The proteomics of drusen (Q26997523)

Crossref

language of work or name

1 reference

5 May 2014

1 reference

Cold Spring Harbor Perspectives in Medicine

published in

1 reference

Crossref

volume

4

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issue

7

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page(s)

a017194

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A variant of mitochondrial protein LOC387715/ARMS2, not HTRA1, is strongly associated with age-related macular degeneration

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A common haplotype in the complement regulatory gene factor H (HF1/CFH) predisposes individuals to age-related macular degeneration

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Aberrant accumulation of EFEMP1 underlies drusen formation in Malattia Leventinese and age-related macular degeneration

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A single EFEMP1 mutation associated with both Malattia Leventinese and Doyne honeycomb retinal dystrophy

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An integrated hypothesis that considers drusen as biomarkers of immune-mediated processes at the RPE-Bruch's membrane interface in aging and age-related macular degeneration

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HTRA1 promoter polymorphism in wet age-related macular degeneration

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Complement factor H variant increases the risk of age-related macular degeneration

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Missense variations in the fibulin 5 gene and age-related macular degeneration

21 March 2017

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Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes

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Seven new loci associated with age-related macular degeneration

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Mouse genetics and proteomic analyses demonstrate a critical role for complement in a model of DHRD/ML, an inherited macular degeneration

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Engagement of platelet toll-like receptor 9 by novel endogenous ligands promotes platelet hyperreactivity and thrombosis.

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Complement factor H genotypes impact risk of age-related macular degeneration by interaction with oxidized phospholipids.

28 September 2017

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Complement factor H binds malondialdehyde epitopes and protects from oxidative stress

28 September 2017

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Cell culture model that mimics drusen formation and triggers complement activation associated with age-related macular degeneration

28 September 2017

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Anti-amyloid therapy protects against retinal pigmented epithelium damage and vision loss in a model of age-related macular degeneration.

28 September 2017

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Oxidative stress induces angiogenesis by activating TLR2 with novel endogenous ligands

28 September 2017

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Abundant lipid and protein components of drusen

28 September 2017

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Structural characterization of bisretinoid A2E photocleavage products and implications for age-related macular degeneration

28 September 2017

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Quantitative proteomics: comparison of the macular Bruch membrane/choroid complex from age-related macular degeneration and normal eyes

28 September 2017

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The pivotal role of the complement system in aging and age-related macular degeneration: hypothesis re-visited

28 September 2017

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Soluble and mature amyloid fibrils in drusen deposits

28 September 2017

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The dynamic nature of Bruch's membrane

28 September 2017

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The role of RAGE in amyloid-beta peptide-mediated pathology in Alzheimer's disease.

28 September 2017

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Plasma protein pentosidine and carboxymethyllysine, biomarkers for age-related macular degeneration

28 September 2017

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RAGE (Receptor for Advanced Glycation Endproducts), RAGE ligands, and their role in cancer and inflammation.

28 September 2017

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Assessing susceptibility to age-related macular degeneration with proteomic and genomic biomarkers.

28 September 2017

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Molecular pathology of age-related macular degeneration

28 September 2017

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Advanced glycation end product (AGE) accumulation on Bruch's membrane: links to age-related RPE dysfunction

28 September 2017

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Retinal pigment epithelium lipofuscin proteomics.

28 September 2017

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TLR2 - promiscuous or specific? A critical re-evaluation of a receptor expressing apparent broad specificity

28 September 2017

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Mitochondrial proteomics of the retinal pigment epithelium at progressive stages of age-related macular degeneration

28 September 2017

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Oxidized phospholipids as endogenous pattern recognition ligands in innate immunity

28 September 2017

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Oxidative damage-induced inflammation initiates age-related macular degeneration.

28 September 2017

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Clinical review: The role of advanced glycation end products in progression and complications of diabetes

28 September 2017

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The all-trans-retinal dimer series of lipofuscin pigments in retinal pigment epithelial cells in a recessive Stargardt disease model.

