Mechanism of two classes of cancer mutations in the phosphoinositide 3-kinase catalytic subunit (Q27646654)

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2 January 2020

title

Mechanism of two classes of cancer mutations in the phosphoinositide 3-kinase catalytic subunit (English)

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2 January 2020

4

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2 January 2020

Marketa J Zvelebil

5

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2 January 2020

Roger L. Williams

10

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Haim J Wolfson

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2 January 2020

Dina Schneidman-Duhovny

7

object named as

Dina Schneidman-Duhovny

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2 January 2020

author name string

Nabil Miled

1

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2 January 2020

Ying Yan

2

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2 January 2020

Wai-Ching Hon

3

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2 January 2020

Yuval Inbar

6

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2 January 2020

Jonathan M Backer

9

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2 January 2020

language of work or name

English

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publication date

1 July 2007

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2 January 2020

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2 January 2020

volume

317

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2 January 2020

page(s)

239-242

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2 January 2020

issue

5835

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The phosphoinositide 3-kinase pathway

2 January 2020

cites work

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https://api.crossref.org/works/10.1126/SCIENCE.1135394

Synthesis and function of 3-phosphorylated inositol lipids

21 April 2017

1 reference

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PIK3CA mutations correlate with hormone receptors, node metastasis, and ERBB2, and are mutually exclusive with PTEN loss in human breast carcinoma

21 April 2017

1 reference

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High frequency of mutations of the PIK3CA gene in human cancers

21 April 2017

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Phosphatidylinositol 3-kinase mutations identified in human cancer are oncogenic

21 April 2017

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ConSurf 2005: the projection of evolutionary conservation scores of residues on protein structures

21 April 2017

1 reference

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Crystal structure of the PI 3-kinase p85 amino-terminal SH2 domain and its phosphopeptide complexes

21 April 2017

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Phosphoinositide 3-kinase signalling--which way to target?

21 April 2017

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Targeting the PI3K-Akt pathway in human cancer: rationale and promise

21 January 2018

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Phosphoinositide 3-kinases as targets for therapeutic intervention

21 January 2018

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Phosphoinositide 3-kinase in disease: timing, location, and scaffolding

21 January 2018

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Inhibiting the phosphoinositide 3-kinase pathway for cancer treatment

21 January 2018

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Class IA phosphoinositide 3-kinases are obligate p85-p110 heterodimers

21 January 2018

1 reference

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Regulation of the p85/p110 phosphatidylinositol 3'-kinase: stabilization and inhibition of the p110alpha catalytic subunit by the p85 regulatory subunit

21 January 2018

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New responsibilities for the PI3K regulatory subunit p85 alpha.

21 January 2018

1 reference

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The p85 regulatory subunit controls sequential activation of phosphoinositide 3-kinase by Tyr kinases and Ras.

21 January 2018

1 reference

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Regulation of the p85/p110alpha phosphatidylinositol 3'-kinase. Distinct roles for the n-terminal and c-terminal SH2 domains

21 January 2018

1 reference

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Oncogenic PI3K deregulates transcription and translation

21 January 2018

1 reference

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Functional analysis of PIK3CA gene mutations in human colorectal cancer

21 January 2018

1 reference

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Breast cancer-associated PIK3CA mutations are oncogenic in mammary epithelial cells

21 January 2018

1 reference

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Rare cancer-specific mutations in PIK3CA show gain of function

21 January 2018

1 reference

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Phosphoinositide 3-kinases as drug targets in cancer

21 January 2018

1 reference

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Activation loop sequences confer substrate specificity to phosphoinositide 3-kinase alpha (PI3Kalpha ). Functions of lipid kinase-deficient PI3Kalpha in signaling.

21 January 2018

1 reference

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The structure of the inter-SH2 domain of class IA phosphoinositide 3-kinase determined by site-directed spin labeling EPR and homology modeling

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1135394

Mutations in the inter-SH2 domain of the regulatory subunit of phosphoinositide 3-kinase: effects on catalytic subunit binding and holoenzyme function.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1135394

Mechanism of constitutive phosphoinositide 3-kinase activation by oncogenic mutants of the p85 regulatory subunit

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1135394

Structural insights into phosphoinositide 3-kinase catalysis and signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1135394

21 January 2018

Identifiers

DOI

10.1126/SCIENCE.1135394

2 references

Consolidated OpenCitations Corpus – April 2017

190262

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17626883%20AND%20SRC:MED&resulttype=core&format=json

2 January 2020

190262

1 reference

Consolidated OpenCitations Corpus – April 2017

Consolidated OpenCitations Corpus – April 2017

2 references

190262