Emerging therapies for severe asthma (Q26861260)

language of work or name

1 reference

6 September 2011

6 references

25 June 2019

27 September 2019

27 November 2019

13 December 2019

29 October 2020

6 references

25 June 2019

27 September 2019

27 November 2019

13 December 2019

29 October 2020

9

1 reference

page(s)

102

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Creative Commons Attribution 2.0 Generic

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5 references

25 June 2019

27 September 2019

27 November 2019

13 December 2019

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29 October 2020

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ScienceSource

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cites work

BOL-303242-X, a novel selective glucocorticoid receptor agonist, with full anti-inflammatory properties in human ocular cells

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Anti-IgE for chronic asthma in adults and children

21 March 2017

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Dissociation of transactivation from transrepression by a selective glucocorticoid receptor agonist leads to separation of therapeutic effects from side effects

21 March 2017

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Expert Panel Report 3 (EPR-3): Guidelines for the Diagnosis and Management of Asthma-Summary Report 2007

21 March 2017

1 reference

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Effects of short-term treatment with atorvastatin in smokers with asthma--a randomized controlled trial

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3175451

Cytokine inhibition in severe asthma: current knowledge and future directions

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3175451

Long-term (5 year) safety of bronchial thermoplasty: Asthma Intervention Research (AIR) trial

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3175451

Diagnosis and definition of severe refractory asthma: an international consensus statement from the Innovative Medicine Initiative (IMI).

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3175451

Future forms of immunotherapy

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3175451

Mast cell phenotype, location, and activation in severe asthma. Data from the Severe Asthma Research Program

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3175451

Refractory asthma in the UK: cross-sectional findings from a UK multicentre registry

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3175451

Efficacy and safety of subcutaneous omalizumab vs placebo as add-on therapy to corticosteroids for children and adults with asthma: a systematic review

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3175451

CRTH2 and D-type prostanoid receptor antagonists as novel therapeutic agents for inflammatory diseases

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3175451

New therapies for asthma: is there any progress?

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3175451

Targeting inflammation using selective glucocorticoid receptor modulators

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3175451

Challenges of treating asthma in people who smoke

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3175451

The inhaled phosphodiesterase 4 inhibitor GSK256066 reduces allergen challenge responses in asthma

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3175451

Kinase inhibitors: a new approach to rheumatoid arthritis treatment

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3175451

Narrative review: the role of Th2 immune pathway modulation in the treatment of severe asthma and its phenotypes

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3175451

A new look at the pathogenesis of asthma

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3175451

"Go upstream, young man": lessons learned from the p38 saga

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3175451

Novel bronchodilators in asthma

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3175451

Effectiveness and safety of bronchial thermoplasty in the treatment of severe asthma: a multicenter, randomized, double-blind, sham-controlled clinical trial

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3175451

Simvastatin inhibits airway hyperreactivity: implications for the mevalonate pathway and beyond

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3175451

T-helper type 2-driven inflammation defines major subphenotypes of asthma.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3175451

Characterization of ZK 245186, a novel, selective glucocorticoid receptor agonist for the topical treatment of inflammatory skin diseases

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3175451

Safety and tolerability of omalizumab

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3175451

Mepolizumab and exacerbations of refractory eosinophilic asthma

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3175451

Additive role of tiotropium in severe asthmatics and Arg16Gly in ADRB2 as a potential marker to predict response

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3175451

New targets for drug development in asthma

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3175451

Rhinovirus-induced lower respiratory illness is increased in asthma and related to virus load and Th1/2 cytokine and IL-10 production

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3175451

Novel long-acting bronchodilators for COPD and asthma

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3175451

What's all the FLAP about?: 5-lipoxygenase-activating protein inhibitors for inflammatory diseases

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3175451

Augmented epithelial endothelin-1 expression in refractory asthma

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3175451

Clarithromycin targets neutrophilic airway inflammation in refractory asthma.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3175451

Noneosinophilic asthma: a distinct clinical and pathologic phenotype

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3175451

Pharmacogenetics of the 5-lipoxygenase biosynthetic pathway and variable clinical response to montelukast

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3175451

Pathological features and inhaled corticosteroid response of eosinophilic and non-eosinophilic asthma.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3175451

Peroxisome proliferator-activated receptor-gamma agonists as potential anti-inflammatory agents in asthma and chronic obstructive pulmonary disease

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3175451

Asthma: defining of the persistent adult phenotypes

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3175451

The mechanisms, diagnosis, and management of severe asthma in adults

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3175451

Potential therapeutic role for statins in respiratory disease

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3175451

Attitudes and actions of asthma patients on regular maintenance therapy: the INSPIRE study

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3175451

The link between fungi and severe asthma: a summary of the evidence.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3175451

Influence of leukotriene pathway polymorphisms on response to montelukast in asthma

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3175451

Tumour necrosis factor (TNFalpha) as a novel therapeutic target in symptomatic corticosteroid dependent asthma

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3175451

Phosphodiesterase-4 inhibitors for asthma and chronic obstructive pulmonary disease

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3175451

Radiofrequency ablation of airway smooth muscle for sustained treatment of asthma: preliminary investigations

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3175451

Non-invasive markers of airway inflammation as predictors of oral steroid responsiveness in asthma

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3175451

Inhibition of antigen-induced bronchial smooth muscle hyperresponsiveness by lovastatin in mice

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3175451

Profound adrenal suppression secondary to treatment with low dose inhaled steroids and itraconazole in allergic bronchopulmonary aspergillosis in cystic fibrosis

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3175451

The limitations of severe asthma: the results of a European survey.

