Targeting cardiac mast cells: pharmacological modulation of the local renin-angiotensin system (Q27026966)

Brazin JA

2

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Morrey C

3

1 reference

Silver RB

4

1 reference

Levi R

5

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language of work or name

1 reference

November 2011

1 reference

Current Pharmaceutical Design

published in

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volume

17

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issue

34

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page(s)

3744-52

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Angiotensin-(1-7) is an endogenous ligand for the G protein-coupled receptor Mas

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Aldehyde dehydrogenase activation prevents reperfusion arrhythmias by inhibiting local renin release from cardiac mast cells

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Interaction between sensory C-fibers and cardiac mast cells in ischemia/reperfusion: activation of a local renin-angiotensin system culminating in severe arrhythmic dysfunction

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Mast cell chymase limits the cardiac efficacy of Ang I-converting enzyme inhibitor therapy in rodents

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Essential hypertension and the sympathetic nervous system

28 September 2017

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Mast cell renin and a local renin-angiotensin system in the airway: role in bronchoconstriction

28 September 2017

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Reactive oxygen species produced up- or downstream of calcium influx regulate proinflammatory mediator release from mast cells: role of NADPH oxidase and mitochondria

28 September 2017

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The role of histamine H1 and H4 receptors in allergic inflammation: the search for new antihistamines

28 September 2017

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Direct renin inhibition: focus on aliskiren

28 September 2017

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The role of reactive oxygen species and nitric oxide in mast cell-dependent inflammatory processes

28 September 2017

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Renin: at the heart of the mast cell

28 September 2017

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Pathological roles of angiotensin II produced by mast cell chymase and the effects of chymase inhibition in animal models

28 September 2017

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Role of angiotensin receptor blockers in the prevention and treatment of arrhythmias

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Measurement of sympathetic nervous system activity in heart failure: the role of norepinephrine kinetics

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28 September 2017

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The human mast cell: an overview

28 September 2017

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Regulation of cys-based protein tyrosine phosphatases via reactive oxygen and nitrogen species in mast cells and basophils

28 September 2017

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Serine proteases and cardiac function.

28 September 2017

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Cardiovascular actions of angiotensin-(1-7).

28 September 2017

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Cardiac chymase: pathophysiological role and therapeutic potential of chymase inhibitors

28 September 2017

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Mast cells: a unique source of renin

28 September 2017

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Coupling of angiotensin II AT1 receptors to neuronal NHE activity and carrier-mediated norepinephrine release in myocardial ischemia

28 September 2017

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Newly recognized components of the renin-angiotensin system: potential roles in cardiovascular and renal regulation

28 September 2017

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Local renin-angiotensin systems: the unanswered questions

28 September 2017

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Regulatory effects of G protein-coupled receptors on cardiac sarcolemmal Na+/H+ exchanger activity: signalling and significance.

28 September 2017

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Role of the local renin-angiotensin system in cardiac damage: a minireview focussing on transgenic animal models

28 September 2017

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The inflammatory response in myocardial infarction

28 September 2017

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Tissue renin-angiotensin systems: new insights from experimental animal models in hypertension research

28 September 2017

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Cardiomyocytes bind and activate native human prorenin : role of soluble mannose 6-phosphate receptors.

28 September 2017

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Role of angiotensin and its inhibition in hypertension, ischemic heart disease, and heart failure

28 September 2017

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Coupling of histamine H3 receptors to neuronal Na+/H+ exchange: a novel protective mechanism in myocardial ischemia

28 September 2017

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Canine ventricular myocytes possess a renin-angiotensin system that is upregulated with heart failure

28 September 2017

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Angiotensin II provokes cesium-induced ventricular tachyarrhythmias

28 September 2017

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Therapeutic potential of H(3)-receptor agonists in myocardial infarction

28 September 2017

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The sympathetic system and hypertension

28 September 2017

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Histamine H(3)-receptors: a new frontier in myocardial ischemia.

28 September 2017

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The cardiac renin-angiotensin system: conceptual, or a regulator of cardiac function?

