Targeting myocardial remodelling to develop novel therapies for heart failure: a position paper from the Working Group on Myocardial Function of the European Society of Cardiology (Q27024879)

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English	Targeting myocardial remodelling to develop novel therapies for heart failure: a position paper from the Working Group on Myocardial Function of the European Society of Cardiology	scientific article

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10 March 2020

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Europe PubMed Central

Targeting myocardial remodelling to develop novel therapies for heart failure: a position paper from the Working Group on Myocardial Function of the European Society of Cardiology (English)

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10 March 2020

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Jean-Luc Balligand

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10 March 2020

Guido Iaccarino

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10 March 2020

Adelino F Leite-Moreira

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10 March 2020

André P. Lourenço

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10 March 2020

Carlo Gabriele Tocchetti

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10 March 2020

Denise Hilfiker-Kleiner

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Denise Hilfiker-Kleiner

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10 March 2020

Johann Bauersachs

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Johann Bauersachs

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10 March 2020

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Guido Tarone

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10 March 2020

Angela Clerk

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10 March 2020

Leon De Windt

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10 March 2020

Stephane Heymans

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10 March 2020

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17 March 2014

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10 March 2020

European Journal of Heart Failure

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10 March 2020

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10 March 2020

494-508

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10 March 2020

ESC guidelines for the diagnosis and treatment of acute and chronic heart failure 2012: The Task Force for the Diagnosis and Treatment of Acute and Chronic Heart Failure 2012 of the European Society of Cardiology. Developed in collaboration with the

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Targeting myocardial substrate metabolism in heart failure: potential for new therapies

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G protein-coupled receptor kinase 2 activity impairs cardiac glucose uptake and promotes insulin resistance after myocardial ischemia.

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Protein kinase activity of phosphoinositide 3-kinase regulates beta-adrenergic receptor endocytosis

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Distinct effects of leukocyte and cardiac phosphoinositide 3-kinase γ activity in pressure overload-induced cardiac failure

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Upregulation of beta(3)-adrenoceptors and altered contractile response to inotropic amines in human failing myocardium

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Regulation of endothelial nitric-oxide synthase (NOS) S-glutathionylation by neuronal NOS: evidence of a functional interaction between myocardial constitutive NOS isoforms

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Endothelial beta3-adrenoreceptors mediate nitric oxide-dependent vasorelaxation of coronary microvessels in response to the third-generation beta-blocker nebivolol.

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Randomized trial to determine the effect of nebivolol on mortality and cardiovascular hospital admission in elderly patients with heart failure (SENIORS).

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Ventricular phosphodiesterase-5 expression is increased in patients with advanced heart failure and contributes to adverse ventricular remodeling after myocardial infarction in mice

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21 January 2018

Phosphodiesterases and cyclic GMP regulation in heart muscle

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21 January 2018

PDE5 inhibition with sildenafil improves left ventricular diastolic function, cardiac geometry, and clinical status in patients with stable systolic heart failure: results of a 1-year, prospective, randomized, placebo-controlled study

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Effect of phosphodiesterase-5 inhibition on exercise capacity and clinical status in heart failure with preserved ejection fraction: a randomized clinical trial

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Oxidative and nitrosative stress in the maintenance of myocardial function.

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Playing with cardiac "redox switches": the "HNO way" to modulate cardiac function

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Nitroxyl (HNO): A novel approach for the acute treatment of heart failure

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Calcium cycling proteins and heart failure: mechanisms and therapeutics

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Calcium Upregulation by Percutaneous Administration of Gene Therapy in Cardiac Disease (CUPID): a phase 2 trial of intracoronary gene therapy of sarcoplasmic reticulum Ca2+-ATPase in patients with advanced heart failure

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Cardiac myosin activation: a potential therapeutic approach for systolic heart failure

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Improvement of cardiac function by a cardiac Myosin activator in conscious dogs with systolic heart failure

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The effects of the cardiac myosin activator, omecamtiv mecarbil, on cardiac function in systolic heart failure: a double-blind, placebo-controlled, crossover, dose-ranging phase 2 trial.

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21 January 2018

MicroRNAs: novel regulators in cardiac development and disease

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MicroRNA-208a is a regulator of cardiac hypertrophy and conduction in mice.

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21 January 2018

Therapeutic inhibition of miR-208a improves cardiac function and survival during heart failure

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21 January 2018

MicroRNA-199b targets the nuclear kinase Dyrk1a in an auto-amplification loop promoting calcineurin/NFAT signalling.

