Link between type 2 diabetes and Alzheimer's disease: from epidemiology to mechanism and treatment (Q26860246)

Crossref

Sean Leng

series ordinal

2

1 reference

Crossref

Dalin Song

series ordinal

3

1 reference

Crossref

language of work or name

1 reference

2015

1 reference

Clinical Interventions in Aging

10 March 2015

5 references

13 March 2019

14 March 2019

24 March 2019

25 April 2019

4 February 2021

6 references

13 March 2019

14 March 2019

24 March 2019

25 April 2019

4 February 2021

10

1 reference

page(s)

549-60

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Creative Commons Attribution-NonCommercial

copyright license

5 references

13 March 2019

14 March 2019

24 March 2019

25 April 2019

4 February 2021

on focus list of Wikimedia project

ScienceSource

0 references

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Reduction in the Incidence of Type 2 Diabetes with Lifestyle Intervention or Metformin

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Glucagon-like peptide-1 receptor is involved in learning and neuroprotection

21 March 2017

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GSK-3alpha regulates production of Alzheimer's disease amyloid-beta peptides

21 March 2017

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The incretin system: glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetes

21 March 2017

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Mechanisms underlying insulin deficiency-induced acceleration of β-amyloidosis in a mouse model of Alzheimer's disease

21 March 2017

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21 March 2017

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Impaired insulin and insulin-like growth factor expression and signaling mechanisms in Alzheimer's disease--is this type 3 diabetes?

7 April 2017

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A central role for JNK in obesity and insulin resistance

7 April 2017

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Amyloid deposition as the central event in the aetiology of Alzheimer's disease

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Diabetes mellitus and risk of dementia: A meta-analysis of prospective observational studies

7 April 2017

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The global prevalence of dementia: a systematic review and metaanalysis

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28 September 2017

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Demonstrated brain insulin resistance in Alzheimer's disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline

28 September 2017

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An anti-diabetes agent protects the mouse brain from defective insulin signaling caused by Alzheimer's disease- associated Aβ oligomers

28 September 2017

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28 September 2017

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28 September 2017

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Contributions of brain insulin resistance and deficiency in amyloid-related neurodegeneration in Alzheimer's disease

28 September 2017

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28 September 2017

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Metabolic syndrome, cognitive performance, and dementia.

28 September 2017

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Intranasal insulin therapy for Alzheimer disease and amnestic mild cognitive impairment: a pilot clinical trial

28 September 2017

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GSK3 and Alzheimer's Disease: Facts and Fiction….

28 September 2017

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Type 2 diabetes and late-onset Alzheimer's disease

28 September 2017

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Insulin-activated Akt rescues Aβ oxidative stress-induced cell death by orchestrating molecular trafficking.

28 September 2017

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Body mass index in midlife and late-life as a risk factor for dementia: a meta-analysis of prospective studies.

28 September 2017

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Cognitive function, dementia and type 2 diabetes mellitus in the elderly

28 September 2017

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Therapy for Alzheimer's Disease: How Effective are Current Treatments?

28 September 2017

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Dipeptidyl peptidase-4 inhibitors in the treatment of type 2 diabetes: a comparative review

28 September 2017

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Apolipoprotein E and central nervous system disorders: reviews of clinical findings

28 September 2017

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Fasting plasma insulin, C-peptide and cognitive change in older men without diabetes: results from the Physicians' Health Study II.

28 September 2017

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Effect of tarenflurbil on cognitive decline and activities of daily living in patients with mild Alzheimer disease: a randomized controlled trial

28 September 2017

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The influence of glucose-lowering therapies on cancer risk in type 2 diabetes

28 September 2017

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Incretin-based therapies for type 2 diabetes mellitus

28 September 2017

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Adiposity, type 2 diabetes, and Alzheimer's disease

28 September 2017

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Meta-analysis of Alzheimer's disease risk with obesity, diabetes, and related disorders

28 September 2017

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Midlife and late-life obesity and the risk of dementia: cardiovascular health study

28 September 2017

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Metabolic syndrome and risk for incident Alzheimer's disease or vascular dementia: the Three-City Study

28 September 2017

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Association of adiposity status and changes in early to mid-adulthood with incidence of Alzheimer's disease

28 September 2017

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Identification and characterization of metabolically benign obesity in humans

28 September 2017

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Plasma C-peptide levels and rates of cognitive decline in older, community-dwelling women without diabetes

28 September 2017

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Enhanced risk for Alzheimer disease in persons with type 2 diabetes and APOE epsilon4: the Cardiovascular Health Study Cognition Study

28 September 2017

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Metabolic syndrome and dementia risk in a multiethnic elderly cohort

28 September 2017

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Insulin resistance and Alzheimer's disease pathogenesis: potential mechanisms and implications for treatment

28 September 2017

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The epidemiology of adiposity and dementia

28 September 2017

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Brain mitochondrial dysfunction as a link between Alzheimer's disease and diabetes.