28 September 2017

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Activation of histamine H3 receptors inhibits carrier-mediated norepinephrine release in a human model of protracted myocardial ischemia

28 September 2017

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28 September 2017

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28 September 2017

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Immunological characterization and functional importance of human heart mast cells

28 September 2017

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Renin is not synthesized by cardiac and extrarenal vascular tissues. A review of experimental evidence

28 September 2017

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28 September 2017

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The use of the human neuroblastoma SH-SY5Y to study the effect of second messengers on noradrenaline release

28 September 2017

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The release and fate of vaso-active hormones in the circulation

28 September 2017

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Implications of local angiotensin production in cardiovascular physiology and pharmacology

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28 September 2017

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Histamine and cardiac arrhythmias

28 September 2017

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Catecholamines in myocardial ischemia. Systemic and cardiac release

28 September 2017

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A third histamine receptor subtype: Characterisation, localisation and functions of the H3-receptor

28 September 2017

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Renin-angiotensin system: biochemistry and mechanisms of action

28 September 2017

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Effects of acidosis on anoxic and exocytotic noradrenaline release from the heart

28 September 2017

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Suppression of allergen-induced respiratory dysfunction and airway inflammation in sensitized guinea pigs by Mn(II)(Me(2)DO2A), a novel superoxide scavenger compound

28 September 2017

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Histamine H3-receptor signaling in cardiac sympathetic nerves: Identification of a novel MAPK-PLA2-COX-PGE2-EP3R pathway

31 May 2018

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Cardiac mast cell-derived renin promotes local angiotensin formation, norepinephrine release, and arrhythmias in ischemia/reperfusion

31 May 2018

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Histochemical and morphological characteristics of canine cardiac mast cells.

31 May 2018

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AT1 receptor blockade in experimental myocardial ischemia/reperfusion.

31 May 2018

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Angiotensin production by the heart: a quantitative study in pigs with the use of radiolabeled angiotensin infusions.

31 May 2018

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Local angiotensin II generation in the rat heart: role of renin uptake.

31 May 2018

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Mast-cell degranulation in human hearts

31 May 2018

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The effect of chronic bilateral nephrectomy on plasma and brain angiotensin

31 May 2018

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Isorenin, pseudorenin, cathepsin D and renin. A comparative enzymatic study of angiotensin-forming enzymes

31 May 2018

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Kinetic analysis of the interaction between noradrenaline and Na+ in neuronal uptake: Kinetic evidence for CO-transport

31 May 2018

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Cardiac mast cell proteases do not contribute to the regulation of the rat coronary vascular responsiveness to arterial delivered angiotensin I and II.

31 May 2018

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Prognostically relevant breakdown of 123 patients with systemic mastocytosis associated with other myeloid malignancies

28 November 2018

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Cardiac Renin levels are not influenced by the amount of resident mast cells.

28 November 2018

1 reference

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Sympathetic activation in congestive heart failure: evidence, consequences and therapeutic implications.

28 November 2018

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Transition from atherosclerosis to aortic aneurysm in humans coincides with an increased expression of RAS components

28 November 2018

1 reference

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Direct pro-arrhythmogenic effects of angiotensin II can be suppressed by AT1 receptor blockade in human atrial myocardium

28 November 2018

1 reference

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Immediate hypersensitivity elicits renin release from cardiac mast cells

28 November 2018

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Angiotensin-(1-7) through receptor Mas mediates endothelial nitric oxide synthase activation via Akt-dependent pathways.

28 November 2018

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Evidence of a functional role for mast cells in the development of type 1 diabetes mellitus in the BioBreeding rat.

28 November 2018

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Species differences in angiotensin II generation and degradation by mast cell chymases

28 November 2018

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Rodent and human mast cells produce functionally significant intracellular reactive oxygen species but not nitric oxide

28 November 2018

1 reference

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Histamine H3-receptor-induced attenuation of norepinephrine exocytosis: a decreased protein kinase a activity mediates a reduction in intracellular calcium

28 November 2018

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Increased severity of reperfusion arrhythmias in mouse hearts lacking histamine H3-receptors

28 November 2018

1 reference

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Role for chymase in heart failure: angiotensin II-dependent or -independent mechanisms?

