Phosphodiesterases and cyclic GMP regulation in heart muscle (Q38033089)

27 August 2017

Phosphodiesterases and cyclic GMP regulation in heart muscle (English)

1 reference

27 August 2017

Dong I Lee

1

1 reference

PubMed ID

22875455

27 August 2017

David A Kass

series ordinal

2

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27 August 2017

1 August 2012

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27 August 2017

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27 August 2017

27

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27 August 2017

4

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27 August 2017

248-258

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Sildenafil reverses cardiac dysfunction in the mdx mouse model of Duchenne muscular dystrophy.

27 August 2017

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00011.2012

Effects of phosphodiesterase-5 inhibition by sildenafil in the pressure overloaded right heart.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00011.2012

Cyclic nucleotide phosphodiesterases: molecular regulation to clinical use

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00011.2012

Sildenafil and B-type natriuretic peptide acutely phosphorylate titin and improve diastolic distensibility in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00011.2012

Sildenafil inhibits beta-adrenergic-stimulated cardiac contractility in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00011.2012

Feedback control through cGMP-dependent protein kinase contributes to differential regulation and compartmentation of cGMP in rat cardiac myocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00011.2012

Cyclic guanosine monophosphate compartmentation in rat cardiac myocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00011.2012

Mitigation of the progression of heart failure with sildenafil involves inhibition of RhoA/Rho-kinase pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00011.2012

Cloning of dog heart PDE1A - a first detailed characterization at the molecular level in this species

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00011.2012

Sildenafil citrate does not affect cardiac contractility in human or dog heart

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00011.2012

ERK phosphorylation mediates sildenafil-induced myocardial protection against ischemia-reperfusion injury in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00011.2012

Phosphodiesterase-5 inhibitor sildenafil preconditions adult cardiac myocytes against necrosis and apoptosis. Essential role of nitric oxide signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00011.2012

Protein kinase G-dependent cardioprotective mechanism of phosphodiesterase-5 inhibition involves phosphorylation of ERK and GSK3beta

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00011.2012

Characterization of inhibitors of phosphodiesterase 1C on a human cellular system

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00011.2012

Species- and tissue-dependent effects of NO and cyclic GMP on cardiac ion channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00011.2012

Phosphodiesterase-5 inhibition with sildenafil attenuates cardiomyocyte apoptosis and left ventricular dysfunction in a chronic model of doxorubicin cardiotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00011.2012

The role of cGMP-dependent protein kinase in controlling cardiomyocyte cGMP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00011.2012

Mammalian cyclic nucleotide phosphodiesterases: molecular mechanisms and physiological functions

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00011.2012

The Impact of Pharmacotherapy on the Cardiopulmonary Exercise Test Response in Patients with Heart Failure: A Mini Review

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00011.2012

PDE5 inhibition with sildenafil improves left ventricular diastolic function, cardiac geometry, and clinical status in patients with stable systolic heart failure: results of a 1-year, prospective, randomized, placebo-controlled study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00011.2012

Cyclic nucleotide binding GAF domains from phosphodiesterases: structural and mechanistic insights

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00011.2012

Preconditioning by phosphodiesterase-5 inhibition improves therapeutic efficacy of adipose-derived stem cells following myocardial infarction in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00011.2012

Phosphodiesterase 5 inhibition blocks pressure overload-induced cardiac hypertrophy independent of the calcineurin pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00011.2012

Profiling of cAMP and cGMP phosphodiesterases in isolated ventricular cardiomyocytes from human hearts: comparison with rat and guinea pig.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00011.2012

Upregulation of phosphodiesterase 1A1 expression is associated with the development of nitrate tolerance

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00011.2012

Sarcolemma-localized nNOS is required to maintain activity after mild exercise

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00011.2012

Cyclic GMP/PKG-dependent inhibition of TRPC6 channel activity and expression negatively regulates cardiomyocyte NFAT activation Novel mechanism of cardiac stress modulation by PDE5 inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00011.2012

