Review article: the pathophysiological roles of the renin-angiotensin system in the gastrointestinal tract (Q27009109)

P. W. Angus

2

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L. M. Burrell

3

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C. Herath

4

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P. R. Gibson

5

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J. S. Lubel

6

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language of work or name

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February 2012

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Alimentary Pharmacology & Therapeutics

published in

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volume

35

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page(s)

414-28

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issue

4

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Renin, (pro)renin and receptor: an update

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Angiotensin II type 2 receptor stimulation: a novel option of therapeutic interference with the renin-angiotensin system in myocardial infarction?

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Differential expression of angiotensin receptors in human cutaneous wound healing.

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Protective role of angiotensin II type 2 receptor signaling in a mouse model of pancreatic fibrosis

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The angiotensin II AT2 receptor inhibits proliferation and promotes differentiation in PC12W cells

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Enzymatic pathways of the brain renin-angiotensin system: unsolved problems and continuing challenges.

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Angiotensin IV in the central nervous system.

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AT1A angiotensin receptors in the renal proximal tubule regulate blood pressure

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Gene expression of the renin-angiotensin system in human tissues. Quantitative analysis by the polymerase chain reaction

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Angiotensin-forming enzyme in brain tissue.

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Immunohistochemical localization of the angiotensin II type 1 receptor in human hypothalamus and brainstem.

21 January 2018

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Angiotensin-(1-7), an alternative metabolite of the renin-angiotensin system, is up-regulated in human liver disease and has antifibrotic activity in the bile-duct-ligated rat.

21 January 2018

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Effect of angiotensin II type 1 receptor blockade on experimental hepatic fibrogenesis

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Angiotensin-converting enzyme inhibition attenuates the progression of rat hepatic fibrosis

21 January 2018

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A local pancreatic renin-angiotensin system: endocrine and exocrine roles

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Review article: pancreatic renin-angiotensin systems in health and disease

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The renin-angiotensin-system in the skin. Evidence for its presence and possible functional implications

21 January 2018

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The renin-angiotensin system and male reproduction: new functions for old hormones.

21 January 2018

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The uteroplacental renin-angiotensin system: a review

21 January 2018

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Human skin: source of and target organ for angiotensin II.

21 January 2018

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Role of adipose tissue renin-angiotensin system in metabolic and inflammatory diseases associated with obesity

21 January 2018

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Role of the renin-angiotensin system in autoimmune inflammation of the central nervous system

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1365-2036.2011.04971.X

New insights into angiotensin receptor actions: from blood pressure to aging

21 January 2018

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Liver disease and the renin-angiotensin system: recent discoveries and clinical implications.

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Tissue distribution of ACE2 protein, the functional receptor for SARS coronavirus. A first step in understanding SARS pathogenesis.

21 January 2018

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Quantitative mRNA expression profiling of ACE 2, a novel homologue of angiotensin converting enzyme

21 January 2018

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A human homolog of angiotensin-converting enzyme. Cloning and functional expression as a captopril-insensitive carboxypeptidase

21 January 2018

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Differential tissue and enzyme inhibitory effects of the vasopeptidase inhibitor omapatrilat in the rat.

21 January 2018

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Intestinal renin-angiotensin system is stimulated after deletion of Lkb1.

21 January 2018

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Angiotensin II-induced contractions in human jejunal wall musculature in vitro

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Identification of a previously unrecognized production site of human renin

21 January 2018

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Angiotensinogen gene is expressed and differentially regulated in multiple tissues of the rat

21 January 2018

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Plasma and tissue levels of proangiotensin-12 and components of the renin-angiotensin system (RAS) following low- or high-salt feeding in rats

21 January 2018

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Interactions between angiotensin peptides and the sympathetic nervous system mediating intestinal sodium and water absorption in the rat.

21 January 2018

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Compartmentalization of extracellular cGMP determines absorptive or secretory responses in the rat jejunum

21 January 2018

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A protein complex in the brush-border membrane explains a Hartnup disorder allele.

