Inositol lipids: from an archaeal origin to phosphatidylinositol 3,5-bisphosphate faults in human disease (Q26852772)

PubMed

issue

24

1 reference

PubMed

page(s)

6281-94

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Phosphoinositides in cell regulation and membrane dynamics

PubMed

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A revised biosynthetic pathway for phosphatidylinositol in Mycobacteria

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Studies of inositol 1-phosphate analogues as inhibitors of the phosphatidylinositol phosphate synthase in mycobacteria

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Stress-induced synthesis of phosphatidylinositol 3-phosphate in mycobacteria

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Inositol lipid metabolism in mycobacteria: biosynthesis and regulatory mechanisms.

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Strategies for acquiring the phospholipid metabolite inositol in pathogenic bacteria, fungi and protozoa: making it and taking it.

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The Mycobacterium tuberculosis ino1 gene is essential for growth and virulence

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The glycosylphosphatidylinositol (GPI) biosynthetic pathway of bloodstream-form Trypanosoma brucei is dependent on the de novo synthesis of inositol

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PDGF-dependent tyrosine phosphorylation stimulates production of novel polyphosphoinositides in intact cells

21 January 2018

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Phosphatidylinositol 3,5-bisphosphate defines a novel PI 3-kinase pathway in resting mouse fibroblasts

21 January 2018

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Osmotic stress activates phosphatidylinositol-3,5-bisphosphate synthesis

21 January 2018

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Acquisition of unprecedented phosphatidylinositol 3,5-bisphosphate rise in hyperosmotically stressed 3T3-L1 adipocytes, mediated by ArPIKfyve-PIKfyve pathway

21 January 2018

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The Arabidopsis thaliana immunophilin ROF1 directly interacts with PI(3)P and PI(3,5)P2 and affects germination under osmotic stress

21 January 2018

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The Fab1 phosphatidylinositol kinase pathway in the regulation of vacuole morphology.

21 January 2018

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Phosphatidylinositol 3,5-bisphosphate: metabolism and cellular functions

21 January 2018

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Phosphatidylinositol 3,5-bisphosphate and Fab1p/PIKfyve underPPIn endo-lysosome function

21 January 2018

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Phosphatidylinositol-3,5-bisphosphate: no longer the poor PIP2.

21 January 2018

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Autophagy genes are essential for dauer development and life-span extension in C. elegans

21 January 2018

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WIPI-1alpha (WIPI49), a member of the novel 7-bladed WIPI protein family, is aberrantly expressed in human cancer and is linked to starvation-induced autophagy

21 January 2018

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Autophagy contributes to lysosomal storage disorders

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The phosphoinositide kinase PIKfyve is vital in early embryonic development: preimplantation lethality of PIKfyve-/- embryos but normality of PIKfyve+/- mice

21 January 2018

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Pathogenic mechanism of the FIG4 mutation responsible for Charcot-Marie-Tooth disease CMT4J

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Neuronal expression of Fig4 is both necessary and sufficient to prevent spongiform neurodegeneration.

21 January 2018

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Yunis-Varón syndrome is caused by mutations in FIG4, encoding a phosphoinositide phosphatase

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Phosphatidylinositol-3,5-bisphosphate: metabolism and physiological functions.

21 January 2018

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Novel PI(4)P 5-kinase homologue, Fab1p, essential for normal vacuole function and morphology in yeast

21 January 2018

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The stress-activated phosphatidylinositol 3-phosphate 5-kinase Fab1p is essential for vacuole function in S. cerevisiae

21 January 2018

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Fab1p is essential for PtdIns(3)P 5-kinase activity and the maintenance of vacuolar size and membrane homeostasis

21 January 2018

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Complementation analysis in PtdInsP kinase-deficient yeast mutants demonstrates that Schizosaccharomyces pombe and murine Fab1p homologues are phosphatidylinositol 3-phosphate 5-kinases

21 January 2018

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PIKfyve, a mammalian ortholog of yeast Fab1p lipid kinase, synthesizes 5-phosphoinositides. Effect of insulin

21 January 2018

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21 January 2018

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Functional dissociation between PIKfyve-synthesized PtdIns5P and PtdIns(3,5)P2 by means of the PIKfyve inhibitor YM201636

21 January 2018

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In vivo, Pikfyve generates PI(3,5)P2, which serves as both a signaling lipid and the major precursor for PI5P.

21 January 2018

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Production of phosphatidylinositol 5-phosphate via PIKfyve and MTMR3 regulates cell migration

21 January 2018

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PtdIns5P is an oxidative stress-induced second messenger that regulates PKB activation

21 January 2018

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Vac14 controls PtdIns(3,5)P(2) synthesis and Fab1-dependent protein trafficking to the multivesicular body

21 January 2018

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Osmotic stress-induced increase of phosphatidylinositol 3,5-bisphosphate requires Vac14p, an activator of the lipid kinase Fab1p

21 January 2018

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21 January 2018

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VAC14 nucleates a protein complex essential for the acute interconversion of PI3P and PI(3,5)P(2) in yeast and mouse

21 January 2018

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ArPIKfyve homomeric and heteromeric interactions scaffold PIKfyve and Sac3 in a complex to promote PIKfyve activity and functionality

21 January 2018

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Vac14 protein multimerization is a prerequisite step for Fab1 protein complex assembly and function

21 January 2018

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Assembly of a Fab1 phosphoinositide kinase signaling complex requires the Fig4 phosphoinositide phosphatase

21 January 2018

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Svp1p defines a family of phosphatidylinositol 3,5-bisphosphate effectors

21 January 2018

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A selective PIKfyve inhibitor blocks PtdIns(3,5)P(2) production and disrupts endomembrane transport and retroviral budding

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Structure-based analyses reveal distinct binding sites for Atg2 and phosphoinositides in Atg18.

21 January 2018

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Structural and functional characterization of the two phosphoinositide binding sites of PROPPINs, a β-propeller protein family

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Atg18 function in autophagy is regulated by specific sites within its β-propeller

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21 January 2018

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Rapid structural changes and acidification of guard cell vacuoles during stomatal closure require phosphatidylinositol 3,5-bisphosphate

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PI(3,5)P2 controls membrane trafficking by direct activation of mucolipin Ca2+ release channels in the endolysosome

21 January 2018

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TPC proteins are phosphoinositide- activated sodium-selective ion channels in endosomes and lysosomes

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Role for a novel signaling intermediate, phosphatidylinositol 5-phosphate, in insulin-regulated F-actin stress fiber breakdown and GLUT4 translocation

21 January 2018

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Protein kinase B phosphorylation of PIKfyve regulates the trafficking of GLUT4 vesicles.

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The visceral yolk sac endoderm provides for absorption of nutrients to the embryo during neurulation

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Critical roles of type III phosphatidylinositol phosphate kinase in murine embryonic visceral endoderm and adult intestine

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Phosphatidylinositol 4-kinases: old enzymes with emerging functions

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PIKfyve, a class III PI kinase, is the target of the small molecular IL-12/IL-23 inhibitor apilimod and a player in Toll-like receptor signaling

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Inositol-1-phosphate synthetase mRNA as a new target for antisense inhibition of Mycobacterium tuberculosis

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7 January 2021

PtdIns5P regulation through evolution: roles in membrane trafficking?

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7 January 2021

The early evolution of lipid membranes and the three domains of life

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7 January 2021

Role of TRPML and two-pore channels in endolysosomal cation homeostasis

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7 January 2021

The inositol phosphates in soils and manures: Abundance, cycling, and measurement

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7 January 2021