Mutant N143P Reveals How Na+ Activates Thrombin (Q27657884)

2

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Leslie A Bush-Pelc

3

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Alaji Bah

4

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Prafull S Gandhi

5

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Enrico Di Cera

Journal of Biological Chemistry

6

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language of work or name

English

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publication date

25 December 2009

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published in

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volume

284

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issue

52

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page(s)

36175-85

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cites work

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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An extensive interaction interface between thrombin and factor V is required for factor V activation

21 January 2018

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Exosite-interactive regions in the A1 and A2 domains of factor VIII facilitate thrombin-catalyzed cleavage of heavy chain

21 January 2018

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Thrombin activation of factor XI on activated platelets requires the interaction of factor XI and platelet glycoprotein Ib alpha with thrombin anion-binding exosites I and II, respectively

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Protein engineering thrombin for optimal specificity and potency of anticoagulant activity in vivo

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21 January 2018

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Dissecting substrate recognition by thrombin using the inactive mutant S195A.

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Use of a fluorescence plate reader for measuring kinetic parameters with inner filter effect correction

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Processing of X-ray diffraction data collected in oscillation mode

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Energetic and structural consequences of perturbing Gly-193 in the oxyanion hole of serine proteases

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Residue Asp-189 controls both substrate binding and the monovalent cation specificity of thrombin

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21 January 2018

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12 December 2020

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[Purification and properties of the beta-galactosidase (lactase) of Escherichia coli]

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Prothrombin deficiency caused by compound heterozygosity for two novel mutations in the prothrombin gene associated with a bleeding tendency

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Kinetic studies of the role of monovalent cations in the amidolytic activity of activated bovine plasma protein C

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12 December 2020

Modeling coordination sites in metallobiomolecules

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12 December 2020

Evidence that human alpha-thrombin is a monovalent cation-activated enzyme

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12 December 2020

The Na+ binding site of thrombin

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12 December 2020

Release of fibrinopeptides by the slow and fast forms of thrombin

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Large heat capacity change in a protein-monovalent cation interaction

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12 December 2020

Rational engineering of activity and specificity in a serine protease

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Selective loss of fibrinogen clotting in a loop-less thrombin

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12 December 2020

Kinetic pathway for the slow to fast transition of thrombin. Evidence of linked ligand binding at structurally distinct domains

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Prothrombin Greenville, Arg517-->Gln, identified in an individual heterozygous for dysprothrombinemia

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Identification and characterization of the sodium-binding site of activated protein C

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Identifiers

DOI

10.1074/JBC.M109.069500

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/yp4iityo7bd2bewnmwujbkc22u

30 July 2022

release_yp4iityo7bd2bewnmwujbkc22u

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/yp4iityo7bd2bewnmwujbkc22u

30 July 2022

https://api.fatcat.wiki/v0/release/yp4iityo7bd2bewnmwujbkc22u

1 reference

30 July 2022

https://api.fatcat.wiki/v0/release/yp4iityo7bd2bewnmwujbkc22u

PubMed publication ID

1 reference

30 July 2022