Cyclin-dependent serine/threonine-protein kinase CDC28 YBR160W (Q27548957)

Protein kinase domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Protein kinase, ATP binding site, protein family

1 reference

based on heuristic

inferred from protein domain or family

Serine/threonine-protein kinase, active site, protein family

1 reference

based on heuristic

inferred from protein domain or family

found in taxon

Saccharomyces cerevisiae S288c

1 reference

25 May 2022

1 reference

25 May 2022

cyclin-dependent protein serine/threonine kinase activity

3 references

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P00546&geneProductId=UniProtKB:P00546

21 June 2018

G1-specific cyclins of S. cerevisiae: cell cycle periodicity, regulation by mating pheromone, and association with the p34CDC28 protein kinase

http://www.ebi.ac.uk/QuickGO/annotations?protein=P00546&geneProductId=UniProtKB:P00546

21 June 2018

Fimbrin phosphorylation by metaphase Cdk1 regulates actin cable dynamics in budding yeast.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P00546&geneProductId=UniProtKB:P00546

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00546

1 reference

9 May 2019

Cks1, Cdk1, and the 19S proteasome collaborate to regulate gene induction-dependent nucleosome eviction in yeast

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00546

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00546

RNA polymerase II complex binding

1 reference

9 May 2019

Cdc28 kinase activity regulates the basal transcription machinery at a subset of genes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00546

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00546

protein serine/threonine kinase activity

11 references

9 May 2019

Spatiotemporal regulation of Ipl1/Aurora activity by direct Cdk1 phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00546

9 May 2019

Cell cycle regulation of DNA double-strand break end resection by Cdk1-dependent Dna2 phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00546

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00546

9 May 2019

The Yeast Cyclin-Dependent Kinase Routes Carbon Fluxes to Fuel Cell Cycle Progression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00546

9 May 2019

Cyclin-dependent kinase-dependent phosphorylation of Lif1 and Sae2 controls imprecise nonhomologous end joining accompanied by double-strand break resection

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00546

9 May 2019

Spatiotemporal regulation of Ipl1/Aurora activity by direct Cdk1 phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00546

9 May 2019

CDC28 phosphorylates Cac1p and regulates the association of chromatin assembly factor I with chromatin.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00546

9 May 2019

Sequential primed kinases create a damage-responsive phosphodegron on Eco1.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00546

9 May 2019

Cdk1-dependent regulation of the mitotic inhibitor Wee1.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00546

9 May 2019

Global analysis of cdc14 dephosphorylation sites reveals essential regulatory role in mitosis and cytokinesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00546

9 May 2019

Cdc28 kinase activity regulates the basal transcription machinery at a subset of genes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00546

http://www.ebi.ac.uk/QuickGO/annotations?protein=P00546&geneProductId=UniProtKB:P00546

protein kinase activity

1 reference

7 November 2018

13 references

9 May 2019

Simian virus 40 large T antigen affects the Saccharomyces cerevisiae cell cycle and interacts with p34CDC28

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00546

9 May 2019

A mechanism for cell-cycle regulation of MAP kinase signaling in a yeast differentiation pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00546

9 May 2019

Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00546

9 May 2019

A comprehensive two-hybrid analysis to explore the yeast protein interactome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00546

9 May 2019

A new pair of B-type cyclins from Saccharomyces cerevisiae that function early in the cell cycle

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00546

9 May 2019

CDK-dependent Hsp70 Phosphorylation controls G1 cyclin abundance and cell-cycle progression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00546

9 May 2019

Functional organization of the yeast proteome by systematic analysis of protein complexes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00546

9 May 2019

Proteome-wide protein interaction measurements of bacterial proteins of unknown function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00546

9 May 2019

A global protein kinase and phosphatase interaction network in yeast.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00546

9 May 2019

Proteome survey reveals modularity of the yeast cell machinery

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00546

9 May 2019

Assigning function to yeast proteins by integration of technologies.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00546

9 May 2019

A comprehensive analysis of protein-protein interactions in Saccharomyces cerevisiae

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00546

9 May 2019

Cks1 is required for G(1) cyclin-cyclin-dependent kinase activity in budding yeast

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00546

cyclin-dependent protein serine/threonine kinase activity

IPI

4 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00546

9 May 2019

G1-specific cyclins of S. cerevisiae: cell cycle periodicity, regulation by mating pheromone, and association with the p34CDC28 protein kinase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00546

9 May 2019

Fimbrin phosphorylation by metaphase Cdk1 regulates actin cable dynamics in budding yeast.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00546

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00546

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00546

1 reference

14 January 2019

Systematic identification and functional screens of uncharacterized proteins associated with eukaryotic ribosomal complexes

http://www.ebi.ac.uk/QuickGO/annotations?protein=P00546&geneProductId=UniProtKB:P00546

Cyclin Cln3 is retained at the ER and released by the J chaperone Ydj1 in late G1 to trigger cell cycle entry.

