DNA demethylation and invasive cancer: implications for therapeutics (Q27011914)

Lisa Boureau

series ordinal

2

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language of work or name

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June 2015

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British Journal of Pharmacology

published in

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volume

172

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issue

11

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page(s)

2705-15

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Cross-talk between site-specific transcription factors and DNA methylation states

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UHRF1 plays a role in maintaining DNA methylation in mammalian cells

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Valproic acid defines a novel class of HDAC inhibitors inducing differentiation of transformed cells

21 March 2017

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Cloning and characterization of a family of novel mammalian DNA (cytosine-5) methyltransferases

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MeCP2 is a transcriptional repressor with abundant binding sites in genomic chromatin

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Histone deacetylase is a direct target of valproic acid, a potent anticonvulsant, mood stabilizer, and teratogen

7 April 2017

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Synergy of demethylation and histone deacetylase inhibition in the re-expression of genes silenced in cancer

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Genetic instability in colorectal cancers

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S-adenosyl methionine specifically protects the anticancer effect of 5-FU via DNMTs expression in human A549 lung cancer cells

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A randomised, phase II trial of the DNA-hypomethylating agent 5-aza-2'-deoxycytidine (decitabine) in combination with carboplatin vs carboplatin alone in patients with recurrent, partially platinum-sensitive ovarian cancer.

28 September 2017

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Genomic patterns and context specific interpretation of DNA methylation

28 September 2017

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Immune regulation by low doses of the DNA methyltransferase inhibitor 5-azacitidine in common human epithelial cancers.

28 September 2017

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Distribution, recognition and regulation of non-CpG methylation in the adult mammalian brain

28 September 2017

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Active demethylation in mouse zygotes involves cytosine deamination and base excision repair

28 September 2017

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28 September 2017

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The DNA hypomethylating agent, 5-aza-2'-deoxycytidine, enhances tumor cell invasion through a transcription-dependent modulation of MMP-1 expression in human fibrosarcoma cells.

28 September 2017

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Synergistic anti-breast cancer effect of a combined treatment with the methyl donor S-adenosyl methionine and the DNA methylation inhibitor 5-aza-2'-deoxycytidine

28 September 2017

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Intragenic DNA methylation modulates alternative splicing by recruiting MeCP2 to promote exon recognition

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TETonic shift: biological roles of TET proteins in DNA demethylation and transcription

28 September 2017

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S-adenosylmethionine, a methyl donor, up regulates tissue inhibitor of metalloproteinase-2 in colorectal cancer

28 September 2017

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Frequent inactivation of cysteine dioxygenase type 1 contributes to survival of breast cancer cells and resistance to anthracyclines.

28 September 2017

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5-Aza-2'-deoxycytidine enhances maspin expression and inhibits proliferation, migration, and invasion of the bladder cancer T24 cell line

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DNA-methylation effect on cotranscriptional splicing is dependent on GC architecture of the exon-intron structure

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28 September 2017

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Associations with early-life socio-economic position in adult DNA methylation

28 September 2017

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Recognition and potential mechanisms for replication and erasure of cytosine hydroxymethylation

28 September 2017

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Subcutaneous 5-azacitidine treatment of naturally occurring canine urothelial carcinoma: a novel epigenetic approach to human urothelial carcinoma drug development

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28 September 2017

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Epigenetic drugs can stimulate metastasis through enhanced expression of the pro-metastatic Ezrin gene

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Multicenter, phase II study of decitabine for the first-line treatment of older patients with acute myeloid leukemia

28 September 2017

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A human B cell methylome at 100-base pair resolution

28 September 2017

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28 September 2017

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28 September 2017

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Pharmacological inhibition of DNA methylation induces proinvasive and prometastatic genes in vitro and in vivo

28 September 2017

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DNA methyltransferase and histone deacetylase inhibitors in the treatment of myelodysplastic syndromes

28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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Synergic antiproliferative effect of DNA methyltransferase inhibitor in combination with anticancer drugs in gastric carcinoma

28 September 2017

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28 September 2017

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Regulation of RNA splicing by the methylation-dependent transcriptional repressor methyl-CpG binding protein 2.