28 September 2017

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A century of Alzheimer's disease

28 September 2017

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Vascular risk factors for incident Alzheimer disease and vascular dementia: the Cache County study

28 September 2017

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Efficacy of rosiglitazone in a genetically defined population with mild-to-moderate Alzheimer's disease

28 September 2017

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Brain and brawn: parallels in oxidative strength

28 September 2017

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Risk of dementia in diabetes mellitus: a systematic review

28 September 2017

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Insulin and insulin-like growth factor expression and function deteriorate with progression of Alzheimer's disease: link to brain reductions in acetylcholine

28 September 2017

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Preserved cognition in patients with early Alzheimer disease and amnestic mild cognitive impairment during treatment with rosiglitazone: a preliminary study

28 September 2017

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Cognitive decline and dementia in diabetes--systematic overview of prospective observational studies

28 September 2017

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New twist on neuronal insulin receptor signaling in health, disease, and therapeutics

28 September 2017

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Aggregation of vascular risk factors and risk of incident Alzheimer disease

28 September 2017

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Role of insulin secretion and sensitivity in the evolution of type 2 diabetes in the diabetes prevention program: effects of lifestyle intervention and metformin

28 September 2017

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Inflammation and the etiology of type 2 diabetes

28 September 2017

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Intensive lifestyle intervention or metformin on inflammation and coagulation in participants with impaired glucose tolerance

28 September 2017

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The effect of metformin and intensive lifestyle intervention on the metabolic syndrome: the Diabetes Prevention Program randomized trial

28 September 2017

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The role of insulin receptor signaling in the brain

28 September 2017

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The role of inflammation in Alzheimer's disease

28 September 2017

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28 September 2017

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Diabetes mellitus and risk of Alzheimer disease and decline in cognitive function

28 September 2017

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The role of insulin and insulin-like growth factor I in the molecular and cellular mechanisms underlying the pathology of Alzheimer's disease

28 September 2017

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An 18-year follow-up of overweight and risk of Alzheimer disease

28 September 2017

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Causative and susceptibility genes for Alzheimer's disease: a review.

28 September 2017

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Does insulin dysfunction play a role in Alzheimer's disease?

28 September 2017

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Anorexia, sarcopenia, and aging

28 September 2017

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Rosiglitazone in the treatment of type 2 diabetes mellitus: a critical review

28 September 2017

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Lilly lecture 1987. The triumvirate: beta-cell, muscle, liver. A collusion responsible for NIDDM.

28 September 2017

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Insulin resistance and Alzheimer-like reductions in regional cerebral glucose metabolism for cognitively normal adults with prediabetes or early type 2 diabetes.

28 September 2017

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Is type II diabetes associated with an increased risk of cognitive dysfunction? A critical review of published studies

31 May 2018

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2014 Alzheimer's disease facts and figures

31 May 2018

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DPP-4 inhibitors improve cognition and brain mitochondrial function of insulin-resistant rats

28 November 2018

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DPP4-inhibitor improves neuronal insulin receptor function, brain mitochondrial function and cognitive function in rats with insulin resistance induced by high-fat diet consumption.

28 November 2018

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Alzheimer disease: Insulin resistance and AD--extending the translational path.

28 November 2018

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Type 2 diabetes and/or its treatment leads to less cognitive impairment in Alzheimer's disease patients.

28 November 2018

1 reference

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Glucose tolerance status and risk of dementia in the community: the Hisayama study

28 November 2018

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The diabetes drug liraglutide prevents degenerative processes in a mouse model of Alzheimer's disease.

28 November 2018

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Vascular risk factors promote conversion from mild cognitive impairment to Alzheimer disease.