Long-acting phosphodiesterase-5 inhibitor tadalafil attenuates doxorubicin-induced cardiomyopathy without interfering with chemotherapeutic effect.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00011.2012

Protein kinase G modulates human myocardial passive stiffness by phosphorylation of the titin springs.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00011.2012

Titin-based mechanical signalling in normal and failing myocardium

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00011.2012

Pharmacological preconditioning with sildenafil: Basic mechanisms and clinical implications

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00011.2012

TRPC6 fulfills a calcineurin signaling circuit during pathologic cardiac remodeling

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00011.2012

PDE5A suppression of acute beta-adrenergic activation requires modulation of myocyte beta-3 signaling coupled to PKG-mediated troponin I phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00011.2012

Sildenafil improves exercise capacity and quality of life in patients with systolic heart failure and secondary pulmonary hypertension.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00011.2012

Isolation and characterization of cDNAs corresponding to two human calcium, calmodulin-regulated, 3',5'-cyclic nucleotide phosphodiesterases

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00011.2012

Oxidative stress regulates left ventricular PDE5 expression in the failing heart

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00011.2012

Cyclic nucleotide phosphodiesterase (PDE) superfamily: A new target for the development of specific therapeutic agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00011.2012

Phospholemman Ser69 phosphorylation contributes to sildenafil-induced cardioprotection against reperfusion injury.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00011.2012

Crystal structure of the tandem GAF domains from a cyanobacterial adenylyl cyclase: modes of ligand binding and dimerization

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00011.2012

The two GAF domains in phosphodiesterase 2A have distinct roles in dimerization and in cGMP binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00011.2012

Cyclic nucleotide phosphodiesterase 1A: a key regulator of cardiac fibroblast activation and extracellular matrix remodeling in the heart

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00011.2012

Role of Ca2+/calmodulin-stimulated cyclic nucleotide phosphodiesterase 1 in mediating cardiomyocyte hypertrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00011.2012

Targeting cyclic nucleotide phosphodiesterase in the heart: therapeutic implications

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00011.2012

Concerted regulation of cGMP and cAMP phosphodiesterases in early cardiac hypertrophy induced by angiotensin II

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00011.2012

Compartmentalized phosphodiesterase-2 activity blunts beta-adrenergic cardiac inotropy via an NO/cGMP-dependent pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00011.2012

Phosphodiesterase inhibition in heart failure

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00011.2012

Pressure-overload magnitude-dependence of the anti-hypertrophic efficacy of PDE5A inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00011.2012

Sildenafil stops progressive chamber, cellular, and molecular remodeling and improves calcium handling and function in hearts with pre-existing advanced hypertrophy caused by pressure overload

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00011.2012

Sustained soluble guanylate cyclase stimulation offsets nitric-oxide synthase inhibition to restore acute cardiac modulation by sildenafil

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00011.2012

Role of nuclear Ca2+/calmodulin-stimulated phosphodiesterase 1A in vascular smooth muscle cell growth and survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00011.2012

Phosphodiesterase type 5 is highly expressed in the hypertrophied human right ventricle, and acute inhibition of phosphodiesterase type 5 improves contractility

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00011.2012

Phosphorylation of TRPC6 channels at Thr69 is required for anti-hypertrophic effects of phosphodiesterase 5 inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00011.2012

Effect of classic preconditioning on the gene expression pattern of rat hearts: a DNA microarray study

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00011.2012

Mechanism for the allosteric regulation of phosphodiesterase 2A deduced from the X-ray structure of a near full-length construct

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00011.2012

Ventricular phosphodiesterase-5 expression is increased in patients with advanced heart failure and contributes to adverse ventricular remodeling after myocardial infarction in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00011.2012

Identification and distribution of different mRNA variants produced by differential splicing in the human phosphodiesterase 9A gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00011.2012