28 September 2017

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Epigenetic therapy of cancer with 5-aza-2'-deoxycytidine (decitabine).

28 September 2017

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Role of methionine adenosyltransferase and S-adenosylmethionine in alcohol-associated liver cancer

28 September 2017

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DNA methylation and demethylation as targets for anticancer therapy

28 September 2017

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Evaluation of a 7-day continuous intravenous infusion of decitabine: inhibition of promoter-specific and global genomic DNA methylation

28 September 2017

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DNA methylation and cancer therapy: new developments and expectations

28 September 2017

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Role of the putative tumor metastasis suppressor gene Drg-1 in breast cancer progression.

28 September 2017

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Reversal of the hypomethylation status of urokinase (uPA) promoter blocks breast cancer growth and metastasis

28 September 2017

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Role of promoter methylation in regulation of the mammalian heparanase gene

28 September 2017

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28 September 2017

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Valproate induces replication-independent active DNA demethylation

28 September 2017

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Diet and DNA Methylation Interactions in Cancer Prevention

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4439869

Regulation of DNA methylation in human breast cancer. Effect on the urokinase-type plasminogen activator gene production and tumor invasion

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4439869

Chemoprevention of hepatocarcinogenesis: S-adenosyl-L-methionine

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4439869

DNA methylation in cancer: too much, but also too little

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4439869

Review of the clinical experience with 5-azacytidine and 5-aza-2'-deoxycytidine in solid tumors.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4439869

DNA methyltransferase and demethylase in human prostate cancer

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4439869

Overexpression of S100A4 in pancreatic ductal adenocarcinomas is associated with poor differentiation and DNA hypomethylation.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4439869

Gene silencing by S-adenosylmethionine in muscle differentiation

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4439869

Demethylase activity is directed by histone acetylation

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4439869

Aberrant patterns of DNA methylation, chromatin formation and gene expression in cancer

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4439869

A mammalian protein with specific demethylase activity for mCpG DNA.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4439869

DNA hypomethylation leads to elevated mutation rates

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4439869

Inhibition of tumorigenesis by a cytosine-DNA, methyltransferase, antisense oligodeoxynucleotide

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4439869

Murine DNA cytosine-C5 methyltransferase: pre-steady- and steady-state kinetic analysis with regulatory DNA sequences

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4439869

Expression of an exogenous eukaryotic DNA methyltransferase gene induces transformation of NIH 3T3 cells.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4439869

Genomic imprinting proposed as a surveillance mechanism for chromosome loss

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4439869

Regulation of the DNA methyltransferase by the Ras-AP-1 signaling pathway

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4439869

Toxicity of 5-aza-2'-deoxycytidine to mammalian cells is mediated primarily by covalent trapping of DNA methyltransferase rather than DNA demethylation

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4439869

In vitro methylation of the hamster adenine phosphoribosyltransferase gene inhibits its expression in mouse L cells

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4439869

DNA methylation in 5-aza-2'-deoxycytidine-resistant variants of C3H 10T1/2 C18 cells

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4439869

Induction of the metastatic phenotype in a mouse tumor model by 5-azacytidine, and characterization of an antigen associated with metastatic activity

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4439869

CpG methylation inhibits binding of several sequence-specific DNA-binding proteins from pea, wheat, soybean and cauliflower

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4439869

CpG methylation inhibits proenkephalin gene expression and binding of the transcription factor AP-2

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4439869

Distribution of 5-methylcytosine in chromatin

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4439869

Phase II study of 5-azacytidine in solid tumors

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4439869

DNA methyltransferase is a downstream effector of cellular transformation triggered by simian virus 40 large T antigen

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4439869

Regulation of DNA methylation by the Ras signaling pathway

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4439869

Expression of antisense to DNA methyltransferase mRNA induces DNA demethylation and inhibits tumorigenesis

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4439869

Cellular differentiation, cytidine analogs and DNA methylation

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4439869

Methionine metabolism and cancer

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4439869

Induction of invasive and metastatic potential in mouse T-lymphoma cells (BW5147) by treatment with 5-azacytidine

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4439869

Suppression of intestinal neoplasia by DNA hypomethylation.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4439869

Phase I study of 5-aza-2'-deoxycytidine in combination with valproic acid in non-small-cell lung cancer.

