Resistance to linezolid caused by modifications at its binding site on the ribosome (Q27006772)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22143525%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

title

Resistance to linezolid caused by modifications at its binding site on the ribosome (English)

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22143525%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

1 reference

2

1 reference

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17 January 2020

author name string

Katherine S Long

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22143525%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

language of work or name

1 reference

5 December 2011

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22143525%20AND%20SRC:MED&resulttype=core&format=json

Antimicrobial Agents and Chemotherapy

17 January 2020

published in

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22143525%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

volume

56

2 references

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17 January 2020

page(s)

603-612

1 reference

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17 January 2020

issue

2

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22143525%20AND%20SRC:MED&resulttype=core&format=json

Insights into the structure, function and evolution of the radical-SAM 23S rRNA methyltransferase Cfr that confers antibiotic resistance in bacteria

17 January 2020

cites work

1 reference

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Genome sequencing of linezolid-resistant Streptococcus pneumoniae mutants reveals novel mechanisms of resistance

21 March 2017

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Identification of 8-methyladenosine as the modification catalyzed by the radical SAM methyltransferase Cfr that confers antibiotic resistance in bacteria

21 March 2017

1 reference

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The oxazolidinone antibiotics perturb the ribosomal peptidyl-transferase center and effect tRNA positioning

21 March 2017

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Linezolid resistance in Staphylococcus aureus: gene dosage effect, stability, fitness costs, and cross-resistances

21 March 2017

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The methyltransferase YfgB/RlmN is responsible for modification of adenosine 2503 in 23S rRNA

21 March 2017

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Radical SAM, a novel protein superfamily linking unresolved steps in familiar biosynthetic pathways with radical mechanisms: functional characterization using new analysis and information visualization methods

21 March 2017

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Structural Basis for Methyl Transfer by a Radical SAM Enzyme

21 March 2017

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Revisiting the structures of several antibiotics bound to the bacterial ribosome

21 March 2017

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Structures of the Escherichia coli ribosome with antibiotics bound near the peptidyl transferase center explain spectra of drug action

21 March 2017

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Crystal structure of the oxazolidinone antibiotic linezolid bound to the 50S ribosomal subunit

21 March 2017

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Structure of the 70S ribosome complexed with mRNA and tRNA

21 March 2017

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Structures of the bacterial ribosome at 3.5 A resolution

21 March 2017

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Resistance to linezolid is mediated by the cfr gene in the first report of an outbreak of linezolid-resistant Staphylococcus aureus

21 March 2017

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AZD2563, a novel oxazolidinone: definition of antibacterial spectrum, assessment of bactericidal potential and the impact of miscellaneous factors on activity in vitro

21 March 2017

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In vitro activities of U-100592 and U-100766, novel oxazolidinone antibacterial agents

21 March 2017

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Whole genome analysis of linezolid resistance in Streptococcus pneumoniae reveals resistance and compensatory mutations.

21 March 2017

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LEADER Program results for 2009: an activity and spectrum analysis of linezolid using 6,414 clinical isolates from 56 medical centers in the United States

28 September 2017

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Low fitness cost of the multidrug resistance gene cfr.

28 September 2017

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Trends towards lower antimicrobial susceptibility and characterization of acquired resistance among clinical isolates of Brachyspira hyodysenteriae in Spain

28 September 2017

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Inactivation of the indigenous methyltransferase RlmN in Staphylococcus aureus increases linezolid resistance

28 September 2017

1 reference

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A radically different mechanism for S-adenosylmethionine-dependent methyltransferases

28 September 2017

1 reference

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Emergence of linezolid-resistant Staphylococcus aureus after prolonged treatment of cystic fibrosis patients in Cleveland, Ohio

28 September 2017

1 reference

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Identification and characterization of the multidrug resistance gene cfr in a Panton-Valentine leukocidin-positive sequence type 8 methicillin-resistant Staphylococcus aureus IVa (USA300) isolate

28 September 2017

1 reference

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LmrS is a multidrug efflux pump of the major facilitator superfamily from Staphylococcus aureus

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3264260

Mutations in 23S rRNA at the peptidyl transferase center and their relationship to linezolid binding and cross-resistance

28 September 2017

1 reference

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Two novel point mutations in clinical Staphylococcus aureus reduce linezolid susceptibility and switch on the stringent response to promote persistent infection

28 September 2017

1 reference

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Polyphyletic emergence of linezolid-resistant staphylococci in the United States

28 September 2017

1 reference

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The A-Z of bacterial translation inhibitors

28 September 2017

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An indigenous posttranscriptional modification in the ribosomal peptidyl transferase center confers resistance to an array of protein synthesis inhibitors

28 September 2017

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First report of cfr-mediated resistance to linezolid in human staphylococcal clinical isolates recovered in the United States

28 September 2017

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Linezolid (ZYVOX), the first member of a completely new class of antibacterial agents for treatment of serious gram-positive infections

28 September 2017

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Transcriptional and translational control of the mlr operon, which confers resistance to seven classes of protein synthesis inhibitors

