Structural and Functional Characterization of the Human Protein Kinase ASK1 (Q27648785)

identical protein binding

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

author

Panagis Filippakopoulos

3

0 references

Eidarus Salah

2

0 references

Oleg Fedorov

Oleg Fedorov

4

0 references

Susanne Müller

Susanne Müller

5

0 references

Stefan Knapp

Stefan Knapp

11

0 references

Frank Sobott

Frank Sobott

6

0 references

Sirlester A Parker

7

Sirlester A Parker

0 references

Benjamin E Turk

10

Benjamin E Turk

0 references

author name string

Gabor Bunkoczi

1

0 references

Haifeng Zhang

8

0 references

Wang Min

Crystal Structures of the p21-Activated Kinases PAK4, PAK5, and PAK6 Reveal Catalytic Domain Plasticity of Active Group II PAKs

9

0 references

publication date

October 2007

0 references

published in

Structure

0 references

volume

15

0 references

issue

10

0 references

page(s)

1215-26

0 references

cites work

1 reference

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Apoptosis signal-regulating kinase (ASK) 2 functions as a mitogen-activated protein kinase kinase kinase in a heteromeric complex with ASK1

20 March 2017

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Structural characterization of the GSK-3beta active site using selective and non-selective ATP-mimetic inhibitors

20 March 2017

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Catalytically active MAP KAP kinase 2 structures in complex with staurosporine and ADP reveal differences with the autoinhibited enzyme

20 March 2017

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Crystal structure of an activated Akt/protein kinase B ternary complex with GSK3-peptide and AMP-PNP

20 March 2017

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Structural basis for Chk1 inhibition by UCN-01

20 March 2017

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Crystal structures of MAP kinase p38 complexed to the docking sites on its nuclear substrate MEF2A and activator MKK3b

20 March 2017

1 reference

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ASK1 is essential for endoplasmic reticulum stress-induced neuronal cell death triggered by expanded polyglutamine repeats

20 March 2017

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Activation of apoptosis signal-regulating kinase 1 by the stress-induced activating phosphorylation of pre-formed oligomer

20 March 2017

1 reference

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Negative feedback regulation of ASK1 by protein phosphatase 5 (PP5) in response to oxidative stress

20 March 2017

1 reference

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The cell cycle-regulatory CDC25A phosphatase inhibits apoptosis signal-regulating kinase 1

20 March 2017

1 reference

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Akt phosphorylates and negatively regulates apoptosis signal-regulating kinase 1

20 March 2017

1 reference

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Suppression of apoptosis signal-regulating kinase 1-induced cell death by 14-3-3 proteins

20 March 2017

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Structural analysis of the lymphocyte-specific kinase Lck in complex with non-selective and Src family selective kinase inhibitors

20 March 2017

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Structure of the protein tyrosine kinase domain of C-terminal Src kinase (CSK) in complex with staurosporine

20 March 2017

1 reference

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Mammalian thioredoxin is a direct inhibitor of apoptosis signal-regulating kinase (ASK) 1.

20 March 2017

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Staurosporine-induced conformational changes of cAMP-dependent protein kinase catalytic subunit explain inhibitory potential

20 March 2017

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Protein kinase inhibition by staurosporine revealed in details of the molecular interaction with CDK2

20 March 2017

1 reference

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Induction of apoptosis by ASK1, a mammalian MAPKKK that activates SAPK/JNK and p38 signaling pathways

20 March 2017

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Crystal Structure of the Catalytic Subunit of Cyclic Adenosine Monophosphate-Dependent Protein Kinase

20 March 2017

1 reference

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Likelihood-enhanced fast translation functions

20 March 2017

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Refinement of macromolecular structures by the maximum-likelihood method

20 March 2017

1 reference

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Size-Distribution Analysis of Macromolecules by Sedimentation Velocity Ultracentrifugation and Lamm Equation Modeling

20 March 2017

1 reference

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Double-stranded RNA-activated protein kinase interacts with apoptosis signal-regulating kinase 1. Implications for apoptosis signaling pathways

20 March 2017

1 reference

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Beta-arrestin 2: a receptor-regulated MAPK scaffold for the activation of JNK3

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2100151

Recruitment of tumor necrosis factor receptor-associated factor family proteins to apoptosis signal-regulating kinase 1 signalosome is essential for oxidative stress-induced cell death

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2100151

Conserved docking site is essential for activation of mammalian MAP kinase kinases by specific MAP kinase kinase kinases

20 March 2017

1 reference

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Regulation of zipper-interacting protein kinase activity in vitro and in vivo by multisite phosphorylation

20 March 2017

1 reference

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Regulation of protein kinases; controlling activity through activation segment conformation

20 March 2017

1 reference

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Structure of a peptide inhibitor bound to the catalytic subunit of cyclic adenosine monophosphate-dependent protein kinase

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2100151

The ASK1-MAP kinase signaling in ER stress and neurodegenerative diseases

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2100151

Role of apoptosis signal-regulating kinase 1 in stress-induced neural cell apoptosis in vivo

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2100151

ROS-dependent activation of the TRAF6-ASK1-p38 pathway is selectively required for TLR4-mediated innate immunity.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2100151

Humanin attenuates apoptosis induced by DRPLA proteins with expanded polyglutamine stretches

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2100151

A rapid method for determining protein kinase phosphorylation specificity

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2100151

The ASK1-MAP kinase cascades in mammalian stress response

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2100151

Amyloid beta induces neuronal cell death through ROS-mediated ASK1 activation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2100151

Structural basis for the selective inhibition of JNK1 by the scaffolding protein JIP1 and SP600125.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2100151

ASK1 (MAP3K5) as a potential therapeutic target in malignant fibrous histiocytomas with 12q14-q15 and 6q23 amplifications

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2100151

Thioredoxin promotes ASK1 ubiquitination and degradation to inhibit ASK1-mediated apoptosis in a redox activity-independent manner

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2100151

Apoptosis signal-regulating kinase 1 (ASK1) is an intracellular inducer of keratinocyte differentiation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2100151

ASK1 mediates apoptotic cell death induced by genotoxic stress.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2100151

The active conformation of the PAK1 kinase domain

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2100151

Thioredoxin-2 inhibits mitochondria-located ASK1-mediated apoptosis in a JNK-independent manner.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2100151

Negative control of apoptosis signal-regulating kinase 1 through phosphorylation of Ser-1034.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2100151

Essential role of E2-25K/Hip-2 in mediating amyloid-beta neurotoxicity

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2100151

The cytoplasmic domain of Alzheimer's amyloid-beta protein precursor causes sustained apoptosis signal-regulating kinase 1/c-Jun NH2-terminal kinase-mediated neurotoxic signal via dimerization.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2100151

The hCds1 (Chk2)-FHA domain is essential for a chain of phosphorylation events on hCds1 that is induced by ionizing radiation

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2100151

Hsp90-Akt phosphorylates ASK1 and inhibits ASK1-mediated apoptosis

27 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/17937911

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Docking interactions induce exposure of activation loop in the MAP kinase ERK2

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/17937911

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

[27] Maximum-likelihood heavy-atom parameter refinement for multiple isomorphous replacement and multiwavelength anomalous diffraction methods.

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/17937911