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Signal transducer and activator of transcription 3-mediated regulation of miR-199a-5p links cardiomyocyte and endothelial cell function in the heart: a key role for ubiquitin-conjugating enzymes.

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The miRNA-212/132 family regulates both cardiac hypertrophy and cardiomyocyte autophagy.

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Macrophage microRNA-155 promotes cardiac hypertrophy and failure.

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Inhibition of miR-15 protects against cardiac ischemic injury

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Cell death in the pathogenesis of heart disease: mechanisms and significance

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Programmed necrosis, not apoptosis, in the heart

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The 'complexities' of life and death: death receptor signalling platforms

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Necroptosis, necrostatins and tissue injury

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Inhibition of RIP1-dependent necrosis prevents adverse cardiac remodeling after myocardial ischemia-reperfusion in vivo.

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Necrostatin-1 analogues: critical issues on the specificity, activity and in vivo use in experimental disease models

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Cyclosporin A and cardioprotection: from investigative tool to therapeutic agent.

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Effect of cyclosporine on reperfusion injury in acute myocardial infarction

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Cardiovascular side effects of cancer therapies: a position statement from the Heart Failure Association of the European Society of Cardiology

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Parenteral administration of recombinant human neuregulin‐1 to patients with stable chronic heart failure produces favourable acute and chronic haemodynamic responses

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Proteotoxicity and cardiac dysfunction--Alzheimer's disease of the heart?

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Sustained activation of nuclear erythroid 2-related factor 2/antioxidant response element signaling promotes reductive stress in the human mutant protein aggregation cardiomyopathy in mice

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H11 kinase/heat shock protein 22 deletion impairs both nuclear and mitochondrial functions of STAT3 and accelerates the transition into heart failure on cardiac overload

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Cardiac overexpression of melusin protects from dilated cardiomyopathy due to long-standing pressure overload.

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Emerging roles of molecular chaperones and co-chaperones in selective autophagy: focus on BAG proteins.

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Dilated cardiomyopathy-associated BAG3 mutations impair Z-disc assembly and enhance sensitivity to apoptosis in cardiomyocytes

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Effects of a heat shock protein inducer on the atrial fibrillation substrate caused by acute atrial ischaemia

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The protein kinase complement of the human genome

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Mitogen-activated protein kinase signaling in the heart: angels versus demons in a heart-breaking tale

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Oxidative Stress-Induced Diseases via the ASK1 Signaling Pathway

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p21-Activated kinase-1 and its role in integrated regulation of cardiac contractility

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Role of SPAK and OSR1 signalling in the regulation of NaCl cotransporters

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A novel role for the Ste20 kinase SLK in adhesion signaling and cell migration

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Focal adhesion kinase -- the basis of local hypertrophic signaling domains

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Therapeutic angiogenesis: a new treatment approach for ischemic heart disease--part I.

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Intramyocardial VEGF-B167 gene delivery delays the progression towards congestive failure in dogs with pacing-induced dilated cardiomyopathy

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Placental growth factor and cardiac inflammation.

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Antagomir-mediated silencing of endothelial cell specific microRNA-126 impairs ischemia-induced angiogenesis

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MicroRNA-210 as a novel therapy for treatment of ischemic heart disease

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A cathepsin D-cleaved 16 kDa form of prolactin mediates postpartum cardiomyopathy.

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Evaluation of bromocriptine in the treatment of acute severe peripartum cardiomyopathy: a proof-of-concept pilot study

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MicroRNA-146a is a therapeutic target and biomarker for peripartum cardiomyopathy

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MicroRNA-24 regulates vascularity after myocardial infarction

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Erythropoietin preserves the endothelial differentiation capacity of cardiac progenitor cells and reduces heart failure during anticancer therapies.

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21 January 2018

Acute doxorubicin cardiotoxicity is associated with miR-146a-induced inhibition of the neuregulin-ErbB pathway

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Matricellular proteins in cardiac adaptation and disease

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Myofibroblast-mediated mechanisms of pathological remodelling of the heart

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21 January 2018

Thrombospondin-4 regulates fibrosis and remodeling of the myocardium in response to pressure overload

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21 January 2018

A thrombospondin-dependent pathway for a protective ER stress response

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21 January 2018

Syndecan-4 over-expression preserves cardiac function in a rat model of myocardial infarction

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Role of lysyl oxidase in myocardial fibrosis: from basic science to clinical aspects

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21 January 2018

Impact of treatment on myocardial lysyl oxidase expression and collagen cross-linking in patients with heart failure

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21 January 2018

MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts

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21 January 2018

Role of miR-21 in the pathogenesis of atrial fibrosis

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21 January 2018

MicroRNA-101 inhibited postinfarct cardiac fibrosis and improved left ventricular compliance via the FBJ osteosarcoma oncogene/transforming growth factor-β1 pathway.

