Srs2 mediates PCNA-SUMO-dependent inhibition of DNA repair synthesis (Q27935386)

DNA helicase SRS2 YJL092W

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

Peter Kolesar

9

0 references

Marek Sebesta

object named as

Marek Sebesta

2

0 references

Serge Gangloff

object named as

Serge Gangloff

11

0 references

Lumír Krejčí

object named as

Lumir Krejci

12

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author name string

Peter Burkovics

1

0 references

Alexandra Sisakova

3

0 references

Nicolas Plault

4

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Valeria Szukacsov

5

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Thomas Robert

6

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Lajos Pinter

7

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Victoria Marini

8

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Lajos Haracska

Recognition of SUMO-modified PCNA requires tandem receptor motifs in Srs2

10

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language of work or name

English

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publication date

6 March 2013

0 references

1 reference

1 December 2016

32

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page(s)

742-55

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issue

5

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cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3594751

Inhibition of homologous recombination by the PCNA-interacting protein PARI

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3594751

Elg1, an alternative subunit of the RFC clamp loader, preferentially interacts with SUMOylated PCNA.

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3594751

The DNA-damage response in human biology and disease

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3594751

Srs2 disassembles Rad51 filaments by a protein-protein interaction triggering ATP turnover and dissociation of Rad51 from DNA.

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3594751

Localization of recombination proteins and Srs2 reveals anti-recombinase function in vivo

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3594751

Yeast Mph1 helicase dissociates Rad51-made D-loops: implications for crossover control in mitotic recombination.

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3594751

Yeast Rad5 protein required for postreplication repair has a DNA helicase activity specific for replication fork regression

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3594751

Ubc9- and mms21-mediated sumoylation counteracts recombinogenic events at damaged replication forks

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3594751

The Srs2 helicase prevents recombination by disrupting Rad51 nucleoprotein filaments.

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3594751

RAD6-dependent DNA repair is linked to modification of PCNA by ubiquitin and SUMO.

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3594751

RAD51 is required for the repair of plasmid double-stranded DNA gaps from either plasmid or chromosomal templates

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3594751

Efficient bypass of a thymine-thymine dimer by yeast DNA polymerase, Poleta

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3594751

Structure of the C-terminal region of p21(WAF1/CIP1) complexed with human PCNA

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3594751

Deoxycytidyl transferase activity of yeast REV1 protein

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3594751

Purification and characterization of the SRS2 DNA helicase of the yeast Saccharomyces cerevisiae

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3594751

Crystal structure of the eukaryotic DNA polymerase processivity factor PCNA

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3594751

SUMO-modified PCNA recruits Srs2 to prevent recombination during S phase

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3594751

Reconstitution of complete SV40 DNA replication with purified replication factors

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3594751

Functional identity of proliferating cell nuclear antigen and a DNA polymerase-delta auxiliary protein

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3594751

Mechanism of eukaryotic homologous recombination

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3594751

Eukaryotic translesion synthesis DNA polymerases: specificity of structure and function

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3594751

Srs2 and Sgs1-Top3 suppress crossovers during double-strand break repair in yeast

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3594751

Control of spontaneous and damage-induced mutagenesis by SUMO and ubiquitin conjugation

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3594751

DNA helicase Srs2 disrupts the Rad51 presynaptic filament

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3594751

Unwinding of synthetic replication and recombination substrates by Srs2.

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3594751

Dual roles of the SUMO-interacting motif in the regulation of Srs2 sumoylation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3594751

Homologous recombination and its regulation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3594751

Reconstitution of DNA repair synthesis in vitro and the role of polymerase and helicase activities

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3594751

Srs2 overexpression reveals a helicase-independent role at replication forks that requires diverse cell functions

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3594751

Replication fork stalling by bulky DNA damage: localization at active origins and checkpoint modulation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3594751

The role of replication bypass pathways in dicentric chromosome formation in budding yeast

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3594751

Ubiquitin-dependent DNA damage bypass is separable from genome replication

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3594751

Role of yeast Rad5 and its human orthologs, HLTF and SHPRH in DNA damage tolerance

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3594751

Srs2: the "Odd-Job Man" in DNA repair

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3594751

PCNA is required for initiation of recombination-associated DNA synthesis by DNA polymerase delta

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3594751

Identification of SMARCAL1 as a component of the DNA damage response

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3594751

Mammalian polymerase zeta is essential for post-replication repair of UV-induced DNA lesions

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3594751

Functional significance of the Rad51-Srs2 complex in Rad51 presynaptic filament disruption

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3594751

Regulation of Rad51 recombinase presynaptic filament assembly via interactions with the Rad52 mediator and the Srs2 anti-recombinase.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3594751

ATR/Mec1: coordinating fork stability and repair.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3594751

Srs2 removes deadly recombination intermediates independently of its interaction with SUMO-modified PCNA

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3594751

PCNA ubiquitination and REV1 define temporally distinct mechanisms for controlling translesion synthesis in the avian cell line DT40.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3594751