31 May 2018

1 reference

The methyl donor S-Adenosylmethionine inhibits active demethylation of DNA: a candidate novel mechanism for the pharmacological effects of S-Adenosylmethionine

21 January 2018

1 reference

On the mechanism of demethylation of 5-methylcytosine in DNA.

21 January 2018

1 reference

Activation and transposition of endogenous retroviral elements in hypomethylation induced tumors in mice.

21 January 2018

1 reference

Intragenic DNA methylation alters chromatin structure and elongation efficiency in mammalian cells

21 January 2018

1 reference

Demethylating agent 5-aza-2-deoxycytidine enhances susceptibility of breast cancer cells to anticancer agents

21 January 2018

1 reference

Potential of 5-aza-2'-deoxycytidine (Decitabine) a potent inhibitor of DNA methylation for therapy of advanced non-small cell lung cancer

21 January 2018

1 reference

Azacitidine in CMML: matched-pair analyses of daily-life patients reveal modest effects on clinical course and survival

21 January 2018

1 reference

Effects of 5-aza-2'-deoxycytidine on matrix metalloproteinase expression and pancreatic cancer cell invasiveness

21 January 2018

1 reference

S-Adenosylmethionine; a new intermediate formed enzymatically from L-methionine and adenosinetriphosphate.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4439869

Phase I trial of continuous infusion 5-aza-2'-deoxycytidine

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4439869

Genistein alters methylation patterns in mice.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4439869

Pilot phase I-II study on 5-aza-2'-deoxycytidine (Decitabine) in patients with metastatic lung cancer

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4439869

Phase II study of 5-azacytidine in solid tumors

28 November 2018

1 reference

12 December 2020

Effect of DNA methylation on gene expression

1 reference

12 December 2020

Ras induces a general DNA demethylation activity in mouse embryonal P19 cells

1 reference

12 December 2020

5-Azacytidine-induced undercondensations in human chromosomes

1 reference

12 December 2020

5-Azacytidine, a new, highly effective cancerostatic

1 reference

12 December 2020

Increased cytosine DNA-methyltransferase activity during colon cancer progression

1 reference

12 December 2020

Histone deacetylase inhibitor Trichostatin A induces global and gene-specific DNA demethylation in human cancer cell lines

1 reference

12 December 2020

Purification of human DNA (cytosine-5-)-methyltransferase

1 reference

12 December 2020

DNA demethylating agent 5-azacytidine inhibits myeloid-derived suppressor cells induced by tumor growth and cyclophosphamide treatment

1 reference

12 December 2020

On the mechanism and inhibition of DNA cytosine methyltransferases

1 reference

12 December 2020

Cytotoxicity and mode of action of 5-azacytidine on L1210 leukemia

1 reference

12 December 2020

Kinetic interaction of 5-AZA-2'-deoxycytidine-5'-monophosphate and its 5'-triphosphate with deoxycytidylate deaminase

1 reference

12 December 2020

Thymidine kinase and polyribosome distribution in regenerating rat liver following 5-azacytidine

1 reference

12 December 2020

High-performance Liquid Chromatographic Analysis of Chemical Stability of 5-aza-2′-Deoxycytidine

1 reference

12 December 2020

DNA methylation properties: consequences for pharmacology

1 reference

12 December 2020

Hypomethylation of the metastasis-associated S100A4 gene correlates with gene activation in human colon adenocarcinoma cell lines

1 reference

12 December 2020

Definition of the landscape of promoter DNA hypomethylation in liver cancer

1 reference

12 December 2020

A fraction of the mouse genome that is derived from islands of nonmethylated, CpG-rich DNA

1 reference

12 December 2020

The outcomes and costs of acute myeloid leukemia among the elderly

1 reference

12 December 2020

Identifiers

0 references

1 reference

PubMed publication ID

25134627

1 reference