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Personalized medicine: hope or hype?

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Genetic tailoring of pharmacotherapy in heart failure: optimize the old, while we wait for something new.

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Pharmacogenomics as a risk mitigation strategy for chemotherapeutic cardiotoxicity

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Nitroxyl-mediated disulfide bond formation between cardiac myofilament cysteines enhances contractile function.

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21 January 2018

Control of stress-dependent cardiac growth and gene expression by a microRNA

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21 January 2018

Mechanism of simvastatin on induction of heat shock protein in osteoblasts

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Telethonin deficiency is associated with maladaptation to biomechanical stress in the mammalian heart

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21 January 2018

Therapeutic angiogenesis: a new treatment approach for ischemic heart disease--Part II.

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21 January 2018

Absence of SPARC results in increased cardiac rupture and dysfunction after acute myocardial infarction

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21 January 2018

Role for MicroRNA-21 in atrial profibrillatory fibrotic remodeling associated with experimental postinfarction heart failure.

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21 January 2018

Increased Expression of Syndecan-1 Protects Against Cardiac Dilatation and Dysfunction After Myocardial Infarction

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21 January 2018

Gbetagamma-dependent phosphoinositide 3-kinase activation in hearts with in vivo pressure overload hypertrophy

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7 January 2021

based on heuristic

inferred from DOI database lookup

Nebivolol exerts beneficial effects on endothelial function, early endothelial progenitor cells, myocardial neovascularization, and left ventricular dysfunction early after myocardial infarction beyond conventional β1-blockade

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Nebivolol prevents desensitization of β-adrenoceptor signaling and induction of cardiac hypertrophy in response to isoprenaline beyond β1-adrenoceptor blockage

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Neuregulin-1/erbB-activation improves cardiac function and survival in models of ischemic, dilated, and viral cardiomyopathy

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

A Phase II, randomized, double-blind, multicenter, based on standard therapy, placebo-controlled study of the efficacy and safety of recombinant human neuregulin-1 in patients with chronic heart failure

1 reference

https://api.crossref.org/works/10.1002%2FEJHF.62

7 January 2021

based on heuristic

inferred from DOI database lookup

Inhibition of endogenous Mst1 prevents apoptosis and cardiac dysfunction without affecting cardiac hypertrophy after myocardial infarction

1 reference

https://api.crossref.org/works/10.1002%2FEJHF.62

7 January 2021

based on heuristic

inferred from DOI database lookup

Signal transduction by vascular endothelial growth factor receptors

1 reference

https://api.crossref.org/works/10.1002%2FEJHF.62

7 January 2021

based on heuristic

inferred from DOI database lookup

Effect of intracoronary recombinant human vascular endothelial growth factor on myocardial perfusion: evidence for a dose-dependent effect

1 reference

https://api.crossref.org/works/10.1002%2FEJHF.62

7 January 2021

based on heuristic

inferred from DOI database lookup

The VIVA trial: Vascular endothelial growth factor in Ischemia for Vascular Angiogenesis

1 reference

https://api.crossref.org/works/10.1002%2FEJHF.62

7 January 2021

based on heuristic

inferred from DOI database lookup

Regional Angiogenesis with Vascular Endothelial Growth Factor (VEGF) in peripheral arterial disease: Design of the RAVE trial

1 reference

https://api.crossref.org/works/10.1002%2FEJHF.62

7 January 2021

based on heuristic

inferred from DOI database lookup

BAG-1 induces autophagy for cardiac cell survival

1 reference

https://api.crossref.org/works/10.1002%2FEJHF.62

7 January 2021

based on heuristic

inferred from DOI database lookup

Identifiers

10.1002/EJHF.62

2 references

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24639064%20AND%20SRC:MED&resulttype=core&format=json

10 March 2020

OpenCitations bibliographic resource ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

PubMed publication ID

2 references

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24639064%20AND%20SRC:MED&resulttype=core&format=json

10 March 2020

ResearchGate publication ID

0 references

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