Phosphoinositide 3-kinase signalling--which way to target? (Q35181798)

7 August 2017

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title

Phosphoinositide 3-kinase signalling--which way to target? (English)

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7 August 2017

Matthias P Wymann

1

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ORCID Public Data File 2021

Marketa J Zvelebil

object named as

Marketa Zvelebil

series ordinal

2

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ORCID Public Data File 2021

author name string

Muriel Laffargue

series ordinal

3

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PubMed ID

12871670

7 August 2017

language of work or name

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1 July 2003

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Trends in Pharmacological Sciences

7 August 2017

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7 August 2017

24

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7 August 2017

7

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7 August 2017

366-376

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The phosphoinositide 3-kinase pathway

7 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900163-9

7 January 2021

Structure and function of phosphoinositide 3-kinases.

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900163-9

7 January 2021

Synthesis and function of 3-phosphorylated inositol lipids

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https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900163-9

7 January 2021

Central role for G protein-coupled phosphoinositide 3-kinase gamma in inflammation.

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900163-9

7 January 2021

Function of PI3Kgamma in thymocyte development, T cell activation, and neutrophil migration

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900163-9

7 January 2021

Roles of PLC-beta2 and -beta3 and PI3Kgamma in chemoattractant-mediated signal transduction

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900163-9

7 January 2021

Phosphoinositide 3-kinase gamma is an essential amplifier of mast cell function

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900163-9

7 January 2021

Regulation of myocardial contractility and cell size by distinct PI3K-PTEN signaling pathways

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900163-9

7 January 2021

Phosphoinositide 3-kinase regulates beta2-adrenergic receptor endocytosis by AP-2 recruitment to the receptor/beta-arrestin complex

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900163-9

7 January 2021

Role of Gab1 in heart, placenta, and skin development and growth factor- and cytokine-induced extracellular signal-regulated kinase mitogen-activated protein kinase activation

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900163-9

7 January 2021

Essential role for Gab2 in the allergic response

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900163-9

7 January 2021

Critical role for Gab2 in transformation by BCR/ABL

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900163-9

7 January 2021

Tissue hyperplasia and enhanced T-cell signalling via ZAP-70 in c-Cbl-deficient mice

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900163-9

7 January 2021

Negative regulation of lymphocyte activation and autoimmunity by the molecular adaptor Cbl-b

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900163-9

7 January 2021

Impairment of T-cell-dependent B-cell responses and B-1 cell development in CD19-deficient mice.

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900163-9

7 January 2021

Essential immunoregulatory role for BCAP in B cell development and function

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900163-9

7 January 2021

Essential role of LAT in T cell development

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900163-9

7 January 2021

Ten years of protein kinase B signalling: a hard Akt to follow

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900163-9

7 January 2021

Phosphoinositide-regulated kinases and phosphoinositide phosphatases.

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https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900163-9

7 January 2021

Phosphoinositide-binding domains: Functional units for temporal and spatial regulation of intracellular signalling

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900163-9

7 January 2021

Regulation of cell size in growth, development and human disease: PI3K, PKB and S6K.

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900163-9

7 January 2021

The phosphatidylinositol 3-Kinase AKT pathway in human cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900163-9

7 January 2021

Forkhead transcription factors contribute to execution of the mitotic programme in mammals

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900163-9

7 January 2021

Phosphoinositide 3-kinase activates Rac by entering in a complex with Eps8, Abi1, and Sos-1.

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900163-9

7 January 2021

P-Rex1, a PtdIns(3,4,5)P3- and Gbetagamma-regulated guanine-nucleotide exchange factor for Rac

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900163-9

7 January 2021

Lipids on the move: phosphoinositide 3-kinases in leukocyte function

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900163-9

7 January 2021

Roles of PI3Ks in leukocyte chemotaxis and phagocytosis

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900163-9

7 January 2021

Proliferative defect and embryonic lethality in mice homozygous for a deletion in the p110alpha subunit of phosphoinositide 3-kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900163-9

7 January 2021

Essential role of PDK1 in regulating cell size and development in mice

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900163-9

7 January 2021

Increased insulin sensitivity and hypoglycaemia in mice lacking the p85 alpha subunit of phosphoinositide 3-kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900163-9

7 January 2021

Increased insulin sensitivity in mice lacking p85beta subunit of phosphoinositide 3-kinase

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https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900163-9

7 January 2021

Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene.

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900163-9

7 January 2021

Disruption of IRS-2 causes type 2 diabetes in mice

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900163-9

7 January 2021

Akt1/PKBalpha is required for normal growth but dispensable for maintenance of glucose homeostasis in mice

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900163-9

7 January 2021

Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKB beta)

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900163-9

7 January 2021

Pten is essential for embryonic development and tumour suppression

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900163-9

7 January 2021

Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900163-9

7 January 2021

Genetic deletion of the Pten tumor suppressor gene promotes cell motility by activation of Rac1 and Cdc42 GTPases

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900163-9

7 January 2021

Mice deficient in the Rac activator Tiam1 are resistant to Ras-induced skin tumours.