28 September 2017

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The grateful dead: damage-associated molecular pattern molecules and reduction/oxidation regulate immunity

28 September 2017

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Complement C3 variant and the risk of age-related macular degeneration

28 September 2017

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Confocal Raman microscopy can quantify advanced glycation end product (AGE) modifications in Bruch's membrane leading to accurate, nondestructive prediction of ocular aging

28 September 2017

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Receptor for advanced glycation end products (RAGE) in a dash to the rescue: inflammatory signals gone awry in the primal response to stress

28 September 2017

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A variant of the HTRA1 gene increases susceptibility to age-related macular degeneration

28 September 2017

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Carboxyethylpyrrole oxidative protein modifications stimulate neovascularization: Implications for age-related macular degeneration

28 September 2017

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Maculopathy due to the R345W substitution in fibulin-3: distinct clinical features, disease variability, and extent of retinal dysfunction

28 September 2017

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Variation in factor B (BF) and complement component 2 (C2) genes is associated with age-related macular degeneration

28 September 2017

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Drusen deposits associated with aging and age-related macular degeneration contain nonfibrillar amyloid oligomers

28 September 2017

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Hypothetical LOC387715 is a second major susceptibility gene for age-related macular degeneration, contributing independently of complement factor H to disease risk

28 September 2017

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Apolipoprotein E allele-dependent pathogenesis: a model for age-related retinal degeneration

28 September 2017

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RPE lipofuscin and its role in retinal pathobiology

28 September 2017

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Toll-like receptor 4 variant D299G is associated with susceptibility to age-related macular degeneration

28 September 2017

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Current concepts in the pathogenesis of age-related macular degeneration

28 September 2017

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Characterization of beta amyloid assemblies in drusen: the deposits associated with aging and age-related macular degeneration

28 September 2017

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Generation and function of reactive oxygen species in dendritic cells during antigen presentation

28 September 2017

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Proteins modified by malondialdehyde, 4-hydroxynonenal, or advanced glycation end products in lipofuscin of human retinal pigment epithelium

28 September 2017

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Apolipoprotein B in cholesterol-containing drusen and basal deposits of human eyes with age-related maculopathy

28 September 2017

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New insights and new approaches toward the study of age-related macular degeneration

28 September 2017

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Drusen proteome analysis: an approach to the etiology of age-related macular degeneration.

28 September 2017

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The Alzheimer's A beta -peptide is deposited at sites of complement activation in pathologic deposits associated with aging and age-related macular degeneration

28 September 2017

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Reactive oxygen species accelerate production of vascular endothelial growth factor by advanced glycation end products in RAW264.7 mouse macrophages

28 September 2017

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Hydroxynonenal inactivates cathepsin B by forming Michael adducts with active site residues.

28 September 2017

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Regulation of vascular endothelial growth factor expression by advanced glycation end products

28 September 2017

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The role of AGEs in aging: causation or correlation

28 September 2017

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Immunological and aetiological aspects of macular degeneration

28 September 2017

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The role of oxidative stress in the pathogenesis of age-related macular degeneration.

28 September 2017

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Further evidence for an association of ABCR alleles with age-related macular degeneration. The International ABCR Screening Consortium

28 September 2017

1 reference

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Drusen associated with aging and age-related macular degeneration contain proteins common to extracellular deposits associated with atherosclerosis, elastosis, amyloidosis, and dense deposit disease

28 September 2017

1 reference

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Drusen in age-related macular degeneration: pathogenesis, natural course, and laser photocoagulation-induced regression

28 September 2017

1 reference

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Advanced glycation end products increase retinal vascular endothelial growth factor expression

28 September 2017

1 reference

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Chemistry and metabolism of lipids in the vertebrate retina

28 September 2017

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28 September 2017

1 reference

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Complement activation by beta-amyloid in Alzheimer disease

28 September 2017

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Ageing and degeneration in the macular region: a clinico-pathological study

28 September 2017

1 reference

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Drusen and Pro-inflammatory Mediators in the Post-Mortem Human Eye.

28 September 2017

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Esterified and unesterified cholesterol in drusen and basal deposits of eyes with age-related maculopathy

31 May 2018

1 reference

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Basal deposits and drusen in eyes with age-related maculopathy: evidence for solid lipid particles

31 May 2018

1 reference

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A potential role for immune complex pathogenesis in drusen formation

31 May 2018

1 reference

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Development of a polyclonal antibody with broad epitope specificity for advanced glycation endproducts and localization of these epitopes in Bruch's membrane of the aging eye.

31 May 2018

1 reference

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Basal linear deposit and large drusen are specific for early age-related maculopathy

31 May 2018

1 reference

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Increase in the advanced glycation end product pentosidine in Bruch's membrane with age.

31 May 2018

1 reference

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Advanced glycation end products in age-related macular degeneration

31 May 2018

1 reference

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beta-Amyloid activates complement by binding to a specific region of the collagen-like domain of the C1q A chain.

