TLRs and interferons: a central paradigm in autoimmunity (Q27023982)

Crossref

Roberto Baccala

series ordinal

2

1 reference

Crossref

Argyrios N. Theofilopoulos

series ordinal

3

1 reference

Crossref

language of work or name

1 reference

December 2013

1 reference

Current Opinion in Immunology

published in

1 reference

volume

25

1 reference

issue

6

1 reference

page(s)

720-7

1 reference

Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway

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1 reference

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TLR8: the forgotten relative revindicated

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Intracellular nucleic acid sensors and autoimmunity

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Immune signaling by RIG-I-like receptors

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A large-scale replication study identifies TNIP1, PRDM1, JAZF1, UHRF1BP1 and IL10 as risk loci for systemic lupus erythematosus

21 March 2017

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Trex1 prevents cell-intrinsic initiation of autoimmunity

21 March 2017

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Clinical and molecular phenotype of Aicardi-Goutieres syndrome

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Adjuvant-enhanced antibody responses in the absence of toll-like receptor signaling

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Cyclic GMP-AMP is an endogenous second messenger in innate immune signaling by cytosolic DNA

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Mutations in ADAR1 cause Aicardi-Goutières syndrome associated with a type I interferon signature

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Constitutive type I interferon modulates homeostatic balance through tonic signaling

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TLR8 deficiency leads to autoimmunity in mice

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Admixture mapping in lupus identifies multiple functional variants within IFIH1 associated with apoptosis, inflammation, and autoantibody production

21 March 2017

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Lethal anemia caused by interferon-beta produced in mouse embryos carrying undigested DNA

21 March 2017

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Interferon and granulopoiesis signatures in systemic lupus erythematosus blood

21 March 2017

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Role of nucleic acid-sensing TLRs in diverse autoantibody specificities and anti-nuclear antibody-producing B cells

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Signals via the adaptor MyD88 in B cells and DCs make distinct and synergistic contributions to immune activation and tissue damage in lupus

28 September 2017

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Fueling autoimmunity: type I interferon in autoimmune diseases.

28 September 2017

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Molecular basis of DNA recognition in the immune system

28 September 2017

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Sifalimumab, a human anti-interferon-α monoclonal antibody, in systemic lupus erythematosus: a phase I randomized, controlled, dose-escalation study

28 September 2017

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Essential requirement for IRF8 and SLC15A4 implicates plasmacytoid dendritic cells in the pathogenesis of lupus

28 September 2017

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TLR9 promotes tolerance by restricting survival of anergic anti-DNA B cells, yet is also required for their activation

28 September 2017

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Interferon regulatory factor 5 in the pathogenesis of systemic lupus erythematosus

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The interferon signature in autoimmune diseases

28 September 2017

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Anti-IFN-α/β receptor antibody treatment ameliorates disease in lupus-predisposed mice

28 September 2017

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MAPK phosphatase-1 is required for regulatory natural autoantibody-mediated inhibition of TLR responses

28 September 2017

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STING manifests self DNA-dependent inflammatory disease

28 September 2017

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High-mobility group box family of proteins: ligand and sensor for innate immunity

28 September 2017

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NADPH oxidase inhibits the pathogenesis of systemic lupus erythematosus.

28 September 2017

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The Yaa locus and IFN-α fine-tune germinal center B cell selection in murine systemic lupus erythematosus

28 September 2017

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Dual signaling by innate and adaptive immune receptors is required for TLR7-induced B-cell-mediated autoimmunity

28 September 2017

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The genetics of type I interferon in systemic lupus erythematosus

28 September 2017

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Type I IFN system in the development and manifestations of SLE.

28 September 2017

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Lupus neutrophils: 'NET' gain in understanding lupus pathogenesis

28 September 2017

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Induction of type I IFNs by intracellular DNA-sensing pathways

28 September 2017

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Autoimmunity initiates in nonhematopoietic cells and progresses via lymphocytes in an interferon-dependent autoimmune disease

28 September 2017

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Ifih1 gene dose effect reveals MDA5-mediated chronic type I IFN gene signature, viral resistance, and accelerated autoimmunity

28 September 2017

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Autoimmune disease risk variant of IFIH1 is associated with increased sensitivity to IFN-α and serologic autoimmunity in lupus patients

28 September 2017

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Neutrophils activate plasmacytoid dendritic cells by releasing self-DNA-peptide complexes in systemic lupus erythematosus

28 September 2017

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A loss-of-function variant of the antiviral molecule MAVS is associated with a subset of systemic lupus patients

28 September 2017

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Tartrate-resistant acid phosphatase deficiency causes a bone dysplasia with autoimmunity and a type I interferon expression signature

28 September 2017

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Dendritic cells in lupus are not required for activation of T and B cells but promote their expansion, resulting in tissue damage

28 September 2017

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Autoimmune skin inflammation is dependent on plasmacytoid dendritic cell activation by nucleic acids via TLR7 and TLR9.