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900163-9

7 January 2021

Targeted disruption of SHIP leads to hemopoietic perturbations, lung pathology, and a shortened life span

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900163-9

7 January 2021

The lipid phosphatase SHIP2 controls insulin sensitivity

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https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900163-9

7 January 2021

Altered T cell receptor signaling and disrupted T cell development in mice lacking Itk.

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https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900163-9

7 January 2021

A Requirement for the Rho-Family GTP Exchange Factor Vav in Positive and Negative Selection of Thymocytes

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https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900163-9

7 January 2021

Signal transduction through Vav-2 participates in humoral immune responses and B cell maturation

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900163-9

7 January 2021

Impaired B cell development and proliferation in absence of phosphoinositide 3-kinase p85alpha.

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900163-9

7 January 2021

Xid-like immunodeficiency in mice with disruption of the p85alpha subunit of phosphoinositide 3-kinase.

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900163-9

7 January 2021

Defective B cell development and function in Btk-deficient mice

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900163-9

7 January 2021

Phospholipase Cgamma2 is essential in the functions of B cell and several Fc receptors

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900163-9

7 January 2021

Essential, nonredundant role for the phosphoinositide 3-kinase p110delta in signaling by the B-cell receptor complex.

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900163-9

7 January 2021

A crucial role for the p110delta subunit of phosphatidylinositol 3-kinase in B cell development and activation

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900163-9

7 January 2021

Polarization of chemoattractant receptor signaling during neutrophil chemotaxis

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900163-9

7 January 2021

Neutrophils lacking phosphoinositide 3-kinase gamma show loss of directionality during N-formyl-Met-Leu-Phe-induced chemotaxis

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900163-9

7 January 2021

Colorectal carcinomas in mice lacking the catalytic subunit of PI(3)Kgamma.

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900163-9

7 January 2021

Weakening link to colorectal cancer?

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900163-9

7 January 2021

The potential for novel anti-inflammatory therapies for coronary artery disease

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900163-9

7 January 2021

Wortmannin is a potent phosphatidylinositol 3-kinase inhibitor: the role of phosphatidylinositol 3,4,5-trisphosphate in neutrophil responses.

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900163-9

7 January 2021

Wortmannin inactivates phosphoinositide 3-kinase by covalent modification of Lys-802, a residue involved in the phosphate transfer reaction

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900163-9

7 January 2021

Structural Determinants of Phosphoinositide 3-Kinase Inhibition by Wortmannin, LY294002, Quercetin, Myricetin, and Staurosporine

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900163-9

7 January 2021

Inhibition of the phagocytosis-induced respiratory burst by the fungal metabolite wortmannin and some analogues

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900163-9

7 January 2021

Rapamycin inhibits primary and metastatic tumor growth by antiangiogenesis: involvement of vascular endothelial growth factor

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900163-9

7 January 2021

Essential role of phosphoinositide 3-kinase delta in neutrophil directional movement

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900163-9

7 January 2021

The role of ubiquitylation in signaling by growth factors: implications to cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900163-9

7 January 2021

Cbl-b, a RING-type E3 ubiquitin ligase, targets phosphatidylinositol 3-kinase for ubiquitination in T cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900163-9

7 January 2021

The G beta gamma sensitivity of a PI3K is dependent upon a tightly associated adaptor, p101

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900163-9

7 January 2021

Roles of G beta gamma in membrane recruitment and activation of p110 gamma/p101 phosphoinositide 3-kinase gamma

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900163-9

7 January 2021

Crystal structure and functional analysis of Ras binding to its effector phosphoinositide 3-kinase gamma

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900163-9

7 January 2021

Activation of phosphoinositide 3-kinase gamma by Ras.

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900163-9

7 January 2021

Amplification of B cell antigen receptor signaling by a Syk/ITAM positive feedback loop

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900163-9

7 January 2021

LAT, the Linker for Activation of T Cells: A Bridge Between T Cell-Specific and General Signaling Pathways

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900163-9

7 January 2021

High resolution mapping of mast cell membranes reveals primary and secondary domains of Fc(epsilon)RI and LAT.

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900163-9

7 January 2021

Cell cycle and death control: long live Forkheads

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900163-9

7 January 2021

Role of Akt signaling in vascular homeostasis and angiogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900163-9

7 January 2021

Phosphoinositide 3-kinase in immunological systems

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900163-9

7 January 2021

Resistance to thromboembolism in PI3Kgamma-deficient mice.

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900163-9

7 January 2021

Insulin resistance and growth retardation in mice lacking insulin receptor substrate-1.

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900163-9

7 January 2021

Severe B cell deficiency in mice lacking the tec kinase family members Tec and Btk.

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900163-9

7 January 2021

SWAP-70 is a guanine-nucleotide-exchange factor that mediates signalling of membrane ruffling

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900163-9

7 January 2021

Essential role of the tyrosine kinase substrate phospholipase C-gamma1 in mammalian growth and development

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900163-9

7 January 2021

SHIP-deficient mice are severely osteoporotic due to increased numbers of hyper-resorptive osteoclasts

1 reference

https://api.crossref.org/works/10.1016%2FS0165-6147%2803%2900163-9

7 January 2021

10.1016/S0165-6147(03)00163-9

Identifiers

DOI

1 reference

7 August 2017

1 reference

PubMed ID

12871670