21 January 2018

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The action of angiotensin on the human colon in vitro

21 January 2018

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Angiotensin II-generating enzymes, angiotensin-converting enzyme (ACE) and mast cell chymase (CMA1), in gastric inflammation may be regulated by H. pylori and associated cytokines.

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1365-2036.2011.04971.X

Cigarette smoke increases gastric ulcer size in part by an angiotensin II-mediated mechanism in rats

21 January 2018

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Angiotensin II receptors are expressed and functional in human esophageal mucosa

21 January 2018

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Actions by angiotensin II on esophageal contractility in humans.

21 January 2018

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Serum angiotensin I-converting enzyme is reduced in Crohn's disease and ulcerative colitis irrespective of genotype

21 January 2018

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Serum angiotensin-converting enzyme (SACE) in sarcoidosis and other granulomatous disorders

21 January 2018

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Genetics of angiotensin I-converting enzyme

21 January 2018

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Angiotensin-converting enzyme insertion/deletion gene polymorphism in inflammatory bowel diseases

21 January 2018

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Angiotensinogen and transforming growth factor beta1: novel genes in the pathogenesis of Crohn's disease.

21 January 2018

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Dextran sulfate sodium-induced acute colonic inflammation in angiotensin II type 1a receptor deficient mice.

21 January 2018

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Reduced severity of a mouse colitis model with angiotensin converting enzyme inhibition

21 January 2018

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Transanal delivery of angiotensin converting enzyme inhibitor prevents colonic fibrosis in a mouse colitis model: development of a unique mode of treatment.

21 January 2018

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An angiotensin II receptor antagonist reduces inflammatory parameters in two models of colitis

21 January 2018

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Amelioration of 2,4,6-trinitrobenzene sulphonic acid induced colitis in angiotensinogen gene knockout mice

21 January 2018

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Prevention of fibrosis in experimental colitis by captopril: the role of tgf-beta1.

21 January 2018

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Neutral endopeptidase (EC 3.4.24.11) terminates colitis by degrading substance P

21 January 2018

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Blocking angiotensin-converting enzyme induces potent regulatory T cells and modulates TH1- and TH17-mediated autoimmunity.

21 January 2018

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Angiotensin II sustains brain inflammation in mice via TGF-beta

21 January 2018

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Do inhibitors of angiotensin-I-converting enzyme protect against risk of cancer?

21 January 2018

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Association between captopril, other antihypertensive drugs and risk of prostate cancer

21 January 2018

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Angiotensin-receptor blockade and risk of cancer: meta-analysis of randomised controlled trials

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Use of Angiotensin Receptor Blockers and the Risk of Cancer

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Effects of telmisartan, irbesartan, valsartan, candesartan, and losartan on cancers in 15 trials enrolling 138,769 individuals

21 January 2018

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The renin-angiotensin system and cancer: old dog, new tricks.

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Local angiotensin II-generation in human gastric cancer: correlation with tumor progression through the activation of ERK1/2, NF-kappaB and survivin

21 January 2018

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The angiotensin II/angiotensin II receptor system correlates with nodal spread in intestinal type gastric cancer.

21 January 2018

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Functional expression of the angiotensin II type 1 receptor in human ovarian carcinoma cells and its blockade therapy resulting in suppression of tumor invasion, angiogenesis, and peritoneal dissemination

21 January 2018

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Angiotensin II induces vascular endothelial growth factor in pancreatic cancer cells through an angiotensin II type 1 receptor and ERK1/2 signaling

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Angiotensin II type 1 receptor antagonist candesartan as an angiogenic inhibitor in a xenograft model of bladder cancer.

21 January 2018

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Angiotensin-converting enzyme inhibitors and risk of esophageal and gastric cancer: a nested case-control study.

21 January 2018

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The angiotensin II type 2 receptor and the gastrointestinal tract

21 January 2018

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Differentiation of the peptidergic vasoregulatory response to standardized splanchnic hypoperfusion by acute hypovolaemia or sepsis in anaesthetized pigs.

