Activation of Rho GTPases by DOCK exchange factors is mediated by a nucleotide sensor (Q27657391)

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S Mark Roe

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Christopher J Marshall

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David Barford

Rho GTPases: biochemistry and biology

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language of work or name

English

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publication date

11 September 2009

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published in

Science

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volume

325

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issue

5946

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page(s)

1398-402

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cites work

1 reference

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The guanine nucleotide-binding switch in three dimensions

20 April 2017

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GEFs and GAPs: critical elements in the control of small G proteins

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CZH proteins: a new family of Rho-GEFs

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GEF what? Dock180 and related proteins help Rac to polarize cells in new ways

20 April 2017

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Rac activation and inactivation control plasticity of tumor cell movement

20 April 2017

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DOCK10-mediated Cdc42 activation is necessary for amoeboid invasion of melanoma cells

20 April 2017

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A novel and evolutionarily conserved PtdIns(3,4,5)P3-binding domain is necessary for DOCK180 signalling

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CED-12/ELMO, a novel member of the CrkII/Dock180/Rac pathway, is required for phagocytosis and cell migration

20 April 2017

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An alpha-helical extension of the ELMO1 pleckstrin homology domain mediates direct interaction to DOCK180 and is critical in Rac signaling

20 April 2017

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Structures of Cdc42 bound to the active and catalytically compromised forms of Cdc42GAP

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Effector Proteins Exert an Important Influence on the Signaling-active State of the Small GTPase Cdc42

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The structural basis of the activation of Ras by Sos

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Crystal structure of Rac1 in complex with the guanine nucleotide exchange region of Tiam1

20 April 2017

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Structural basis for the reversible activation of a Rho protein by the bacterial toxin SopE.

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Structural evidence for a common intermediate in small G protein-GEF reactions

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Membrane recruitment of DOCK180 by binding to PtdIns(3,4,5)P3

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GEF means go: turning on RHO GTPases with guanine nucleotide-exchange factors

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Mammalian Rho GTPases: new insights into their functions from in vivo studies

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Zizimin1, a novel Cdc42 activator, reveals a new GEF domain for Rho proteins

20 April 2017

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Dock6, a Dock-C subfamily guanine nucleotide exchanger, has the dual specificity for Rac1 and Cdc42 and regulates neurite outgrowth

21 January 2018

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DOCK180, a major CRK-binding protein, alters cell morphology upon translocation to the cell membrane

21 January 2018

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The novel Cdc42 guanine nucleotide exchange factor, zizimin1, dimerizes via the Cdc42-binding CZH2 domain

21 January 2018

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Nucleotide binding to the G12V-mutant of Cdc42 investigated by X-ray diffraction and fluorescence spectroscopy: Two different nucleotide states in one crystal

21 January 2018

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Functional analysis of cdc42 residues required for Guanine nucleotide exchange

21 January 2018

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