Structures of modified eEF2 80S ribosome complexes reveal the role of GTP hydrolysis in translocation (Q27644523)

22 June 2017

title

Structures of modified eEF2 80S ribosome complexes reveal the role of GTP hydrolysis in translocation (English)

1 reference

22 June 2017

5

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Joachim Frank

6

object named as

Joachim Frank

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Jakob Nilsson

object named as

Jakob Nilsson

2

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author name string

Derek J Taylor

1

1 reference

22 June 2017

A Rod Merrill

3

1 reference

22 June 2017

Gregers Rom Andersen

4

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22 June 2017

language of work or name

English

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publication date

19 April 2007

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22 June 2017

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22 June 2017

volume

26

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22 June 2017

issue

9

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22 June 2017

page(s)

2421-2431

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Domain movements of elongation factor eEF2 and the eukaryotic 80S ribosome facilitate tRNA translocation

22 June 2017

cites work

1 reference

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20 March 2017

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Locking and unlocking of ribosomal motions

20 March 2017

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Study of the structural dynamics of the E coli 70S ribosome using real-space refinement

20 March 2017

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Two crystal structures demonstrate large conformational changes in the eukaryotic ribosomal translocase

20 March 2017

1 reference

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Recognition of cognate transfer RNA by the 30S ribosomal subunit

20 March 2017

1 reference

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Crystal structure of the ribosome at 5.5 A resolution

20 March 2017

1 reference

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X-Ray structures of the universal translation initiation factor IF2/eIF5B: conformational changes on GDP and GTP binding

20 March 2017

1 reference

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Solution structure of the E. coli 70S ribosome at 11.5 A resolution

20 March 2017

1 reference

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Three-dimensional structure of the ribosomal translocase: elongation factor G from Thermus thermophilus

20 March 2017

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The crystal structure of elongation factor G complexed with GDP, at 2.7 A resolution

20 March 2017

1 reference

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The crystal structure of elongation factor EF-Tu from Thermus aquaticus in the GTP conformation

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1864975

Crystal structure of the ternary complex of Phe-tRNAPhe, EF-Tu, and a GTP analog

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1864975

Structures of the bacterial ribosome at 3.5 A resolution

20 March 2017

1 reference

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SPIDER and WEB: processing and visualization of images in 3D electron microscopy and related fields

20 March 2017

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Improved methods for building protein models in electron density maps and the location of errors in these models

20 March 2017

1 reference

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Translation elongation factor 2 anticodon mimicry domain mutants affect fidelity and diphtheria toxin resistance

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1864975

Three-dimensional cryo-electron microscopy localization of EF2 in the Saccharomyces cerevisiae 80S ribosome at 17.5 A resolution

20 March 2017

1 reference

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The guanine nucleotide-binding switch in three dimensions

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1864975

Hydrolysis of GTP by elongation factor G drives tRNA movement on the ribosome

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1864975

Kinetic determination of the effects of ADP-ribosylation on the interaction of eukaryotic elongation factor 2 with ribosomes

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1864975

The role of guanosine 5′-triphosphate in polypeptide chain elongation

20 March 2017

1 reference

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Structure of the 80S ribosome from Saccharomyces cerevisiae--tRNA-ribosome and subunit-subunit interactions

20 March 2017

2 references

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7 April 2017

https://api.crossref.org/works/10.1038%2FSJ.EMBOJ.7601677

7 January 2021

inferred from DOI database lookup

A ratchet-like inter-subunit reorganization of the ribosome during translocation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1864975

Role and timing of GTP binding and hydrolysis during EF-G-dependent tRNA translocation on the ribosome

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1864975

The cryo-EM structure of a translation initiation complex from Escherichia coli

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1864975

Fitting of high-resolution structures into electron microscopy reconstruction images.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1864975

Mechanisms of elongation on the ribosome: dynamics of a macromolecular machine

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1864975

EF-G-independent reactivity of a pre-translocation-state ribosome complex with the aminoacyl tRNA substrate puromycin supports an intermediate (hybrid) state of tRNA binding

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1864975

Three-dimensional cryoelectron microscopy of ribosomes

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1864975

Thiostrepton inhibits the turnover but not the GTPase of elongation factor G on the ribosome.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1864975

Visualization of elongation factor G on the Escherichia coli 70S ribosome: the mechanism of translocation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1864975

Crystal structure of active elongation factor Tu reveals major domain rearrangements

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1864975

Chemical crosslinking of elongation factor G to the 23S RNA in 70S ribosomes fromEscherichia coli

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1864975

Ribosomal translocation: facts and models

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1864975

Comparative anatomy of 16-S-like ribosomal RNA.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1864975

Ribotoxin recognition of ribosomal RNA and a proposal for the mechanism of translocation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1864975

Visualization of release factor 3 on the ribosome during termination of protein synthesis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1864975

Movement of the decoding region of the 16 S ribosomal RNA accompanies tRNA translocation

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1864975

Large-scale movement of elongation factor G and extensive conformational change of the ribosome during translocation

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1864975

EF-G-dependent GTP hydrolysis induces translocation accompanied by large conformational changes in the 70S ribosome

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1864975

Saccharomyces cerevisiae elongation factor 2. Mutagenesis of the histidine precursor of diphthamide yields a functional protein that is resistant to diphtheria toxin.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1864975

Evidence that the G2661 region of 23S rRNA is located at the ribosomal binding sites of both elongation factors.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1864975

Translocation reaction promoted by polypeptide chain elongation factor-2 from pig liver

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1864975

Conformational transition of initiation factor 2 from the GTP- to GDP-bound state visualized on the ribosome.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1864975

Exotoxin A-eEF2 complex structure indicates ADP ribosylation by ribosome mimicry

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1864975

Crystal structure of a mutant elongation factor G trapped with a GTP analogue

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1864975

Identification of the versatile scaffold protein RACK1 on the eukaryotic ribosome by cryo-EM.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1864975

Crystal structure of ADP-ribosylated ribosomal translocase from Saccharomyces cerevisiae

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1864975

An elongation factor G-induced ribosome rearrangement precedes tRNA-mRNA translocation

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1864975

Insight into the catalytic mechanism of Pseudomonas aeruginosa exotoxin A. Studies of toxin interaction with eukaryotic elongation factor-2.

27 November 2018

1 reference

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Visualization of elongation factor Tu on the Escherichia coli ribosome.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1864975

Three-dimensional reconstruction with contrast transfer function correction from energy-filtered cryoelectron micrographs: procedure and application to the 70S Escherichia coli ribosome.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1864975

ADP-ribosylated elongation factor 2 (ADP-ribosyl-EF-2) is unable to promote translocation within the ribosome

27 November 2018

1 reference

12 December 2020

Elongation factor 2 mutants deficient in diphthamide formation show temperature-sensitive cell growth

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12 December 2020

Elongation factor 2 as a novel target for selective inhibition of fungal protein synthesis

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12 December 2020

Role of Domains 4 and 5 in Elongation Factor G Functions on the Ribosome

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12 December 2020

Identifiers

DOI

10.1038/SJ.EMBOJ.7601677

1 reference

release_toh52sfa7nc45fnt6vkvhnld6y

22 June 2017

Fatcat ID

0 references

OpenCitations bibliographic resource ID

1781137

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

1781137

1 reference