21 January 2018

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Intestinal nitric oxide output during reduced mucosal blood flow in healthy volunteers

21 January 2018

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Signal transduction mechanisms of the angiotensin II type AT(1)-receptor: looking beyond the heterotrimeric G protein paradigm

21 January 2018

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Potential roles of angiotensin receptor-activating autoantibody in the pathophysiology of preeclampsia

21 January 2018

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Angiotensin II regulates the synthesis of proinflammatory cytokines and chemokines in the kidney.

21 January 2018

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Angiotensin receptor blockers and angiogenesis: clinical and experimental evidence

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Recent advances in the angiotensin-converting enzyme 2-angiotensin(1-7)-Mas axis.

21 January 2018

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Angiotensin III stimulates aldosterone secretion from adrenal gland partially via angiotensin II type 2 receptor but not angiotensin II type 1 receptor.

21 January 2018

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Direct angiotensin II type 2 receptor stimulation acts anti-inflammatory through epoxyeicosatrienoic acid and inhibition of nuclear factor kappaB.

21 January 2018

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Angiotensin II stimulates thick ascending limb NO production via AT(2) receptors and Akt1-dependent nitric-oxide synthase 3 (NOS3) activation

21 January 2018

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The angiotensin II AT2 receptor is an AT1 receptor antagonist.

21 January 2018

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New approaches to blockade of the renin-angiotensin-aldosterone system: chymase as an important target to prevent organ damage

21 January 2018

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Design, synthesis, and biological evaluation of the first selective nonpeptide AT2 receptor agonist.

21 January 2018

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Development of selective non-peptide angiotensin II type 2 receptor agonists

21 January 2018

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Prophylactic and therapeutic treatments with AT 1 and AT 2 receptor antagonists and their effects on changes in the severity of pancreatitis

21 January 2018

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Protective effect of candesartan in experimental ischemic stroke in the rat mediated by AT2 and AT4 receptors

21 January 2018

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The angiotensin-(1-7)/Mas receptor axis is expressed in sinoatrial node cells of rats.

21 January 2018

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Impairment of cardiac function and remodeling induced by myocardial infarction in rats are attenuated by the nonpeptide angiotensin-(1-7) analog AVE 0991.

21 January 2018

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Anti-inflammatory effects of the activation of the angiotensin-(1-7) receptor, MAS, in experimental models of arthritis.

21 January 2018

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Angiotensin-converting enzyme 2 suppresses pathological hypertrophy, myocardial fibrosis, and cardiac dysfunction.

21 January 2018

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Recombinant human angiotensin-converting enzyme 2 as a new renin-angiotensin system peptidase for heart failure therapy

21 January 2018

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Effects of ACE2 inhibition in the post-myocardial infarction heart

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1365-2036.2011.04971.X

Comparison of vasopeptidase inhibitor, omapatrilat, and lisinopril on exercise tolerance and morbidity in patients with heart failure: IMPRESS randomised trial

21 January 2018

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Comparison of omapatrilat and enalapril in patients with chronic heart failure: the Omapatrilat Versus Enalapril Randomized Trial of Utility in Reducing Events (OVERTURE).

21 January 2018

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Omapatrilat and enalapril in patients with hypertension: the Omapatrilat Cardiovascular Treatment vs. Enalapril (OCTAVE) trial

21 January 2018

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Blood-pressure reduction with LCZ696, a novel dual-acting inhibitor of the angiotensin II receptor and neprilysin: a randomised, double-blind, placebo-controlled, active comparator study

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1365-2036.2011.04971.X

Inhibition of diabetic nephropathy by a decoy peptide corresponding to the "handle" region for nonproteolytic activation of prorenin

21 January 2018

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Pathologic roles of prorenin and (pro)renin receptor in the eye.

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1365-2036.2011.04971.X

Suppression of ocular inflammation in endotoxin-induced uveitis by inhibiting nonproteolytic activation of prorenin.

