Bcl-2 and Bax interact via the BH1-3 groove-BH3 motif interface and a novel interface involving the BH4 motif (Q34121322)

31 July 2017

title

Bcl-2 and Bax interact via the BH1-3 groove-BH3 motif interface and a novel interface involving the BH4 motif (English)

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31 July 2017

author

David William Andrews

object named as

David W Andrews

8

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author name string

Jingzhen Ding

1

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31 July 2017

Zhi Zhang

2

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31 July 2017

G Jane Roberts

3

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31 July 2017

Mina Falcone

4

1 reference

31 July 2017

Yiwei Miao

5

1 reference

31 July 2017

Yuanlong Shao

6

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31 July 2017

Xuejun C Zhang

7

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31 July 2017

Jialing Lin

9

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31 July 2017

language of work or name

English

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publication date

28 June 2010

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Journal of Biological Chemistry

31 July 2017

published in

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31 July 2017

volume

285

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31 July 2017

issue

37

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31 July 2017

page(s)

28749-28763

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Bax forms an oligomer via separate, yet interdependent, surfaces

31 July 2017

cites work

1 reference

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28 July 2018

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Oligomerization of membrane-bound Bcl-2 is involved in its pore formation induced by tBid

28 July 2018

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BAX activation is initiated at a novel interaction site

28 July 2018

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Structural plasticity underpins promiscuous binding of the prosurvival protein A1

28 July 2018

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28 July 2018

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28 July 2018

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28 July 2018

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28 July 2018

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Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak

28 July 2018

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tBid elicits a conformational alteration in membrane-bound Bcl-2 such that it inhibits Bax pore formation

28 July 2018

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28 July 2018

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28 July 2018

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Auto-activation of the apoptosis protein Bax increases mitochondrial membrane permeability and is inhibited by Bcl-2

28 July 2018

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Bax forms multispanning monomers that oligomerize to permeabilize membranes during apoptosis

28 July 2018

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28 July 2018

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The first alpha helix of Bax plays a necessary role in its ligand-induced activation by the BH3-only proteins Bid and PUMA.

28 July 2018

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Bcl-2 homodimerization involves two distinct binding surfaces, a topographic arrangement that provides an effective mechanism for Bcl-2 to capture activated Bax

28 July 2018

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During apoptosis bcl-2 changes membrane topology at both the endoplasmic reticulum and mitochondria

28 July 2018

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28 July 2018

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28 July 2018

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Interaction with a membrane surface triggers a reversible conformational change in Bax normally associated with induction of apoptosis

28 July 2018

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28 July 2018

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BCL-2 Selectively Interacts with the BID-induced Open Conformer of BAK, Inhibiting BAK Auto-oligomerization

28 July 2018

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Bid, Bax, and lipids cooperate to form supramolecular openings in the outer mitochondrial membrane

28 July 2018

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Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics

28 July 2018

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Membrane topography and topogenesis of prenylated Rab acceptor (PRA1)

28 July 2018

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Solution structure of the antiapoptotic protein bcl-2

28 July 2018

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28 July 2018

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Structure of Bax: coregulation of dimer formation and intracellular localization

28 July 2018

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NMR studies of the anti-apoptotic protein Bcl-xL in micelles

28 July 2018

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Bid induces the oligomerization and insertion of Bax into the outer mitochondrial membrane

28 July 2018

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NH2-terminal BH4 domain of Bcl-2 is functional for heterodimerization with Bax and inhibition of apoptosis

28 July 2018

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Mutagenesis of the BH3 domain of BAX identifies residues critical for dimerization and killing

28 July 2018

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Bax in murine thymus is a soluble monomeric protein that displays differential detergent-induced conformations

28 July 2018

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Structure of Bcl-xL-Bak peptide complex: recognition between regulators of apoptosis

28 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2937903

BH1 and BH2 domains of Bcl-2 are required for inhibition of apoptosis and heterodimerization with Bax.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2937903

Multiple Bcl-2 family members demonstrate selective dimerizations with Bax

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2937903

Photocrosslinking of the signal sequence of nascent preprolactin to the 54-kilodalton polypeptide of the signal recognition particle

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2937903

The bcl-2 candidate proto-oncogene product is a 24-kilodalton integral-membrane protein highly expressed in lymphoid cell lines and lymphomas carrying the t(14;18) translocation

28 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2937903

Vaccinia virus anti-apoptotic F1L is a novel Bcl-2-like domain-swapped dimer that binds a highly selective subset of BH3-containing death ligands

28 July 2018

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https://api.crossref.org/works/10.1074%2FJBC.M110.148361

Bax is present as a high molecular weight oligomer/complex in the mitochondrial membrane of apoptotic cells

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M110.148361

Bcl-XL inhibits membrane permeabilization by competing with Bax.

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M110.148361

Membrane binding by tBid initiates an ordered series of events culminating in membrane permeabilization by Bax

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M110.148361

Bcl-2 changes conformation to inhibit Bax oligomerization

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M110.148361

Bax-type apoptotic proteins porate pure lipid bilayers through a mechanism sensitive to intrinsic monolayer curvature.

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M110.148361

BH3 domains of BH3-only proteins differentially regulate Bax-mediated mitochondrial membrane permeabilization both directly and indirectly

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M110.148361

Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function

21 January 2018

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Proapoptotic protein Bax heterodimerizes with Bcl-2 and homodimerizes with Bax via a novel domain (BH3) distinct from BH1 and BH2

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M110.148361

BCL-XL dimerization by three-dimensional domain swapping.

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M110.148361

Bcl-xL forms two distinct homodimers at non-ionic detergents: implications in the dimerization of Bcl-2 family proteins

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M110.148361

Heterodimerization-independent functions of cell death regulatory proteins Bax and Bcl-2 in yeast and mammalian cells

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M110.148361

Bak activation for apoptosis involves oligomerization of dimers via their alpha6 helices

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M110.148361

A stapled BID BH3 helix directly binds and activates BAX

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M110.148361

Heat-Induced Dimerization of BCL-xLthrough α-Helix Swapping†

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M110.148361

Characterization of the protein product of bcl-2, the gene involved in human follicular lymphoma

21 January 2018

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12 December 2020

Assembly of Bcl-2 into microsomal and outer mitochondrial membranes

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12 December 2020

Nonionic detergents induce dimerization among members of the Bcl-2 family

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12 December 2020

Structural and functional complementation of an inactive Bcl-2 mutant by Bax truncation

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12 December 2020

Hierarchical regulation of mitochondrion-dependent apoptosis by BCL-2 subfamilies

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12 December 2020

Identifiers

DOI

10.1074/JBC.M110.148361

1 reference

31 July 2017

1 reference

31 July 2017

1 reference