Isolation and characterization of human cDNAs encoding a cGMP-stimulated 3',5'-cyclic nucleotide phosphodiesterase

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00011.2012

TRP-ing up heart and vessels: canonical transient receptor potential channels and cardiovascular disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00011.2012

Cyclic nucleotide phosphodiesterase 1C promotes human arterial smooth muscle cell proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00011.2012

PDE5 is converted to an activated state upon cGMP binding to the GAF A domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00011.2012

Cyclic GMP phosphodiesterases and regulation of smooth muscle function

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00011.2012

Functional muscle ischemia in neuronal nitric oxide synthase-deficient skeletal muscle of children with Duchenne muscular dystrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00011.2012

Chronic inhibition of phosphodiesterase 5 does not prevent pressure-overload-induced right-ventricular remodelling

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00011.2012

Cardiac phosphodiesterase 5 (cGMP-specific) modulates beta-adrenergic signaling in vivo and is down-regulated in heart failure

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00011.2012

Differential expression of PDE5 in failing and nonfailing human myocardium

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00011.2012

Differential regulation of bovine brain calmodulin-dependent cyclic nucleotide phosphodiesterase isoenzymes by cyclic AMP-dependent protein kinase and calmodulin-dependent phosphatase

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00011.2012

Identification of inhibitory and calmodulin-binding domains of the PDE1A1 and PDE1A2 calmodulin-stimulated cyclic nucleotide phosphodiesterases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00011.2012

Modeling and mutational analysis of the GAF domain of the cGMP-binding, cGMP-specific phosphodiesterase, PDE5.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00011.2012

cGMP Signals Modulate cAMP Levels in a Compartment-Specific Manner to Regulate Catecholamine-Dependent Signaling in Cardiac Myocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00011.2012

Immunohistochemical localization of phosphodiesterase 2A in multiple mammalian species

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00011.2012

Compartmentalization of cardiac beta-adrenergic inotropy modulation by phosphodiesterase type 5.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00011.2012

cGMP catabolism by phosphodiesterase 5A regulates cardiac adrenergic stimulation by NOS3-dependent mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00011.2012

Chronic inhibition of cyclic GMP phosphodiesterase 5A prevents and reverses cardiac hypertrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00011.2012

Regulator of G-protein signaling subtype 4 mediates antihypertrophic effect of locally secreted natriuretic peptides in the heart

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00011.2012

Cyclic GMP signaling in cardiovascular pathophysiology and therapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00011.2012

Cyclic GMP regulation of the L-type Ca(2+) channel current in human atrial myocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00011.2012

cGMP-hydrolytic activity and its inhibition by sildenafil in normal and failing human and mouse myocardium

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00011.2012

Cyclic nucleotide phosphodiesterase PDE1C1 in human cardiac myocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00011.2012

Phosphodiesterase 5 restricts NOS3/Soluble guanylate cyclase signaling to L-type Ca2+ current in cardiac myocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00011.2012

Conformation Changes, N-terminal Involvement, and cGMP Signal Relay in the Phosphodiesterase-5 GAF Domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00011.2012

Molecular determinants for cyclic nucleotide binding to the regulatory domains of phosphodiesterase 2A

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00011.2012

cGMP-phosphodiesterase activity is up-regulated in response to pressure overload of rat ventricles

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00011.2012

cAMP and cGMP signaling cross-talk: role of phosphodiesterases and implications for cardiac pathophysiology

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00011.2012

Phosphodiesterases and cardiac cGMP: evolving roles and controversies

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00011.2012

Expression, activity, and pro-hypertrophic effects of PDE5A in cardiac myocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00011.2012

Myocardial remodeling is controlled by myocyte-targeted gene regulation of phosphodiesterase type 5.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FPHYSIOL.00011.2012

10.1152/PHYSIOL.00011.2012

21 January 2018

Identifiers

DOI

1 reference

27 August 2017

1 reference

PubMed ID

22875455