Sequential primed kinases create a damage-responsive phosphodegron on Eco1. (Q27938911)

Cyclin-dependent serine/threonine-protein kinase CDC28 YBR160W

1 reference

SCF ubiquitin ligase complex subunit CDC4 YFL009W

1 reference

Serine/threonine/tyrosine protein kinase MCK1 YNL307C

1 reference

author name string

Nicholas A Lyons

1

0 references

Bryan R Fonslow

2

0 references

Jolene K Diedrich

3

0 references

John R Yates

4

0 references

David O Morgan

Nature Structural & Molecular Biology

5

0 references

language of work or name

English

0 references

publication date

February 2013

0 references

published in

1 reference

1 December 2016

20

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issue

2

0 references

page(s)

194-201

0 references

cites work

A yeast GSK-3 kinase Mck1 promotes Cdc6 degradation to inhibit DNA re-replication

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Composite low affinity interactions dictate recognition of the cyclin-dependent kinase inhibitor Sic1 by the SCFCdc4 ubiquitin ligase

20 March 2017

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Cascades of multisite phosphorylation control Sic1 destruction at the onset of S phase

20 March 2017

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Cdk1-dependent destruction of Eco1 prevents cohesion establishment after S phase

20 March 2017

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SCFCdc4 enables mating type switching in yeast by cyclin-dependent kinase-mediated elimination of the Ash1 transcriptional repressor.

20 March 2017

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How do Cdc7 and cyclin-dependent kinases trigger the initiation of chromosome replication in eukaryotic cells?

20 March 2017

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Eco1-dependent cohesin acetylation during establishment of sister chromatid cohesion

20 March 2017

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The kleisin subunit of cohesin dictates damage-induced cohesion

20 March 2017

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The SCFCdc4 ubiquitin ligase regulates calcineurin signaling through degradation of phosphorylated Rcn1, an inhibitor of calcineurin

20 March 2017

1 reference

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Suprafacial orientation of the SCFCdc4 dimer accommodates multiple geometries for substrate ubiquitination

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3565030

Structure of a Fbw7-Skp1-cyclin E complex: multisite-phosphorylated substrate recognition by SCF ubiquitin ligases

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3565030

CDC7 kinase phosphorylates serine residues adjacent to acidic amino acids in the minichromosome maintenance 2 protein

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3565030

Postreplicative recruitment of cohesin to double-strand breaks is required for DNA repair.

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3565030

GSK-3: tricks of the trade for a multi-tasking kinase

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3565030

Sister chromatid cohesion is required for postreplicative double-strand break repair in Saccharomyces cerevisiae.

20 March 2017

1 reference

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Additional modules for versatile and economical PCR-based gene deletion and modification in Saccharomyces cerevisiae

20 March 2017

1 reference

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Cell cycle regulation of the yeast Cdc7 protein kinase by association with the Dbf4 protein

20 March 2017

1 reference

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Function and regulation of cullin-RING ubiquitin ligases

20 March 2017

1 reference

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An automated multidimensional protein identification technology for shotgun proteomics

20 March 2017

1 reference

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Multisite phosphorylation of a CDK inhibitor sets a threshold for the onset of DNA replication

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3565030

20 March 2017

1 reference

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Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution

20 March 2017

1 reference

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FBW7 ubiquitin ligase: a tumour suppressor at the crossroads of cell division, growth and differentiation

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3565030

Targets of the cyclin-dependent kinase Cdk1

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3565030

DTASelect and Contrast: tools for assembling and comparing protein identifications from shotgun proteomics

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3565030

Phosphate-binding tag, a new tool to visualize phosphorylated proteins

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3565030

Cdc7p-Dbf4p kinase binds to chromatin during S phase and is regulated by both the APC and the RAD53 checkpoint pathway

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3565030

Mcm2 is a target of regulation by Cdc7-Dbf4 during the initiation of DNA synthesis

9 May 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3565030

Occurrence and detection of phosphopeptide isomers in large-scale phosphoproteomics experiments

9 May 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3565030

Single-step inline hydroxyapatite enrichment facilitates identification and quantitation of phosphopeptides from mass-limited proteomes with MudPIT

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3565030

Limiting replication initiation factors execute the temporal programme of origin firing in budding yeast.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3565030

Damage-induced phosphorylation of Sld3 is important to block late origin firing

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3565030

Deciphering protein kinase specificity through large-scale analysis of yeast phosphorylation site motifs

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3565030

Regulation of protein stability by GSK3 mediated phosphorylation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3565030

Multisite phosphorylation of the Saccharomyces cerevisiae filamentous growth regulator Tec1 is required for its recognition by the E3 ubiquitin ligase adaptor Cdc4 and its subsequent destruction in vivo

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3565030

Cyclin-specific control of ribosomal DNA segregation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3565030

Validation of tandem mass spectrometry database search results using DTASelect

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3565030

Fbw7/hCDC4 dimerization regulates its substrate interactions

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3565030

The Saccharomyces cerevisiae GSK-3 beta homologs

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3565030

A Dbf4p BRCA1 C-terminal-like domain required for the response to replication fork arrest in budding yeast

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3565030

A neutral loss activation method for improved phosphopeptide sequence analysis by quadrupole ion trap mass spectrometry

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3565030

Cleavage N-terminal to proline: analysis of a database of peptide tandem mass spectra

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3565030

Regulation of initiation of S phase, replication checkpoint signaling, and maintenance of mitotic chromosome structures during S phase by Hsk1 kinase in the fission yeast

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3565030

GSK-3 kinase Mck1 and calcineurin coordinately mediate Hsl1 down-regulation by Ca2+ in budding yeast

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3565030

Characterization of the yeast Cdc7p/Dbf4p complex purified from insect cells. Its protein kinase activity is regulated by Rad53p

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3565030

Cell cycle control of Cdc7p kinase activity through regulation of Dbf4p stability.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3565030

Mec1 is one of multiple kinases that prime the Mcm2-7 helicase for phosphorylation by Cdc7

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3565030

Checkpoint-dependent inhibition of DNA replication initiation by Sld3 and Dbf4 phosphorylation

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3565030

Distinct targets of the Eco1 acetyltransferase modulate cohesion in S phase and in response to DNA damage

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3565030

Meiosis: DDK is not just for replication

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3565030

Building sister chromatid cohesion: smc3 acetylation counteracts an antiestablishment activity.

2 June 2018

1 reference

Budding yeast Wpl1(Rad61)-Pds5 complex counteracts sister chromatid cohesion-establishing reaction.

21 January 2018

1 reference

A molecular determinant for the establishment of sister chromatid cohesion

21 January 2018

1 reference

DNA double-strand breaks trigger genome-wide sister-chromatid cohesion through Eco1 (Ctf7).

21 January 2018

1 reference

Origin association of Sld3, Sld7, and Cdc45 proteins is a key step for determination of origin-firing timing

21 January 2018

1 reference

Additional modules for versatile and economical PCR-based gene deletion and modification in Saccharomyces cerevisiae

21 January 2018

1 reference

Cyclin specificity in the phosphorylation of cyclin-dependent kinase substrates.

21 January 2018

1 reference

Postreplicative Formation of Cohesion Is Required for Repair and Induced by a Single DNA Break

21 January 2018

2 references

https://pubmed.ncbi.nlm.nih.gov/23314252

31 March 2020

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Formation of protein kinase recognition sites by covalent modification of the substrate. Molecular mechanism for the synergistic action of casein kinase II and glycogen synthase kinase 3

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23314252