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1365-2036.2011.04971.X

Identity of angiotensinogen precursors of rat brain and liver

21 January 2018

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Angiotensin II receptor subtypes in the human central nervous system

21 January 2018

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12 December 2020

Involvement of an enterocyte renin-angiotensin system in the local control of SGLT1-dependent glucose uptake across the rat small intestinal brush border membrane

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Beneficial effects of angiotensin (1-7) in diabetic rats with cardiomyopathy

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12 December 2020

Upregulation of hepatic angiotensin-converting enzyme 2 (ACE2) and angiotensin-(1-7) levels in experimental biliary fibrosis

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Angiotensin II type 2 receptor-mediated duodenal mucosal alkaline secretion in the rat.

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12 December 2020

Angiotensin II stimulates interleukin-6 release from cultured mouse mesangial cells

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Angiotensin-[1-7]: evidence for novel actions in the brain

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Stimulatory action of angiotensin II on water and electrolyte transport by the proximal colon of the rat

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12 December 2020

Identification of a highly specific chymase as the major angiotensin II-forming enzyme in the human heart

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12 December 2020

Immunohistochemical localization of angiotensin II receptor and local renin-angiotensin system in human colonic mucosa

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12 December 2020

Beneficial renal and hemodynamic effects of omapatrilat in mild and severe heart failure

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12 December 2020

The nonpeptide AVE0991 attenuates myocardial hypertrophy as induced by angiotensin II through downregulation of transforming growth factor-beta1/Smad2 expression

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12 December 2020

Autoradiographic characterization of angiotensin II receptor subtypes in rat intestine

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12 December 2020

Effects of bradykinin and angiotensin on smooth muscle

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12 December 2020

Characterization of a dipeptide hydrolase (kininase II: angiotensin I converting enzyme).

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12 December 2020

Predictors of distant metastasis and mortality in patients with stage II colorectal cancer

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12 December 2020

Monocyte- and cytokine-induced downregulation of angiotensin-converting enzyme in cultured human and porcine endothelial cells

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12 December 2020

Serum angiotensin converting enzyme activity in Crohn's disease and ulcerative colitis

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12 December 2020

Follicular maturation and atresia--possible role of intraovarian regulatory factors

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12 December 2020

Angiotensin and cell growth: a link to cardiovascular hypertrophy?

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12 December 2020

Regulation of intestinal fluid transport by angiotensin II: mechanisms and physiological significance

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12 December 2020

Angiotensin-converting-enzyme (ACE) in Crohn's disease

1 reference

12 December 2020

Captopril decreases stress ulceration without affecting gastric perfusion during canine hemorrhagic shock

1 reference

12 December 2020

Up-regulation of components of the renin-angiotensin system in the bile duct-ligated rat liver

1 reference

12 December 2020

Chymase-dependent angiotensin II formation in human vascular tissue

1 reference

12 December 2020

Angiotensin I converting enzyme in human intestine and kidney. Ultrastructural immunohistochemical localization

1 reference

12 December 2020

Angiotensin-converting Enzyme in Crohn’s Disease and Ulcerative Colitis

1 reference

12 December 2020

Involvement of receptor-bound prorenin in development of nephropathy in diabetic db/db mice

1 reference

12 December 2020

Effect of adrenergic agents on responses of smooth muscle to angiotensin

1 reference

12 December 2020

Response of rat jejunum to angiotensin III: pharmacology and mechanism of action

1 reference

12 December 2020

Distribution of brush-border membrane peptidases along the rat intestine

1 reference

12 December 2020

Angiotensin II receptor antagonism increases gut oxygen delivery but fails to improve intestinal mucosal acidosis in porcine endotoxin shock.

