulation of adaptive immunity

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12 December 2020

Regulation of interleukin-12 by complement receptor 3 signaling

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12 December 2020

C3d of complement as a molecular adjuvant: bridging innate and acquired immunity

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12 December 2020

Complement fragment C3a stimulates Ca2+ influx in neutrophils via a pertussis-toxin-sensitive G protein

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12 December 2020

Cell-surface protein identified on phagocytic cells modulates the C1q-mediated enhancement of phagocytosis

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12 December 2020

Formation of the initial C3 convertase of the alternative complement pathway. Acquisition of C3b-like activities by spontaneous hydrolysis of the putative thioester in native C3

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12 December 2020

A regulatory role for the C5a anaphylatoxin in type 2 immunity in asthma

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12 December 2020

Immunological recognition of self

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12 December 2020

Renal expression of the C3a receptor and functional responses of primary human proximal tubular epithelial cells

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12 December 2020

Selective suppression of IL-12 production by chemoattractants

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12 December 2020

Apoptosis is associated with reduced expression of complement regulatory molecules, adhesion molecules and other receptors on polymorphonuclear leucocytes: functional relevance and role in inflammation

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12 December 2020

Complement in allergy and asthma

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12 December 2020

New insights into the role of the complement pathway in allergy and asthma

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12 December 2020

An anti-inflammatory function for the complement anaphylatoxin C5a-binding protein, C5L2

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12 December 2020

Regulation of B lymphocyte responses to foreign and self-antigens by the CD19/CD21 complex

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12 December 2020

Host recognition and target differentiation by factor H, a regulator of the alternative pathway of complement

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12 December 2020

Signaling the brain in systemic inflammation: the role of complement

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12 December 2020

Emerging roles and new functions of CD46

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12 December 2020

Activation of human CD4+ cells with CD3 and CD46 induces a T-regulatory cell 1 phenotype

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12 December 2020

Complement facilitates early prion pathogenesis.

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12 December 2020

cC1q-R (calreticulin) and gC1q-R/p33: ubiquitously expressed multi-ligand binding cellular proteins involved in inflammation and infection

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12 December 2020

Regulation of IL-6 synthesis in human peripheral blood mononuclear cells by C3a and C3a(desArg)

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12 December 2020

Approaching the asymptote? Evolution and revolution in immunology

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12 December 2020

Gram-negative bacteria and phagocytic cell interaction mediated by complement receptor 3.

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12 December 2020

Cellular expression of the C5a anaphylatoxin receptor (C5aR): demonstration of C5aR on nonmyeloid cells of the liver and lung

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12 December 2020

Expression and modulation of C5a receptor (CD88) on skin dendritic cells. Chemotactic effect of C5a on skin migratory dendritic cells

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12 December 2020

Deletion of the complement anaphylatoxin C3a receptor attenuates, whereas ectopic expression of C3a in the brain exacerbates, experimental autoimmune encephalomyelitis

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12 December 2020

The C5a receptor is expressed in normal renal proximal tubular but not in normal pulmonary or hepatic epithelial cells

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12 December 2020

Identification of complement factor 5 as a susceptibility locus for experimental allergic asthma

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12 December 2020

Complement c3a and c5a induce different signal transduction cascades in endothelial cells

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12 December 2020

The role of mannose-binding lectin in health and disease

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12 December 2020

Pentraxins at the crossroads between innate immunity, inflammation, matrix deposition, and female fertility

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12 December 2020

The chemotactic receptor for human C5a anaphylatoxin

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12 December 2020

Identifiers

DOI

10.1385/IR:34:2:157

1 reference

PubMed ID

16760575

Dimensions Publication ID

14 August 2017

0 references

1 reference

PubMed ID

16760575