BAX unleashed: the biochemical transformation of an inactive cytosolic monomer into a toxic mitochondrial pore (Q27002044)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21978892%20AND%20SRC:MED&resulttype=core&format=json

14 February 2020

review article

1 reference

title

BAX unleashed: the biochemical transformation of an inactive cytosolic monomer into a toxic mitochondrial pore (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21978892%20AND%20SRC:MED&resulttype=core&format=json

14 February 2020

0 references

1 reference

Evripidis Gavathiotis

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21978892%20AND%20SRC:MED&resulttype=core&format=json

14 February 2020

1

Loren D Walensky

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21978892%20AND%20SRC:MED&resulttype=core&format=json

14 February 2020

language of work or name

1 reference

4 October 2011

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21978892%20AND%20SRC:MED&resulttype=core&format=json

14 February 2020

number of pages

11

1 reference

Trends in Biochemical Sciences

inferred from page(s)

published in

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21978892%20AND%20SRC:MED&resulttype=core&format=json

14 February 2020

volume

36

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21978892%20AND%20SRC:MED&resulttype=core&format=json

14 February 2020

issue

12

2 references

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14 February 2020

page(s)

642-652

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21978892%20AND%20SRC:MED&resulttype=core&format=json

Bcl-x(L) retrotranslocates Bax from the mitochondria into the cytosol

14 February 2020

cites work

1 reference

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Mutation to Bax beyond the BH3 domain disrupts interactions with pro-survival proteins and promotes apoptosis

21 March 2017

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Membrane binding by tBid initiates an ordered series of events culminating in membrane permeabilization by Bax

21 March 2017

1 reference

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Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak

21 March 2017

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A stapled BID BH3 helix directly binds and activates BAX

21 March 2017

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Mitochondria primed by death signals determine cellular addiction to antiapoptotic BCL-2 family members

21 March 2017

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Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function

21 March 2017

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Activation of apoptosis in vivo by a hydrocarbon-stapled BH3 helix

21 March 2017

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Humanin peptide suppresses apoptosis by interfering with Bax activation

21 March 2017

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Bcl-B, a novel Bcl-2 family member that differentially binds and regulates Bax and Bak

21 March 2017

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tBID, a membrane-targeted death ligand, oligomerizes BAK to release cytochrome c

21 March 2017

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Bax oligomerization is required for channel-forming activity in liposomes and to trigger cytochrome c release from mitochondria

21 March 2017

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Conformation of the Bax C-terminus regulates subcellular location and cell death

21 March 2017

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Hematopoietic malignancies demonstrate loss-of-function mutations of BAX

21 March 2017

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Bim: a novel member of the Bcl-2 family that promotes apoptosis

21 March 2017

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Movement of Bax from the cytosol to mitochondria during apoptosis

21 March 2017

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Bok is a pro-apoptotic Bcl-2 protein with restricted expression in reproductive tissues and heterodimerizes with selective anti-apoptotic Bcl-2 family members

21 March 2017

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Inhibition of Bax channel-forming activity by Bcl-2

21 March 2017

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Cytosol-to-membrane redistribution of Bax and Bcl-X(L) during apoptosis

21 March 2017

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Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blocked

21 March 2017

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BID: a novel BH3 domain-only death agonist

21 March 2017

1 reference

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Induction of apoptosis by human Nbk/Bik, a BH3-containing protein that interacts with E1B 19K

21 March 2017

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bcl-w, a novel member of the bcl-2 family, promotes cell survival

21 March 2017

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Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome c

21 March 2017

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A conserved domain in Bak, distinct from BH1 and BH2, mediates cell death and protein binding functions

21 March 2017

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Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death

21 March 2017

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bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death

21 March 2017

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Bad, a heterodimeric partner for Bcl-XL and Bcl-2, displaces Bax and promotes cell death

21 March 2017

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MCL1, a gene expressed in programmed myeloid cell differentiation, has sequence similarity to BCL2

21 March 2017

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The MCL-1 BH3 helix is an exclusive MCL-1 inhibitor and apoptosis sensitizer

21 March 2017

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BAX activation is initiated at a novel interaction site

21 March 2017

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Structure of Bax: coregulation of dimer formation and intracellular localization

21 March 2017

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Solution structure of the proapoptotic molecule BID: a structural basis for apoptotic agonists and antagonists

21 March 2017

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Solution structure of BID, an intracellular amplifier of apoptotic signaling

21 March 2017

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Structure of Bcl-xL-Bak peptide complex: recognition between regulators of apoptosis

