The cGMP signaling pathway as a therapeutic target in heart failure with preserved ejection fraction (Q27024279)

M. Gheorghiade

2

1 reference

B. A. Borlaug

3

1 reference

B. Pieske

4

1 reference

M. Vaduganathan

5

1 reference

J. C. Burnett

6

1 reference

L. Roessig

7

1 reference

J.-P. Stasch

8

1 reference

S. D. Solomon

9

1 reference

W. J. Paulus

10

1 reference

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease

language of work or name

1 reference

11 December 2013

10 references

22 March 2019

17 June 2019

25 June 2019

17 September 2019

23 August 2020

4 September 2020

13 November 2020

4 December 2020

5 December 2020

10 references

22 March 2019

17 June 2019

25 June 2019

17 September 2019

23 August 2020

4 September 2020

13 November 2020

4 December 2020

5 December 2020

2

1 reference

issue

6

1 reference

page(s)

e000536

1 reference

Creative Commons Attribution-NonCommercial

copyright license

9 references

22 March 2019

17 June 2019

25 June 2019

17 September 2019

23 August 2020

4 September 2020

13 November 2020

4 December 2020

5 December 2020

on focus list of Wikimedia project

ScienceSource

0 references

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Effect of endurance training on the determinants of peak exercise oxygen consumption in elderly patients with stable compensated heart failure and preserved ejection fraction

28 September 2017

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Soluble guanylate cyclase: a potential therapeutic target for heart failure

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28 September 2017

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Heart failure with preserved ejection fraction: pathophysiology, diagnosis, and treatment

28 September 2017

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Treatment of heart failure with normal ejection fraction: an inconvenient truth!

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Contractility and ventricular systolic stiffening in hypertensive heart disease insights into the pathogenesis of heart failure with preserved ejection fraction

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Modulation of cGMP in heart failure: a new therapeutic paradigm

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28 September 2017

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Cardiac structure and ventricular-vascular function in persons with heart failure and preserved ejection fraction from Olmsted County, Minnesota

28 September 2017

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28 September 2017

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Maximizing the renal cyclic 3'-5'-guanosine monophosphate system with type V phosphodiesterase inhibition and exogenous natriuretic peptide: a novel strategy to improve renal function in experimental overt heart failure

28 September 2017

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NO-independent activation of soluble guanylate cyclase prevents disease progression in rats with 5/6 nephrectomy

28 September 2017

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28 September 2017

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28 September 2017

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The effectiveness and relative effectiveness of intravenous inotropic drugs acting through the adrenergic pathway in patients with heart failure-a meta-regression analysis

28 September 2017

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Left ventricular long axis function in diastolic heart failure is reduced in both diastole and systole: time for a redefinition?

28 September 2017

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28 September 2017

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Effects of controlled-release metoprolol on total mortality, hospitalizations, and well-being in patients with heart failure: the Metoprolol CR/XL Randomized Intervention Trial in congestive heart failure (MERIT-HF). MERIT-HF Study Group

28 September 2017

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Coronary endothelial dysfunction in patients with acute-onset idiopathic dilated cardiomyopathy

28 September 2017

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Nitric Oxide as a Mediator of Relaxation of the Corpus Cavernosum in Response to Nonadrenergic, Noncholinergic Neurotransmission

28 September 2017

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28 September 2017

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Protein kinase G modulates human myocardial passive stiffness by phosphorylation of the titin springs.

31 May 2018

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Stimulation of soluble guanylate cyclase slows progression in anti-thy1-induced chronic glomerulosclerosis

31 May 2018

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31 May 2018

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31 May 2018

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B-type natriuretic peptide and prognosis in heart failure patients with preserved and reduced ejection fraction

31 May 2018

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The angiotensin receptor neprilysin inhibitor LCZ696 in heart failure with preserved ejection fraction: a phase 2 double-blind randomised controlled trial.

28 November 2018

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Low myocardial protein kinase G activity in heart failure with preserved ejection fraction.

28 November 2018

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Cinaciguat, a soluble guanylate cyclase activator: results from the randomized, controlled, phase IIb COMPOSE programme in acute heart failure syndromes

28 November 2018

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Trends in patients hospitalized with heart failure and preserved left ventricular ejection fraction: prevalence, therapies, and outcomes.

28 November 2018

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Chronic therapy with isosorbide-5-mononitrate causes endothelial dysfunction, oxidative stress, and a marked increase in vascular endothelin-1 expression.

28 November 2018

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Effects of vasodilation in heart failure with preserved or reduced ejection fraction implications of distinct pathophysiologies on response to therapy

28 November 2018

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Phosphodiesterase 5 inhibition with sildenafil reverses exercise oscillatory breathing in chronic heart failure: a long-term cardiopulmonary exercise testing placebo-controlled study

28 November 2018

1 reference

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Exercise training improves exercise capacity and diastolic function in patients with heart failure with preserved ejection fraction: results of the Ex-DHF (Exercise training in Diastolic Heart Failure) pilot study.