28 September 2017

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Engineering the rRNA decoding site of eukaryotic cytosolic ribosomes in bacteria

28 September 2017

1 reference

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Dose dependence of emergence of resistance to linezolid in Enterococcus faecalis in vivo

28 September 2017

1 reference

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S-adenosylmethionine as an oxidant: the radical SAM superfamily

28 September 2017

1 reference

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In vitro activity of the oxazolidinone RWJ-416457 against linezolid-resistant and -susceptible staphylococci and enterococci

28 September 2017

1 reference

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Intracellular accumulation of linezolid in Escherichia coli, Citrobacter freundii and Enterobacter aerogenes: role of enhanced efflux pump activity and inactivation

28 September 2017

1 reference

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The Cfr rRNA methyltransferase confers resistance to Phenicols, Lincosamides, Oxazolidinones, Pleuromutilins, and Streptogramin A antibiotics

28 September 2017

1 reference

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A genetic model to investigate drug-target interactions at the ribosomal decoding site

28 September 2017

1 reference

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Structure-based drug design meets the ribosome

28 September 2017

1 reference

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Single- and multistep resistance selection studies on the activity of retapamulin compared to other agents against Staphylococcus aureus and Streptococcus pyogenes

28 September 2017

1 reference

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Novel mechanism of resistance to oxazolidinones, macrolides, and chloramphenicol in ribosomal protein L4 of the pneumococcus

28 September 2017

1 reference

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Antimicrobial resistance to linezolid

28 September 2017

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Clinical-use-associated decrease in susceptibility of vancomycin-resistant Enterococcus faecium to linezolid: a comparison with quinupristin-dalfopristin

28 September 2017

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Recombination Proficiency Influences Frequency and Locus of Mutational Resistance to Linezolid in Enterococcus faecalis

28 September 2017

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Resistance to the peptidyl transferase inhibitor tiamulin caused by mutation of ribosomal protein l3.

28 September 2017

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Oxazolidinone Structure–Activity Relationships Leading to Linezolid

28 September 2017

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Cross-linking in the Living Cell Locates the Site of Action of Oxazolidinone Antibiotics

28 September 2017

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Gene dosage and linezolid resistance in Enterococcus faecium and Enterococcus faecalis

28 September 2017

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Resistance to linezolid: characterization of mutations in rRNA and comparison of their occurrences in vancomycin-resistant enterococci

28 September 2017

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Oxazolidinone resistance mutations in 23S rRNA of Escherichia coli reveal the central region of domain V as the primary site of drug action.

28 September 2017

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Identification of a plasmid-borne chloramphenicol-florfenicol resistance gene in Staphylococcus sciuri

28 September 2017

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In vitro activities of telithromycin, linezolid, and quinupristin-dalfopristin against Streptococcus pneumoniae with macrolide resistance due to ribosomal mutations

28 September 2017

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Elevated linezolid resistance in clinical cfr-positive Staphylococcus aureus isolates is associated with co-occurring mutations in ribosomal protein L3.

28 September 2017

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Structure-activity relationships of diverse oxazolidinones for linezolid-resistant Staphylococcus aureus strains possessing the cfr methyltransferase gene or ribosomal mutations.

31 May 2018

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First report of the multidrug resistance gene cfr and the phenicol resistance gene fexA in a Bacillus strain from swine feces

31 May 2018

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Resistance to linezolid in a porcine Clostridium perfringens strain carrying a mutation in the rplD gene encoding the ribosomal protein L4.

31 May 2018

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Mutations in ribosomal protein L3 are associated with oxazolidinone resistance in staphylococci of clinical origin.

31 May 2018

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Novel ribosomal mutations in Staphylococcus aureus strains identified through selection with the oxazolidinones linezolid and torezolid (TR-700).

31 May 2018

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In vitro activity of TR-700, the antibacterial moiety of the prodrug TR-701, against linezolid-resistant strains.

31 May 2018

1 reference

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Sequential linezolid-resistant Staphylococcus epidermidis isolates with G2576T mutation

31 May 2018

1 reference

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Stepwise exposure of Staphylococcus aureus to pleuromutilins is associated with stepwise acquisition of mutations in rplC and minimally affects susceptibility to retapamulin

31 May 2018

1 reference

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Distribution of florfenicol resistance genes fexA and cfr among chloramphenicol-resistant Staphylococcus isolates

31 May 2018

1 reference

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Single and dual mutations at positions 2058, 2503 and 2504 of 23S rRNA and their relationship to resistance to antibiotics that target the large ribosomal subunit.

31 May 2018

1 reference

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The new genetic environment of cfr on plasmid pBS-02 in a Bacillus strain.

28 November 2018

1 reference

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DNA methylase modifications and other linezolid resistance mutations in coagulase-negative staphylococci in Italy.