21 March 2017

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X-ray and NMR structure of human Bcl-xL, an inhibitor of programmed cell death

21 March 2017

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Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition

21 March 2017

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BCL-2, BCL-X(L) sequester BH3 domain-only molecules preventing BAX- and BAK-mediated mitochondrial apoptosis

21 March 2017

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Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death

21 March 2017

1 reference

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Characterization of A1, a novel hemopoietic-specific early-response gene with sequence similarity to bcl-2

21 March 2017

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Modulation of apoptosis by the widely distributed Bcl-2 homologue Bak

21 March 2017

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Induction of apoptosis by the Bcl-2 homologue Bak

21 March 2017

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Cloning of a bcl-2 homologue by interaction with adenovirus E1B 19K

21 March 2017

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Bik, a novel death-inducing protein shares a distinct sequence motif with Bcl-2 family proteins and interacts with viral and cellular survival-promoting proteins

21 March 2017

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A novel Bcl-2 related gene, Bfl-1, is overexpressed in stomach cancer and preferentially expressed in bone marrow

21 March 2017

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Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells

21 March 2017

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Enhanced Oligodendrocyte Survival after Spinal Cord Injury in Bax-Deficient Mice and Mice with Delayed Wallerian Degeneration

21 March 2017

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Bax in murine thymus is a soluble monomeric protein that displays differential detergent-induced conformations

21 March 2017

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VDAC2 inhibits BAK activation and mitochondrial apoptosis

21 March 2017

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Bid induces the oligomerization and insertion of Bax into the outer mitochondrial membrane

21 March 2017

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Prolongation of ovarian lifespan into advanced chronological age by Bax-deficiency

21 March 2017

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Bax directly induces release of cytochrome c from isolated mitochondria

21 March 2017

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BAX is required for neuronal death after trophic factor deprivation and during development

21 March 2017

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Bax-deficient mice with lymphoid hyperplasia and male germ cell death

21 March 2017

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An inhibitor of Bcl-2 family proteins induces regression of solid tumours

21 March 2017

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BH3 domains of BH3-only proteins differentially regulate Bax-mediated mitochondrial membrane permeabilization both directly and indirectly

7 April 2017

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Bid, Bax, and lipids cooperate to form supramolecular openings in the outer mitochondrial membrane

7 April 2017

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Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics

7 April 2017

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Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death

7 April 2017

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Phase I study of Navitoclax (ABT-263), a novel Bcl-2 family inhibitor, in patients with small-cell lung cancer and other solid tumors

7 April 2017

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Navitoclax, a targeted high-affinity inhibitor of BCL-2, in lymphoid malignancies: a phase 1 dose-escalation study of safety, pharmacokinetics, pharmacodynamics, and antitumour activity

28 September 2017

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Inhibition of Bak activation by VDAC2 is dependent on the Bak transmembrane anchor

28 September 2017

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Bcl-2 and Bax interact via the BH1-3 groove-BH3 motif interface and a novel interface involving the BH4 motif

28 September 2017

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Stepwise activation of BAX and BAK by tBID, BIM, and PUMA initiates mitochondrial apoptosis.

28 September 2017

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Bax contains two functional mitochondrial targeting sequences and translocates to mitochondria in a conformational change- and homo-oligomerization-driven process

28 September 2017

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Cholesterol effects on BAX pore activation

28 September 2017

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Small molecule obatoclax (GX15-070) antagonizes MCL-1 and overcomes MCL-1-mediated resistance to apoptosis

28 September 2017

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A three-helix homo-oligomerization domain containing BH3 and BH1 is responsible for the apoptotic activity of Bax.

28 September 2017

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Programmed anuclear cell death delimits platelet life span.

28 September 2017

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The N-terminal conformation of Bax regulates cell commitment to apoptosis

28 September 2017

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Structure-based design of potent small-molecule inhibitors of anti-apoptotic Bcl-2 proteins

28 September 2017

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Auto-activation of the apoptosis protein Bax increases mitochondrial membrane permeability and is inhibited by Bcl-2

28 September 2017

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The multidomain proapoptotic molecules Bax and Bak are directly activated by heat

28 September 2017

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Bax channel inhibitors prevent mitochondrion-mediated apoptosis and protect neurons in a model of global brain ischemia.

28 September 2017

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Peptides derived from apoptotic Bax and Bid reproduce the poration activity of the parent full-length proteins

28 September 2017

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Conformational control of Bax localization and apoptotic activity by Pro168.