28 November 2018

1 reference

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Arterial vasodilatory and ventricular diastolic reserves determine the stroke volume response to exercise in elderly female hypertensive patients.

28 November 2018

1 reference

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PDE5 inhibition with sildenafil improves left ventricular diastolic function, cardiac geometry, and clinical status in patients with stable systolic heart failure: results of a 1-year, prospective, randomized, placebo-controlled study.

28 November 2018

1 reference

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Nitric oxide-independent stimulation of soluble guanylate cyclase reduces organ damage in experimental low-renin and high-renin models

28 November 2018

1 reference

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Pressure-independent effects of pharmacological stimulation of soluble guanylate cyclase on fibrosis in pressure-overloaded rat heart.

28 November 2018

1 reference

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Hypophosphorylation of the Stiff N2B titin isoform raises cardiomyocyte resting tension in failing human myocardium.

28 November 2018

1 reference

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Preserved left ventricular twist and circumferential deformation, but depressed longitudinal and radial deformation in patients with diastolic heart failure.

28 November 2018

1 reference

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Long-term use of sildenafil in the therapeutic management of heart failure

28 November 2018

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Sildenafil improves exercise capacity and quality of life in patients with systolic heart failure and secondary pulmonary hypertension.

28 November 2018

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28 November 2018

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Targeting heme-oxidized soluble guanylate cyclase in experimental heart failure.

28 November 2018

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28 November 2018

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Sildenafil inhibits beta-adrenergic-stimulated cardiac contractility in humans

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3886746

Role of oxidative-nitrosative stress and downstream pathways in various forms of cardiomyopathy and heart failure.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3886746

Chronic inhibition of cyclic GMP phosphodiesterase 5A prevents and reverses cardiac hypertrophy

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3886746

A comparative study of sildenafil, NCX-911 and BAY41-2272 on the anococcygeus muscle of diabetic rats

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3886746

Comparison of omapatrilat and enalapril in patients with chronic heart failure: the Omapatrilat Versus Enalapril Randomized Trial of Utility in Reducing Events (OVERTURE).

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3886746

cGMP-dependent protein kinase I mediates the negative inotropic effect of cGMP in the murine myocardium

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3886746

Myocardial contractile response to nitric oxide and cGMP.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3886746

Lisinopril-mediated regression of myocardial fibrosis in patients with hypertensive heart disease

28 November 2018

1 reference

12 December 2020

Blood pressure-independent effect of long-term treatment with the soluble heme-independent guanylyl cyclase activator HMR1766 on progression in a model of noninflammatory chronic renal damage

1 reference

12 December 2020

Combined ventricular systolic and arterial stiffening in patients with heart failure and preserved ejection fraction: implications for systolic and diastolic reserve limitations

1 reference

12 December 2020

Acute type 5 phosphodiesterase inhibition with sildenafil enhances flow-mediated vasodilation in patients with chronic heart failure

1 reference

12 December 2020

Myocardial Structure and Function Differ in Systolic and Diastolic Heart Failure

1 reference

12 December 2020

8-bromo-cGMP reduces the myofilament response to Ca2+ in intact cardiac myocytes

1 reference

12 December 2020

Targeting heme-oxidized soluble guanylate cyclase: solution for all cardiorenal problems in heart failure?

1 reference

12 December 2020

Effects of the nitric oxide donor sodium nitroprusside on intracellular pH and contraction in hypertrophied myocytes

1 reference

12 December 2020

Impaired chronotropic and vasodilator reserves limit exercise capacity in patients with heart failure and a preserved ejection fraction

1 reference

12 December 2020

Progression of systolic abnormalities in patients with "isolated" diastolic heart failure and diastolic dysfunction

1 reference

12 December 2020

Acute effects of nitric oxide on left ventricular relaxation and diastolic distensibility in humans. Assessment by bicoronary sodium nitroprusside infusion

1 reference

12 December 2020

Activation Delay After Premature Stimulation in Chronically Diseased Human Myocardium Relates to the Architecture of Interstitial Fibrosis

1 reference

12 December 2020

Soluble guanylate cyclase stimulation on cardiovascular remodeling in angiotensin II-induced hypertensive rats

1 reference

12 December 2020

Low increase in cGMP induced by organic nitrates and nitrovasodilators improves contractile response of rat ventricular myocytes

1 reference

12 December 2020

Identifiers

DOI

10.1161/JAHA.113.000536

1 reference

2200104

2200104

1 reference

1 reference

1 reference