A crystal structure of the bifunctional antibiotic simocyclinone D8, bound to DNA gyrase (Q27658456)

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13 February 2020

title

A crystal structure of the bifunctional antibiotic simocyclinone D8, bound to DNA gyrase (English)

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13 February 2020

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3

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13 February 2020

Tung Bk Le

5

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13 February 2020

Tom A. Clarke

6

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13 February 2020

Mark J Buttner

9

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13 February 2020

Anthony Maxwell

11

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13 February 2020

author name string

Marcus J Edwards

1

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13 February 2020

Ruth H Flatman

2

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13 February 2020

Clare E M Stevenson

4

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13 February 2020

Adam R McKay

7

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13 February 2020

Hans-Peter Fiedler

8

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13 February 2020

David M Lawson

10

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13 February 2020

language of work or name

English

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publication date

1 December 2009

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13 February 2020

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13 February 2020

volume

326

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13 February 2020

issue

5958

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13 February 2020

page(s)

1415-1418

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The ATP-binding site of type II topoisomerases as a target for antibacterial drugs

13 February 2020

cites work

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1179123

An open conformation of the Thermus thermophilus gyrase B ATP-binding domain

21 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1179123

Structure-activity relationships of aminocoumarin-type gyrase and topoisomerase IV inhibitors obtained by combinatorial biosynthesis

21 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1179123

Crystal structure of the breakage-reunion domain of DNA gyrase

21 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1179123

Structural insight into the quinolone-DNA cleavage complex of type IIA topoisomerases

21 April 2017

1 reference

https://api.crossref.org/works/10.1126/SCIENCE.1179123

DNA gyrase as a drug target

21 April 2017

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1179123

The high-resolution crystal structure of a 24-kDa gyrase B fragment from E. coli complexed with one of the most potent coumarin inhibitors, clorobiocin

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1179123

New aminocoumarin antibiotics from genetically engineered Streptomyces strains.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1179123

Biological activities of novel gyrase inhibitors of the aminocoumarin class

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1179123

Cloning and analysis of the simocyclinone biosynthetic gene cluster of Streptomyces antibioticus Tü 6040.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1179123

Biosynthetic gene cluster of simocyclinone, a natural multihybrid antibiotic

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1179123

Simocyclinone D8, an inhibitor of DNA gyrase with a novel mode of action

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1179123

In vivo and in vitro patterns of the activity of simocyclinone D8, an angucyclinone antibiotic from Streptomyces antibioticus

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1179123

Chemical conditionality: a genetic strategy to probe organelle assembly

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1179123

Quinolone resistance-determining region in the DNA gyrase gyrB gene of Escherichia coli

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1179123

Quinolone resistance-determining region in the DNA gyrase gyrA gene of Escherichia coli

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.1179123

Simocyclinones, Novel Cytostatic Angucyclinone Antibiotics Produced by Streptomyces antibioticus Tue 6040. I. Taxonomy, Fermentation, Isolation and Biological Activities.

21 January 2018

1 reference

12 April 2024

https://opencitations.net/index/api/v1/citations/10.7164/ANTIBIOTICS.53.779

Identifiers

DOI

10.1126/SCIENCE.1179123

2 references

Consolidated OpenCitations Corpus – April 2017

3346567

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19965760%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

3346567

1 reference

Consolidated OpenCitations Corpus – April 2017

Consolidated OpenCitations Corpus – April 2017

2 references

3346567