28 November 2018

1 reference

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Assessment of linezolid resistance mechanisms among Staphylococcus epidermidis causing bacteraemia in Rome, Italy

28 November 2018

1 reference

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Molecular and epidemiologic characteristics of linezolid-resistant coagulase-negative staphylococci at a tertiary care hospital

28 November 2018

1 reference

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Multicity outbreak of linezolid-resistant Staphylococcus epidermidis associated with clonal spread of a cfr-containing strain.

28 November 2018

1 reference

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Linezolid-resistant Staphylococcus aureus isolated from 2006 through 2008 at six hospitals in Japan.

28 November 2018

1 reference

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Clinical outbreak of linezolid-resistant Staphylococcus aureus in an intensive care unit.

28 November 2018

1 reference

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First report of Staphylococcal clinical isolates in Mexico with linezolid resistance caused by cfr: evidence of in vivo cfr mobilization

28 November 2018

1 reference

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From the structure and function of the ribosome to new antibiotics (Nobel Lecture).

28 November 2018

1 reference

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Linezolid-resistant ST36 methicillin-resistant Staphylococcus aureus associated with prolonged linezolid treatment in two paediatric cystic fibrosis patients

28 November 2018

1 reference

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Linezolid-resistant methicillin-resistant Staphylococcus aureus isolated after long-term, repeated use of linezolid

28 November 2018

1 reference

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Linezolid surveillance program results for 2008 (LEADER Program for 2008).

28 November 2018

1 reference

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Detection of new mutations conferring resistance to linezolid in glycopeptide-intermediate susceptibility Staphylococcus hominis subspecies hominis circulating in an intensive care unit.

28 November 2018

1 reference

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A T2504A mutation in the 23S rRNA gene responsible for high-level resistance to linezolid of Staphylococcus epidermidis.

28 November 2018

1 reference

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Linezolid resistance in Staphylococcus epidermidis associated with a G2603T mutation in the 23S rRNA gene

28 November 2018

1 reference

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Single 23S rRNA mutations at the ribosomal peptidyl transferase centre confer resistance to valnemulin and other antibiotics in Mycobacterium smegmatis by perturbation of the drug binding pocket

28 November 2018

1 reference

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Colonisation with vancomycin- and linezolid-resistant Enterococcus faecium in a university hospital: molecular epidemiology and risk factor analysis

28 November 2018

1 reference

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An outbreak of colonization with linezolid-resistant Staphylococcus epidermidis in an intensive therapy unit

28 November 2018

1 reference

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Linezolid and tiamulin cross-resistance in Staphylococcus aureus mediated by point mutations in the peptidyl transferase center

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3264260

In vitro-selected linezolid-resistant Mycobacterium tuberculosis mutants

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3264260

Acquisition of a natural resistance gene renders a clinical strain of methicillin-resistant Staphylococcus aureus resistant to the synthetic antibiotic linezolid

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3264260

The site of action of oxazolidinone antibiotics in living bacteria and in human mitochondria.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3264260

Varying linezolid susceptibility of vancomycin-resistant Enterococcus faecium isolates during therapy: a case report

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3264260

In vitro selection of mutants of Streptococcus pneumoniae resistant to macrolides and linezolid: relationship with susceptibility to penicillin G or macrolides

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3264260

A new mechanism for chloramphenicol, florfenicol and clindamycin resistance: methylation of 23S ribosomal RNA at A2503.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3264260

Protected nucleotide G2608 in 23S rRNA confers resistance to oxazolidinones in E. coli

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3264260

Mutations in ribosomal protein L3 and 23S ribosomal RNA at the peptidyl transferase centre are associated with reduced susceptibility to tiamulin in Brachyspira spp. isolates.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3264260

Linezolid resistance in sequential Staphylococcus aureus isolates associated with a T2500A mutation in the 23S rRNA gene and loss of a single copy of rRNA.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3264260

Ribosomal and non-ribosomal resistance to oxazolidinones: species-specific idiosyncrasy of ribosomal alterations

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3264260

Activity of linezolid against Gram-positive cocci possessing genes conferring resistance to protein synthesis inhibitors

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3264260

Resistance mutations in 23 S rRNA identify the site of action of the protein synthesis inhibitor linezolid in the ribosomal peptidyl transferase center

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3264260

Erythromycin resistance mutations in ribosomal proteins L22 and L4 perturb the higher order structure of 23 S ribosomal RNA.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3264260

Linezolid-resistant Staphylococcus aureus in two pediatric patients receiving low-dose linezolid therapy

28 November 2018

1 reference

12 December 2020

Persistence of rRNA operon mutated copies and rapid re-emergence of linezolid resistance in Staphylococcus aureus

1 reference

12 December 2020

Nosocomial outbreak of methicillin- and linezolid-resistant Staphylococcus epidermidis associated with catheter-related infections in intensive care unit patients

1 reference

12 December 2020

Detection of the staphylococcal multiresistance gene cfr in Proteus vulgaris of food animal origin

1 reference

12 December 2020

Linezolid Resistance in Staphylococci.

1 reference

12 December 2020

Identifiers

DOI

10.1128/AAC.05702-11

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22143525%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22143525%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

2 references