28 November 2018

1 reference

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Chymase Inhibition Prevents Cardiac Fibrosis and Improves Diastolic Dysfunction in the Progression of Heart Failure

28 November 2018

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Ectonucleotidase in sympathetic nerve endings modulates ATP and norepinephrine exocytosis in myocardial ischemia

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3298860

Norepinephrine release from the ischemic heart is greatly enhanced in mice lacking histamine H3 receptors.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3298860

A comparison of reactive oxygen species generation by rat peritoneal macrophages and mast cells using the highly sensitive real-time chemiluminescent probe pholasin: inhibition of antigen-induced mast cell degranulation by macrophage-derived hydroge

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3298860

Mast cells mediate the microvascular inflammatory response to systemic hypoxia

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3298860

Role of AT2 receptors in the cardioprotective effect of AT1 antagonists in mice

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3298860

Ischemia promotes renin activation and angiotensin formation in sympathetic nerve terminals isolated from the human heart: contribution to carrier-mediated norepinephrine release

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3298860

Increased chymase activity in internal thoracic artery of patients with hypercholesterolemia.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3298860

Reactive oxygen species generation and histamine release by activated mast cells: modulation by nitric oxide synthase inhibition

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3298860

In situ characterization of mast cells in the frog Rana esculenta.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3298860

Angiotensin II type 1a receptor is involved in the occurrence of reperfusion arrhythmias.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3298860

Effect of bilateral nephrectomy on active renin, angiotensinogen, and renin glycoforms in plasma and myocardium.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3298860

Prognostic significance of plasma norepinephrine in patients with asymptomatic left ventricular dysfunction. SOLVD Investigators.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3298860

Histamine H3-receptor-mediated inhibition of calcitonin gene-related peptide release from cardiac C fibers. A regulatory negative-feedback loop

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3298860

Histamine H3-receptor signaling in the heart: possible involvement of Gi/Go proteins and N-type Ca++ channels.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3298860

Cardiac and renal mast cells: morphology, distribution, fixation and staining properties in the guinea pig and preliminary comparison with human.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3298860

Response of rat myocardial mast cells to experimental ischemia.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3298860

Evidence of a Selective Increase in Cardiac Sympathetic Activity in Patients with Sustained Ventricular Arrhythmias

28 November 2018

1 reference

12 December 2020

Signal transduction in myocardial ischaemia*

1 reference

12 December 2020

Unmasking of activated histamine H3-receptors in myocardial ischemia: their role as regulators of exocytotic norepinephrine release

1 reference

12 December 2020

Functional identification of histamine H3-receptors in the human heart

1 reference

12 December 2020

Activation of histamine H3-receptors inhibits carrier-mediated norepinephrine release during protracted myocardial ischemia. Comparison with adenosine A1-receptors and alpha2-adrenoceptors

1 reference

12 December 2020

Evidence for the existence of a functional cardiac renin-angiotensin system in humans

1 reference

12 December 2020

Specific receptor binding of renin on human mesangial cells in culture increases plasminogen activator inhibitor-1 antigen

1 reference

12 December 2020

Mannose 6-phosphate receptor-mediated internalization and activation of prorenin by cardiac cells

1 reference

12 December 2020

Stem Cell Factor in Mast Cells and Increased Mast Cell Density in Idiopathic and Ischemic Cardiomyopathy

1 reference

12 December 2020

Active renin and angiotensinogen in cardiac interstitial fluid after myocardial infarction

1 reference

12 December 2020

Increased chymase-dependent angiotensin II formation in human atherosclerotic aorta

1 reference

12 December 2020

Uptake and proteolytic activation of prorenin by cultured human endothelial cells

1 reference

12 December 2020

Increased adventitial mast cells in a patient with coronary spasm

1 reference

12 December 2020

Norepinephrine release and ventricular fibrillation in myocardial ischemia/reperfusion: roles of angiotensin and bradykinin

1 reference

12 December 2020

Angiotensin-converting enzyme-independent angiotensin formation in a human model of myocardial ischemia: modulation of norepinephrine release by angiotensin type 1 and angiotensin type 2 receptors

1 reference

12 December 2020

High cardiac angiotensin-II-forming activity in infarcted and non-infarcted human myocardium

1 reference

12 December 2020

Angiotensin converting enzyme is the main contributor to angiotensin I-II conversion in the interstitium of the isolated perfused rat heart

1 reference

12 December 2020

Mast cells feel the strain

1 reference

12 December 2020

Reperfusion-Induced Arrhythmias Are Suppressed by Inhibition of the Angiotensin II Type 1 Receptor

1 reference

12 December 2020

Neuronal sodium homoeostatis and axoplasmic amine concentration determine calcium-independent noradrenaline release in normoxic and ischemic rat heart

1 reference

12 December 2020