28 September 2017

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C1q deficiency leads to the defective suppression of IFN-alpha in response to nucleoprotein containing immune complexes

28 September 2017

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FcγRIIB regulation of BCR/TLR‐dependent autoreactive B‐cell responses

28 September 2017

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Role of endogenous retroviruses in murine SLE.

28 September 2017

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TLR recognition of self nucleic acids hampers glucocorticoid activity in lupus

28 September 2017

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Intracellular toll-like receptors

28 September 2017

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Sensors of the innate immune system: their link to rheumatic diseases

28 September 2017

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Expanding the phenotypic spectrum of lupus erythematosus in Aicardi-Goutières syndrome

28 September 2017

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TLR9 regulates TLR7- and MyD88-dependent autoantibody production and disease in a murine model of lupus

28 September 2017

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28 September 2017

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Murine B cell response to TLR7 ligands depends on an IFN-beta feedback loop

28 September 2017

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Endosomal TLR signaling is required for anti-nucleic acid and rheumatoid factor autoantibodies in lupus

28 September 2017

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28 September 2017

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IFNalpha kinoid vaccine-induced neutralizing antibodies prevent clinical manifestations in a lupus flare murine model

28 September 2017

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28 September 2017

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Trex1 exonuclease degrades ssDNA to prevent chronic checkpoint activation and autoimmune disease

28 September 2017

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Innate and adaptive immune response to apoptotic cells

28 September 2017

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Immunologically active autoantigens: the role of toll-like receptors in the development of chronic inflammatory disease.

28 September 2017

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Toll-like receptor 9 controls anti-DNA autoantibody production in murine lupus

28 September 2017

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Type-I interferon receptor deficiency reduces lupus-like disease in NZB mice

28 September 2017

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A pivotal role for the natural interferon alpha-producing cells (plasmacytoid dendritic cells) in the pathogenesis of lupus

28 September 2017

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Love triangle between Unc93B1, TLR7, and TLR9 prevents fatal attraction

28 September 2017

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Netting neutrophils are major inducers of type I IFN production in pediatric systemic lupus erythematosus

31 May 2018

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A novel type I IFN-producing cell subset in murine lupus

31 May 2018

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The DNA sugar backbone 2' deoxyribose determines toll-like receptor 9 activation

31 May 2018

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Type i interferons potently enhance humoral immunity and can promote isotype switching by stimulating dendritic cells in vivo.

31 May 2018

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Immunology. Sensing the dark side of DNA.

31 May 2018

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Safety and pharmacodynamics of rontalizumab in patients with systemic lupus erythematosus: results of a phase I, placebo-controlled, double-blind, dose-escalation study.

28 November 2018

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Type I interferonopathies: a novel set of inborn errors of immunity

28 November 2018

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Induction of interferon-alpha production in plasmacytoid dendritic cells by immune complexes containing nucleic acid released by necrotic or late apoptotic cells and lupus IgG.

28 November 2018

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Type I Interferon controls the onset and severity of autoimmune manifestations in lpr mice

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12 December 2020

Chronic polyarthritis caused by mammalian DNA that escapes from degradation in macrophages

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12 December 2020

Type I IFN protects against murine lupus

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12 December 2020

C1q inhibits immune complex-induced interferon-alpha production in plasmacytoid dendritic cells: a novel link between C1q deficiency and systemic lupus erythematosus pathogenesis

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12 December 2020

Treatment of lupus-prone mice with a dual inhibitor of TLR7 and TLR9 leads to reduction of autoantibody production and amelioration of disease symptoms

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12 December 2020

Fc gamma RIIa is expressed on natural IFN-alpha-producing cells (plasmacytoid dendritic cells) and is required for the IFN-alpha production induced by apoptotic cells combined with lupus IgG

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12 December 2020

Protection against autoimmune nephritis in MyD88-deficient MRL/lpr mice

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12 December 2020

Pharmacogenomics and translational simulations to bridge indications for an anti-interferon-α receptor antibody

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12 December 2020

10.1016/J.COI.2013.10.006

Identifiers

DOI

0 references

1 reference

PubMed publication ID

24246388

1 reference