HDA

cell component

endoplasmic reticulum

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00546

cyclin-dependent protein kinase holoenzyme complex

1 reference

14 January 2019

Yeast Cdk1 translocates to the plus end of cytoplasmic microtubules to regulate bud cortex interactions

http://www.ebi.ac.uk/QuickGO/annotations?protein=P00546&geneProductId=UniProtKB:P00546

1 reference

9 May 2019

Yeast Cdk1 translocates to the plus end of cytoplasmic microtubules to regulate bud cortex interactions

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00546

1 reference

14 January 2019

Cdk1-Clb4 controls the interaction of astral microtubule plus ends with subdomains of the daughter cell cortex

http://www.ebi.ac.uk/QuickGO/annotations?protein=P00546&geneProductId=UniProtKB:P00546

cytoplasmic stress granule

1 reference

9 May 2019

ATPase-Modulated Stress Granules Contain a Diverse Proteome and Substructure.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00546

1 reference

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P00546&geneProductId=UniProtKB:P00546

1 reference

21 June 2018

Recruitment of Cdc28 by Whi3 restricts nuclear accumulation of the G1 cyclin-Cdk complex to late G1.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P00546&geneProductId=UniProtKB:P00546

1 reference

21 June 2018

Subcellular localization of a protein kinase required for cell cycle initiation in Saccharomyces cerevisiae: evidence for an association between the CDC28 gene product and the insoluble cytoplasmic matrix

http://www.ebi.ac.uk/QuickGO/annotations?protein=P00546&geneProductId=UniProtKB:P00546

cyclin-dependent protein kinase holoenzyme complex

3 references

9 May 2019

G1-specific cyclins of S. cerevisiae: cell cycle periodicity, regulation by mating pheromone, and association with the p34CDC28 protein kinase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00546

9 May 2019

A cyclin B homolog in S. cerevisiae: Chronic activation of the Cdc28 protein kinase by cyclin prevents exit from mitosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00546

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00546

negative regulation of transcription, DNA-templated

3 references

9 May 2019

Clb6/Cdc28 and Cdc14 regulate phosphorylation status and cellular localization of Swi6

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00546

9 May 2019

The CLN3/SWI6/CLN2 pathway and SNF1 act sequentially to regulate meiotic initiation in Saccharomyces cerevisiae.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00546

9 May 2019

Clb6/Cdc28 and Cdc14 regulate phosphorylation status and cellular localization of Swi6

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00546

positive regulation of transcription, DNA-templated

negative regulation of mitotic cell cycle

1 reference

9 May 2019

Inhibitory phosphorylation of the APC regulator Hct1 is controlled by the kinase Cdc28 and the phosphatase Cdc14.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00546

negative regulation of double-strand break repair via nonhomologous end joining

1 reference

9 May 2019

Regulation of repair choice: Cdk1 suppresses recruitment of end joining factors at DNA breaks

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00546

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00546

phosphorylation of RNA polymerase II C-terminal domain

1 reference

9 May 2019

Cdc28 kinase activity regulates the basal transcription machinery at a subset of genes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00546

regulation of spindle assembly

1 reference

9 May 2019

Ase1p phosphorylation by cyclin-dependent kinase promotes correct spindle assembly in S. cerevisiae.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00546

positive regulation of mitotic spindle pole body separation

3 references

9 May 2019

Spindle pole body separation in Saccharomyces cerevisiae requires dephosphorylation of the tyrosine 19 residue of Cdc28.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00546

9 May 2019

Cdk1 regulates centrosome separation by restraining proteolysis of microtubule-associated proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00546

9 May 2019

Cdk1 regulates centrosome separation by restraining proteolysis of microtubule-associated proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00546

regulation of filamentous growth

1 reference

9 May 2019

Control of Saccharomyces cerevisiae filamentous growth by cyclin-dependent kinase Cdc28

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00546

regulation of double-strand break repair via homologous recombination

1 reference

9 May 2019

DNA end resection, homologous recombination and DNA damage checkpoint activation require CDK1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00546

mitotic sister chromatid biorientation

1 reference

9 May 2019

Cdk1 promotes kinetochore bi-orientation and regulates Cdc20 expression during recovery from spindle checkpoint arrest

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00546

protein localization to nucleus

1 reference

9 May 2019

Antagonistic regulation of Fus2p nuclear localization by pheromone signaling and the cell cycle

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00546

synaptonemal complex assembly

1 reference

9 May 2019

Cyclin‐dependent kinase promotes formation of the synaptonemal complex in yeast meiosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00546

positive regulation of nuclear cell cycle DNA replication

4 references

9 May 2019

Three Additional Genes Required for Deoxyribonucleic Acid Synthesis in Saccharomyces cerevisiae

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00546

9 May 2019

Control of landmark events in meiosis by the CDK Cdc28 and the meiosis-specific kinase Ime2.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00546

9 May 2019

Cell cycle-dependent phosphorylation of the DNA polymerase epsilon subunit, Dpb2, by the Cdc28 cyclin-dependent protein kinase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00546

9 May 2019

Cell cycle-dependent phosphorylation of the DNA polymerase epsilon subunit, Dpb2, by the Cdc28 cyclin-dependent protein kinase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00546

meiotic DNA double-strand break processing

1 reference

9 May 2019

Processing of meiotic DNA double strand breaks requires cyclin-dependent kinase and multiple nucleases

