Mechanistic target of rapamycin (mTOR): a point of convergence in the action of insulin/IGF-1 and G protein-coupled receptor agonists in pancreatic cancer cells (Q26827387)

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English	Mechanistic target of rapamycin (mTOR): a point of convergence in the action of insulin/IGF-1 and G protein-coupled receptor agonists in pancreatic cancer cells	scientific article

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Europe PubMed Central

Mechanistic target of rapamycin (mTOR): a point of convergence in the action of insulin/IGF-1 and G protein-coupled receptor agonists in pancreatic cancer cells (English)

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G protein-coupled receptor

0 references

1 reference

based on heuristic

inferred from title

pancreatic cancer

1 reference

based on heuristic

inferred from title

author name string

Enrique Rozengurt

1

1 reference

language of work or name

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publication date

2014

1 reference

Frontiers in Physiology

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5

1 reference

357

1 reference

Metformin therapy and risk of cancer in patients with type 2 diabetes: systematic review

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4171984

7 April 2017

mTOR: from growth signal integration to cancer, diabetes and ageing

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4171984

7 April 2017

Catabolic efficiency of aerobic glycolysis: the Warburg effect revisited

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4171984

7 April 2017

Mammalian target of rapamycin (mTOR): conducting the cellular signaling symphony

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7 April 2017

Understanding the Warburg effect: the metabolic requirements of cell proliferation

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7 April 2017

Core signaling pathways in human pancreatic cancers revealed by global genomic analyses

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7 April 2017

AMPK phosphorylation of raptor mediates a metabolic checkpoint

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7 April 2017

Insulin receptor substrate is a mediator of phosphoinositide 3-kinase activation in quiescent pancreatic cancer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4171984

7 April 2017

Regulation of mTORC1 by amino acids

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7 April 2017

Repurposing of metformin and aspirin by targeting AMPK-mTOR and inflammation for pancreatic cancer prevention and treatment

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7 April 2017

Cancer statistics, 2014

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7 April 2017

TSC2 mediates cellular energy response to control cell growth and survival

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7 April 2017

Intracellular redistribution of protein kinase D2 in response to G-protein-coupled receptor agonists

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7 April 2017

TSC2 integrates Wnt and energy signals via a coordinated phosphorylation by AMPK and GSK3 to regulate cell growth

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7 April 2017

The LKB1 tumor suppressor negatively regulates mTOR signaling

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7 April 2017

EGF receptor is required for KRAS-induced pancreatic tumorigenesis

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7 April 2017

The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin

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7 April 2017

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7 April 2017

Diverse somatic mutation patterns and pathway alterations in human cancers

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7 April 2017

Critical nodes in signalling pathways: insights into insulin action

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7 April 2017

AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism

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7 April 2017

Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse

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7 April 2017

Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain

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7 April 2017

Metformin and cancer risk and mortality: a systematic review and meta-analysis taking into account biases and confounders

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28 September 2017

Projecting cancer incidence and deaths to 2030: the unexpected burden of thyroid, liver, and pancreas cancers in the United States

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28 September 2017

Targeting insulin-like growth factor 1 receptor inhibits pancreatic cancer growth and metastasis

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28 September 2017

Calorie restriction decreases murine and human pancreatic tumor cell growth, nuclear factor-κB activation, and inflammation-related gene expression in an insulin-like growth factor-1-dependent manner

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28 September 2017

Metabolic determinants of cancer cell sensitivity to glucose limitation and biguanides.

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28 September 2017

Risk factors for pancreatic cancer: underlying mechanisms and potential targets

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28 September 2017

Mechanisms of obesity-induced gastrointestinal neoplasia

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28 September 2017

AMP is a true physiological regulator of AMP-activated protein kinase by both allosteric activation and enhancing net phosphorylation

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28 September 2017

High-fat, high-calorie diet promotes early pancreatic neoplasia in the conditional KrasG12D mouse model.

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28 September 2017

Genetic alterations associated with progression from pancreatic intraepithelial neoplasia to invasive pancreatic tumor

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28 September 2017

Signal integration by mTORC1 coordinates nutrient input with biosynthetic output.

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28 September 2017

Metformin inhibits the growth of human pancreatic cancer xenografts

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28 September 2017

Different patterns of Akt and ERK feedback activation in response to rapamycin, active-site mTOR inhibitors and metformin in pancreatic cancer cells

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4171984

28 September 2017

Anti-diabetic medications and risk of pancreatic cancer in patients with diabetes mellitus: a systematic review and meta-analysis

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4171984

28 September 2017

The evolution of the TOR pathway and its role in cancer

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28 September 2017

Metformin inhibition of mTORC1 activation, DNA synthesis and proliferation in pancreatic cancer cells: dependence on glucose concentration and role of AMPK.

