DNA helicase SRS2 YJL092W (Q27552081)

DNA helicase, UvrD/REP type

1 reference

DExx box DNA helicase domain superfamily

1 reference

UvrD-like DNA helicase, C-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

UvrD-like helicase, ATP-binding domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

found in taxon

Saccharomyces cerevisiae S288c

1 reference

25 May 2022

1 reference

25 May 2022

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12954

Purification and characterization of the SRS2 DNA helicase of the yeast Saccharomyces cerevisiae

IEA

DNA helicase activity

1 reference

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P12954&geneProductId=UniProtKB:P12954

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12954

DNA helicase activity

1 reference

9 May 2019

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12954

enzyme activator activity

IEA

1 reference

9 May 2019

Srs2 promotes Mus81-Mms4-mediated resolution of recombination intermediates

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12954

6 references

9 May 2019

Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12954

9 May 2019

Recognition of SUMO-modified PCNA requires tandem receptor motifs in Srs2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12954

9 May 2019

Srs2 mediates PCNA-SUMO-dependent inhibition of DNA repair synthesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12954

9 May 2019

Nej1 recruits the Srs2 helicase to DNA double-strand breaks and supports repair by a single-strand annealing-like mechanism.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12954

9 May 2019

A comprehensive analysis of protein-protein interactions in Saccharomyces cerevisiae

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12954

9 May 2019

Rad51 paralogues Rad55-Rad57 balance the antirecombinase Srs2 in Rad51 filament formation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12954

3 references

7 November 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P12954&geneProductId=UniProtKB:P12954

7 November 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P12954&geneProductId=UniProtKB:P12954

7 November 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P12954&geneProductId=UniProtKB:P12954

3'-5' DNA helicase activity

IBA

1 reference

10 September 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P12954&geneProductId=UniProtKB:P12954

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12954

9 May 2019

Localization of recombination proteins and Srs2 reveals anti-recombinase function in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12954

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12954

negative regulation of double-strand break repair via homologous recombination

IBA

biological process

1 reference

9 May 2019

Srs2 disassembles Rad51 filaments by a protein-protein interaction triggering ATP turnover and dissociation of Rad51 from DNA.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12954

positive regulation of endodeoxyribonuclease activity

1 reference

9 May 2019

Srs2 promotes Mus81-Mms4-mediated resolution of recombination intermediates

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12954

cellular response to DNA damage stimulus

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12954

double-strand break repair via nonhomologous end joining

IEA

1 reference

9 May 2019

Requirement for the SRS2 DNA helicase gene in non-homologous end joining in yeast

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12954

1 reference

9 May 2019

Rapid unwinding of triplet repeat hairpins by Srs2 helicase of Saccharomyces cerevisiae

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12954

negative regulation of DNA recombination

1 reference

9 May 2019

Remodeling of the Rad51 DNA strand-exchange protein by the Srs2 helicase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12954

DNA recombinase disassembly

IMP

3 references

9 May 2019

Remodeling of the Rad51 DNA strand-exchange protein by the Srs2 helicase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12954

9 May 2019

DNA helicase Srs2 disrupts the Rad51 presynaptic filament

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12954

9 May 2019

The Srs2 helicase prevents recombination by disrupting Rad51 nucleoprotein filaments.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12954

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

recombinational repair

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12954

3 references

9 May 2019

Modulation of Saccharomyces cerevisiae DNA double-strand break repair by SRS2 and RAD51.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12954

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12954

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12954

UvrD-like helicase, ATP-binding domain

IBA

has part(s)

1 reference

UvrD-like DNA helicase, C-terminal

1 reference