Crystal structure of human XLF/Cernunnos reveals unexpected differences from XRCC4 with implications for NHEJ (Q27649166)

Victor M Bolanos-Garcia

3

0 references

Stephen P Jackson

Stephen P Jackson

7

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Tom Blundell

8

Tom L Blundell

0 references

Dimitri Y Chirgadze

2

Dimitri Y Chirgadze

0 references

author name string

Yi Li

1

0 references

Bancinyane L Sibanda

4

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Peter Ahnesorg

Modes of interaction among yeast Nej1, Lif1 and Dnl4 proteins and comparison to human XLF, XRCC4 and Lig4

6

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language of work or name

English

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publication date

9 January 2008

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published in

The EMBO Journal

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volume

27

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issue

1

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page(s)

290-300

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cites work

1 reference

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Cernunnos/XLF promotes the ligation of mismatched and noncohesive DNA ends

20 March 2017

1 reference

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Structural model of full-length human Ku70-Ku80 heterodimer and its recognition of DNA and DNA-PKcs

20 March 2017

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20 March 2017

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XLF interacts with the XRCC4-DNA ligase IV complex to promote DNA nonhomologous end-joining

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2104711

Cernunnos, a novel nonhomologous end-joining factor, is mutated in human immunodeficiency with microcephaly

20 March 2017

1 reference

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20 March 2017

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Nonhomologous end joining and V(D)J recombination require an additional factor

20 March 2017

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Synapsis of DNA ends by DNA-dependent protein kinase

20 March 2017

1 reference

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Crystal structure of an Xrcc4-DNA ligase IV complex

20 March 2017

1 reference

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Crystal structure of the Xrcc4 DNA repair protein and implications for end joining

20 March 2017

1 reference

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Mammalian DNA double-strand break repair protein XRCC4 interacts with DNA ligase IV

20 March 2017

1 reference

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Activity of DNA ligase IV stimulated by complex formation with XRCC4 protein in mammalian cells

20 March 2017

1 reference

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Coot: model-building tools for molecular graphics

20 March 2017

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Size-Distribution Analysis of Macromolecules by Sedimentation Velocity Ultracentrifugation and Lamm Equation Modeling

20 March 2017

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Predicting coiled coils from protein sequences

20 March 2017

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FUGUE: sequence-structure homology recognition using environment-specific substitution tables and structure-dependent gap penalties

20 March 2017

1 reference

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Chromosomal stability and the DNA double-stranded break connection

20 March 2017

1 reference

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DNA double-strand breaks: signaling, repair and the cancer connection

20 March 2017

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Ku, a DNA repair protein with multiple cellular functions?

20 March 2017

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The Artemis:DNA-PKcs endonuclease cleaves DNA loops, flaps, and gaps

20 March 2017

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The DNA-dependent protein kinase: requirement for DNA ends and association with Ku antigen

20 March 2017

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Protein disorder prediction: implications for structural proteomics

20 March 2017

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7 April 2017

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Length-dependent binding of human XLF to DNA and stimulation of XRCC4.DNA ligase IV activity

7 April 2017

1 reference

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DNA double-strand break repair: all's well that ends well

29 September 2017

1 reference

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Cernunnos interacts with the XRCC4 x DNA-ligase IV complex and is homologous to the yeast nonhomologous end-joining factor Nej1.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2104711

DNA double-strand break repair: a relentless hunt uncovers new prey.

29 September 2017

1 reference

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FoldIndex: a simple tool to predict whether a given protein sequence is intrinsically unfolded

29 September 2017

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An overview of three new disorders associated with genetic instability: LIG4 syndrome, RS-SCID and ATR-Seckel syndrome

29 September 2017

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The role of the non-homologous end-joining pathway in lymphocyte development

29 September 2017

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Human severe combined immune deficiency and DNA repair

29 September 2017

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Evolutionary trace analysis of TGF-beta and related growth factors: implications for site-directed mutagenesis.

29 September 2017

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Prediction of the stability of protein mutants based on structural environment-dependent amino acid substitution and propensity tables

29 September 2017

1 reference

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Evolutionary and functional conservation of the DNA non-homologous end-joining protein, XLF/Cernunnos

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2104711

Tying loose ends: roles of Ku and DNA-dependent protein kinase in the repair of double-strand breaks

2 June 2018

1 reference

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Optimal docking area: a new method for predicting protein-protein interaction sites

2 June 2018

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Protein sequence alignments: a strategy for the hierarchical analysis of residue conservation.

27 November 2018

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[29] Identification of functional residues and secondary structure from protein multiple sequence alignment

27 November 2018

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PubMed

https://pubmed.ncbi.nlm.nih.gov/18046455

12 December 2020

inferred from PubMed ID database lookup

DNA end-joining: from yeast to man

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18046455

12 December 2020

inferred from PubMed ID database lookup

[How to make good use of CLUSTALW]

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18046455

12 December 2020

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CRYSOL– a Program to Evaluate X-ray Solution Scattering of Biological Macromolecules from Atomic Coordinates

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FSJ.EMBOJ.7601942

7 January 2021

inferred from DOI database lookup

Identifiers

DOI

10.1038/SJ.EMBOJ.7601942

1 reference

3748379

3748379

1 reference

1 reference

1 reference