Induction of type I IFNs by intracellular DNA-sensing pathways (Q37997334)

26 August 2017

Induction of type I IFNs by intracellular DNA-sensing pathways (English)

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26 August 2017

3

Veit Hornung

1 reference

26 August 2017

2

Andrea Ablasser

1 reference

26 August 2017

Taner Cavlar

1

1 reference

26 August 2017

27 March 2012

1 reference

Immunology & Cell Biology

26 August 2017

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26 August 2017

90

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26 August 2017

474-482

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26 August 2017

5

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The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

26 August 2017

1 reference

https://api.crossref.org/works/10.1038%2FICB.2012.11

RIG-I-like receptors: cytoplasmic sensors for non-self RNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2012.11

Virus interference. I. The interferon

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2012.11

Inhibition of virus multiplication by foreign nucleic acid

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2012.11

Inducers of interferon and host resistance. II. Multistranded synthetic polynucleotide complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2012.11

CpG motifs in bacterial DNA trigger direct B-cell activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2012.11

A Toll-like receptor recognizes bacterial DNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2012.11

Activation of target-tissue immune-recognition molecules by double-stranded polynucleotides

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2012.11

Toll-like receptor-independent gene induction program activated by mammalian DNA escaped from apoptotic DNA degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2012.11

Lethal anemia caused by interferon-beta produced in mouse embryos carrying undigested DNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2012.11

Induction of IFN-regulated factors and antitumoral surveillance by transfected placebo plasmid DNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2012.11

Endosomal translocation of vertebrate DNA activates dendritic cells via TLR9-dependent and -independent pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2012.11

A Toll-like receptor-independent antiviral response induced by double-stranded B-form DNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2012.11

Recognition of cytosolic DNA activates an IRF3-dependent innate immune response

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2012.11

DAI (DLM-1/ZBP1) is a cytosolic DNA sensor and an activator of innate immune response

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2012.11

Regulation of innate immune responses by DAI (DLM-1/ZBP1) and other DNA-sensing molecules

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2012.11

TANK-binding kinase-1 delineates innate and adaptive immune responses to DNA vaccines

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2012.11

DAI/ZBP1 recruits RIP1 and RIP3 through RIP homotypic interaction motifs to activate NF-kappaB

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2012.11

The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2012.11

The RNA helicase Lgp2 inhibits TLR-independent sensing of viral replication by retinoic acid-inducible gene-I.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2012.11

Shared and unique functions of the DExD/H-box helicases RIG-I, MDA5, and LGP2 in antiviral innate immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2012.11

5'-Triphosphate RNA is the ligand for RIG-I

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2012.11

RIG-I-mediated antiviral responses to single-stranded RNA bearing 5'-phosphates

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2012.11

Recognition of 5' triphosphate by RIG-I helicase requires short blunt double-stranded RNA as contained in panhandle of negative-strand virus

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2012.11

The chase for the RIG-I ligand--recent advances

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2012.11

Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2012.11

Activation of MDA5 requires higher-order RNA structures generated during virus infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2012.11

Early innate recognition of herpes simplex virus in human primary macrophages is mediated via the MDA5/MAVS-dependent and MDA5/MAVS/RNA polymerase III-independent pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2012.11

IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2012.11

Peroxisomes are signaling platforms for antiviral innate immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2012.11

Double-stranded DNA and double-stranded RNA induce a common antiviral signaling pathway in human cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2012.11

RIG-I-dependent sensing of poly(dA:dT) through the induction of an RNA polymerase III-transcribed RNA intermediate

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2012.11

RNA polymerase III detects cytosolic DNA and induces type I interferons through the RIG-I pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2012.11

An unexpected role for RNA in the recognition of DNA by the innate immune system

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2012.11

Identification of host cytosolic sensors and bacterial factors regulating the type I interferon response to Legionella pneumophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2012.11

STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2012.11

The adaptor protein MITA links virus-sensing receptors to IRF3 transcription factor activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2012.11

ERIS, an endoplasmic reticulum IFN stimulator, activates innate immune signaling through dimerization

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2012.11

MPYS, a novel membrane tetraspanner, is associated with major histocompatibility complex class II and mediates transduction of apoptotic signals