The Srs2 helicase activity is stimulated by Rad51 filaments on dsDNA: implications for crossover incidence during mitotic recombination

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3594751

Requirement of RAD52 group genes for postreplication repair of UV-damaged DNA in Saccharomyces cerevisiae

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3594751

Ubiquitylation of yeast proliferating cell nuclear antigen and its implications for translesion DNA synthesis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3594751

The error-free component of the RAD6/RAD18 DNA damage tolerance pathway of budding yeast employs sister-strand recombination

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3594751

Rad51-dependent DNA structures accumulate at damaged replication forks in sgs1 mutants defective in the yeast ortholog of BLM RecQ helicase

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3594751

Role of the fission yeast SUMO E3 ligase Pli1p in centromere and telomere maintenance.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3594751

Opposing effects of ubiquitin conjugation and SUMO modification of PCNA on replicational bypass of DNA lesions in Saccharomyces cerevisiae

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3594751

Implications of human genome architecture for rearrangement-based disorders: the genomic basis of disease

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3594751

Role of the error-free damage bypass postreplication repair pathway in the maintenance of genomic stability

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3594751

Role of yeast and human DNA polymerase eta in error-free replication of damaged DNA.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3594751

Extensive loss of heterozygosity is suppressed during homologous repair of chromosomal breaks

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3594751

Alternate pathways involving Sgs1/Top3, Mus81/ Mms4, and Srs2 prevent formation of toxic recombination intermediates from single-stranded gaps created by DNA replication

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3594751

Requirement of RAD5 and MMS2 for postreplication repair of UV-damaged DNA in Saccharomyces cerevisiae

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3594751

Homology search and choice of homologous partner during mitotic recombination

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3594751

Induced chromosomal exchange directs the segregation of recombinant chromatids in mitosis of Drosophila

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3594751

Mutations in yeast proliferating cell nuclear antigen define distinct sites for interaction with DNA polymerase delta and DNA polymerase epsilon

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3594751

The SRS2 suppressor of rad6 mutations of Saccharomyces cerevisiae acts by channeling DNA lesions into the RAD52 DNA repair pathway

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3594751

Analysis of mitotic and meiotic defects in Saccharomyces cerevisiae SRS2 DNA helicase mutants

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3594751

Evidence that spontaneous mitotic recombination occurs at the two-strand stage

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3594751

Rad51 protects nascent DNA from Mre11-dependent degradation and promotes continuous DNA synthesis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3594751

The RAD6 DNA damage tolerance pathway operates uncoupled from the replication fork and is functional beyond S phase.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3594751

DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3594751

Mrc1 and Srs2 are major actors in the regulation of spontaneous crossover

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3594751

Clamp loading, unloading and intrinsic stability of the PCNA, beta and gp45 sliding clamps of human, E. coli and T4 replicases

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3594751

PCNA: structure, functions and interactions

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3594751

Transcriptional activation by a DNA-tracking protein: structural consequences of enhancement at the T4 late promoter

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3594751

Stable interactions between DNA polymerase δ catalytic and structural subunits are essential for efficient DNA repair.

2 June 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMBOJ.2013.9

Srs2 and Sgs1 DNA helicases associate with Mre11 in different subcomplexes following checkpoint activation and CDK1-mediated Srs2 phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMBOJ.2013.9

Srs2 possesses a non-canonical PIP box in front of its SBM for precise recognition of SUMOylated PCNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMBOJ.2013.9

Role of ATP hydrolysis in the antirecombinase function of Saccharomyces cerevisiae Srs2 protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMBOJ.2013.9

Crosstalk between SUMO and ubiquitin on PCNA is mediated by recruitment of the helicase Srs2p

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMBOJ.2013.9

SUMO modification of PCNA is controlled by DNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMBOJ.2013.9

Control of cross-over by single-strand DNA resection

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMBOJ.2013.9

ATPase and DNA helicase activities of the Saccharomyces cerevisiae anti-recombinase Srs2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMBOJ.2013.9

SUMOylation regulates Rad18-mediated template switch

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMBOJ.2013.9

Multiple Mechanisms Control Chromosome Integrity after Replication Fork Uncoupling and Restart at Irreparable UV Lesions

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FEMBOJ.2013.9

A model for replication repair in mammalian cells

21 January 2018

1 reference

12 December 2020

Possible involvement of the yeast POLIII DNA polymerase in induced gene conversion

1 reference

12 December 2020

DNA repeat rearrangements mediated by DnaK-dependent replication fork repair

1 reference

12 December 2020

Architecture and Assembly of Poly-SUMO Chains on PCNA in Saccharomyces cerevisiae

1 reference

12 December 2020

Determination of mitotic recombination rates by fluctuation analysis in Saccharomyces cerevisiae

1 reference

12 December 2020

Identifiers

DOI

10.1038/EMBOJ.2013.9

1 reference

release_svuyyhewt5ca5nut4fwxbqgr4m

224461

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/svuyyhewt5ca5nut4fwxbqgr4m

24 November 2022

mapped directly with Wikidata item

224461

1 reference

1 reference

1 reference