31 May 2018

1 reference

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Enrichment of polyunsaturated fatty acids from rat retinal pigment epithelium to rod outer segments

31 May 2018

1 reference

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Ncf1-associated reduced oxidative burst promotes IL-33R+ T cell-mediated adjuvant-free arthritis in mice.

31 May 2018

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Targeting age-related macular degeneration with Alzheimer's disease based immunotherapies: anti-amyloid-beta antibody attenuates pathologies in an age-related macular degeneration mouse model

28 November 2018

1 reference

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Oxidative damage in age-related macular degeneration

28 November 2018

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The R345W mutation in EFEMP1 is pathogenic and causes AMD-like deposits in mice

28 November 2018

1 reference

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Formation and progression of sub-retinal pigment epithelium deposits in Efemp1 mutation knock-in mice: a model for the early pathogenic course of macular degeneration.

28 November 2018

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Peroxidation of subcellular organelles: formation of lipofuscinlike fluorescent pigments

28 November 2018

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Relationship of Basal laminar deposit and membranous debris to the clinical presentation of early age-related macular degeneration

28 November 2018

1 reference

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Apolipoprotein (APOE) gene is associated with progression of age-related macular degeneration (AMD)

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4066642

Molecular composition of drusen and possible involvement of anti-retinal autoimmunity in two different forms of macular degeneration in cynomolgus monkey (Macaca fascicularis).

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4066642

LPS receptor (CD14): a receptor for phagocytosis of Alzheimer's amyloid peptide.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4066642

Receptor for advanced glycation end products and age-related macular degeneration

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4066642

Association of apolipoprotein E alleles with susceptibility to age-related macular degeneration in a large cohort from a single center

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4066642

The LPS receptor (CD14) links innate immunity with Alzheimer's disease

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4066642

Carboxyethylpyrrole protein adducts and autoantibodies, biomarkers for age-related macular degeneration.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4066642

Amyloid-beta is found in drusen from some age-related macular degeneration retinas, but not in drusen from normal retinas.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4066642

Oxidatively Truncated Docosahexaenoate Phospholipids: Total Synthesis, Generation, and Peptide Adduction Chemistry

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4066642

Advanced glycation end products induce choroidal endothelial cell proliferation, matrix metalloproteinase-2 and VEGF upregulation in vitro

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4066642

Advanced glycation end products induce angiogenesis in vivo

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4066642

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4066642

Vitronectin is a constituent of ocular drusen and the vitronectin gene is expressed in human retinal pigmented epithelial cells

28 November 2018

1 reference

12 December 2020

Oxidative stress up-regulates IL-8 and TNF-alpha synthesis by human dendritic cells

1 reference

12 December 2020

Retinal age pigments generated by self-assembling lysosomotropic detergents

1 reference

12 December 2020

Age-related macular degeneration

1 reference

12 December 2020

A prospective study of cigarette smoking and age-related macular degeneration in women

1 reference

12 December 2020

RAGE: a potential target for Abeta-mediated cellular perturbation in Alzheimer's disease

1 reference

12 December 2020

TIMP-3 in Bruch's membrane: changes during aging and in age-related macular degeneration

1 reference

12 December 2020

Docosapentaenoic acid is converted to docosahexaenoic acid in the retinas of normal and prcd-affected miniature poodle dogs

1 reference

12 December 2020

Characteristics of Drusen and Bruch's membrane in postmortem eyes with age-related macular degeneration

1 reference

12 December 2020

Involvement of hydrogen peroxide in collagen cross-linking by high glucose in vitro and in vivo

1 reference

12 December 2020

Modification of glucose-6-phosphate dehydrogenase by 4-hydroxy-2-nonenal. Formation of cross-linked protein that inhibits the multicatalytic protease

1 reference

12 December 2020

Clusterin is present in drusen in age-related macular degeneration

1 reference

12 December 2020

Advanced glycation end products induce expression of vascular endothelial growth factor by retinal Muller cells

1 reference

12 December 2020

Editorial: Bruch's membrane and vascular growth

1 reference

12 December 2020

N(epsilon)(carboxymethyl)lysin and the AGE receptor RAGE colocalize in age-related macular degeneration

1 reference

12 December 2020

10.1101/CSHPERSPECT.A017194

Identifiers

DOI

0 references

1 reference

PubMed publication ID

24799364

1 reference