28 November 2018

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Incidence of dementia is increased in type 2 diabetes and reduced by the use of sulfonylureas and metformin

28 November 2018

1 reference

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Diabetes, Alzheimer disease, and vascular dementia: a population-based neuropathologic study

28 November 2018

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Metabolic syndrome and the risk of vascular dementia: the Italian Longitudinal Study on Ageing

28 November 2018

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Presence of the APOE epsilon4 allele modifies the relationship between type 2 diabetes and cognitive performance: the Maine-Syracuse Study

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4360697

Impairment of synaptic plasticity and memory formation in GLP-1 receptor KO mice: Interaction between type 2 diabetes and Alzheimer's disease.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4360697

Diabetes, cognitive impairment, and dementia

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4360697

Intranasal insulin improves cognition and modulates beta-amyloid in early AD.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4360697

Diabetes mellitus and risk of developing Alzheimer disease: results from the Framingham Study.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4360697

Association of metabolic syndrome with Alzheimer disease: a population-based study.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4360697

Accelerated weight loss may precede diagnosis in Alzheimer disease

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4360697

Glycosylated hemoglobin level and development of mild cognitive impairment or dementia in older women.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4360697

Blockade of the insulin-like growth factor I receptor in the choroid plexus originates Alzheimer's-like neuropathology in rodents: new cues into the human disease?

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4360697

Plasma C peptide level and cognitive function among older women without diabetes mellitus.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4360697

Effects of intranasal insulin on cognition in memory-impaired older adults: modulation by APOE genotype

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4360697

Activation of glycogen synthase kinase-3 induces Alzheimer-like tau hyperphosphorylation in rat hippocampus slices in culture

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4360697

Midlife cardiovascular risk factors and risk of dementia in late life

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4360697

Developmental and vascular risk factors for Alzheimer's disease.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4360697

Diabetes mellitus in midlife and the risk of dementia three decades later

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4360697

The metabolic syndrome, inflammation, and risk of cognitive decline

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4360697

Hyperinsulinemia and risk of Alzheimer disease.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4360697

Diabetes mellitus and risk of dementia in the Kungsholmen project: a 6-year follow-up study.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4360697

Fasting insulin and incident dementia in an elderly population of Japanese-American men.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4360697

C-reactive protein, its role in inflammation, Type 2 diabetes and cardiovascular disease, and the effects of insulin-sensitizing treatment with thiazolidinediones

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4360697

Stroke and the risk of Alzheimer disease.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4360697

Both GLP-1 and GIP are insulinotropic at basal and postprandial glucose levels and contribute nearly equally to the incretin effect of a meal in healthy subjects

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4360697

Diabetes mellitus is a risk factor for vascular dementia, but not for Alzheimer's disease: a population-based study of the oldest old.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4360697

Type 2 diabetes, APOE gene, and the risk for dementia and related pathologies: The Honolulu-Asia Aging Study

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4360697

Risk factors for Alzheimer's disease: a population-based, longitudinal study in Manitoba, Canada.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4360697

Diabetes mellitus and the risk of dementia: The Rotterdam Study.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4360697

Longitudinal association of vascular and Alzheimer's dementias, diabetes, and glucose tolerance.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4360697

Amyloid beta oligomers induce impairment of neuronal insulin receptors

28 November 2018

1 reference

12 December 2020

Diabetes mellitus and the risk of dementia, Alzheimer's disease and vascular cognitive impairment in the Canadian Study of Health and Aging

1 reference

12 December 2020

Cerebral excess release of neurotransmitter amino acids subsequent to reduced cerebral glucose metabolism in early-onset dementia of Alzheimer type

1 reference

12 December 2020

1 reference

12 December 2020

Diabetes as a risk factor for dementia and mild cognitive impairment: a meta-analysis of longitudinal studies

1 reference

12 December 2020

Metabolic cardiovascular syndrome and risk of dementia in Japanese-American elderly men. The Honolulu-Asia aging study

1 reference

12 December 2020

Alzheimer's disease results from the cerebral accumulation and cytotoxicity of amyloid beta-protein

1 reference

12 December 2020

Delivery of insulin-like growth factor-I to the rat brain and spinal cord along olfactory and trigeminal pathways following intranasal administration

1 reference

12 December 2020

Dementia (including Alzheimer's disease) can be prevented: statement supported by international experts

1 reference

12 December 2020

Identifiers

DOI

10.2147/CIA.S74042

1 reference

release_zujf3cmytrh2lf5kk75hj4sbji

782728

Fatcat ID

0 references

782728

1 reference

1 reference

1 reference