Human antibody production in transgenic animals (Q27023477)

Michael J. Osborn

2

1 reference

Biao Ma

3

1 reference

Jasvinder Hayre

4

1 reference

Suzanne Avis

5

1 reference

Brian Lundstrom

6

1 reference

Roland Buelow

7

1 reference

language of work or name

1 reference

April 2015

1 reference

Archivum Immunologiae et Therapiae Experimentalis

1 April 2015

8 references

25 June 2019

27 September 2019

9 October 2019

12 October 2019

27 November 2019

13 December 2019

9 September 2020

6 December 2020

9 references

25 June 2019

27 September 2019

9 October 2019

12 October 2019

27 November 2019

13 December 2019

9 September 2020

6 December 2020

63

1 reference

page(s)

101-8

1 reference

issue

2

1 reference

Creative Commons Attribution 4.0 International

copyright license

start time

3 December 2014

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

exact match

https://scigraph.springernature.com/pub.10.1007/s00005-014-0322-x

0 references

cites work

Efficient immunoglobulin gene disruption and targeted replacement in rabbit using zinc finger nucleases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4359279

21 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4359279

Knockout rats via embryo microinjection of zinc-finger nucleases

21 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4359279

Continuous cultures of fused cells secreting antibody of predefined specificity

21 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4359279

Targeted integration in rat and mouse embryos with zinc-finger nucleases

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4359279

Physiological level production of antigen-specific human immunoglobulin in cloned transchromosomic cattle

21 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4359279

High-affinity IgG antibodies develop naturally in Ig-knockout rats carrying germline human IgH/Igκ/Igλ loci bearing the rat CH region

21 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4359279

Compartmentalization of lambda subtype expression in the B cell repertoire of mice with a disrupted or normal C kappa gene segment

21 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4359279

Human artificial chromosome (HAC) vector provides long-term therapeutic transgene expression in normal human primary fibroblasts

21 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4359279

Mice with megabase humanization of their immunoglobulin genes generate antibodies as efficiently as normal mice

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4359279

Triple immunoglobulin gene knockout transchromosomic cattle: bovine lambda cluster deletion and its effect on fully human polyclonal antibody production

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4359279

Characterization of a new V gene replacement in the absence of activation-induced cytidine deaminase and its contribution to human B-cell receptor diversity.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4359279

Fcγ receptors enable anticancer action of proapoptotic and immune-modulatory antibodies

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4359279

Transgenic mouse strains as platforms for the successful discovery and development of human therapeutic monoclonal antibodies

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4359279

Regulation of VH replacement by B cell receptor-mediated signaling in human immature B cells

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4359279

A critical review of the role of Fc gamma receptor polymorphisms in the response to monoclonal antibodies in cancer

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4359279

Antigen and cytokine receptor signals guide the development of the naïve mature B cell repertoire

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4359279

Human monoclonal antibodies to HIV-1 gp140 from mice bearing YAC-based human immunoglobulin transloci

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4359279

Fc-receptors as regulators of immunity.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4359279

Antibody-mediated regulation of the immune response

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4359279

Engineering of therapeutic antibodies to minimize immunogenicity and optimize function

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4359279

Production of human monoclonal and polyclonal antibodies in TransChromo animals

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4359279

Human antibody expression in transgenic mice

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4359279

Revising B cell receptors

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4359279

Double trans-chromosomic mice: maintenance of two individual human chromosome fragments containing Ig heavy and kappa loci and expression of fully human antibodies

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4359279

The human immunoglobulin heavy variable genes

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4359279

B cell development in mice that lack one or both immunoglobulin kappa light chain genes.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4359279

Extension of yeast artificial chromosomes by cosmid multimers

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4359279

Transgenic mice containing a human heavy chain immunoglobulin gene fragment cloned in a yeast artificial chromosome

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4359279

The human immunoglobulin VH repertoire

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4359279

Creation of mice expressing human antibody light chains by introduction of a yeast artificial chromosome containing the core region of the human immunoglobulin kappa locus.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4359279

Organization of the human immunoglobulin lambda light-chain locus on chromosome 22q11.2.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4359279

The immunogenicity of chimeric antibodies

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4359279

A repertoire of monoclonal antibodies with human heavy chains from transgenic mice

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4359279

Phage antibodies: filamentous phage displaying antibody variable domains

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4359279

Targeted alterations in yeast artificial chromosomes for inter-species gene transfer

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4359279

A human immunoglobulin lambda locus is similarly well expressed in mice and humans

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4359279

Regulation of B cell development by variable gene complexity in mice reconstituted with human immunoglobulin yeast artificial chromosomes

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4359279

Structure and physical map of 64 variable segments in the 3'0.8-megabase region of the human immunoglobulin heavy-chain locus

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4359279

The human immunoglobulin kappa locus consists of two copies that are organized in opposite polarity

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4359279

Human immunoglobulin transgenes undergo rearrangement, somatic mutation and class switching in mice that lack endogenous IgM.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4359279

A B cell-deficient mouse by targeted disruption of the membrane exon of the immunoglobulin mu chain gene

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4359279

High-avidity human IgG kappa monoclonal antibodies from a novel strain of minilocus transgenic mice.

31 May 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00005-014-0322-X

Antigen-specific human monoclonal antibodies from mice engineered with human Ig heavy and light chain YACs

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00005-014-0322-X

The use of chromosome-based vectors for animal transgenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00005-014-0322-X

Complete humanization of the mouse immunoglobulin loci enables efficient therapeutic antibody discovery.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00005-014-0322-X

Human antibody expression in transgenic rats: comparison of chimeric IgH loci with human VH, D and JH but bearing different rat C-gene regions

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00005-014-0322-X

Functional transplant of megabase human immunoglobulin loci recapitulates human antibody response in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00005-014-0322-X

Characterization of immunoglobulin heavy chain knockout rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00005-014-0322-X

Silencing of the immunoglobulin heavy chain locus by removal of all eight constant-region genes in a 200-kb region.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00005-014-0322-X

Antibody expression from the core region of the human IgH locus reconstructed in transgenic mice using bacteriophage P1 clones

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00005-014-0322-X

Contribution of Vh gene replacement to the primary B cell repertoire.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00005-014-0322-X

Block in development at the pre-B-II to immature B cell stage in mice without Ig kappa and Ig lambda light chain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00005-014-0322-X

Human antibody production in transgenic mice: expression from 100 kb of the human IgH locus

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00005-014-0322-X

Antibody repertoires of four- and five-feature translocus mice carrying human immunoglobulin heavy chain and kappa and lambda light chain yeast artificial chromosomes.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4359279

Antigen-specific human antibodies from mice comprising four distinct genetic modifications

28 November 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00005-014-0322-X

Three rat monoclonal antibodies to human C3

21 January 2018

1 reference

12 December 2020

Immunoglobulin gene rearrangement in B cell deficient mice generated by targeted deletion of the JH locus

1 reference

12 December 2020

The diversity of antigen-specific monoclonal antibodies from transgenic mice bearing human immunoglobulin gene miniloci

1 reference

12 December 2020

Strategies for expressing human antibody repertoires in transgenic mice

1 reference

12 December 2020

Assembly and extension of yeast artificial chromosomes to build up a large locus

1 reference

12 December 2020

Mice perform a human repertoire

1 reference

12 December 2020