28 September 2017

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Role of BAX in the apoptotic response to anticancer agents

28 September 2017

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Withdrawal of IL-7 induces Bax translocation from cytosol to mitochondria through a rise in intracellular pH.

28 September 2017

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Bid-induced conformational change of Bax is responsible for mitochondrial cytochrome c release during apoptosis

28 September 2017

1 reference

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Mutagenesis of the BH3 domain of BAX identifies residues critical for dimerization and killing

28 September 2017

1 reference

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Comparison of the ion channel characteristics of proapoptotic BAX and antiapoptotic BCL-2.

28 September 2017

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The E1B 19K protein blocks apoptosis by interacting with and inhibiting the p53-inducible and death-promoting Bax protein

28 September 2017

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A 14;18 and an 8;14 chromosome translocation in a cell line derived from an acute B-cell leukemia

28 September 2017

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Cloning of the chromosome breakpoint of neoplastic B cells with the t(14;18) chromosome translocation

28 September 2017

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Nucleotide sequence of a t(14;18) chromosomal breakpoint in follicular lymphoma and demonstration of a breakpoint-cluster region near a transcriptionally active locus on chromosome 18.

28 September 2017

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Reconstitution of proapoptotic BAK function in liposomes reveals a dual role for mitochondrial lipids in the BAK-driven membrane permeabilization process

28 September 2017

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BH3-triggered structural reorganization drives the activation of proapoptotic BAX.

31 May 2018

1 reference

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3,6-Dibromocarbazole Piperazine Derivatives of 2-Propanol as First Inhibitors of Cytochrome c Release via Bax Channel Modulation

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3454508

Cloning the chromosomal breakpoint of t(14;18) human lymphomas: clustering around JH on chromosome 14 and near a transcriptional unit on 18.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3454508

bcl-2-immunoglobulin transgenic mice demonstrate extended B cell survival and follicular lymphoproliferation

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3454508

Molecular details of Bax activation, oligomerization, and membrane insertion.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3454508

Bak activation for apoptosis involves oligomerization of dimers via their alpha6 helices

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3454508

To trigger apoptosis, Bak exposes its BH3 domain and homodimerizes via BH3:groove interactions.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3454508

Bax ablation protects against hepatic ischemia/reperfusion injury in transgenic mice.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3454508

Bax deficiency reduces infarct size and improves long-term function after myocardial infarction

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3454508

Peptides corresponding to helices 5 and 6 of Bax can independently form large lipid pores

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3454508

Distinct domains control the addressing and the insertion of Bax into mitochondria.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3454508

Lipidic pore formation by the concerted action of proapoptotic BAX and tBID.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3454508

Preventing retinal detachment-associated photoreceptor cell loss in Bax-deficient mice.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3454508

Bax ablation protects against myocardial ischemia-reperfusion injury in transgenic mice

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3454508

Involvement of the N-terminus of Bax in its intracellular localization and function.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3454508

Bax is present as a high molecular weight oligomer/complex in the mitochondrial membrane of apoptotic cells

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3454508

Somatic frameshift mutations in the BAX gene in colon cancers of the microsatellite mutator phenotype.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3454508

Immunohistochemical analysis of in vivo patterns of Bak expression, a proapoptotic member of the Bcl-2 protein family.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3454508

Direct evidence for membrane pore formation by the apoptotic protein Bax

28 November 2018

1 reference

12 December 2020

A membrane-targeted BID BCL-2 homology 3 peptide is sufficient for high potency activation of BAX in vitro

1 reference

12 December 2020

TNF-alpha signals apoptosis through a bid-dependent conformational change in Bax that is inhibited by E1B 19K

1 reference

12 December 2020

Ultrastructural localization of bcl-2 protein

1 reference

12 December 2020

Bax mutations in cell lines derived from hematological malignancies

1 reference

12 December 2020

Nonionic detergents induce dimerization among members of the Bcl-2 family

1 reference

12 December 2020

Regulation of apoptosis by BH3 domains in a cell-free system

1 reference

12 December 2020

Membrane-insertion fragments of Bcl-xL, Bax, and Bid

1 reference

12 December 2020

Impact of pH on Bax alpha conformation, oligomerisation and mitochondrial integration

1 reference

12 December 2020

10.1016/J.TIBS.2011.08.009

Identifiers

DOI

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21978892%20AND%20SRC:MED&resulttype=core&format=json

14 February 2020

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21978892%20AND%20SRC:MED&resulttype=core&format=json

14 February 2020

PubMed publication ID

21978892

2 references