1 reference

12 December 2020

Angiotensin II induced contraction of rat and human small intestinal wall musculature in vitro

1 reference

12 December 2020

Angiotensin II-forming pathways in normal and failing human hearts

1 reference

12 December 2020

Angiotensin II stimulates human gastric smooth muscle in vitro

1 reference

12 December 2020

Glomerular type 1 angiotensin receptors augment kidney injury and inflammation in murine autoimmune nephritis

1 reference

12 December 2020

The expression of renin-angiotensin system components in the human gastric mucosa

1 reference

12 December 2020

Angiotensin II-mediated growth and antigrowth effects in cultured neonatal rat cardiac myocytes and fibroblasts

1 reference

12 December 2020

Angiotensin III increases MCP-1 and activates NF-kappaB and AP-1 in cultured mesangial and mononuclear cells

1 reference

12 December 2020

Important role for angiotensin III and IV in the brain renin-angiotensin system

1 reference

12 December 2020

Characterisation of AT1 angiotensin receptors on cultured rat intestinal epithelial (RIE-1) cells.

1 reference

12 December 2020

Specific angiotensin II receptor blockage improves intestinal perfusion during graded hypovolemia in pigs

1 reference

12 December 2020

Characterization of chymase from human vascular tissues

1 reference

12 December 2020

Localization of angiotensin converting enzyme by in vitro autoradiography in the rabbit brain

1 reference

12 December 2020

Angiotensin receptors and angiotensin I-converting enzyme in rat intestine

1 reference

12 December 2020

Effect of ACE inhibitors and angiotensin II receptor antagonists in a mouse model of colorectal cancer liver metastases

1 reference

12 December 2020

Increased plasma inactive renin in diabetes mellitus. A marker of microvascular complications

1 reference

12 December 2020

Serum angiotensin-converting-enzyme in Crohn's disease

1 reference

12 December 2020

Angiotensin-(1-7) inhibits vascular smooth muscle cell growth

1 reference

12 December 2020

Increased colonic mucosal angiotensin I and II concentrations in Crohn's colitis

1 reference

12 December 2020

Stimulation of different subtypes of angiotensin II receptors, AT1 and AT2 receptors, regulates STAT activation by negative crosstalk

1 reference

12 December 2020

Angiotensin II induction of neurite outgrowth by AT2 receptors in NG108-15 cells. Effect counteracted by the AT1 receptors

1 reference

12 December 2020

Prorenin receptor blockade inhibits development of glomerulosclerosis in diabetic angiotensin II type 1a receptor-deficient mice

1 reference

12 December 2020

Prorenin receptor blockers: effects on cardiovascular complications of diabetes and hypertension

1 reference

12 December 2020

Ablation of angiotensin IV receptor attenuates hypofibrinolysis via PAI-1 downregulation and reduces occlusive arterial thrombosis

1 reference

12 December 2020

Serum angiotensin-I-converting enzyme and carboxypeptidase N in Crohn's disease and ulcerative colitis

1 reference

12 December 2020

Response of isolated rat jejunum to angiotensin peptides

1 reference

12 December 2020

Role of nonproteolytically activated prorenin in pathologic, but not physiologic, retinal neovascularization

1 reference

12 December 2020

Angiotensin II blockade in existing hypovolemia: effects of candesartan in the porcine splanchnic and renal circulation

1 reference

12 December 2020

Angiotensin II inhibitor DuP753 attenuates burn- and endotoxin-induced gut ischemia, lipid peroxidation, mucosal permeability, and bacterial translocation

1 reference

12 December 2020

AVE 0991-angiotensin-(1-7) receptor agonist, inhibits atherogenesis in apoE-knockout mice

1 reference

12 December 2020

Rat intestinal angiotensin-converting enzyme: purification, properties, expression, and function

1 reference

12 December 2020

Roles of the renin–angiotensin system and its blockade in pancreatic inflammation

1 reference

12 December 2020

Angiotensin-(1-7) improves the post-ischemic function in isolated perfused rat hearts

1 reference

12 December 2020

Regulation of jejunal sodium and water absorption by angiotensin subtype receptors.

1 reference

12 December 2020