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00546

negative regulation of meiotic cell cycle

1 reference

9 May 2019

The CLN3/SWI6/CLN2 pathway and SNF1 act sequentially to regulate meiotic initiation in Saccharomyces cerevisiae.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00546

7-methylguanosine mRNA capping

1 reference

9 May 2019

Cdc28 kinase activity regulates the basal transcription machinery at a subset of genes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00546

positive regulation of transcription by RNA polymerase II

1 reference

9 May 2019

Cdc28 kinase activity regulates the basal transcription machinery at a subset of genes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00546

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00546

positive regulation of meiotic cell cycle

3 references

9 May 2019

Pachytene arrest and other meiotic effects of the start mutations in Saccharomyces cerevisiae

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00546

9 May 2019

Cyclin-dependent kinase directly regulates initiation of meiotic recombination

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00546

9 May 2019

Cyclin-dependent kinase directly regulates initiation of meiotic recombination

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00546

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00546

peptidyl-serine phosphorylation

3 references

9 May 2019

Sequential primed kinases create a damage-responsive phosphodegron on Eco1.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00546

9 May 2019

The Yeast Cyclin-Dependent Kinase Routes Carbon Fluxes to Fuel Cell Cycle Progression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00546

9 May 2019

CDC28 phosphorylates Cac1p and regulates the association of chromatin assembly factor I with chromatin.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00546

regulation of telomere maintenance via telomerase

1 reference

9 May 2019

Cdk1-dependent phosphorylation of Cdc13 coordinates telomere elongation during cell-cycle progression.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00546

protein localization to nuclear periphery

1 reference

9 May 2019

Cdk phosphorylation of a nucleoporin controls localization of active genes through the cell cycle

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00546

negative regulation of sister chromatid cohesion

1 reference

9 May 2019

Cdk1-dependent destruction of Eco1 prevents cohesion establishment after S phase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00546

http://www.ebi.ac.uk/QuickGO/annotations?protein=P00546&geneProductId=UniProtKB:P00546

protein phosphorylation

1 reference

21 June 2018

positive regulation of glycogen catabolic process

1 reference

9 May 2019

Cyclin-Dependent Kinase Co-Ordinates Carbohydrate Metabolism and Cell Cycle in S. cerevisiae

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00546

1 reference

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P00546&geneProductId=UniProtKB:P00546

mitotic cell cycle phase transition

1 reference

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P00546&geneProductId=UniProtKB:P00546

regulation of protein localization to chromatin

1 reference

9 May 2019

CDC28 phosphorylates Cac1p and regulates the association of chromatin assembly factor I with chromatin.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00546

negative regulation of transcription by RNA polymerase II

1 reference

9 May 2019

Cdk1 promotes kinetochore bi-orientation and regulates Cdc20 expression during recovery from spindle checkpoint arrest

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00546

DNA double-strand break processing

1 reference

9 May 2019

Cell cycle regulation of DNA double-strand break end resection by Cdk1-dependent Dna2 phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00546

double-strand break repair via nonhomologous end joining

1 reference

9 May 2019

Cyclin-dependent kinase-dependent phosphorylation of Lif1 and Sae2 controls imprecise nonhomologous end joining accompanied by double-strand break resection

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00546

Ase1p phosphorylation by cyclin-dependent kinase promotes correct spindle assembly in S. cerevisiae.

mitotic spindle assembly

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00546

protein localization to spindle microtubule

1 reference

9 May 2019

Spatiotemporal regulation of Ipl1/Aurora activity by direct Cdk1 phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00546

post-Golgi vesicle-mediated transport

1 reference

9 May 2019

Cdk1-dependent control of membrane-trafficking dynamics.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00546

negative regulation of DNA replication origin binding

1 reference

9 May 2019

Multiple kinases inhibit origin licensing and helicase activation to ensure reductive cell division during meiosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00546

G1/S transition of mitotic cell cycle

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00546

positive regulation of cell population proliferation

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00546

regulation of G2/M transition of mitotic cell cycle

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00546

negative regulation of mitotic actomyosin contractile ring assembly

1 reference

9 May 2019

Cdk1-dependent phosphorylation of Iqg1 governs actomyosin ring assembly prior to cytokinesis.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P00546

serine/threonine-protein kinase, active site

protein phosphorylation

3 references

1 reference

protein kinase domain

1 reference

protein kinase, ATP binding site

1 reference

D08.811.913.696.620.682.700.646.500.500.375

Identifiers

MeSH descriptor ID

D017489

subject named as

CDC28 Protein Kinase, S cerevisiae

0 references

MeSH tree code

0 references

D12.776.167.200.067.500

0 references

D12.776.354.750.124

0 references

D12.776.476.563.646.500.500.375

0 references

1 reference

20 March 2022

1 reference

25 May 2022

1 reference

Saccharomyces Genome Database ID

1 reference

20 March 2022

1 reference

inferred by common MeSH mappings on source and on Wikidata