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2012.11

STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2012.11

Innate immune recognition of an AT-rich stem-loop DNA motif in the Plasmodium falciparum genome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2012.11

The N-ethyl-N-nitrosourea-induced Goldenticket mouse mutant reveals an essential function of Sting in the in vivo interferon response to Listeria monocytogenes and cyclic dinucleotides

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2012.11

Activation of STAT6 by STING is critical for antiviral innate immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2012.11

c-di-AMP secreted by intracellular Listeria monocytogenes activates a host type I interferon response

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2012.11

STING is a direct innate immune sensor of cyclic di-GMP

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2012.11

AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2012.11

AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2012.11

HIN-200 proteins regulate caspase activation in response to foreign cytoplasmic DNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2012.11

An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2012.11

IFI16 is an innate immune sensor for intracellular DNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2012.11

IFI16 protein mediates the anti-inflammatory actions of the type-I interferons through suppression of activation of caspase-1 by inflammasomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2012.11

IFI16 acts as a nuclear pathogen sensor to induce the inflammasome in response to Kaposi Sarcoma-associated herpesvirus infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2012.11

TRIP: a novel double stranded RNA binding protein which interacts with the leucine rich repeat of flightless I

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2012.11

The cytosolic nucleic acid sensor LRRFIP1 mediates the production of type I interferon via a beta-catenin-dependent pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2012.11

Interplay of Fli-I and FLAP1 for regulation of beta-catenin dependent transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2012.11

Beta-catenin hits chromatin: regulation of Wnt target gene activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2012.11

SF1 and SF2 helicases: family matters

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2012.11

Aspartate-glutamate-alanine-histidine box motif (DEAH)/RNA helicase A helicases sense microbial DNA in human plasmacytoid dendritic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2012.11

CpG motifs in bacterial DNA and their immune effects

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2012.11

DExD/H box RNA helicases: multifunctional proteins with important roles in transcriptional regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2012.11

Herpes simplex virus type-1 induces IFN-alpha production via Toll-like receptor 9-dependent and -independent pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2012.11

DDX1, DDX21, and DHX36 helicases form a complex with the adaptor molecule TRIF to sense dsRNA in dendritic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2012.11

DHX9 pairs with IPS-1 to sense double-stranded RNA in myeloid dendritic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2012.11

The helicase DDX41 senses intracellular DNA mediated by the adaptor STING in dendritic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2012.11

Cutting edge: Ku70 is a novel cytosolic DNA sensor that induces type III rather than type I IFN.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2012.11

DNA-PKcs is required for activation of innate immunity by immunostimulatory DNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2012.11

Contribution of interferon-beta to the immune activation induced by double-stranded DNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2012.11

The innate immune system in SLE: type I interferons and dendritic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2012.11

Role of type I interferons in the activation of autoreactive B cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2012.11

Emerging roles of TLR7 and TLR9 in murine SLE.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2012.11

Mutations in the gene encoding the 3'-5' DNA exonuclease TREX1 are associated with systemic lupus erythematosus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2012.11

Trex1 exonuclease degrades ssDNA to prevent chronic checkpoint activation and autoimmune disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2012.11

Trex1 prevents cell-intrinsic initiation of autoimmunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2012.11

The cytosolic exonuclease TREX1 inhibits the innate immune response to human immunodeficiency virus type 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2012.11

Foreign nucleic acids as the stimulus to make interferon

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FICB.2012.11

7 January 2021

Up-regulation of the expression of major histocompatibility complex class I antigens by plasmid DNA transfection in non-hematopoietic cells

1 reference

https://api.crossref.org/works/10.1038%2FICB.2012.11

7 January 2021

The specific and essential role of MAVS in antiviral innate immune responses

1 reference

https://api.crossref.org/works/10.1038%2FICB.2012.11

7 January 2021

IFN-alphabeta-mediated inflammatory responses and antiviral defense in liver is TLR9-independent but MyD88-dependent during murine cytomegalovirus infection

1 reference

https://api.crossref.org/works/10.1038%2FICB.2012.11

7 January 2021

Identifiers

DOI

10.1038/ICB.2012.11

1 reference

26 August 2017

1 reference

PubMed ID

22450802