Discovery of a New Phosphotyrosine Mimetic for PTP1B Using Breakaway Tethering (Q27641159)

interface and colloid science

30 December 2023

main subject

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30 December 2023

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30 December 2023

author name string

Mike Randal

4

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Jenny Kung

6

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Andrew Waight

7

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Daniel A. Erlanson

1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A12733877

30 December 2023

Robert S. McDowell

2

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A12733877

30 December 2023

Molly M. He

3

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A12733877

30 December 2023

Robert L. Simmons

5

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A12733877

30 December 2023

Stig K. Hansen

8

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A12733877

full work available at URL

30 December 2023

language of work or name

English

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publication date

14 May 2003

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https://pubs.acs.org/doi/pdf/10.1021/ja034440c

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Journal of the American Chemical Society

30 December 2023

published in

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volume

125

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issue

19

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page(s)

5602-3

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cites work

Protein tyrosine phosphatase 1B inhibitors for diabetes

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Protein tyrosine phosphatases: structure and function, substrate specificity, and inhibitor development

30 December 2023

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Combinatorial control of the specificity of protein tyrosine phosphatases

30 December 2023

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Discovery of a potent, selective protein tyrosine phosphatase 1B inhibitor using a linked-fragment strategy

30 December 2023

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Design and synthesis of non-peptidic inhibitors for the Syk C-terminal SH2 domain based on structure-based in-silico screening

30 December 2023

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Molecular docking and high-throughput screening for novel inhibitors of protein tyrosine phosphatase-1B.

30 December 2023

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Phosphoryltyrosyl mimetics in the design of peptide-based signal transduction inhibitors

30 December 2023

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Discovery and SAR of a novel selective and orally bioavailable nonpeptide classical competitive inhibitor class of protein-tyrosine phosphatase 1B.

30 December 2023

8

1 reference

Protein tyrosine phosphatase substrate specificity: size and phosphotyrosine positioning requirements in peptide substrates

30 December 2023

9

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VHR and PTP1 protein phosphatases exhibit remarkably different active site specificities toward low molecular weight nonpeptidic substrates

30 December 2023

10

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Site-directed ligand discovery

30 December 2023

11

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In situ assembly of enzyme inhibitors using extended tethering

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12

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Discovery of a potent small molecule IL-2 inhibitor through fragment assembly

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13

1 reference

Structural basis of plasticity in protein tyrosine phosphatase 1B substrate recognition

30 December 2023

14

1 reference

Molecular basis for the dephosphorylation of the activation segment of the insulin receptor by protein tyrosine phosphatase 1B

30 December 2023

15

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Small molecule peptidomimetics containing a novel phosphotyrosine bioisostere inhibit protein tyrosine phosphatase 1B and augment insulin action

30 December 2023

16

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Structure determination of T cell protein-tyrosine phosphatase

30 December 2023

17

1 reference