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4171984

28 September 2017

Metformin use is associated with better survival of diabetic patients with pancreatic cancer

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4171984

28 September 2017

Use of antidiabetic agents and the risk of pancreatic cancer: a case-control analysis.

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28 September 2017

Metformin, independent of AMPK, induces mTOR inhibition and cell-cycle arrest through REDD1.

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28 September 2017

Type 2 diabetes increases and metformin reduces total, colorectal, liver and pancreatic cancer incidences in Taiwanese: a representative population prospective cohort study of 800,000 individuals

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28 September 2017

The association of AMPK with ULK1 regulates autophagy

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28 September 2017

Metformin and cancer risk in diabetic patients: a systematic review and meta-analysis.

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4171984

28 September 2017

Protein kinase D1 promotes anchorage-independent growth, invasion, and angiogenesis by human pancreatic cancer cells

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4171984

28 September 2017

Use of cells expressing gamma subunit variants to identify diverse mechanisms of AMPK activation

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28 September 2017

Anthropometric measures, body mass index, and pancreatic cancer: a pooled analysis from the Pancreatic Cancer Cohort Consortium (PanScan).

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28 September 2017

Metformin, independent of AMPK, inhibits mTORC1 in a rag GTPase-dependent manner

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28 September 2017

A novel small-molecule inhibitor of protein kinase D blocks pancreatic cancer growth in vitro and in vivo

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28 September 2017

Insulin-like growth factor axis gene polymorphisms and clinical outcomes in pancreatic cancer

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28 September 2017

The regulation of energy metabolism and the IGF-1/mTOR pathways by the p53 protein

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28 September 2017

Crosstalk between insulin/insulin-like growth factor-1 receptors and G protein-coupled receptor signaling systems: a novel target for the antidiabetic drug metformin in pancreatic cancer

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28 September 2017

AMP-activated protein kinase inhibits IGF-I signaling and protein synthesis in vascular smooth muscle cells via stimulation of insulin receptor substrate 1 S794 and tuberous sclerosis 2 S1345 phosphorylation

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28 September 2017

Induced overexpression of protein kinase D1 stimulates mitogenic signaling in human pancreatic carcinoma PANC-1 cells

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28 September 2017

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28 September 2017

Metformin disrupts crosstalk between G protein-coupled receptor and insulin receptor signaling systems and inhibits pancreatic cancer growth

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4171984

28 September 2017

Antidiabetic therapies affect risk of pancreatic cancer

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4171984

28 September 2017

PI3K/Akt: getting it right matters

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28 September 2017

The antidiabetic drug metformin exerts an antitumoral effect in vitro and in vivo through a decrease of cyclin D1 level.

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28 September 2017

Mitogenic signaling pathways induced by G protein-coupled receptors

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28 September 2017

PKD, PKD2, and p38 MAPK mediate Hsp27 serine-82 phosphorylation induced by neurotensin in pancreatic cancer PANC-1 cells

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28 September 2017

LKB1 and AMPK maintain epithelial cell polarity under energetic stress

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28 September 2017

Energy depletion inhibits phosphatidylinositol 3-kinase/Akt signaling and induces apoptosis via AMP-activated protein kinase-dependent phosphorylation of IRS-1 at Ser-794.

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28 September 2017

Protein kinase Calpha mediates feedback inhibition of EGF receptor transactivation induced by Gq-coupled receptor agonists

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28 September 2017

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28 September 2017

Protein kinase D signaling

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28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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31 May 2018

Increased insulin-like growth factor-I levels in women with polycystic ovary syndrome, and beneficial effects of metformin therapy

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21 January 2018

Insulin-lowering effects of metformin in women with early breast cancer

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21 January 2018

Insulin receptor substrate regulation of phosphoinositide 3-kinase.

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21 January 2018

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21 January 2018

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21 January 2018

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12 December 2020

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Amplification and overexpression of the AKT2 oncogene in a subset of human pancreatic ductal adenocarcinomas

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inferred from PubMed ID database lookup

Identifiers

10.3389/FPHYS.2014.00357

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

OpenCitations bibliographic resource ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

PMC publication ID

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Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

PubMed publication ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

ResearchGate publication ID

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