31 May 2018

1 reference

https://api.crossref.org/works/10.1186%2F1741-7015-9-102

Role of symptoms and lung function in determining asthma control in smokers with asthma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1741-7015-9-102

Baseline characteristics of patients enrolled in EXCELS: a cohort study

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1741-7015-9-102

Evidence of a role of tumor necrosis factor alpha in refractory asthma

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1741-7015-9-102

Efficacy and safety of etanercept in moderate-to-severe asthma: a randomised, controlled trial.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1741-7015-9-102

Mepolizumab for prednisone-dependent asthma with sputum eosinophilia

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1741-7015-9-102

Eosinophils in asthma--closing the loop or opening the door?

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1741-7015-9-102

The prevalence of nonadherence in difficult asthma

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1741-7015-9-102

IL-13 in asthma. The successful integration of lessons from mice and humans.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1741-7015-9-102

Reduction in airway hyperresponsiveness to methacholine by the application of RF energy in dogs

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1741-7015-9-102

In vivo evaluation of the effectiveness of bronchial thermoplasty with computed tomography

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1741-7015-9-102

Effect of bronchial thermoplasty on airway distensibility

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1741-7015-9-102

Bronchial thermoplasty for asthma

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1741-7015-9-102

Asthma control during the year after bronchial thermoplasty.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1741-7015-9-102

Safety and efficacy of bronchial thermoplasty in symptomatic, severe asthma

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1741-7015-9-102

Pharmacology of a potent and selective inhibitor of PDE4 for inhaled administration

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1741-7015-9-102

Effect of p38 MAPK inhibition on corticosteroid suppression of cytokine release in severe asthma

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1741-7015-9-102

Randomized controlled trial of oral antifungal treatment for severe asthma with fungal sensitization: The Fungal Asthma Sensitization Trial (FAST) study

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1741-7015-9-102

Iatrogenic adrenal insufficiency as a side-effect of combined treatment of itraconazole and budesonide

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1741-7015-9-102

Bronchodilatory effect of the PPAR-gamma agonist rosiglitazone in smokers with asthma

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1741-7015-9-102

Anti-inflammatory mechanism of simvastatin in mouse allergic asthma model.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1741-7015-9-102

Pravastatin attenuates allergic airway inflammation by suppressing antigen sensitisation, interleukin 17 production and antigen presentation in the lung

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1741-7015-9-102

Lovastatin inhibits bronchial hyperresponsiveness by reducing RhoA signaling in rat allergic asthma

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1741-7015-9-102

A novel anti-inflammatory role of simvastatin in a murine model of allergic asthma

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1741-7015-9-102

Effects of atorvastatin added to inhaled corticosteroids on lung function and sputum cell counts in atopic asthma

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1741-7015-9-102

Simvastatin in the treatment of asthma: lack of steroid-sparing effect

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1741-7015-9-102

Non-eosinophilic cor ticosteroid unresponsive asthma

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1741-7015-9-102

Asthma exacerbations and sputum eosinophil counts: a randomised controlled trial.

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1741-7015-9-102

Low sputum eosinophils predict the lack of response to beclomethasone in symptomatic asthmatic patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1741-7015-9-102

British Guideline on the Management of Asthma

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1741-7015-9-102

Comparison of roflumilast, an oral anti-inflammatory, with beclomethasone dipropionate in the treatment of persistent asthma

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3175451

Pharmacogenetic association between ALOX5 promoter genotype and the response to anti-asthma treatment

28 November 2018

1 reference

12 December 2020

Inflammatory subtypes in asthma: assessment and identification using induced sputum

1 reference

12 December 2020

Efficacy and safety of roflumilast in the treatment of asthma

1 reference

12 December 2020

Endothelin-1 induces hypertrophy and inhibits apoptosis in human airway smooth muscle cells

1 reference

12 December 2020

Simvastatin does not exhibit therapeutic anti-inflammatory effects in asthma

1 reference

12 December 2020

Daclizumab improves asthma control in patients with moderate to severe persistent asthma: a randomized, controlled trial

1 reference

12 December 2020

A randomized, double-blind, placebo-controlled study of tumor necrosis factor-α blockade in severe persistent asthma

1 reference

12 December 2020

Effects of Interleukin-13 Blockade on Allergen-induced Airway Responses in Mild Atopic Asthma

1 reference

12 December 2020

Effect of an interleukin-4 variant on late phase asthmatic response to allergen challenge in asthmatic patients: results of two phase 2a studies

1 reference

12 December 2020